PMC:7352545 / 22024-26133
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T65 | 61-63 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T66 | 178-184 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T67 | 186-188 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T68 | 226-228 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T69 | 258-264 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T70 | 467-473 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T71 | 538-541 | https://glytoucan.org/Structures/Glycans/G56516VH | denotes | GM3 |
| T72 | 538-541 | https://glytoucan.org/Structures/Glycans/G91237TK | denotes | GM3 |
| T73 | 605-611 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T74 | 853-859 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T75 | 991-997 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T76 | 1052-1054 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T77 | 1116-1122 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T78 | 1139-1141 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T79 | 1207-1209 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T80 | 1504-1510 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | Neu5Ac |
| T81 | 1832-1834 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T82 | 2563-2565 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T83 | 2595-2597 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T84 | 3006-3029 | https://glytoucan.org/Structures/Glycans/G50850NI | denotes | N-acetylneuraminic acid |
| T85 | 3006-3029 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | N-acetylneuraminic acid |
| T86 | 3143-3145 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T87 | 3210-3212 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T88 | 3297-3299 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T89 | 3429-3431 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T90 | 3519-3521 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
| T91 | 3852-3854 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | SA |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T211 | 300-302 | Body_part | denotes | A2 | http://purl.org/sig/ont/fma/fma66595 |
| T212 | 526-537 | Body_part | denotes | erythrocyte | http://purl.org/sig/ont/fma/fma62845 |
| T213 | 668-673 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T214 | 803-811 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T215 | 1729-1739 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T216 | 2079-2087 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T217 | 3006-3029 | Body_part | denotes | N-acetylneuraminic acid | http://purl.org/sig/ont/fma/fma82788 |
| T218 | 3673-3682 | Body_part | denotes | endosomes | http://purl.org/sig/ont/fma/fma67180 |
| T219 | 3745-3757 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T220 | 3780-3787 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T221 | 3870-3875 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T222 | 3958-3963 | Body_part | denotes | mucus | http://purl.org/sig/ont/fma/fma66938 |
| T223 | 4028-4033 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T5 | 3958-3963 | Body_part | denotes | mucus | http://purl.obolibrary.org/obo/UBERON_0000912 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T84 | 290-299 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T85 | 684-693 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T86 | 703-713 | Disease | denotes | infectious | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T87 | 721-727 | Disease | denotes | anemia | http://purl.obolibrary.org/obo/MONDO_0002280 |
| T88 | 954-963 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T89 | 1598-1607 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T90 | 1893-1902 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T91 | 2021-2053 | Disease | denotes | human parainfluenza virus type 3 | http://purl.obolibrary.org/obo/MONDO_0042974 |
| T92 | 2645-2654 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T93 | 2724-2726 | Disease | denotes | FH | http://purl.obolibrary.org/obo/MONDO_0016525 |
| T94 | 2783-2792 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T95 | 3070-3079 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T96 | 3274-3280 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T97 | 3489-3498 | Disease | denotes | Influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T98 | 3548-3557 | Disease | denotes | Influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T99 | 3697-3706 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T100 | 4081-4090 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T259 | 33-35 | http://purl.obolibrary.org/obo/CLO_0037284 | denotes | C4 |
| T260 | 98-100 | http://purl.obolibrary.org/obo/CLO_0037284 | denotes | C4 |
| T261 | 143-148 | http://purl.obolibrary.org/obo/NCBITaxon_9796 | denotes | horse |
| T262 | 150-152 | http://purl.obolibrary.org/obo/CLO_0037284 | denotes | C4 |
| T263 | 242-244 | http://purl.obolibrary.org/obo/CLO_0037284 | denotes | C4 |
| T264 | 300-302 | http://purl.obolibrary.org/obo/CLO_0001562 | denotes | A2 |
| T265 | 303-308 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T266 | 427-429 | http://purl.obolibrary.org/obo/CLO_0037284 | denotes | C4 |
| T267 | 455-457 | http://purl.obolibrary.org/obo/CLO_0037284 | denotes | C4 |
| T268 | 519-525 | http://purl.obolibrary.org/obo/NCBITaxon_9796 | denotes | equine |
| T269 | 526-537 | http://purl.obolibrary.org/obo/CL_0000232 | denotes | erythrocyte |
| T270 | 552-553 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T271 | 566-570 | http://purl.obolibrary.org/obo/NCBITaxon_117565 | denotes | fish |
| T272 | 589-591 | http://purl.obolibrary.org/obo/CLO_0037284 | denotes | C4 |
| T273 | 650-657 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T274 | 668-673 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T275 | 696-701 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T276 | 728-733 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T277 | 742-743 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T278 | 823-828 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T279 | 845-847 | http://purl.obolibrary.org/obo/CLO_0037284 | denotes | C4 |
| T280 | 966-971 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T281 | 1038-1040 | http://purl.obolibrary.org/obo/CLO_0037284 | denotes | C4 |
| T282 | 1077-1078 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T283 | 1164-1165 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T284 | 1186-1188 | http://purl.obolibrary.org/obo/CLO_0001302 | denotes | 34 |
| T285 | 1322-1324 | http://purl.obolibrary.org/obo/CLO_0037284 | denotes | C4 |
| T286 | 1473-1476 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T287 | 1498-1500 | http://purl.obolibrary.org/obo/CLO_0037284 | denotes | C4 |
| T288 | 1531-1532 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T289 | 1608-1609 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T290 | 1614-1615 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T291 | 1616-1623 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T292 | 1698-1700 | http://purl.obolibrary.org/obo/CLO_0037284 | denotes | C4 |
| T293 | 1763-1769 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T294 | 1808-1810 | http://purl.obolibrary.org/obo/CLO_0037284 | denotes | C4 |
| T295 | 1814-1816 | http://purl.obolibrary.org/obo/CLO_0002105 | denotes | C2 |
| T296 | 1814-1816 | http://purl.obolibrary.org/obo/CLO_0051742 | denotes | C2 |
| T297 | 1856-1864 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T298 | 1903-1904 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T299 | 1905-1910 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T300 | 1932-1933 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T301 | 1934-1939 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T302 | 1950-1953 | http://purl.obolibrary.org/obo/CLO_0054060 | denotes | 102 |
| T303 | 2021-2026 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T304 | 2041-2046 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T305 | 2061-2064 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T306 | 2065-2067 | http://purl.obolibrary.org/obo/CLO_0003788 | denotes | HN |
| T307 | 2098-2100 | http://purl.obolibrary.org/obo/CLO_0037284 | denotes | C4 |
| T308 | 2196-2199 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T309 | 2200-2201 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T310 | 2220-2221 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T311 | 2307-2309 | http://purl.obolibrary.org/obo/CLO_0037284 | denotes | C4 |
| T312 | 2476-2478 | http://purl.obolibrary.org/obo/CLO_0053794 | denotes | 41 |
| T313 | 2655-2656 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T314 | 2657-2662 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T315 | 2795-2800 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T316 | 2895-2898 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T317 | 2965-2968 | http://purl.obolibrary.org/obo/CLO_0001618 | denotes | a 9 |
| T318 | 2965-2968 | http://purl.obolibrary.org/obo/CLO_0001619 | denotes | a 9 |
| T319 | 2965-2968 | http://purl.obolibrary.org/obo/CLO_0001620 | denotes | a 9 |
| T320 | 3044-3045 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T321 | 3082-3087 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T322 | 3134-3140 | http://purl.obolibrary.org/obo/CLO_0050457 | denotes | HE [42 |
| T323 | 3407-3415 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T324 | 3499-3500 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T325 | 3501-3502 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T326 | 3507-3514 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T327 | 3558-3559 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T328 | 3564-3565 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T329 | 3583-3586 | http://purl.obolibrary.org/obo/CLO_0051568 | denotes | SAs |
| T330 | 3629-3634 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T331 | 3870-3875 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T332 | 3947-3952 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T333 | 3982-3987 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T334 | 4028-4033 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T335 | 4050-4058 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T336 | 4091-4092 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T337 | 4098-4103 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T530 | 61-63 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T535 | 155-161 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T537 | 178-184 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T539 | 186-188 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T544 | 226-228 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T549 | 258-264 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T551 | 309-311 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T552 | 328-336 | Chemical | denotes | reagents | http://purl.obolibrary.org/obo/CHEBI_33893 |
| T553 | 345-349 | Chemical | denotes | NaOH | http://purl.obolibrary.org/obo/CHEBI_32145 |
| T554 | 353-358 | Chemical | denotes | NaIO4 | http://purl.obolibrary.org/obo/CHEBI_75226 |
| T555 | 432-444 | Chemical | denotes | acetyl group | http://purl.obolibrary.org/obo/CHEBI_40574 |
| T556 | 432-438 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_46887 |
| T557 | 439-444 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T558 | 460-466 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T560 | 467-473 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T562 | 538-541 | Chemical | denotes | GM3 | http://purl.obolibrary.org/obo/CHEBI_15681|http://purl.obolibrary.org/obo/CHEBI_84118 |
| T564 | 605-611 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T566 | 803-811 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T567 | 850-852 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T569 | 853-859 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T571 | 988-990 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T573 | 991-997 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T575 | 1043-1045 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T577 | 1052-1054 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T582 | 1113-1115 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T584 | 1116-1122 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T586 | 1139-1141 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T591 | 1207-1209 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T596 | 1327-1329 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T598 | 1357-1359 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T600 | 1375-1377 | Chemical | denotes | NA | http://purl.obolibrary.org/obo/CHEBI_33696 |
| T601 | 1378-1388 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T602 | 1447-1449 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T604 | 1467-1469 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T606 | 1504-1510 | Chemical | denotes | Neu5Ac | http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133 |
| T608 | 1584-1594 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T609 | 1683-1685 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T611 | 1686-1691 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T612 | 1729-1739 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T613 | 1729-1734 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T614 | 1735-1739 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T615 | 1740-1743 | Chemical | denotes | Glu | http://purl.obolibrary.org/obo/CHEBI_16015|http://purl.obolibrary.org/obo/CHEBI_18237|http://purl.obolibrary.org/obo/CHEBI_29972 |
| T618 | 1814-1816 | Chemical | denotes | C2 | http://purl.obolibrary.org/obo/CHEBI_30083 |
| T619 | 1832-1834 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T624 | 2079-2087 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T625 | 2133-2145 | Chemical | denotes | alkyl groups | http://purl.obolibrary.org/obo/CHEBI_22323 |
| T626 | 2160-2171 | Chemical | denotes | ethyl group | http://purl.obolibrary.org/obo/CHEBI_37807 |
| T627 | 2160-2165 | Chemical | denotes | ethyl | http://purl.obolibrary.org/obo/CHEBI_62801 |
| T628 | 2166-2171 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T629 | 2224-2239 | Chemical | denotes | guanidino group | http://purl.obolibrary.org/obo/CHEBI_48551 |
| T630 | 2234-2239 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T631 | 2344-2355 | Chemical | denotes | oseltamivir | http://purl.obolibrary.org/obo/CHEBI_7798 |
| T632 | 2375-2382 | Chemical | denotes | Tamiflu | http://purl.obolibrary.org/obo/CHEBI_7798|http://purl.obolibrary.org/obo/CHEBI_7799 |
| T634 | 2408-2417 | Chemical | denotes | zanamivir | http://purl.obolibrary.org/obo/CHEBI_50663 |
| T635 | 2437-2444 | Chemical | denotes | Relenza | http://purl.obolibrary.org/obo/CHEBI_50663 |
| T636 | 2487-2492 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T637 | 2563-2565 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T642 | 2595-2597 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T647 | 2678-2680 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T648 | 2724-2726 | Chemical | denotes | FH | http://purl.obolibrary.org/obo/CHEBI_73634 |
| T649 | 2801-2803 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T650 | 2877-2889 | Chemical | denotes | acetyl group | http://purl.obolibrary.org/obo/CHEBI_40574 |
| T651 | 2877-2883 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_46887 |
| T652 | 2884-2889 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T653 | 2971-2977 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T655 | 2988-2997 | Chemical | denotes | acetamido | http://purl.obolibrary.org/obo/CHEBI_48374 |
| T656 | 3006-3029 | Chemical | denotes | N-acetylneuraminic acid | http://purl.obolibrary.org/obo/CHEBI_17012 |
| T657 | 3025-3029 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T658 | 3143-3145 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T663 | 3195-3197 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T665 | 3206-3208 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T667 | 3210-3212 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T672 | 3297-3299 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T677 | 3384-3386 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T679 | 3429-3431 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T684 | 3519-3521 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T689 | 3591-3593 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T690 | 3598-3600 | Chemical | denotes | NA | http://purl.obolibrary.org/obo/CHEBI_33696 |
| T691 | 3745-3757 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T692 | 3780-3787 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T693 | 3815-3817 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
| T694 | 3822-3824 | Chemical | denotes | NA | http://purl.obolibrary.org/obo/CHEBI_33696 |
| T695 | 3845-3851 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T697 | 3852-3854 | Chemical | denotes | SA | http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667 |
| T702 | 3915-3921 | Chemical | denotes | acetyl | http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887 |
| T704 | 4022-4024 | Chemical | denotes | Ac | http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574 |
| T706 | 4047-4049 | Chemical | denotes | NA | http://purl.obolibrary.org/obo/CHEBI_33696 |
| T707 | 4063-4065 | Chemical | denotes | HA | http://purl.obolibrary.org/obo/CHEBI_73924 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T44 | 3610-3621 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
| T45 | 4005-4012 | http://purl.obolibrary.org/obo/GO_0007114 | denotes | budding |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T209 | 0-4 | Sentence | denotes | 4.2. |
| T210 | 5-89 | Sentence | denotes | Evolutionary Acquisition of C4-O-Acetyl and C9-O-Acetyl SA Recognition by HE Enzymes |
| T211 | 91-97 | Sentence | denotes | 4.2.1. |
| T212 | 98-122 | Sentence | denotes | C4-O-Acetyl Modification |
| T213 | 123-237 | Sentence | denotes | For example, in the horse, C4-O-acetyl modification of Neu5Ac (SA) occupies more than 50% of the total SA content. |
| T214 | 238-312 | Sentence | denotes | The C4-O-acetylated Neu5Ac, Neu4,5Ac2, inhibits the influenza A2 virus HA. |
| T215 | 313-450 | Sentence | denotes | De-acetylation reagents such as NaOH or NaIO4 treatment completely hemagglutinate Neu4,5Ac2 by elimination of the C4-O-acetyl group [33]. |
| T216 | 451-588 | Sentence | denotes | The C4-O-acetyl Neu5Ac species are found in various sources such as equine erythrocyte GM3, starfish A. rubens and fish [34,35,36,37,38]. |
| T217 | 589-674 | Sentence | denotes | C4-O-acetylated Neu5Ac facilitates the initial attachment of viruses to target cells. |
| T218 | 675-844 | Sentence | denotes | Like the influenza C virus, infectious salmon anemia virus (ISAV), a member of the Orthomyxoviridae family, contains HE and HEF proteins to mediate virus entry and exit. |
| T219 | 845-998 | Sentence | denotes | C4-O-Ac Neu5Ac is the major receptor determinant of ISAV in receptor binding and destruction [38], while the influenza C virus recognizes C9-O-Ac Neu5Ac. |
| T220 | 999-1190 | Sentence | denotes | The acetylesterase RDE of ISAV cleaves C4-O-Ac via 4-SA-O-acetylesterase with a short turnover time, whereas C9-O-Ac Neu5Ac is cleaved by 9-SA-O-acetylesterase with a long turnover time [34]. |
| T221 | 1191-1330 | Sentence | denotes | The position of SA O-acetylation is linked to functions including substrate differentiation of enzymes such as NAs and esterase by C4 O-Ac. |
| T222 | 1331-1460 | Sentence | denotes | Previous development of O-Ac site-selective NA inhibitors were based on the conceptual consideration of different O-Ac positions. |
| T223 | 1461-1569 | Sentence | denotes | The O-Ac of SAs is site-specific, as C4 of Neu5Ac is considered to be a potential position for modification. |
| T224 | 1570-1678 | Sentence | denotes | Historically, inhibitors of influenza A and B viruses-sialidases were designed by Von-Itzstein in 1993 [39]. |
| T225 | 1679-1788 | Sentence | denotes | The Ac group-based C4 substitution interacts with amino acid Glu-119 present in the active site of sialidase. |
| T226 | 1789-1958 | Sentence | denotes | Guanidine-attached C4 of C2–C3 unsaturated SA (Neu5Ac2en) inhibits activity of sialidases isolated from influenza A virus (Singapore/1/57) and B virus (Victoria/102/85). |
| T227 | 1959-2093 | Sentence | denotes | The same scenario was applied for sialidase inhibition of the human parainfluenza virus type 3, which has HN and fusion proteins [40]. |
| T228 | 2094-2172 | Sentence | denotes | The C4 of Neu5Ac2en was substituted by alkyl groups such as the O-ethyl group. |
| T229 | 2173-2262 | Sentence | denotes | For example, Zanamivir has a substitution with a 4-guanidino group with an IC50 of 25 μM. |
| T230 | 2263-2336 | Sentence | denotes | Thus, sialidase inhibition is important for C4 modification of Neu5Ac2en. |
| T231 | 2337-2480 | Sentence | denotes | Later, oseltamivir with the tradename Tamiflu (Basel, Switzerland) and zanamivir with the tradename Relenza (London, UK) were established [41]. |
| T232 | 2481-2554 | Sentence | denotes | These drugs exhibit some adverse side effects that restrict clinical use. |
| T233 | 2556-2562 | Sentence | denotes | 4.2.2. |
| T234 | 2563-2590 | Sentence | denotes | SA C9-O-Acetyl Modification |
| T235 | 2591-2769 | Sentence | denotes | The SA 9-O-acetylation in hosts allows hosts to evade influenza A virus hemagglutinin (HA) recognition and some lectins of factor H (FH), CD22/Siglec-2 and sialoadhesin/Siglec-1. |
| T236 | 2770-2899 | Sentence | denotes | Instead, the influenza C virus HA recognizes the hosts. β-elimination and permethylation eliminate the 9-O-acetyl group from SAs. |
| T237 | 2900-3142 | Sentence | denotes | Chemical modification of the C-9 position of Neu5,9Ac2 generates a 9-N-acetyl analog, 9-acetamido-9-deoxy-N-acetylneuraminic acid (Neu5Ac9NAc), a mimic of Neu5,9Ac2 with influenza C virus-binding capacity, which is not cleaved by the HE [42]. |
| T238 | 3143-3209 | Sentence | denotes | SA O-acetylesterase regulates the presence of 7,9-O-Ac and 9-O-Ac. |
| T239 | 3210-3296 | Sentence | denotes | SA O-acetylation and deacetylation are involved in development, cancer and immunology. |
| T240 | 3297-3363 | Sentence | denotes | SA O-acetylation alters host lectin bindings such as siglecs [29]. |
| T241 | 3364-3428 | Sentence | denotes | The presence of 9-O-Ac can also reduce the activity of NAs [43]. |
| T242 | 3429-3488 | Sentence | denotes | SA modifications regulate pathogen binding or pathogen NAs. |
| T243 | 3489-3547 | Sentence | denotes | Influenza A/B/C/D viruses use SA as their entry receptors. |
| T244 | 3548-3683 | Sentence | denotes | Influenza A and B subtypes bind to SAs via HA and NA to allow endocytosis of the virus and fusion of the viral envelope with endosomes. |
| T245 | 3684-3794 | Sentence | denotes | In contrast, influenza C and D subtypes bear only one coated glycoprotein, termed the HE fusion protein (HEF). |
| T246 | 3795-3825 | Sentence | denotes | The HEF acts as the HA and NA. |
| T247 | 3826-4013 | Sentence | denotes | HEF recognizes 9-O-acetyl SA for entry into cells, while the esterase domain removes 9-O-acetyl-groups and liberates the virus from mucus and mis-assembled virus aggregates after budding. |
| T248 | 4014-4109 | Sentence | denotes | The 9-O-Ac on cells prevents the NA activity and HA binding of the influenza A type virus [44]. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-21618128-51943973 | 446-448 | 21618128 | denotes | 33 |
| 32604730-31683930-51943974 | 572-574 | 31683930 | denotes | 34 |
| 32604730-9090814-51943975 | 575-577 | 9090814 | denotes | 35 |
| 32604730-16181722-51943976 | 578-580 | 16181722 | denotes | 36 |
| 32604730-24833039-51943977 | 581-583 | 24833039 | denotes | 37 |
| 32604730-14990724-51943978 | 584-586 | 14990724 | denotes | 38 |
| 32604730-14990724-51943979 | 939-941 | 14990724 | denotes | 38 |
| 32604730-31683930-51943980 | 1186-1188 | 31683930 | denotes | 34 |
| 32604730-8502295-51943981 | 1674-1676 | 8502295 | denotes | 39 |
| 32604730-17236768-51943982 | 2089-2091 | 17236768 | denotes | 40 |
| 32604730-19770846-51943983 | 2476-2478 | 19770846 | denotes | 41 |
| 32604730-29341588-51943984 | 3424-3426 | 29341588 | denotes | 43 |
| 32604730-31796537-51943985 | 4105-4107 | 31796537 | denotes | 44 |
| T78050 | 446-448 | 21618128 | denotes | 33 |
| T53753 | 572-574 | 31683930 | denotes | 34 |
| T38465 | 575-577 | 9090814 | denotes | 35 |
| T72587 | 578-580 | 16181722 | denotes | 36 |
| T75131 | 581-583 | 24833039 | denotes | 37 |
| T15211 | 584-586 | 14990724 | denotes | 38 |
| T68693 | 939-941 | 14990724 | denotes | 38 |
| T49725 | 1186-1188 | 31683930 | denotes | 34 |
| T21609 | 1674-1676 | 8502295 | denotes | 39 |
| T5112 | 2089-2091 | 17236768 | denotes | 40 |
| T69375 | 2476-2478 | 19770846 | denotes | 41 |
| T17811 | 3424-3426 | 29341588 | denotes | 43 |
| T51599 | 4105-4107 | 31796537 | denotes | 44 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T7 | 721-727 | Phenotype | denotes | anemia | http://purl.obolibrary.org/obo/HP_0001903 |
| T8 | 3274-3280 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |