PMC:7352545 / 26135-32535
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T92 | 353-355 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T93 | 561-563 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T94 | 870-872 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T95 | 949-955 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T96 | 972-974 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T97 | 1100-1106 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T98 | 1266-1268 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T99 | 1441-1443 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T100 | 1768-1770 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T101 | 1866-1868 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T102 | 2230-2232 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T103 | 2721-2723 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T104 | 2778-2780 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T105 | 2850-2852 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T106 | 3336-3338 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T107 | 3356-3358 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T108 | 3554-3560 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T109 | 3614-3620 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T110 | 3665-3671 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T111 | 3754-3760 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T112 | 3818-3824 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T113 | 3892-3898 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T114 | 4031-4033 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T115 | 4095-4097 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T116 | 4803-4805 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T117 | 4898-4900 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T118 | 5169-5171 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T119 | 5325-5327 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T120 | 5388-5390 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T121 | 5577-5579 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T122 | 5639-5641 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T123 | 5687-5693 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T124 | 5795-5797 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T125 | 5823-5825 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T126 | 6002-6004 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T127 | 6049-6051 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T128 | 6084-6086 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T129 | 6298-6300 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T130 | 6367-6369 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T224 | 93-106 | Body_part | denotes | glycoproteins | http://purl.org/sig/ont/fma/fma62925 |
| T225 | 395-403 | Body_part | denotes | Proteins | http://purl.org/sig/ont/fma/fma67257 |
| T226 | 1192-1196 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T227 | 1660-1666 | Body_part | denotes | genome | http://purl.org/sig/ont/fma/fma84116 |
| T228 | 1895-1908 | Body_part | denotes | glycoproteins | http://purl.org/sig/ont/fma/fma62925 |
| T229 | 1980-1984 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T230 | 2016-2024 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T231 | 2038-2048 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T232 | 2433-2436 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T233 | 2471-2475 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T234 | 2607-2615 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T235 | 2736-2743 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T236 | 2802-2817 | Body_part | denotes | red blood cells | http://purl.org/sig/ont/fma/fma62845 |
| T237 | 2812-2817 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T238 | 2909-2916 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T239 | 2970-2982 | Body_part | denotes | carbohydrate | http://purl.org/sig/ont/fma/fma82737 |
| T240 | 3101-3106 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T241 | 3165-3177 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T242 | 3211-3223 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T243 | 3247-3259 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
| T244 | 3247-3251 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T245 | 3268-3275 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T246 | 3407-3429 | Body_part | denotes | cell adhesion molecule | http://purl.org/sig/ont/fma/fma67214 |
| T247 | 3407-3411 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T248 | 3523-3527 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T249 | 4255-4267 | Body_part | denotes | carbohydrate | http://purl.org/sig/ont/fma/fma82737 |
| T250 | 4278-4286 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T251 | 4500-4504 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T252 | 4568-4572 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T253 | 5455-5463 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T254 | 5852-5865 | Body_part | denotes | glycoproteins | http://purl.org/sig/ont/fma/fma62925 |
| T255 | 5962-5974 | Body_part | denotes | erythrocytes | http://purl.org/sig/ont/fma/fma62845 |
| T256 | 6143-6155 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T257 | 6206-6211 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T258 | 6263-6268 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T259 | 6351-6363 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T260 | 6394-6399 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T6 | 2806-2811 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T101 | 365-374 | Disease | denotes | Influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T102 | 417-426 | Disease | denotes | Influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T103 | 503-512 | Disease | denotes | Influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T104 | 606-615 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T105 | 846-855 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T106 | 1007-1016 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T107 | 1155-1164 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T108 | 1512-1521 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T109 | 1924-1933 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T110 | 2182-2191 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T111 | 2335-2344 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T112 | 3286-3295 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
| T113 | 4396-4405 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T114 | 4629-4638 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T115 | 5514-5531 | Disease | denotes | encephalomyelitis | http://purl.obolibrary.org/obo/MONDO_0005156 |
| T116 | 6218-6227 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T338 | 81-88 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T339 | 119-124 | http://purl.obolibrary.org/obo/CLO_0053120 | denotes | HE, S |
| T340 | 249-252 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T341 | 322-327 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T342 | 375-380 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | Virus |
| T343 | 381-382 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T344 | 387-388 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T345 | 427-428 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T346 | 433-434 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T347 | 435-442 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T348 | 490-492 | http://purl.obolibrary.org/obo/CLO_0053799 | denotes | 45 |
| T349 | 515-520 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T350 | 597-598 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T351 | 599-600 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T352 | 618-623 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T353 | 672-673 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T354 | 858-863 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T355 | 978-979 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T356 | 1019-1024 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T357 | 1072-1080 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T358 | 1108-1110 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
| T359 | 1165-1170 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T360 | 1192-1196 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T361 | 1501-1508 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T362 | 1524-1529 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T363 | 1638-1639 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T364 | 1751-1753 | http://purl.obolibrary.org/obo/CLO_0053799 | denotes | 45 |
| T365 | 1936-1941 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T366 | 1980-1984 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T367 | 2007-2015 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T368 | 2038-2057 | http://purl.obolibrary.org/obo/CHEBI_33708 | denotes | amino acid residues |
| T369 | 2038-2057 | http://purl.obolibrary.org/obo/PR_000036907 | denotes | amino acid residues |
| T370 | 2194-2199 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T371 | 2261-2264 | http://purl.obolibrary.org/obo/CLO_0053120 | denotes | HEs |
| T372 | 2347-2352 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T373 | 2471-2475 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T374 | 2503-2506 | http://purl.obolibrary.org/obo/CLO_0053120 | denotes | HEs |
| T375 | 2587-2590 | http://purl.obolibrary.org/obo/CLO_0053120 | denotes | HEs |
| T376 | 2591-2594 | http://purl.obolibrary.org/obo/CLO_0053120 | denotes | HEs |
| T377 | 2681-2684 | http://purl.obolibrary.org/obo/CLO_0053120 | denotes | HEs |
| T378 | 2701-2706 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T379 | 2802-2817 | http://purl.obolibrary.org/obo/CL_0000232 | denotes | red blood cells |
| T380 | 2837-2839 | http://purl.obolibrary.org/obo/CLO_0001407 | denotes | 52 |
| T381 | 2968-2969 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T382 | 3069-3074 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T383 | 3089-3092 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T384 | 3101-3106 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T385 | 3196-3197 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T386 | 3247-3251 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T387 | 3296-3301 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T388 | 3407-3411 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T389 | 3496-3499 | http://purl.obolibrary.org/obo/CLO_0053120 | denotes | HEs |
| T390 | 3523-3527 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T391 | 3587-3590 | http://purl.obolibrary.org/obo/CLO_0053120 | denotes | HEs |
| T392 | 3606-3608 | http://purl.obolibrary.org/obo/CLO_0037284 | denotes | C4 |
| T393 | 3635-3640 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
| T394 | 3746-3748 | http://purl.obolibrary.org/obo/CLO_0037284 | denotes | C4 |
| T395 | 3800-3802 | http://purl.obolibrary.org/obo/CLO_0002131 | denotes | C5 |
| T396 | 3872-3876 | http://purl.obolibrary.org/obo/CLO_0053061 | denotes | a C5 |
| T397 | 3884-3886 | http://purl.obolibrary.org/obo/CLO_0037284 | denotes | C4 |
| T398 | 3970-3973 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T399 | 3982-3985 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T400 | 4022-4025 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T401 | 4188-4189 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T402 | 4195-4196 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T403 | 4333-4340 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T404 | 4406-4411 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T405 | 4479-4480 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T406 | 4500-4504 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T407 | 4524-4525 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T408 | 4540-4541 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T409 | 4568-4572 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T410 | 4587-4590 | http://purl.obolibrary.org/obo/CLO_0001618 | denotes | a 9 |
| T411 | 4587-4590 | http://purl.obolibrary.org/obo/CLO_0001619 | denotes | a 9 |
| T412 | 4587-4590 | http://purl.obolibrary.org/obo/CLO_0001620 | denotes | a 9 |
| T413 | 4639-4644 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T414 | 4872-4877 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T415 | 4985-4988 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T416 | 5004-5005 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T417 | 5045-5046 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T418 | 5075-5076 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T419 | 5143-5144 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T420 | 5260-5265 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T421 | 5412-5417 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T422 | 5532-5537 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T423 | 5635-5638 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T424 | 5737-5740 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T425 | 5759-5762 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T426 | 5954-5961 | http://purl.obolibrary.org/obo/NCBITaxon_9031 | denotes | chicken |
| T427 | 5962-5974 | http://purl.obolibrary.org/obo/CL_0000232 | denotes | erythrocytes |
| T428 | 6014-6016 | http://purl.obolibrary.org/obo/CLO_0001407 | denotes | 52 |
| T429 | 6107-6108 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T430 | 6206-6211 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T431 | 6263-6268 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T432 | 6394-6399 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T708 | 93-106 | Chemical | denotes | glycoproteins | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T709 | 115-117 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T710 | 264-273 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T711 | 350-352 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T713 | 353-355 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T718 | 407-409 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T719 | 414-416 | Chemical | denotes | NA | http://purl.obolibrary.org/obo/CHEBI_33696 |
| T720 | 479-481 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T721 | 486-488 | Chemical | denotes | NA | http://purl.obolibrary.org/obo/CHEBI_33696 |
| T722 | 521-523 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T723 | 561-563 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T728 | 763-775 | Chemical | denotes | acetyl group | http://purl.obolibrary.org/obo/CHEBI_40574 |
| T729 | 763-769 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_46887 |
| T730 | 770-775 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T731 | 870-872 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T736 | 915-921 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T738 | 926-931 | Chemical | denotes | NeuAc | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_49018 |
| T740 | 949-955 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T742 | 965-971 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T744 | 972-974 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T749 | 1090-1096 | Chemical | denotes | Neu5Gc | http://purl.obolibrary.org/obo/CHEBI_62084 |
| T750 | 1100-1106 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T752 | 1249-1254 | Chemical | denotes | D-Gal | http://purl.obolibrary.org/obo/CHEBI_12936 |
| T753 | 1251-1254 | Chemical | denotes | Gal | http://purl.obolibrary.org/obo/CHEBI_28260 |
| T754 | 1258-1264 | Chemical | denotes | GalNAc | http://purl.obolibrary.org/obo/CHEBI_28037|http://purl.obolibrary.org/obo/CHEBI_28800 |
| T756 | 1266-1268 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T761 | 1306-1312 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T763 | 1341-1346 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T764 | 1365-1380 | Chemical | denotes | guanidino group | http://purl.obolibrary.org/obo/CHEBI_48551 |
| T765 | 1375-1380 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T766 | 1409-1414 | Chemical | denotes | CH3CO | http://purl.obolibrary.org/obo/CHEBI_46887 |
| T767 | 1415-1423 | Chemical | denotes | carbonyl | http://purl.obolibrary.org/obo/CHEBI_23019 |
| T768 | 1424-1430 | Chemical | denotes | oxygen | http://purl.obolibrary.org/obo/CHEBI_25805 |
| T769 | 1441-1443 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T774 | 1768-1770 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T779 | 1863-1865 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T781 | 1866-1868 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T786 | 1895-1908 | Chemical | denotes | glycoproteins | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T787 | 2016-2024 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T788 | 2038-2048 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T789 | 2038-2043 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T790 | 2044-2048 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T791 | 2230-2232 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T796 | 2607-2615 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T797 | 2721-2723 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T802 | 2736-2743 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T803 | 2778-2780 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T808 | 2850-2852 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T813 | 2909-2916 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T814 | 2947-2954 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T815 | 2970-2982 | Chemical | denotes | carbohydrate | http://purl.obolibrary.org/obo/CHEBI_16646 |
| T816 | 3123-3125 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T817 | 3165-3177 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T818 | 3198-3200 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T819 | 3211-3223 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T820 | 3268-3275 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T821 | 3336-3338 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T826 | 3356-3358 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T831 | 3399-3406 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
| T832 | 3421-3429 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T833 | 3551-3553 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T835 | 3554-3560 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T837 | 3611-3613 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T839 | 3614-3620 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T841 | 3662-3664 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T843 | 3665-3671 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T845 | 3751-3753 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T847 | 3754-3760 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T849 | 3815-3817 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T851 | 3818-3824 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T853 | 3889-3891 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T855 | 3892-3898 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T857 | 3979-3981 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T859 | 3993-3995 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T860 | 4019-4021 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T862 | 4031-4033 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T867 | 4095-4097 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T872 | 4255-4267 | Chemical | denotes | carbohydrate | http://purl.obolibrary.org/obo/CHEBI_16646 |
| T873 | 4278-4286 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T874 | 4593-4595 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T876 | 4803-4805 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T881 | 4817-4824 | Chemical | denotes | glycans | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T882 | 4898-4900 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T887 | 4982-4984 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T889 | 5166-5168 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T891 | 5169-5171 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T896 | 5266-5271 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T897 | 5322-5324 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T899 | 5325-5327 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T904 | 5385-5387 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T906 | 5388-5390 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T911 | 5397-5399 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T912 | 5418-5423 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T913 | 5455-5463 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T914 | 5577-5579 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T919 | 5639-5641 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T924 | 5687-5693 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T926 | 5734-5736 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T928 | 5756-5758 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T930 | 5795-5797 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T935 | 5823-5825 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T940 | 5852-5865 | Chemical | denotes | glycoproteins | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T941 | 5999-6001 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T943 | 6002-6004 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T948 | 6049-6051 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T953 | 6081-6083 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T955 | 6084-6086 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T960 | 6143-6155 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T961 | 6274-6276 | Chemical | denotes | NA | http://purl.obolibrary.org/obo/CHEBI_33696 |
| T962 | 6298-6300 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T967 | 6351-6363 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T968 | 6367-6369 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T46 | 1063-1080 | http://purl.obolibrary.org/obo/GO_0038024 | denotes | receptor activity |
| T47 | 1197-1204 | http://purl.obolibrary.org/obo/GO_0009606 | denotes | tropism |
| T48 | 2077-2092 | http://purl.obolibrary.org/obo/GO_0006487 | denotes | N-glycosylation |
| T49 | 2079-2092 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T50 | 3407-3429 | http://purl.obolibrary.org/obo/GO_0098631 | denotes | cell adhesion molecule |
| T51 | 3407-3420 | http://purl.obolibrary.org/obo/GO_0007155 | denotes | cell adhesion |
| T52 | 6380-6393 | http://purl.obolibrary.org/obo/GO_0044409 | denotes | entry to host |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T249 | 0-2 | Sentence | denotes | 5. |
| T250 | 3-13 | Sentence | denotes | HE of CoVs |
| T251 | 15-19 | Sentence | denotes | 5.1. |
| T252 | 20-72 | Sentence | denotes | Evolutionary Origin and Classification of the CoV HE |
| T253 | 73-174 | Sentence | denotes | Certain viruses use glycoproteins such as HA, HE, S and HEF for host receptor binding or destruction. |
| T254 | 175-299 | Sentence | denotes | Coronaviridae, Orthomyxoviridae, Paramyxoviridae and Adenoviridae utilize SAs as binding molecules for attachment and entry. |
| T255 | 300-356 | Sentence | denotes | However, only limited human pathogens recognize O-Ac SA. |
| T256 | 358-364 | Sentence | denotes | 5.1.1. |
| T257 | 365-416 | Sentence | denotes | Influenza Virus A and B Spike Proteins of HA and NA |
| T258 | 417-494 | Sentence | denotes | Influenza A and B viruses bear two spikes of receptor-binding HA and NA [45]. |
| T259 | 496-502 | Sentence | denotes | 5.1.2. |
| T260 | 503-527 | Sentence | denotes | Influenza C virus HA-HEF |
| T261 | 528-581 | Sentence | denotes | HEF is indeed an ancient type of SA-O-acetylesterase. |
| T262 | 582-690 | Sentence | denotes | In contrast to A/B, the influenza C virus bears one spike with triple functions of HEF as a homotrimer [46]. |
| T263 | 691-776 | Sentence | denotes | Each HEF subunit bears two Neu5,9Ac2-binding sites and binds to the 9-O-acetyl group. |
| T264 | 777-837 | Sentence | denotes | In parallel, another modification of O-acetylation is found. |
| T265 | 838-956 | Sentence | denotes | Indeed, influenza C virus bears SA-O-acetylesterase [47], which converts 5-N-acetyl-9-O-NeuAc (Neu5,9Ac2) to 5-Neu5Ac. |
| T266 | 957-1112 | Sentence | denotes | The 9-O-acetyl SA is a unique determinant for the influenza C virus receptor and Neu5,9Ac2 is crucial for receptor activity, but not Neu5Gc or Neu5Ac [48]. |
| T267 | 1113-1205 | Sentence | denotes | Neu5,9Ac2 is an essential determinant for influenza virus C type-specific host cell tropism. |
| T268 | 1206-1265 | Sentence | denotes | NAs cleave the α-ketosidic linkages to the D-Gal or GalNAc. |
| T269 | 1266-1333 | Sentence | denotes | SA-O-acetylesterases cleave different O-acetyl linkages (Figure 5). |
| T270 | 1334-1436 | Sentence | denotes | The OH-group of Tyr224 and the guanidino group of Arg236 interact with the CH3CO-carbonyl oxygen [49]. |
| T271 | 1437-1576 | Sentence | denotes | HEF SA-O-acetylesterase is found in several enveloped (+) ssRNA viruses of influenza C virus and also in certain CoVs and toroviruses [47]. |
| T272 | 1577-1755 | Sentence | denotes | The CoVs are different from the orthomyxoviruses, which hold a segmented (−) ssRNA genome and are instead evolutionary linked to the family Coronaviridae, order Nidovirales [45]. |
| T273 | 1757-1763 | Sentence | denotes | 5.1.3. |
| T274 | 1764-1790 | Sentence | denotes | CoV SA-O-Acetylesterase HE |
| T275 | 1791-1879 | Sentence | denotes | CoVs and toroviruses of the Coronaviridae family are specific for the O-Ac SA receptors. |
| T276 | 1880-1946 | Sentence | denotes | Their S and HE glycoproteins are similar to influenza C virus HEF. |
| T277 | 1947-2104 | Sentence | denotes | CoVs and all toroviruses bear HE gene form class I envelope membrane proteins of about 400 amino acid residues which bear 7 to 12 N-glycosylation sites [50]. |
| T278 | 2105-2137 | Sentence | denotes | HE multimer forms enter virions. |
| T279 | 2138-2256 | Sentence | denotes | Bovine CoV (BCoV) and HCoV-OC43, similar to influenza C virus, recognize Neu5,9Ac2 and bear SA-9-O-acetylesterase [8]. |
| T280 | 2257-2291 | Sentence | denotes | CoV HEs are all O-acetylesterases. |
| T281 | 2292-2485 | Sentence | denotes | The HE enzymes found in torovirus, CoV and influenza C virus are evolutionarily interspecies-mutated with about 30% homology by heterologous RNA recombination [51] and horizontal gene transfer. |
| T282 | 2486-2549 | Sentence | denotes | Therefore, viral HEs are diverse and widespread over evolution. |
| T283 | 2551-2555 | Sentence | denotes | 5.2. |
| T284 | 2556-2590 | Sentence | denotes | Substrate Diversity of the CoV HEs |
| T285 | 2591-2668 | Sentence | denotes | HEs as envelope proteins are found in CoVs, orthomyxoviruses and toroviruses. |
| T286 | 2669-2732 | Sentence | denotes | Coronaviral HEs are involved in virus attachment to SA species. |
| T287 | 2733-2841 | Sentence | denotes | HE protein in β-CoVs binds to Neu5,9Ac2 form SA and agglutinates the red blood cells (RBCs) of rodents [52]. |
| T288 | 2842-2955 | Sentence | denotes | As with SA-O-acetylesterase, HE potentiates viral entry with the S protein and spreading via the mucosal glycans. |
| T289 | 2956-3024 | Sentence | denotes | It contains a carbohydrate-recognizing domain (CRD) known in lectin. |
| T290 | 3025-3107 | Sentence | denotes | The HE glycan-binding domain (GBD) mediates virus attachment to SAs on host cells. |
| T291 | 3108-3126 | Sentence | denotes | HE is the only HA. |
| T292 | 3127-3260 | Sentence | denotes | This indicates that compared to the S glycoprotein, HE is only minor a HA and the S glycoprotein mainly attaches to the cell surface. |
| T293 | 3261-3483 | Sentence | denotes | The HE protein of murine hepatitis virus (MHV), an enveloped CoV, binds to SA-4-acetylester or SA-9-O-acetylester of the carcinoembryonic antigen cell adhesion molecule 1a (CEACAM; known as CD66a) as the key receptor [53]. |
| T294 | 3484-3561 | Sentence | denotes | Murine CoVs HEs acquired by horizontal gene transfer, bind to C9-O-Ac Neu5Ac. |
| T295 | 3562-3621 | Sentence | denotes | However, some murine CoV HEs cannot bind to C4-O-Ac Neu5Ac. |
| T296 | 3622-3772 | Sentence | denotes | The original mouse MHV HE binds to C9-O-Ac Neu5Ac, while the MHV S-strain HE evolutionarily acquired the ability to bind to C4-O-Ac Neu5Ac [12,53,54]. |
| T297 | 3773-3924 | Sentence | denotes | In terms of structure, the C5 N- and C9 O-Ac Neu5Ac-accomodating hydrophobic pocket was shifted to a C5 N- and C4-O-Ac Neu5Ac-accomodating pocket [55]. |
| T298 | 3925-3987 | Sentence | denotes | Type I HE is specific for the 9-O-acetylated SAs (9-O-Ac-SAs). |
| T299 | 3988-4026 | Sentence | denotes | Type II HE is specific for 4-O-Ac-SAs. |
| T300 | 4027-4151 | Sentence | denotes | The SA-binding shift indicates quasi-synchronous adaptations of the SA-recognition sites of the lectin and esterase domains. |
| T301 | 4152-4287 | Sentence | denotes | Type I HE monomers of β-CoV lineage A have a bimodular enzyme–lectin domain similar to cellular glycan/carbohydrate-modifying proteins. |
| T302 | 4288-4492 | Sentence | denotes | Originally, HE homologs are found in various viruses including toroviruses and orthomyxoviruses such as the influenza virus C/D and isavirus, as well as the exceptional case of β-CoV lineage A among CoVs. |
| T303 | 4493-4649 | Sentence | denotes | The HE gene was transmitted to a β-CoV lineage A progenitor via horizontal gene transfer from a 9-O-Ac-Sia–recognizing HEF, as shown in influenza virus C/D. |
| T304 | 4650-4825 | Sentence | denotes | HE acquisition and expansion occurred by cross-species transmission over HE evolution and this phenomenon reflects viral evolutionary adaptation to host SA-containing glycans. |
| T305 | 4826-4938 | Sentence | denotes | Therefore, CoV HE receptor switching precedes virus evolution driven by SA-containing glycan diversity of hosts. |
| T306 | 4939-5040 | Sentence | denotes | For instance, the BcoV HE prefers 7,9-di-O-Ac-SAs, which is also a target of the bovine torovirus HE. |
| T307 | 5041-5184 | Sentence | denotes | For a more outstanding case, such a switching event occurred in the murine CoVs for the β-CoV lineage A type switch toward O-Ac-SA recognition. |
| T308 | 5185-5429 | Sentence | denotes | In the HE specificity of murine CoVs, two different murine CoV subtypes of virus group exist with one subtype possessing the typical 9-O-Ac-SA (type I) attachment factor and the other exclusively 4-O-Ac-SA (type II) attachment virus group [56]. |
| T309 | 5430-5619 | Sentence | denotes | The first coronaviral HE proteins identified were from the porcine hemagglutinating encephalomyelitis virus (PHEV), BCoV and HCoV-OC43, which bear SA-9-O-acetylesterases similar to HEF [8]. |
| T310 | 5620-5705 | Sentence | denotes | Rat CoV (RCoV) has SA-4-O-acetylesterases, converting Neu4,5Ac2 to Neu5Ac [53,57,58]. |
| T311 | 5706-5763 | Sentence | denotes | Some murine CoVs prefer 4-O-Ac-SAs and others 9-O-Ac-SAs. |
| T312 | 5764-5845 | Sentence | denotes | HCoV-OC43 and BCoV prefer α2-6-SA 9-O-acetylation by their SA-O-acetyleseterases. |
| T313 | 5846-6018 | Sentence | denotes | The S glycoproteins of BCoV and HCoV-OC43 are Neu5,9Ac2-recognizing lectins and agglutinate murine, rat and chicken erythrocytes due to the enriched 9-O-Ac-SA species [52]. |
| T314 | 6019-6102 | Sentence | denotes | BCoV and HCoV-OC43 adapted to SA receptor determinants of 9-O-Ac-SA receptors [59]. |
| T315 | 6103-6212 | Sentence | denotes | For a second receptor, the binding of S glycoprotein to Neu5,9Ac2 receptor is essential for entry into cells. |
| T316 | 6213-6400 | Sentence | denotes | BCoV-infection is prevented by prior treatment of cells with NA enzyme or with viral SA-O-acetylesterases, blocking the roles of HE and S glycoprotein in SA-dependent entry to host cells. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-3660588-51943986 | 686-688 | 3660588 | denotes | 46 |
| 32604730-2411539-51943987 | 891-893 | 2411539 | denotes | 47 |
| 32604730-9817207-51943988 | 1432-1434 | 9817207 | denotes | 49 |
| 32604730-2411539-51943989 | 1572-1574 | 2411539 | denotes | 47 |
| 32604730-2319653-51943990 | 2100-2102 | 2319653 | denotes | 50 |
| 32604730-3380803-51943991 | 2253-2254 | 3380803 | denotes | 8 |
| 32604730-1984666-51943992 | 2452-2454 | 1984666 | denotes | 51 |
| 32604730-1920630-51943993 | 2837-2839 | 1920630 | denotes | 52 |
| 32604730-10233932-51943994 | 3479-3481 | 10233932 | denotes | 53 |
| 32604730-16575523-51943995 | 3762-3764 | 16575523 | denotes | 12 |
| 32604730-10233932-51943996 | 3765-3767 | 10233932 | denotes | 53 |
| 32604730-20538854-51943997 | 3768-3770 | 20538854 | denotes | 54 |
| 32604730-16306577-51943998 | 3920-3922 | 16306577 | denotes | 55 |
| 32604730-27185912-51943999 | 5425-5427 | 27185912 | denotes | 56 |
| 32604730-3380803-51944000 | 5616-5617 | 3380803 | denotes | 8 |
| 32604730-10233932-51944001 | 5695-5697 | 10233932 | denotes | 53 |
| 32604730-11807232-51944002 | 5698-5700 | 11807232 | denotes | 57 |
| 32604730-1920630-51944003 | 6014-6016 | 1920630 | denotes | 52 |
| 32604730-1321878-51944004 | 6098-6100 | 1321878 | denotes | 59 |
| T4072 | 686-688 | 3660588 | denotes | 46 |
| T45662 | 891-893 | 2411539 | denotes | 47 |
| T64932 | 1432-1434 | 9817207 | denotes | 49 |
| T56258 | 1572-1574 | 2411539 | denotes | 47 |
| T27350 | 2100-2102 | 2319653 | denotes | 50 |
| T79342 | 2253-2254 | 3380803 | denotes | 8 |
| T89890 | 2452-2454 | 1984666 | denotes | 51 |
| T60595 | 2837-2839 | 1920630 | denotes | 52 |
| T4696 | 3479-3481 | 10233932 | denotes | 53 |
| T80351 | 3762-3764 | 16575523 | denotes | 12 |
| T34204 | 3765-3767 | 10233932 | denotes | 53 |
| T1499 | 3768-3770 | 20538854 | denotes | 54 |
| T25059 | 3920-3922 | 16306577 | denotes | 55 |
| T81483 | 5425-5427 | 27185912 | denotes | 56 |
| T74157 | 5616-5617 | 3380803 | denotes | 8 |
| T77726 | 5695-5697 | 10233932 | denotes | 53 |
| T52426 | 5698-5700 | 11807232 | denotes | 57 |
| T22208 | 6014-6016 | 1920630 | denotes | 52 |
| T60367 | 6098-6100 | 1321878 | denotes | 59 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T9 | 3286-3295 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |