PMC:7347402 / 4972-8224 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7347402","sourcedb":"PMC","sourceid":"7347402","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7347402","text":"Study design and participants\nWe conducted a retrospective study of COVID-19 patients admitted to Wuhan Union West Hospital and Wuhan Red Cross Hospital to ascertain whether FBG was an independent predictor for 28-day mortality in patients with COVID-19 without a previous diagnosis of diabetes. COVID-19 infection was laboratory-confirmed in accordance with the interim guidance formulated by the WHO [15]. The aforementioned hospitals were two mandatorily designated hospitals for the treatment of COVID-19 patients in China. The institutional ethics committees of Wuhan Union Hospital (No. 0036) reviewed and approved this study protocol. No patients or medical staff involved in patient care took part in the study design and statistical analyses.\nAll consecutive patients included in this study had a definitive outcome (died, discharged or still hospitalised) within 28 days, with the time period spanning from 24 January 2020 to 10 February 2020. All patients received standard treatment, including antiviral therapy, respiratory support (nasal cannulation, mask oxygenation, high-flow nasal cannula oxygen therapy, non-invasive positive pressure ventilation or invasive mechanical ventilation), symptomatic and supportive treatment and antimicrobial therapy, as appropriate, to prevent or treat secondary infections, which was in accordance with the COVID-19 diagnosis and treatment protocols released by the National Health Commission of the People’s Republic of China [16]. This retrospective project did not interfere with the course of medical management.\nA total of 1258 confirmed COVID-19 patients were admitted into the two hospitals. Of these, 653 patients were ruled out for one of the following reasons: (1) no definitive 28-day outcome since they were transferred to another hospital; (2) missing key clinical information (e.g. demographic or clinical data); (3) no FBG data available at admission (for one of the following reasons: [a] patients had a blood glucose measurement taken before admission; [b] patients were tested for blood glucose 24 h after admission; [c] patients received a random blood glucose test but were not tested for FBG; [d] patients did not receive a blood glucose test since this was not routinely conducted for every COVID-19 patient); (4) having previously diagnosed diabetes. The flow diagram of patient selection is detailed in Fig. 1.\nFig. 1 Flow diagram of patient selection. aReasons for no FBG measurement at admission: 13 patients had a blood glucose measurement taken before admission; 25 patients were tested for blood glucose 24 h after admission; 84 patients received a random blood glucose test but were not tested for FBG; and 81 patients did not receive a blood glucose test since this was not routinely conducted for every COVID-19 patient\nPatients were discharged when they met the following discharge criteria: (1) body temperature returned to normal, lasting for more than 3 days; (2) respiratory symptoms significantly improved; (3) imaging examinations revealed that acute exudative lesions were significantly improved; (4) two real-time RT-PCR tests for the presence of SARS-CoV-2 virus yielded negative results (with two samples of respiratory specimens taken over 24 h apart) 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