PMC:7352545 / 19599-20517 JSON TXT

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LitCovid_Glycan-Motif-Structure

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T41","span":{"begin":99,"end":122},"obj":"https://glytoucan.org/Structures/Glycans/G50850NI"},{"id":"T42","span":{"begin":99,"end":122},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T43","span":{"begin":124,"end":130},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T44","span":{"begin":190,"end":192},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T45","span":{"begin":391,"end":393},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T46","span":{"begin":623,"end":625},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T47","span":{"begin":640,"end":642},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T48","span":{"begin":643,"end":666},"obj":"https://glytoucan.org/Structures/Glycans/G50850NI"},{"id":"T49","span":{"begin":643,"end":666},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T50","span":{"begin":668,"end":674},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T51","span":{"begin":712,"end":735},"obj":"https://glytoucan.org/Structures/Glycans/G50850NI"},{"id":"T52","span":{"begin":712,"end":735},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T53","span":{"begin":760,"end":766},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T54","span":{"begin":802,"end":804},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"}],"text":"SAs have various derivatives of more than 50 chemically different structures formed from the basic N-acetylneuraminic acid (Neu5Ac) on the main ring of pyranose and the glycerol side chain. SA are modified by acetyl-, lactyl-, methyl- and sulfo-groups individually or in multiple combinations [28]. Multiple enzymes are involved in the modifications [29]. Historically, the first discovered SA was crystallized by Gunner Blix via a hot mild acid extraction of bovine submaxillary mucin in 1936. It consisted of two acetyl groups. Among these, only one acetyl group was attached to nitrogen [30]. Blix isolated a 9-O-acetyl SA of the common SA N-acetylneuraminic acid (Neu5Ac), chemically described as 9-O-acetyl-N-acetylneuraminic acid (Neu5,9Ac2). Neu5,9Ac2, Neu5Ac and Neu5Gc are naturally occurring SA species in mammals. A common modification is O-acetylation. In fact, O-acetylation of SAs is common in organisms."}

LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T206","span":{"begin":99,"end":122},"obj":"Body_part"},{"id":"T207","span":{"begin":643,"end":666},"obj":"Body_part"},{"id":"T208","span":{"begin":712,"end":735},"obj":"Body_part"}],"attributes":[{"id":"A206","pred":"fma_id","subj":"T206","obj":"http://purl.org/sig/ont/fma/fma82788"},{"id":"A207","pred":"fma_id","subj":"T207","obj":"http://purl.org/sig/ont/fma/fma82788"},{"id":"A208","pred":"fma_id","subj":"T208","obj":"http://purl.org/sig/ont/fma/fma82788"}],"text":"SAs have various derivatives of more than 50 chemically different structures formed from the basic N-acetylneuraminic acid (Neu5Ac) on the main ring of pyranose and the glycerol side chain. SA are modified by acetyl-, lactyl-, methyl- and sulfo-groups individually or in multiple combinations [28]. Multiple enzymes are involved in the modifications [29]. Historically, the first discovered SA was crystallized by Gunner Blix via a hot mild acid extraction of bovine submaxillary mucin in 1936. It consisted of two acetyl groups. Among these, only one acetyl group was attached to nitrogen [30]. Blix isolated a 9-O-acetyl SA of the common SA N-acetylneuraminic acid (Neu5Ac), chemically described as 9-O-acetyl-N-acetylneuraminic acid (Neu5,9Ac2). Neu5,9Ac2, Neu5Ac and Neu5Gc are naturally occurring SA species in mammals. A common modification is O-acetylation. In fact, O-acetylation of SAs is common in organisms."}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T231","span":{"begin":0,"end":3},"obj":"http://purl.obolibrary.org/obo/CLO_0051568"},{"id":"T232","span":{"begin":430,"end":431},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T233","span":{"begin":610,"end":613},"obj":"http://purl.obolibrary.org/obo/CLO_0001618"},{"id":"T234","span":{"begin":610,"end":613},"obj":"http://purl.obolibrary.org/obo/CLO_0001619"},{"id":"T235","span":{"begin":610,"end":613},"obj":"http://purl.obolibrary.org/obo/CLO_0001620"},{"id":"T236","span":{"begin":825,"end":826},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T237","span":{"begin":891,"end":894},"obj":"http://purl.obolibrary.org/obo/CLO_0051568"},{"id":"T238","span":{"begin":908,"end":917},"obj":"http://purl.obolibrary.org/obo/OBI_0100026"},{"id":"T239","span":{"begin":908,"end":917},"obj":"http://purl.obolibrary.org/obo/UBERON_0000468"}],"text":"SAs have various derivatives of more than 50 chemically different structures formed from the basic N-acetylneuraminic acid (Neu5Ac) on the main ring of pyranose and the glycerol side chain. SA are modified by acetyl-, lactyl-, methyl- and sulfo-groups individually or in multiple combinations [28]. Multiple enzymes are involved in the modifications [29]. Historically, the first discovered SA was crystallized by Gunner Blix via a hot mild acid extraction of bovine submaxillary mucin in 1936. It consisted of two acetyl groups. Among these, only one acetyl group was attached to nitrogen [30]. Blix isolated a 9-O-acetyl SA of the common SA N-acetylneuraminic acid (Neu5Ac), chemically described as 9-O-acetyl-N-acetylneuraminic acid (Neu5,9Ac2). Neu5,9Ac2, Neu5Ac and Neu5Gc are naturally occurring SA species in mammals. A common modification is O-acetylation. In fact, O-acetylation of SAs is common in organisms."}

LitCovid-PD-CHEBI

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T187","span":{"begin":0,"end":189},"obj":"Sentence"},{"id":"T188","span":{"begin":190,"end":298},"obj":"Sentence"},{"id":"T189","span":{"begin":299,"end":355},"obj":"Sentence"},{"id":"T190","span":{"begin":356,"end":494},"obj":"Sentence"},{"id":"T191","span":{"begin":495,"end":529},"obj":"Sentence"},{"id":"T192","span":{"begin":530,"end":595},"obj":"Sentence"},{"id":"T193","span":{"begin":596,"end":748},"obj":"Sentence"},{"id":"T194","span":{"begin":749,"end":824},"obj":"Sentence"},{"id":"T195","span":{"begin":825,"end":864},"obj":"Sentence"},{"id":"T196","span":{"begin":865,"end":918},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"SAs have various derivatives of more than 50 chemically different structures formed from the basic N-acetylneuraminic acid (Neu5Ac) on the main ring of pyranose and the glycerol side chain. SA are modified by acetyl-, lactyl-, methyl- and sulfo-groups individually or in multiple combinations [28]. Multiple enzymes are involved in the modifications [29]. Historically, the first discovered SA was crystallized by Gunner Blix via a hot mild acid extraction of bovine submaxillary mucin in 1936. It consisted of two acetyl groups. Among these, only one acetyl group was attached to nitrogen [30]. Blix isolated a 9-O-acetyl SA of the common SA N-acetylneuraminic acid (Neu5Ac), chemically described as 9-O-acetyl-N-acetylneuraminic acid (Neu5,9Ac2). Neu5,9Ac2, Neu5Ac and Neu5Gc are naturally occurring SA species in mammals. A common modification is O-acetylation. In fact, O-acetylation of SAs is common in organisms."}

2_test

{"project":"2_test","denotations":[{"id":"32604730-25921326-51943970","span":{"begin":591,"end":593},"obj":"25921326"},{"id":"T55761","span":{"begin":591,"end":593},"obj":"25921326"}],"text":"SAs have various derivatives of more than 50 chemically different structures formed from the basic N-acetylneuraminic acid (Neu5Ac) on the main ring of pyranose and the glycerol side chain. SA are modified by acetyl-, lactyl-, methyl- and sulfo-groups individually or in multiple combinations [28]. Multiple enzymes are involved in the modifications [29]. Historically, the first discovered SA was crystallized by Gunner Blix via a hot mild acid extraction of bovine submaxillary mucin in 1936. It consisted of two acetyl groups. Among these, only one acetyl group was attached to nitrogen [30]. Blix isolated a 9-O-acetyl SA of the common SA N-acetylneuraminic acid (Neu5Ac), chemically described as 9-O-acetyl-N-acetylneuraminic acid (Neu5,9Ac2). Neu5,9Ac2, Neu5Ac and Neu5Gc are naturally occurring SA species in mammals. A common modification is O-acetylation. In fact, O-acetylation of SAs is common in organisms."}