> top > docs > PMC:7352545 > spans > 26150-28684 > annotations

PMC:7352545 / 26150-28684 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T92 338-340 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T93 546-548 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T94 855-857 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T95 934-940 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T96 957-959 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T97 1085-1091 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T98 1251-1253 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T99 1426-1428 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T100 1753-1755 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T101 1851-1853 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T102 2215-2217 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T224 78-91 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T225 380-388 Body_part denotes Proteins http://purl.org/sig/ont/fma/fma67257
T226 1177-1181 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T227 1645-1651 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T228 1880-1893 Body_part denotes glycoproteins http://purl.org/sig/ont/fma/fma62925
T229 1965-1969 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T230 2001-2009 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T231 2023-2033 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T232 2418-2421 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T233 2456-2460 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T101 350-359 Disease denotes Influenza http://purl.obolibrary.org/obo/MONDO_0005812
T102 402-411 Disease denotes Influenza http://purl.obolibrary.org/obo/MONDO_0005812
T103 488-497 Disease denotes Influenza http://purl.obolibrary.org/obo/MONDO_0005812
T104 591-600 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T105 831-840 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T106 992-1001 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T107 1140-1149 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T108 1497-1506 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T109 1909-1918 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T110 2167-2176 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T111 2320-2329 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T338 66-73 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T339 104-109 http://purl.obolibrary.org/obo/CLO_0053120 denotes HE, S
T340 234-237 http://purl.obolibrary.org/obo/CLO_0051568 denotes SAs
T341 307-312 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T342 360-365 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Virus
T343 366-367 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T344 372-373 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T345 412-413 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T346 418-419 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T347 420-427 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T348 475-477 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T349 500-505 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T350 582-583 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T351 584-585 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T352 603-608 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T353 657-658 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T354 843-848 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T355 963-964 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T356 1004-1009 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T357 1057-1065 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T358 1093-1095 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T359 1150-1155 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T360 1177-1181 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T361 1486-1493 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T362 1509-1514 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T363 1623-1624 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T364 1736-1738 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T365 1921-1926 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T366 1965-1969 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T367 1992-2000 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T368 2023-2042 http://purl.obolibrary.org/obo/CHEBI_33708 denotes amino acid residues
T369 2023-2042 http://purl.obolibrary.org/obo/PR_000036907 denotes amino acid residues
T370 2179-2184 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T371 2246-2249 http://purl.obolibrary.org/obo/CLO_0053120 denotes HEs
T372 2332-2337 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T373 2456-2460 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T374 2488-2491 http://purl.obolibrary.org/obo/CLO_0053120 denotes HEs

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T708 78-91 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T709 100-102 Chemical denotes HA http://purl.obolibrary.org/obo/CHEBI_73924
T710 249-258 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T711 335-337 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T713 338-340 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T718 392-394 Chemical denotes HA http://purl.obolibrary.org/obo/CHEBI_73924
T719 399-401 Chemical denotes NA http://purl.obolibrary.org/obo/CHEBI_33696
T720 464-466 Chemical denotes HA http://purl.obolibrary.org/obo/CHEBI_73924
T721 471-473 Chemical denotes NA http://purl.obolibrary.org/obo/CHEBI_33696
T722 506-508 Chemical denotes HA http://purl.obolibrary.org/obo/CHEBI_73924
T723 546-548 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T728 748-760 Chemical denotes acetyl group http://purl.obolibrary.org/obo/CHEBI_40574
T729 748-754 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_46887
T730 755-760 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T731 855-857 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T736 900-906 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887
T738 911-916 Chemical denotes NeuAc http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_49018
T740 934-940 Chemical denotes Neu5Ac http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133
T742 950-956 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887
T744 957-959 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T749 1075-1081 Chemical denotes Neu5Gc http://purl.obolibrary.org/obo/CHEBI_62084
T750 1085-1091 Chemical denotes Neu5Ac http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133
T752 1234-1239 Chemical denotes D-Gal http://purl.obolibrary.org/obo/CHEBI_12936
T753 1236-1239 Chemical denotes Gal http://purl.obolibrary.org/obo/CHEBI_28260
T754 1243-1249 Chemical denotes GalNAc http://purl.obolibrary.org/obo/CHEBI_28037|http://purl.obolibrary.org/obo/CHEBI_28800
T756 1251-1253 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T761 1291-1297 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887
T763 1326-1331 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T764 1350-1365 Chemical denotes guanidino group http://purl.obolibrary.org/obo/CHEBI_48551
T765 1360-1365 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T766 1394-1399 Chemical denotes CH3CO http://purl.obolibrary.org/obo/CHEBI_46887
T767 1400-1408 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T768 1409-1415 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T769 1426-1428 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T774 1753-1755 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T779 1848-1850 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T781 1851-1853 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T786 1880-1893 Chemical denotes glycoproteins http://purl.obolibrary.org/obo/CHEBI_17089
T787 2001-2009 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T788 2023-2033 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T789 2023-2028 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T790 2029-2033 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T791 2215-2217 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T46 1048-1065 http://purl.obolibrary.org/obo/GO_0038024 denotes receptor activity
T47 1182-1189 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T48 2062-2077 http://purl.obolibrary.org/obo/GO_0006487 denotes N-glycosylation
T49 2064-2077 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T251 0-4 Sentence denotes 5.1.
T252 5-57 Sentence denotes Evolutionary Origin and Classification of the CoV HE
T253 58-159 Sentence denotes Certain viruses use glycoproteins such as HA, HE, S and HEF for host receptor binding or destruction.
T254 160-284 Sentence denotes Coronaviridae, Orthomyxoviridae, Paramyxoviridae and Adenoviridae utilize SAs as binding molecules for attachment and entry.
T255 285-341 Sentence denotes However, only limited human pathogens recognize O-Ac SA.
T256 343-349 Sentence denotes 5.1.1.
T257 350-401 Sentence denotes Influenza Virus A and B Spike Proteins of HA and NA
T258 402-479 Sentence denotes Influenza A and B viruses bear two spikes of receptor-binding HA and NA [45].
T259 481-487 Sentence denotes 5.1.2.
T260 488-512 Sentence denotes Influenza C virus HA-HEF
T261 513-566 Sentence denotes HEF is indeed an ancient type of SA-O-acetylesterase.
T262 567-675 Sentence denotes In contrast to A/B, the influenza C virus bears one spike with triple functions of HEF as a homotrimer [46].
T263 676-761 Sentence denotes Each HEF subunit bears two Neu5,9Ac2-binding sites and binds to the 9-O-acetyl group.
T264 762-822 Sentence denotes In parallel, another modification of O-acetylation is found.
T265 823-941 Sentence denotes Indeed, influenza C virus bears SA-O-acetylesterase [47], which converts 5-N-acetyl-9-O-NeuAc (Neu5,9Ac2) to 5-Neu5Ac.
T266 942-1097 Sentence denotes The 9-O-acetyl SA is a unique determinant for the influenza C virus receptor and Neu5,9Ac2 is crucial for receptor activity, but not Neu5Gc or Neu5Ac [48].
T267 1098-1190 Sentence denotes Neu5,9Ac2 is an essential determinant for influenza virus C type-specific host cell tropism.
T268 1191-1250 Sentence denotes NAs cleave the α-ketosidic linkages to the D-Gal or GalNAc.
T269 1251-1318 Sentence denotes SA-O-acetylesterases cleave different O-acetyl linkages (Figure 5).
T270 1319-1421 Sentence denotes The OH-group of Tyr224 and the guanidino group of Arg236 interact with the CH3CO-carbonyl oxygen [49].
T271 1422-1561 Sentence denotes HEF SA-O-acetylesterase is found in several enveloped (+) ssRNA viruses of influenza C virus and also in certain CoVs and toroviruses [47].
T272 1562-1740 Sentence denotes The CoVs are different from the orthomyxoviruses, which hold a segmented (−) ssRNA genome and are instead evolutionary linked to the family Coronaviridae, order Nidovirales [45].
T273 1742-1748 Sentence denotes 5.1.3.
T274 1749-1775 Sentence denotes CoV SA-O-Acetylesterase HE
T275 1776-1864 Sentence denotes CoVs and toroviruses of the Coronaviridae family are specific for the O-Ac SA receptors.
T276 1865-1931 Sentence denotes Their S and HE glycoproteins are similar to influenza C virus HEF.
T277 1932-2089 Sentence denotes CoVs and all toroviruses bear HE gene form class I envelope membrane proteins of about 400 amino acid residues which bear 7 to 12 N-glycosylation sites [50].
T278 2090-2122 Sentence denotes HE multimer forms enter virions.
T279 2123-2241 Sentence denotes Bovine CoV (BCoV) and HCoV-OC43, similar to influenza C virus, recognize Neu5,9Ac2 and bear SA-9-O-acetylesterase [8].
T280 2242-2276 Sentence denotes CoV HEs are all O-acetylesterases.
T281 2277-2470 Sentence denotes The HE enzymes found in torovirus, CoV and influenza C virus are evolutionarily interspecies-mutated with about 30% homology by heterologous RNA recombination [51] and horizontal gene transfer.
T282 2471-2534 Sentence denotes Therefore, viral HEs are diverse and widespread over evolution.

2_test

Id Subject Object Predicate Lexical cue
32604730-3660588-51943986 671-673 3660588 denotes 46
32604730-2411539-51943987 876-878 2411539 denotes 47
32604730-9817207-51943988 1417-1419 9817207 denotes 49
32604730-2411539-51943989 1557-1559 2411539 denotes 47
32604730-2319653-51943990 2085-2087 2319653 denotes 50
32604730-3380803-51943991 2238-2239 3380803 denotes 8
32604730-1984666-51943992 2437-2439 1984666 denotes 51
T4072 671-673 3660588 denotes 46
T45662 876-878 2411539 denotes 47
T64932 1417-1419 9817207 denotes 49
T56258 1557-1559 2411539 denotes 47
T27350 2085-2087 2319653 denotes 50
T79342 2238-2239 3380803 denotes 8
T89890 2437-2439 1984666 denotes 51