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PMC:7352545 / 22115-24578 JSONTXT

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LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T66 87-93 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T67 95-97 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T68 135-137 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T69 167-173 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T70 376-382 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T71 447-450 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T72 447-450 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T73 514-520 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T74 762-768 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T75 900-906 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T76 961-963 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T77 1025-1031 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T78 1048-1050 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T79 1116-1118 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T80 1413-1419 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T81 1741-1743 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T211 209-211 Body_part denotes A2 http://purl.org/sig/ont/fma/fma66595
T212 435-446 Body_part denotes erythrocyte http://purl.org/sig/ont/fma/fma62845
T213 577-582 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T214 712-720 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T215 1638-1648 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T216 1988-1996 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T84 199-208 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T85 593-602 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T86 612-622 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T87 630-636 Disease denotes anemia http://purl.obolibrary.org/obo/MONDO_0002280
T88 863-872 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T89 1507-1516 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T90 1802-1811 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T91 1930-1962 Disease denotes human parainfluenza virus type 3 http://purl.obolibrary.org/obo/MONDO_0042974

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T260 7-9 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T261 52-57 http://purl.obolibrary.org/obo/NCBITaxon_9796 denotes horse
T262 59-61 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T263 151-153 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T264 209-211 http://purl.obolibrary.org/obo/CLO_0001562 denotes A2
T265 212-217 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T266 336-338 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T267 364-366 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T268 428-434 http://purl.obolibrary.org/obo/NCBITaxon_9796 denotes equine
T269 435-446 http://purl.obolibrary.org/obo/CL_0000232 denotes erythrocyte
T270 461-462 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T271 475-479 http://purl.obolibrary.org/obo/NCBITaxon_117565 denotes fish
T272 498-500 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T273 559-566 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T274 577-582 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T275 605-610 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T276 637-642 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T277 651-652 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T278 732-737 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T279 754-756 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T280 875-880 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T281 947-949 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T282 986-987 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T283 1073-1074 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T284 1095-1097 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T285 1231-1233 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T286 1382-1385 http://purl.obolibrary.org/obo/CLO_0051568 denotes SAs
T287 1407-1409 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T288 1440-1441 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T289 1517-1518 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T290 1523-1524 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T291 1525-1532 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T292 1607-1609 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T293 1672-1678 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T294 1717-1719 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T295 1723-1725 http://purl.obolibrary.org/obo/CLO_0002105 denotes C2
T296 1723-1725 http://purl.obolibrary.org/obo/CLO_0051742 denotes C2
T297 1765-1773 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T298 1812-1813 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T299 1814-1819 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T300 1841-1842 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T301 1843-1848 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T302 1859-1862 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T303 1930-1935 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T304 1950-1955 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T305 1970-1973 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T306 1974-1976 http://purl.obolibrary.org/obo/CLO_0003788 denotes HN
T307 2007-2009 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T308 2105-2108 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T309 2109-2110 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T310 2129-2130 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T311 2216-2218 http://purl.obolibrary.org/obo/CLO_0037284 denotes C4
T312 2385-2387 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T535 64-70 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887
T537 87-93 Chemical denotes Neu5Ac http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133
T539 95-97 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T544 135-137 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T549 167-173 Chemical denotes Neu5Ac http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133
T551 218-220 Chemical denotes HA http://purl.obolibrary.org/obo/CHEBI_73924
T552 237-245 Chemical denotes reagents http://purl.obolibrary.org/obo/CHEBI_33893
T553 254-258 Chemical denotes NaOH http://purl.obolibrary.org/obo/CHEBI_32145
T554 262-267 Chemical denotes NaIO4 http://purl.obolibrary.org/obo/CHEBI_75226
T555 341-353 Chemical denotes acetyl group http://purl.obolibrary.org/obo/CHEBI_40574
T556 341-347 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_46887
T557 348-353 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T558 369-375 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887
T560 376-382 Chemical denotes Neu5Ac http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133
T562 447-450 Chemical denotes GM3 http://purl.obolibrary.org/obo/CHEBI_15681|http://purl.obolibrary.org/obo/CHEBI_84118
T564 514-520 Chemical denotes Neu5Ac http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133
T566 712-720 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T567 759-761 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T569 762-768 Chemical denotes Neu5Ac http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133
T571 897-899 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T573 900-906 Chemical denotes Neu5Ac http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133
T575 952-954 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T577 961-963 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T582 1022-1024 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T584 1025-1031 Chemical denotes Neu5Ac http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133
T586 1048-1050 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T591 1116-1118 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T596 1236-1238 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T598 1266-1268 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T600 1284-1286 Chemical denotes NA http://purl.obolibrary.org/obo/CHEBI_33696
T601 1287-1297 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T602 1356-1358 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T604 1376-1378 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T606 1413-1419 Chemical denotes Neu5Ac http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133
T608 1493-1503 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T609 1592-1594 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T611 1595-1600 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T612 1638-1648 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T613 1638-1643 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T614 1644-1648 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T615 1649-1652 Chemical denotes Glu http://purl.obolibrary.org/obo/CHEBI_16015|http://purl.obolibrary.org/obo/CHEBI_18237|http://purl.obolibrary.org/obo/CHEBI_29972
T618 1723-1725 Chemical denotes C2 http://purl.obolibrary.org/obo/CHEBI_30083
T619 1741-1743 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T624 1988-1996 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T625 2042-2054 Chemical denotes alkyl groups http://purl.obolibrary.org/obo/CHEBI_22323
T626 2069-2080 Chemical denotes ethyl group http://purl.obolibrary.org/obo/CHEBI_37807
T627 2069-2074 Chemical denotes ethyl http://purl.obolibrary.org/obo/CHEBI_62801
T628 2075-2080 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T629 2133-2148 Chemical denotes guanidino group http://purl.obolibrary.org/obo/CHEBI_48551
T630 2143-2148 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T631 2253-2264 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T632 2284-2291 Chemical denotes Tamiflu http://purl.obolibrary.org/obo/CHEBI_7798|http://purl.obolibrary.org/obo/CHEBI_7799
T634 2317-2326 Chemical denotes zanamivir http://purl.obolibrary.org/obo/CHEBI_50663
T635 2346-2353 Chemical denotes Relenza http://purl.obolibrary.org/obo/CHEBI_50663
T636 2396-2401 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T211 0-6 Sentence denotes 4.2.1.
T212 7-31 Sentence denotes C4-O-Acetyl Modification
T213 32-146 Sentence denotes For example, in the horse, C4-O-acetyl modification of Neu5Ac (SA) occupies more than 50% of the total SA content.
T214 147-221 Sentence denotes The C4-O-acetylated Neu5Ac, Neu4,5Ac2, inhibits the influenza A2 virus HA.
T215 222-359 Sentence denotes De-acetylation reagents such as NaOH or NaIO4 treatment completely hemagglutinate Neu4,5Ac2 by elimination of the C4-O-acetyl group [33].
T216 360-497 Sentence denotes The C4-O-acetyl Neu5Ac species are found in various sources such as equine erythrocyte GM3, starfish A. rubens and fish [34,35,36,37,38].
T217 498-583 Sentence denotes C4-O-acetylated Neu5Ac facilitates the initial attachment of viruses to target cells.
T218 584-753 Sentence denotes Like the influenza C virus, infectious salmon anemia virus (ISAV), a member of the Orthomyxoviridae family, contains HE and HEF proteins to mediate virus entry and exit.
T219 754-907 Sentence denotes C4-O-Ac Neu5Ac is the major receptor determinant of ISAV in receptor binding and destruction [38], while the influenza C virus recognizes C9-O-Ac Neu5Ac.
T220 908-1099 Sentence denotes The acetylesterase RDE of ISAV cleaves C4-O-Ac via 4-SA-O-acetylesterase with a short turnover time, whereas C9-O-Ac Neu5Ac is cleaved by 9-SA-O-acetylesterase with a long turnover time [34].
T221 1100-1239 Sentence denotes The position of SA O-acetylation is linked to functions including substrate differentiation of enzymes such as NAs and esterase by C4 O-Ac.
T222 1240-1369 Sentence denotes Previous development of O-Ac site-selective NA inhibitors were based on the conceptual consideration of different O-Ac positions.
T223 1370-1478 Sentence denotes The O-Ac of SAs is site-specific, as C4 of Neu5Ac is considered to be a potential position for modification.
T224 1479-1587 Sentence denotes Historically, inhibitors of influenza A and B viruses-sialidases were designed by Von-Itzstein in 1993 [39].
T225 1588-1697 Sentence denotes The Ac group-based C4 substitution interacts with amino acid Glu-119 present in the active site of sialidase.
T226 1698-1867 Sentence denotes Guanidine-attached C4 of C2–C3 unsaturated SA (Neu5Ac2en) inhibits activity of sialidases isolated from influenza A virus (Singapore/1/57) and B virus (Victoria/102/85).
T227 1868-2002 Sentence denotes The same scenario was applied for sialidase inhibition of the human parainfluenza virus type 3, which has HN and fusion proteins [40].
T228 2003-2081 Sentence denotes The C4 of Neu5Ac2en was substituted by alkyl groups such as the O-ethyl group.
T229 2082-2171 Sentence denotes For example, Zanamivir has a substitution with a 4-guanidino group with an IC50 of 25 μM.
T230 2172-2245 Sentence denotes Thus, sialidase inhibition is important for C4 modification of Neu5Ac2en.
T231 2246-2389 Sentence denotes Later, oseltamivir with the tradename Tamiflu (Basel, Switzerland) and zanamivir with the tradename Relenza (London, UK) were established [41].
T232 2390-2463 Sentence denotes These drugs exhibit some adverse side effects that restrict clinical use.

2_test

Id Subject Object Predicate Lexical cue
32604730-21618128-51943973 355-357 21618128 denotes 33
32604730-31683930-51943974 481-483 31683930 denotes 34
32604730-9090814-51943975 484-486 9090814 denotes 35
32604730-16181722-51943976 487-489 16181722 denotes 36
32604730-24833039-51943977 490-492 24833039 denotes 37
32604730-14990724-51943978 493-495 14990724 denotes 38
32604730-14990724-51943979 848-850 14990724 denotes 38
32604730-31683930-51943980 1095-1097 31683930 denotes 34
32604730-8502295-51943981 1583-1585 8502295 denotes 39
32604730-17236768-51943982 1998-2000 17236768 denotes 40
32604730-19770846-51943983 2385-2387 19770846 denotes 41
T78050 355-357 21618128 denotes 33
T53753 481-483 31683930 denotes 34
T38465 484-486 9090814 denotes 35
T72587 487-489 16181722 denotes 36
T75131 490-492 24833039 denotes 37
T15211 493-495 14990724 denotes 38
T68693 848-850 14990724 denotes 38
T49725 1095-1097 31683930 denotes 34
T21609 1583-1585 8502295 denotes 39
T5112 1998-2000 17236768 denotes 40
T69375 2385-2387 19770846 denotes 41

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T7 630-636 Phenotype denotes anemia http://purl.obolibrary.org/obo/HP_0001903