PMC:7352545 / 26150-28684
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T92 | 338-340 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T93 | 546-548 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T94 | 855-857 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T95 | 934-940 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T96 | 957-959 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T97 | 1085-1091 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T98 | 1251-1253 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T99 | 1426-1428 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T100 | 1753-1755 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T101 | 1851-1853 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T102 | 2215-2217 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T224 | 78-91 | Body_part | denotes | glycoproteins | http://purl.org/sig/ont/fma/fma62925 |
| T225 | 380-388 | Body_part | denotes | Proteins | http://purl.org/sig/ont/fma/fma67257 |
| T226 | 1177-1181 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T227 | 1645-1651 | Body_part | denotes | genome | http://purl.org/sig/ont/fma/fma84116 |
| T228 | 1880-1893 | Body_part | denotes | glycoproteins | http://purl.org/sig/ont/fma/fma62925 |
| T229 | 1965-1969 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T230 | 2001-2009 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T231 | 2023-2033 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T232 | 2418-2421 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T233 | 2456-2460 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T101 | 350-359 | Disease | denotes | Influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T102 | 402-411 | Disease | denotes | Influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T103 | 488-497 | Disease | denotes | Influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T104 | 591-600 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T105 | 831-840 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T106 | 992-1001 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T107 | 1140-1149 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T108 | 1497-1506 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T109 | 1909-1918 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T110 | 2167-2176 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T111 | 2320-2329 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T338 | 66-73 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T339 | 104-109 | http://purl.obolibrary.org/obo/CLO_0053120 | denotes | HE, S |
| T340 | 234-237 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T341 | 307-312 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T342 | 360-365 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | Virus |
| T343 | 366-367 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T344 | 372-373 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T345 | 412-413 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T346 | 418-419 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T347 | 420-427 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T348 | 475-477 | http://purl.obolibrary.org/obo/CLO_0053799 | denotes | 45 |
| T349 | 500-505 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T350 | 582-583 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T351 | 584-585 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T352 | 603-608 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T353 | 657-658 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T354 | 843-848 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T355 | 963-964 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T356 | 1004-1009 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T357 | 1057-1065 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T358 | 1093-1095 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
| T359 | 1150-1155 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T360 | 1177-1181 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T361 | 1486-1493 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T362 | 1509-1514 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T363 | 1623-1624 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T364 | 1736-1738 | http://purl.obolibrary.org/obo/CLO_0053799 | denotes | 45 |
| T365 | 1921-1926 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T366 | 1965-1969 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T367 | 1992-2000 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T368 | 2023-2042 | http://purl.obolibrary.org/obo/CHEBI_33708 | denotes | amino acid residues |
| T369 | 2023-2042 | http://purl.obolibrary.org/obo/PR_000036907 | denotes | amino acid residues |
| T370 | 2179-2184 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T371 | 2246-2249 | http://purl.obolibrary.org/obo/CLO_0053120 | denotes | HEs |
| T372 | 2332-2337 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T373 | 2456-2460 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T374 | 2488-2491 | http://purl.obolibrary.org/obo/CLO_0053120 | denotes | HEs |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T708 | 78-91 | Chemical | denotes | glycoproteins | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T709 | 100-102 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T710 | 249-258 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T711 | 335-337 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T713 | 338-340 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T718 | 392-394 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T719 | 399-401 | Chemical | denotes | NA | http://purl.obolibrary.org/obo/CHEBI_33696 |
| T720 | 464-466 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T721 | 471-473 | Chemical | denotes | NA | http://purl.obolibrary.org/obo/CHEBI_33696 |
| T722 | 506-508 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T723 | 546-548 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T728 | 748-760 | Chemical | denotes | acetyl group | http://purl.obolibrary.org/obo/CHEBI_40574 |
| T729 | 748-754 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_46887 |
| T730 | 755-760 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T731 | 855-857 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T736 | 900-906 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T738 | 911-916 | Chemical | denotes | NeuAc | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_49018 |
| T740 | 934-940 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T742 | 950-956 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T744 | 957-959 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T749 | 1075-1081 | Chemical | denotes | Neu5Gc | http://purl.obolibrary.org/obo/CHEBI_62084 |
| T750 | 1085-1091 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T752 | 1234-1239 | Chemical | denotes | D-Gal | http://purl.obolibrary.org/obo/CHEBI_12936 |
| T753 | 1236-1239 | Chemical | denotes | Gal | http://purl.obolibrary.org/obo/CHEBI_28260 |
| T754 | 1243-1249 | Chemical | denotes | GalNAc | http://purl.obolibrary.org/obo/CHEBI_28037|http://purl.obolibrary.org/obo/CHEBI_28800 |
| T756 | 1251-1253 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T761 | 1291-1297 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T763 | 1326-1331 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T764 | 1350-1365 | Chemical | denotes | guanidino group | http://purl.obolibrary.org/obo/CHEBI_48551 |
| T765 | 1360-1365 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T766 | 1394-1399 | Chemical | denotes | CH3CO | http://purl.obolibrary.org/obo/CHEBI_46887 |
| T767 | 1400-1408 | Chemical | denotes | carbonyl | http://purl.obolibrary.org/obo/CHEBI_23019 |
| T768 | 1409-1415 | Chemical | denotes | oxygen | http://purl.obolibrary.org/obo/CHEBI_25805 |
| T769 | 1426-1428 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T774 | 1753-1755 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T779 | 1848-1850 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T781 | 1851-1853 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T786 | 1880-1893 | Chemical | denotes | glycoproteins | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T787 | 2001-2009 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T788 | 2023-2033 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T789 | 2023-2028 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T790 | 2029-2033 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T791 | 2215-2217 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T46 | 1048-1065 | http://purl.obolibrary.org/obo/GO_0038024 | denotes | receptor activity |
| T47 | 1182-1189 | http://purl.obolibrary.org/obo/GO_0009606 | denotes | tropism |
| T48 | 2062-2077 | http://purl.obolibrary.org/obo/GO_0006487 | denotes | N-glycosylation |
| T49 | 2064-2077 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T251 | 0-4 | Sentence | denotes | 5.1. |
| T252 | 5-57 | Sentence | denotes | Evolutionary Origin and Classification of the CoV HE |
| T253 | 58-159 | Sentence | denotes | Certain viruses use glycoproteins such as HA, HE, S and HEF for host receptor binding or destruction. |
| T254 | 160-284 | Sentence | denotes | Coronaviridae, Orthomyxoviridae, Paramyxoviridae and Adenoviridae utilize SAs as binding molecules for attachment and entry. |
| T255 | 285-341 | Sentence | denotes | However, only limited human pathogens recognize O-Ac SA. |
| T256 | 343-349 | Sentence | denotes | 5.1.1. |
| T257 | 350-401 | Sentence | denotes | Influenza Virus A and B Spike Proteins of HA and NA |
| T258 | 402-479 | Sentence | denotes | Influenza A and B viruses bear two spikes of receptor-binding HA and NA [45]. |
| T259 | 481-487 | Sentence | denotes | 5.1.2. |
| T260 | 488-512 | Sentence | denotes | Influenza C virus HA-HEF |
| T261 | 513-566 | Sentence | denotes | HEF is indeed an ancient type of SA-O-acetylesterase. |
| T262 | 567-675 | Sentence | denotes | In contrast to A/B, the influenza C virus bears one spike with triple functions of HEF as a homotrimer [46]. |
| T263 | 676-761 | Sentence | denotes | Each HEF subunit bears two Neu5,9Ac2-binding sites and binds to the 9-O-acetyl group. |
| T264 | 762-822 | Sentence | denotes | In parallel, another modification of O-acetylation is found. |
| T265 | 823-941 | Sentence | denotes | Indeed, influenza C virus bears SA-O-acetylesterase [47], which converts 5-N-acetyl-9-O-NeuAc (Neu5,9Ac2) to 5-Neu5Ac. |
| T266 | 942-1097 | Sentence | denotes | The 9-O-acetyl SA is a unique determinant for the influenza C virus receptor and Neu5,9Ac2 is crucial for receptor activity, but not Neu5Gc or Neu5Ac [48]. |
| T267 | 1098-1190 | Sentence | denotes | Neu5,9Ac2 is an essential determinant for influenza virus C type-specific host cell tropism. |
| T268 | 1191-1250 | Sentence | denotes | NAs cleave the α-ketosidic linkages to the D-Gal or GalNAc. |
| T269 | 1251-1318 | Sentence | denotes | SA-O-acetylesterases cleave different O-acetyl linkages (Figure 5). |
| T270 | 1319-1421 | Sentence | denotes | The OH-group of Tyr224 and the guanidino group of Arg236 interact with the CH3CO-carbonyl oxygen [49]. |
| T271 | 1422-1561 | Sentence | denotes | HEF SA-O-acetylesterase is found in several enveloped (+) ssRNA viruses of influenza C virus and also in certain CoVs and toroviruses [47]. |
| T272 | 1562-1740 | Sentence | denotes | The CoVs are different from the orthomyxoviruses, which hold a segmented (−) ssRNA genome and are instead evolutionary linked to the family Coronaviridae, order Nidovirales [45]. |
| T273 | 1742-1748 | Sentence | denotes | 5.1.3. |
| T274 | 1749-1775 | Sentence | denotes | CoV SA-O-Acetylesterase HE |
| T275 | 1776-1864 | Sentence | denotes | CoVs and toroviruses of the Coronaviridae family are specific for the O-Ac SA receptors. |
| T276 | 1865-1931 | Sentence | denotes | Their S and HE glycoproteins are similar to influenza C virus HEF. |
| T277 | 1932-2089 | Sentence | denotes | CoVs and all toroviruses bear HE gene form class I envelope membrane proteins of about 400 amino acid residues which bear 7 to 12 N-glycosylation sites [50]. |
| T278 | 2090-2122 | Sentence | denotes | HE multimer forms enter virions. |
| T279 | 2123-2241 | Sentence | denotes | Bovine CoV (BCoV) and HCoV-OC43, similar to influenza C virus, recognize Neu5,9Ac2 and bear SA-9-O-acetylesterase [8]. |
| T280 | 2242-2276 | Sentence | denotes | CoV HEs are all O-acetylesterases. |
| T281 | 2277-2470 | Sentence | denotes | The HE enzymes found in torovirus, CoV and influenza C virus are evolutionarily interspecies-mutated with about 30% homology by heterologous RNA recombination [51] and horizontal gene transfer. |
| T282 | 2471-2534 | Sentence | denotes | Therefore, viral HEs are diverse and widespread over evolution. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-3660588-51943986 | 671-673 | 3660588 | denotes | 46 |
| 32604730-2411539-51943987 | 876-878 | 2411539 | denotes | 47 |
| 32604730-9817207-51943988 | 1417-1419 | 9817207 | denotes | 49 |
| 32604730-2411539-51943989 | 1557-1559 | 2411539 | denotes | 47 |
| 32604730-2319653-51943990 | 2085-2087 | 2319653 | denotes | 50 |
| 32604730-3380803-51943991 | 2238-2239 | 3380803 | denotes | 8 |
| 32604730-1984666-51943992 | 2437-2439 | 1984666 | denotes | 51 |
| T4072 | 671-673 | 3660588 | denotes | 46 |
| T45662 | 876-878 | 2411539 | denotes | 47 |
| T64932 | 1417-1419 | 9817207 | denotes | 49 |
| T56258 | 1557-1559 | 2411539 | denotes | 47 |
| T27350 | 2085-2087 | 2319653 | denotes | 50 |
| T79342 | 2238-2239 | 3380803 | denotes | 8 |
| T89890 | 2437-2439 | 1984666 | denotes | 51 |