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PMC:7352545 / 19566-22022 JSONTXT

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LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T40 30-32 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T41 132-155 https://glytoucan.org/Structures/Glycans/G50850NI denotes N-acetylneuraminic acid
T42 132-155 https://glytoucan.org/Structures/Glycans/G81533KY denotes N-acetylneuraminic acid
T43 157-163 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T44 223-225 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T45 424-426 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T46 656-658 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T47 673-675 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T48 676-699 https://glytoucan.org/Structures/Glycans/G50850NI denotes N-acetylneuraminic acid
T49 676-699 https://glytoucan.org/Structures/Glycans/G81533KY denotes N-acetylneuraminic acid
T50 701-707 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T51 745-768 https://glytoucan.org/Structures/Glycans/G50850NI denotes N-acetylneuraminic acid
T52 745-768 https://glytoucan.org/Structures/Glycans/G81533KY denotes N-acetylneuraminic acid
T53 793-799 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T54 835-837 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T55 1033-1035 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T56 1186-1188 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T57 1253-1255 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T58 1382-1384 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T59 1638-1644 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T60 1727-1729 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T61 1908-1910 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA
T62 2127-2138 https://glytoucan.org/Structures/Glycans/G81533KY denotes Sialic acid
T63 2253-2259 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T64 2386-2388 https://glytoucan.org/Structures/Glycans/G81533KY denotes SA

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T206 132-155 Body_part denotes N-acetylneuraminic acid http://purl.org/sig/ont/fma/fma82788
T207 676-699 Body_part denotes N-acetylneuraminic acid http://purl.org/sig/ont/fma/fma82788
T208 745-768 Body_part denotes N-acetylneuraminic acid http://purl.org/sig/ont/fma/fma82788
T209 1401-1416 Body_part denotes Golgi apparatus http://purl.org/sig/ont/fma/fma63843
T210 1417-1428 Body_part denotes compartment http://purl.org/sig/ont/fma/fma76577

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T231 33-36 http://purl.obolibrary.org/obo/CLO_0051568 denotes SAs
T232 463-464 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T233 643-646 http://purl.obolibrary.org/obo/CLO_0001618 denotes a 9
T234 643-646 http://purl.obolibrary.org/obo/CLO_0001619 denotes a 9
T235 643-646 http://purl.obolibrary.org/obo/CLO_0001620 denotes a 9
T236 858-859 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T237 924-927 http://purl.obolibrary.org/obo/CLO_0051568 denotes SAs
T238 941-950 http://purl.obolibrary.org/obo/OBI_0100026 denotes organisms
T239 941-950 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organisms
T240 1008-1011 http://purl.obolibrary.org/obo/CLO_0037284 denotes C-4
T241 1013-1016 http://purl.obolibrary.org/obo/CLO_0002147 denotes C-7
T242 1013-1016 http://purl.obolibrary.org/obo/CLO_0051562 denotes C-7
T243 1117-1120 http://purl.obolibrary.org/obo/CLO_0051568 denotes SAs
T244 1136-1137 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T245 1202-1205 http://purl.obolibrary.org/obo/CLO_0002147 denotes C-7
T246 1202-1205 http://purl.obolibrary.org/obo/CLO_0051562 denotes C-7
T247 1284-1288 http://purl.obolibrary.org/obo/CLO_0002200 denotes Cas1
T248 1382-1386 http://purl.obolibrary.org/obo/UBERON_0009856 denotes SA C
T249 1517-1520 http://purl.obolibrary.org/obo/CLO_0002147 denotes C-7
T250 1517-1520 http://purl.obolibrary.org/obo/CLO_0051562 denotes C-7
T251 1550-1553 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T252 1607-1613 http://purl.obolibrary.org/obo/CLO_0001627 denotes A as a
T253 1685-1693 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T254 1891-1894 http://purl.obolibrary.org/obo/CLO_0051568 denotes SAs
T255 2017-2025 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T256 2323-2330 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T257 2446-2455 http://purl.obolibrary.org/obo/OBI_0100026 denotes organisms
T258 2446-2455 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organisms

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T401 30-32 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T406 132-155 Chemical denotes N-acetylneuraminic acid http://purl.obolibrary.org/obo/CHEBI_17012
T407 151-155 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T408 157-163 Chemical denotes Neu5Ac http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133
T410 202-210 Chemical denotes glycerol http://purl.obolibrary.org/obo/CHEBI_17754
T411 223-225 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T416 242-248 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887
T418 260-266 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T420 272-277 Chemical denotes sulfo http://purl.obolibrary.org/obo/CHEBI_29922
T421 424-426 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T426 474-478 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T427 548-554 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887
T429 585-597 Chemical denotes acetyl group http://purl.obolibrary.org/obo/CHEBI_40574
T430 585-591 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_46887
T431 592-597 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T432 614-622 Chemical denotes nitrogen http://purl.obolibrary.org/obo/CHEBI_25555
T433 649-655 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887
T435 656-658 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T440 673-675 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T445 676-699 Chemical denotes N-acetylneuraminic acid http://purl.obolibrary.org/obo/CHEBI_17012
T446 695-699 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T447 701-707 Chemical denotes Neu5Ac http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133
T449 738-744 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887
T451 745-768 Chemical denotes N-acetylneuraminic acid http://purl.obolibrary.org/obo/CHEBI_17012
T452 764-768 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T453 793-799 Chemical denotes Neu5Ac http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133
T455 804-810 Chemical denotes Neu5Gc http://purl.obolibrary.org/obo/CHEBI_62084
T456 835-837 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T461 958-964 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887
T463 1033-1035 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T468 1186-1188 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T473 1189-1196 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T474 1253-1255 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T479 1361-1367 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887
T481 1382-1384 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T486 1499-1505 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887
T488 1506-1511 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T489 1591-1597 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887
T491 1598-1608 Chemical denotes coenzyme A http://purl.obolibrary.org/obo/CHEBI_15346
T492 1598-1606 Chemical denotes coenzyme http://purl.obolibrary.org/obo/CHEBI_23354
T493 1614-1619 Chemical denotes donor http://purl.obolibrary.org/obo/CHEBI_17891
T494 1634-1644 Chemical denotes CMP-Neu5Ac http://purl.obolibrary.org/obo/CHEBI_16556
T495 1634-1637 Chemical denotes CMP http://purl.obolibrary.org/obo/CHEBI_17361|http://purl.obolibrary.org/obo/CHEBI_60377
T497 1638-1644 Chemical denotes Neu5Ac http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133
T499 1651-1659 Chemical denotes acceptor http://purl.obolibrary.org/obo/CHEBI_15339
T500 1697-1707 Chemical denotes CMP-Neu5Gc http://purl.obolibrary.org/obo/CHEBI_18098
T501 1697-1700 Chemical denotes CMP http://purl.obolibrary.org/obo/CHEBI_17361|http://purl.obolibrary.org/obo/CHEBI_60377
T503 1701-1707 Chemical denotes Neu5Gc http://purl.obolibrary.org/obo/CHEBI_62084
T504 1727-1729 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T509 1908-1910 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667
T514 1922-1929 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T515 1950-1952 Chemical denotes NA http://purl.obolibrary.org/obo/CHEBI_33696
T516 1982-1988 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_40574|http://purl.obolibrary.org/obo/CHEBI_46887
T518 2014-2016 Chemical denotes NA http://purl.obolibrary.org/obo/CHEBI_33696
T519 2059-2071 Chemical denotes acetyl group http://purl.obolibrary.org/obo/CHEBI_40574
T520 2059-2065 Chemical denotes acetyl http://purl.obolibrary.org/obo/CHEBI_46887
T521 2066-2071 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T522 2134-2138 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T523 2253-2259 Chemical denotes Neu5Ac http://purl.obolibrary.org/obo/CHEBI_17012|http://purl.obolibrary.org/obo/CHEBI_75133
T525 2386-2388 Chemical denotes SA http://purl.obolibrary.org/obo/CHEBI_35962|http://purl.obolibrary.org/obo/CHEBI_38358|http://purl.obolibrary.org/obo/CHEBI_45373|http://purl.obolibrary.org/obo/CHEBI_74801|http://purl.obolibrary.org/obo/CHEBI_26667

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T43 1851-1862 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T185 0-4 Sentence denotes 4.1.
T186 5-32 Sentence denotes General O-Acetylation of SA
T187 33-222 Sentence denotes SAs have various derivatives of more than 50 chemically different structures formed from the basic N-acetylneuraminic acid (Neu5Ac) on the main ring of pyranose and the glycerol side chain.
T188 223-331 Sentence denotes SA are modified by acetyl-, lactyl-, methyl- and sulfo-groups individually or in multiple combinations [28].
T189 332-388 Sentence denotes Multiple enzymes are involved in the modifications [29].
T190 389-527 Sentence denotes Historically, the first discovered SA was crystallized by Gunner Blix via a hot mild acid extraction of bovine submaxillary mucin in 1936.
T191 528-562 Sentence denotes It consisted of two acetyl groups.
T192 563-628 Sentence denotes Among these, only one acetyl group was attached to nitrogen [30].
T193 629-781 Sentence denotes Blix isolated a 9-O-acetyl SA of the common SA N-acetylneuraminic acid (Neu5Ac), chemically described as 9-O-acetyl-N-acetylneuraminic acid (Neu5,9Ac2).
T194 782-857 Sentence denotes Neu5,9Ac2, Neu5Ac and Neu5Gc are naturally occurring SA species in mammals.
T195 858-897 Sentence denotes A common modification is O-acetylation.
T196 898-951 Sentence denotes In fact, O-acetylation of SAs is common in organisms.
T197 952-1121 Sentence denotes The O-acetyl modification occurs in single positions of C-4, C-7, C-8 and C-9 of SA as well as in combined C-positions to yield Neu4,5Ac2, Neu5,9Ac2 and Neu5,7,9Ac3 SAs.
T198 1122-1197 Sentence denotes Neu5Ac9NAc is a chemical and biologic mimic of Neu5,9Ac2 in the SA-glycans.
T199 1198-1328 Sentence denotes The C-7 and/or C-9 O-acetylations are catalyzed by the SA O-acetyltransferase enzyme, Cas1 domain containing 1 (CasD1) (Figure 6).
T200 1329-1434 Sentence denotes CasD1 catalyzes the addition of acetyl groups to the SA C-7 at the late Golgi apparatus compartment [31].
T201 1435-1579 Sentence denotes Thereafter, an enzyme termed “migrase” transfers the additional acetyl-group from C-7 to C-9, although this enzyme has not been identified [29].
T202 1580-1708 Sentence denotes CasD1 uses acetyl-coenzyme A as a donor substrate and CMP-Neu5Ac as an acceptor substrate, but with weak activity on CMP-Neu5Gc.
T203 1709-1863 Sentence denotes Biologically, the SA O-acetylation event confers merits to hosts such as protection from pathogenic invasion and maintenance of systemic self-homeostasis.
T204 1864-2026 Sentence denotes The O-acetylation event of SAs protects the SA-containing glycans from neuraminidase (NA)/sialidase action, because O-acetyl-groups inhibit microbial NA activity.
T205 2027-2126 Sentence denotes The chemical structure of the O-acetyl group is quite unstable and susceptible to esterase enzymes.
T206 2127-2260 Sentence denotes Sialic acid cleavage of the di-acetylated Neu5,7,9Ac3 by bacterial NAs decreases two-fold, when compared to mono-O-acetylated Neu5Ac.
T207 2261-2370 Sentence denotes The O-acetylated glycan modification invites interaction with viruses, antibodies and mammalian lectins [32].
T208 2371-2456 Sentence denotes Therefore, the SA O-acetylation modification confers specific functions to organisms.

2_test

Id Subject Object Predicate Lexical cue
32604730-25921326-51943970 624-626 25921326 denotes 30
32604730-26169044-51943971 1430-1432 26169044 denotes 31
32604730-27936566-51943972 2366-2368 27936566 denotes 32
T55761 624-626 25921326 denotes 30
T96738 1430-1432 26169044 denotes 31
T37447 2366-2368 27936566 denotes 32