PMC:7352545 / 21275-22022 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7352545","sourcedb":"PMC","sourceid":"7352545","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7352545","text":"Biologically, the SA O-acetylation event confers merits to hosts such as protection from pathogenic invasion and maintenance of systemic self-homeostasis. The O-acetylation event of SAs protects the SA-containing glycans from neuraminidase (NA)/sialidase action, because O-acetyl-groups inhibit microbial NA activity. The chemical structure of the O-acetyl group is quite unstable and susceptible to esterase enzymes. Sialic acid cleavage of the di-acetylated Neu5,7,9Ac3 by bacterial NAs decreases two-fold, when compared to mono-O-acetylated Neu5Ac. The O-acetylated glycan modification invites interaction with viruses, antibodies and mammalian lectins [32]. Therefore, the SA O-acetylation modification confers specific functions to organisms.","tracks":[{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T60","span":{"begin":18,"end":20},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T61","span":{"begin":199,"end":201},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T62","span":{"begin":418,"end":429},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T63","span":{"begin":544,"end":550},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T64","span":{"begin":677,"end":679},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"}],"attributes":[{"subj":"T60","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T61","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T62","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T63","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T64","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T254","span":{"begin":182,"end":185},"obj":"http://purl.obolibrary.org/obo/CLO_0051568"},{"id":"T255","span":{"begin":308,"end":316},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T256","span":{"begin":614,"end":621},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T257","span":{"begin":737,"end":746},"obj":"http://purl.obolibrary.org/obo/OBI_0100026"},{"id":"T258","span":{"begin":737,"end":746},"obj":"http://purl.obolibrary.org/obo/UBERON_0000468"}],"attributes":[{"subj":"T254","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T255","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T256","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T257","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T258","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T504","span":{"begin":18,"end":20},"obj":"Chemical"},{"id":"T509","span":{"begin":199,"end":201},"obj":"Chemical"},{"id":"T514","span":{"begin":213,"end":220},"obj":"Chemical"},{"id":"T515","span":{"begin":241,"end":243},"obj":"Chemical"},{"id":"T516","span":{"begin":273,"end":279},"obj":"Chemical"},{"id":"T518","span":{"begin":305,"end":307},"obj":"Chemical"},{"id":"T519","span":{"begin":350,"end":362},"obj":"Chemical"},{"id":"T520","span":{"begin":350,"end":356},"obj":"Chemical"},{"id":"T521","span":{"begin":357,"end":362},"obj":"Chemical"},{"id":"T522","span":{"begin":425,"end":429},"obj":"Chemical"},{"id":"T523","span":{"begin":544,"end":550},"obj":"Chemical"},{"id":"T525","span":{"begin":677,"end":679},"obj":"Chemical"}],"attributes":[{"id":"A504","pred":"chebi_id","subj":"T504","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A505","pred":"chebi_id","subj":"T504","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A506","pred":"chebi_id","subj":"T504","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A507","pred":"chebi_id","subj":"T504","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A508","pred":"chebi_id","subj":"T504","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A509","pred":"chebi_id","subj":"T509","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A510","pred":"chebi_id","subj":"T509","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A511","pred":"chebi_id","subj":"T509","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A512","pred":"chebi_id","subj":"T509","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A513","pred":"chebi_id","subj":"T509","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"id":"A514","pred":"chebi_id","subj":"T514","obj":"http://purl.obolibrary.org/obo/CHEBI_18154"},{"id":"A515","pred":"chebi_id","subj":"T515","obj":"http://purl.obolibrary.org/obo/CHEBI_33696"},{"id":"A516","pred":"chebi_id","subj":"T516","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A517","pred":"chebi_id","subj":"T516","obj":"http://purl.obolibrary.org/obo/CHEBI_46887"},{"id":"A518","pred":"chebi_id","subj":"T518","obj":"http://purl.obolibrary.org/obo/CHEBI_33696"},{"id":"A519","pred":"chebi_id","subj":"T519","obj":"http://purl.obolibrary.org/obo/CHEBI_40574"},{"id":"A520","pred":"chebi_id","subj":"T520","obj":"http://purl.obolibrary.org/obo/CHEBI_46887"},{"id":"A521","pred":"chebi_id","subj":"T521","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A522","pred":"chebi_id","subj":"T522","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A523","pred":"chebi_id","subj":"T523","obj":"http://purl.obolibrary.org/obo/CHEBI_17012"},{"id":"A524","pred":"chebi_id","subj":"T523","obj":"http://purl.obolibrary.org/obo/CHEBI_75133"},{"id":"A525","pred":"chebi_id","subj":"T525","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A526","pred":"chebi_id","subj":"T525","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A527","pred":"chebi_id","subj":"T525","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A528","pred":"chebi_id","subj":"T525","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A529","pred":"chebi_id","subj":"T525","obj":"http://purl.obolibrary.org/obo/CHEBI_26667"},{"subj":"T504","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T509","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T514","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T515","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T516","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T518","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T519","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T520","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T521","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T522","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T523","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T525","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T43","span":{"begin":142,"end":153},"obj":"http://purl.obolibrary.org/obo/GO_0042592"}],"attributes":[{"subj":"T43","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T203","span":{"begin":0,"end":154},"obj":"Sentence"},{"id":"T204","span":{"begin":155,"end":317},"obj":"Sentence"},{"id":"T205","span":{"begin":318,"end":417},"obj":"Sentence"},{"id":"T206","span":{"begin":418,"end":551},"obj":"Sentence"},{"id":"T207","span":{"begin":552,"end":661},"obj":"Sentence"},{"id":"T208","span":{"begin":662,"end":747},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T203","pred":"source","obj":"LitCovid-sentences"},{"subj":"T204","pred":"source","obj":"LitCovid-sentences"},{"subj":"T205","pred":"source","obj":"LitCovid-sentences"},{"subj":"T206","pred":"source","obj":"LitCovid-sentences"},{"subj":"T207","pred":"source","obj":"LitCovid-sentences"},{"subj":"T208","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32604730-27936566-51943972","span":{"begin":657,"end":659},"obj":"27936566"},{"id":"T37447","span":{"begin":657,"end":659},"obj":"27936566"}],"attributes":[{"subj":"32604730-27936566-51943972","pred":"source","obj":"2_test"},{"subj":"T37447","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid_Glycan-Motif-Structure","color":"#939aec","default":true},{"id":"LitCovid-PD-CLO","color":"#b4ec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93ce"},{"id":"LitCovid-PD-GO-BP","color":"#93e9ec"},{"id":"LitCovid-sentences","color":"#ecd593"},{"id":"2_test","color":"#bb93ec"}]}]}}