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LitCovid_Glycan-Motif-Structure

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T66","span":{"begin":55,"end":61},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T67","span":{"begin":63,"end":65},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T68","span":{"begin":103,"end":105},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T69","span":{"begin":135,"end":141},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T70","span":{"begin":344,"end":350},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T71","span":{"begin":415,"end":418},"obj":"https://glytoucan.org/Structures/Glycans/G56516VH"},{"id":"T72","span":{"begin":415,"end":418},"obj":"https://glytoucan.org/Structures/Glycans/G91237TK"},{"id":"T73","span":{"begin":482,"end":488},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T74","span":{"begin":730,"end":736},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T75","span":{"begin":868,"end":874},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T76","span":{"begin":929,"end":931},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T77","span":{"begin":993,"end":999},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T78","span":{"begin":1016,"end":1018},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"}],"text":"For example, in the horse, C4-O-acetyl modification of Neu5Ac (SA) occupies more than 50% of the total SA content. The C4-O-acetylated Neu5Ac, Neu4,5Ac2, inhibits the influenza A2 virus HA. De-acetylation reagents such as NaOH or NaIO4 treatment completely hemagglutinate Neu4,5Ac2 by elimination of the C4-O-acetyl group [33]. The C4-O-acetyl Neu5Ac species are found in various sources such as equine erythrocyte GM3, starfish A. rubens and fish [34,35,36,37,38]. C4-O-acetylated Neu5Ac facilitates the initial attachment of viruses to target cells. Like the influenza C virus, infectious salmon anemia virus (ISAV), a member of the Orthomyxoviridae family, contains HE and HEF proteins to mediate virus entry and exit. C4-O-Ac Neu5Ac is the major receptor determinant of ISAV in receptor binding and destruction [38], while the influenza C virus recognizes C9-O-Ac Neu5Ac. The acetylesterase RDE of ISAV cleaves C4-O-Ac via 4-SA-O-acetylesterase with a short turnover time, whereas C9-O-Ac Neu5Ac is cleaved by 9-SA-O-acetylesterase with a long turnover time [34]."}

LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T211","span":{"begin":177,"end":179},"obj":"Body_part"},{"id":"T212","span":{"begin":403,"end":414},"obj":"Body_part"},{"id":"T213","span":{"begin":545,"end":550},"obj":"Body_part"},{"id":"T214","span":{"begin":680,"end":688},"obj":"Body_part"}],"attributes":[{"id":"A211","pred":"fma_id","subj":"T211","obj":"http://purl.org/sig/ont/fma/fma66595"},{"id":"A212","pred":"fma_id","subj":"T212","obj":"http://purl.org/sig/ont/fma/fma62845"},{"id":"A213","pred":"fma_id","subj":"T213","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A214","pred":"fma_id","subj":"T214","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"For example, in the horse, C4-O-acetyl modification of Neu5Ac (SA) occupies more than 50% of the total SA content. The C4-O-acetylated Neu5Ac, Neu4,5Ac2, inhibits the influenza A2 virus HA. De-acetylation reagents such as NaOH or NaIO4 treatment completely hemagglutinate Neu4,5Ac2 by elimination of the C4-O-acetyl group [33]. The C4-O-acetyl Neu5Ac species are found in various sources such as equine erythrocyte GM3, starfish A. rubens and fish [34,35,36,37,38]. C4-O-acetylated Neu5Ac facilitates the initial attachment of viruses to target cells. Like the influenza C virus, infectious salmon anemia virus (ISAV), a member of the Orthomyxoviridae family, contains HE and HEF proteins to mediate virus entry and exit. C4-O-Ac Neu5Ac is the major receptor determinant of ISAV in receptor binding and destruction [38], while the influenza C virus recognizes C9-O-Ac Neu5Ac. The acetylesterase RDE of ISAV cleaves C4-O-Ac via 4-SA-O-acetylesterase with a short turnover time, whereas C9-O-Ac Neu5Ac is cleaved by 9-SA-O-acetylesterase with a long turnover time [34]."}

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T84","span":{"begin":167,"end":176},"obj":"Disease"},{"id":"T85","span":{"begin":561,"end":570},"obj":"Disease"},{"id":"T86","span":{"begin":580,"end":590},"obj":"Disease"},{"id":"T87","span":{"begin":598,"end":604},"obj":"Disease"},{"id":"T88","span":{"begin":831,"end":840},"obj":"Disease"}],"attributes":[{"id":"A84","pred":"mondo_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A85","pred":"mondo_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A86","pred":"mondo_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A87","pred":"mondo_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/MONDO_0002280"},{"id":"A88","pred":"mondo_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"}],"text":"For example, in the horse, C4-O-acetyl modification of Neu5Ac (SA) occupies more than 50% of the total SA content. The C4-O-acetylated Neu5Ac, Neu4,5Ac2, inhibits the influenza A2 virus HA. De-acetylation reagents such as NaOH or NaIO4 treatment completely hemagglutinate Neu4,5Ac2 by elimination of the C4-O-acetyl group [33]. The C4-O-acetyl Neu5Ac species are found in various sources such as equine erythrocyte GM3, starfish A. rubens and fish [34,35,36,37,38]. C4-O-acetylated Neu5Ac facilitates the initial attachment of viruses to target cells. Like the influenza C virus, infectious salmon anemia virus (ISAV), a member of the Orthomyxoviridae family, contains HE and HEF proteins to mediate virus entry and exit. C4-O-Ac Neu5Ac is the major receptor determinant of ISAV in receptor binding and destruction [38], while the influenza C virus recognizes C9-O-Ac Neu5Ac. The acetylesterase RDE of ISAV cleaves C4-O-Ac via 4-SA-O-acetylesterase with a short turnover time, whereas C9-O-Ac Neu5Ac is cleaved by 9-SA-O-acetylesterase with a long turnover time [34]."}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T261","span":{"begin":20,"end":25},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9796"},{"id":"T262","span":{"begin":27,"end":29},"obj":"http://purl.obolibrary.org/obo/CLO_0037284"},{"id":"T263","span":{"begin":119,"end":121},"obj":"http://purl.obolibrary.org/obo/CLO_0037284"},{"id":"T264","span":{"begin":177,"end":179},"obj":"http://purl.obolibrary.org/obo/CLO_0001562"},{"id":"T265","span":{"begin":180,"end":185},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T266","span":{"begin":304,"end":306},"obj":"http://purl.obolibrary.org/obo/CLO_0037284"},{"id":"T267","span":{"begin":332,"end":334},"obj":"http://purl.obolibrary.org/obo/CLO_0037284"},{"id":"T268","span":{"begin":396,"end":402},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9796"},{"id":"T269","span":{"begin":403,"end":414},"obj":"http://purl.obolibrary.org/obo/CL_0000232"},{"id":"T270","span":{"begin":429,"end":430},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T271","span":{"begin":443,"end":447},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_117565"},{"id":"T272","span":{"begin":466,"end":468},"obj":"http://purl.obolibrary.org/obo/CLO_0037284"},{"id":"T273","span":{"begin":527,"end":534},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T274","span":{"begin":545,"end":550},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T275","span":{"begin":573,"end":578},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T276","span":{"begin":605,"end":610},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T277","span":{"begin":619,"end":620},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T278","span":{"begin":700,"end":705},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T279","span":{"begin":722,"end":724},"obj":"http://purl.obolibrary.org/obo/CLO_0037284"},{"id":"T280","span":{"begin":843,"end":848},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T281","span":{"begin":915,"end":917},"obj":"http://purl.obolibrary.org/obo/CLO_0037284"},{"id":"T282","span":{"begin":954,"end":955},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T283","span":{"begin":1041,"end":1042},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T284","span":{"begin":1063,"end":1065},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"}],"text":"For example, in the horse, C4-O-acetyl modification of Neu5Ac (SA) occupies more than 50% of the total SA content. The C4-O-acetylated Neu5Ac, Neu4,5Ac2, inhibits the influenza A2 virus HA. De-acetylation reagents such as NaOH or NaIO4 treatment completely hemagglutinate Neu4,5Ac2 by elimination of the C4-O-acetyl group [33]. The C4-O-acetyl Neu5Ac species are found in various sources such as equine erythrocyte GM3, starfish A. rubens and fish [34,35,36,37,38]. C4-O-acetylated Neu5Ac facilitates the initial attachment of viruses to target cells. Like the influenza C virus, infectious salmon anemia virus (ISAV), a member of the Orthomyxoviridae family, contains HE and HEF proteins to mediate virus entry and exit. C4-O-Ac Neu5Ac is the major receptor determinant of ISAV in receptor binding and destruction [38], while the influenza C virus recognizes C9-O-Ac Neu5Ac. The acetylesterase RDE of ISAV cleaves C4-O-Ac via 4-SA-O-acetylesterase with a short turnover time, whereas C9-O-Ac Neu5Ac is cleaved by 9-SA-O-acetylesterase with a long turnover time [34]."}

LitCovid-PD-CHEBI

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T213","span":{"begin":0,"end":114},"obj":"Sentence"},{"id":"T214","span":{"begin":115,"end":189},"obj":"Sentence"},{"id":"T215","span":{"begin":190,"end":327},"obj":"Sentence"},{"id":"T216","span":{"begin":328,"end":465},"obj":"Sentence"},{"id":"T217","span":{"begin":466,"end":551},"obj":"Sentence"},{"id":"T218","span":{"begin":552,"end":721},"obj":"Sentence"},{"id":"T219","span":{"begin":722,"end":875},"obj":"Sentence"},{"id":"T220","span":{"begin":876,"end":1067},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"For example, in the horse, C4-O-acetyl modification of Neu5Ac (SA) occupies more than 50% of the total SA content. The C4-O-acetylated Neu5Ac, Neu4,5Ac2, inhibits the influenza A2 virus HA. De-acetylation reagents such as NaOH or NaIO4 treatment completely hemagglutinate Neu4,5Ac2 by elimination of the C4-O-acetyl group [33]. The C4-O-acetyl Neu5Ac species are found in various sources such as equine erythrocyte GM3, starfish A. rubens and fish [34,35,36,37,38]. C4-O-acetylated Neu5Ac facilitates the initial attachment of viruses to target cells. Like the influenza C virus, infectious salmon anemia virus (ISAV), a member of the Orthomyxoviridae family, contains HE and HEF proteins to mediate virus entry and exit. C4-O-Ac Neu5Ac is the major receptor determinant of ISAV in receptor binding and destruction [38], while the influenza C virus recognizes C9-O-Ac Neu5Ac. The acetylesterase RDE of ISAV cleaves C4-O-Ac via 4-SA-O-acetylesterase with a short turnover time, whereas C9-O-Ac Neu5Ac is cleaved by 9-SA-O-acetylesterase with a long turnover time [34]."}

2_test

{"project":"2_test","denotations":[{"id":"32604730-21618128-51943973","span":{"begin":323,"end":325},"obj":"21618128"},{"id":"32604730-31683930-51943974","span":{"begin":449,"end":451},"obj":"31683930"},{"id":"32604730-9090814-51943975","span":{"begin":452,"end":454},"obj":"9090814"},{"id":"32604730-16181722-51943976","span":{"begin":455,"end":457},"obj":"16181722"},{"id":"32604730-24833039-51943977","span":{"begin":458,"end":460},"obj":"24833039"},{"id":"32604730-14990724-51943978","span":{"begin":461,"end":463},"obj":"14990724"},{"id":"32604730-14990724-51943979","span":{"begin":816,"end":818},"obj":"14990724"},{"id":"32604730-31683930-51943980","span":{"begin":1063,"end":1065},"obj":"31683930"},{"id":"T78050","span":{"begin":323,"end":325},"obj":"21618128"},{"id":"T53753","span":{"begin":449,"end":451},"obj":"31683930"},{"id":"T38465","span":{"begin":452,"end":454},"obj":"9090814"},{"id":"T72587","span":{"begin":455,"end":457},"obj":"16181722"},{"id":"T75131","span":{"begin":458,"end":460},"obj":"24833039"},{"id":"T15211","span":{"begin":461,"end":463},"obj":"14990724"},{"id":"T68693","span":{"begin":816,"end":818},"obj":"14990724"},{"id":"T49725","span":{"begin":1063,"end":1065},"obj":"31683930"}],"text":"For example, in the horse, C4-O-acetyl modification of Neu5Ac (SA) occupies more than 50% of the total SA content. The C4-O-acetylated Neu5Ac, Neu4,5Ac2, inhibits the influenza A2 virus HA. De-acetylation reagents such as NaOH or NaIO4 treatment completely hemagglutinate Neu4,5Ac2 by elimination of the C4-O-acetyl group [33]. The C4-O-acetyl Neu5Ac species are found in various sources such as equine erythrocyte GM3, starfish A. rubens and fish [34,35,36,37,38]. C4-O-acetylated Neu5Ac facilitates the initial attachment of viruses to target cells. Like the influenza C virus, infectious salmon anemia virus (ISAV), a member of the Orthomyxoviridae family, contains HE and HEF proteins to mediate virus entry and exit. C4-O-Ac Neu5Ac is the major receptor determinant of ISAV in receptor binding and destruction [38], while the influenza C virus recognizes C9-O-Ac Neu5Ac. The acetylesterase RDE of ISAV cleaves C4-O-Ac via 4-SA-O-acetylesterase with a short turnover time, whereas C9-O-Ac Neu5Ac is cleaved by 9-SA-O-acetylesterase with a long turnover time [34]."}

LitCovid-PD-HP

{"project":"LitCovid-PD-HP","denotations":[{"id":"T7","span":{"begin":598,"end":604},"obj":"Phenotype"}],"attributes":[{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0001903"}],"text":"For example, in the horse, C4-O-acetyl modification of Neu5Ac (SA) occupies more than 50% of the total SA content. The C4-O-acetylated Neu5Ac, Neu4,5Ac2, inhibits the influenza A2 virus HA. De-acetylation reagents such as NaOH or NaIO4 treatment completely hemagglutinate Neu4,5Ac2 by elimination of the C4-O-acetyl group [33]. The C4-O-acetyl Neu5Ac species are found in various sources such as equine erythrocyte GM3, starfish A. rubens and fish [34,35,36,37,38]. C4-O-acetylated Neu5Ac facilitates the initial attachment of viruses to target cells. Like the influenza C virus, infectious salmon anemia virus (ISAV), a member of the Orthomyxoviridae family, contains HE and HEF proteins to mediate virus entry and exit. C4-O-Ac Neu5Ac is the major receptor determinant of ISAV in receptor binding and destruction [38], while the influenza C virus recognizes C9-O-Ac Neu5Ac. The acetylesterase RDE of ISAV cleaves C4-O-Ac via 4-SA-O-acetylesterase with a short turnover time, whereas C9-O-Ac Neu5Ac is cleaved by 9-SA-O-acetylesterase with a long turnover time [34]."}

PMC:7352545 / 22147-23214 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:7352545 / 22147-23214 JSON TXT