PMC:7347402 / 195-2185
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2 | 260-267 | https://glytoucan.org/Structures/Glycans/G15021LG | denotes | glucose |
| T3 | 1943-1950 | https://glytoucan.org/Structures/Glycans/G15021LG | denotes | glucose |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T3 | 254-259 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T4 | 260-267 | Body_part | denotes | glucose | http://purl.org/sig/ont/fma/fma82743 |
| T5 | 929-934 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T6 | 968-973 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T7 | 1943-1950 | Body_part | denotes | glucose | http://purl.org/sig/ont/fma/fma82743 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T2 | 254-259 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T3 | 929-934 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T4 | 968-973 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 22 | 334-342 | Species | denotes | patients | Tax:9606 |
| 23 | 260-267 | Chemical | denotes | glucose | MESH:D005947 |
| 24 | 16-30 | Disease | denotes | Hyperglycaemia | |
| 25 | 70-79 | Disease | denotes | mortality | MESH:D003643 |
| 26 | 102-111 | Disease | denotes | pneumonia | MESH:D011014 |
| 27 | 113-119 | Disease | denotes | stroke | MESH:D020521 |
| 28 | 127-148 | Disease | denotes | myocardial infarction | MESH:D009203 |
| 29 | 150-156 | Disease | denotes | trauma | MESH:D014947 |
| 30 | 285-294 | Disease | denotes | mortality | MESH:D003643 |
| 31 | 298-322 | Disease | denotes | coronavirus disease 2019 | MESH:C000657245 |
| 32 | 324-332 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 33 | 378-386 | Disease | denotes | diabetes | MESH:D003920 |
| 40 | 999-1002 | Gene | denotes | age | Gene:5973 |
| 41 | 467-475 | Species | denotes | patients | Tax:9606 |
| 42 | 727-735 | Species | denotes | patients | Tax:9606 |
| 43 | 458-466 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 44 | 718-726 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 45 | 833-842 | Disease | denotes | pneumonia | MESH:D011014 |
| 51 | 1165-1168 | Gene | denotes | age | Gene:5973 |
| 52 | 1055-1063 | Species | denotes | patients | Tax:9606 |
| 53 | 1046-1054 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 54 | 1097-1101 | Disease | denotes | died | MESH:D003643 |
| 55 | 1425-1434 | Disease | denotes | mortality | MESH:D003643 |
| 66 | 1725-1733 | Species | denotes | patients | Tax:9606 |
| 67 | 1848-1856 | Species | denotes | patients | Tax:9606 |
| 68 | 1921-1929 | Species | denotes | patients | Tax:9606 |
| 69 | 1712-1721 | Disease | denotes | mortality | MESH:D003643 |
| 70 | 1739-1747 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 71 | 1778-1786 | Disease | denotes | diabetes | MESH:D003920 |
| 72 | 1839-1847 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 73 | 1894-1902 | Disease | denotes | diabetes | MESH:D003920 |
| 74 | 1912-1920 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 75 | 1943-1970 | Disease | denotes | glucose metabolic disorders | MESH:D044882 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T3 | 102-111 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T4 | 113-119 | Disease | denotes | stroke | http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057 |
| T6 | 121-148 | Disease | denotes | acute myocardial infarction | http://purl.obolibrary.org/obo/MONDO_0004781 |
| T7 | 127-148 | Disease | denotes | myocardial infarction | http://purl.obolibrary.org/obo/MONDO_0005068 |
| T8 | 150-156 | Disease | denotes | trauma | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T9 | 298-322 | Disease | denotes | coronavirus disease 2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T10 | 324-332 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T11 | 378-386 | Disease | denotes | diabetes | http://purl.obolibrary.org/obo/MONDO_0005015 |
| T12 | 458-466 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T13 | 701-704 | Disease | denotes | CRB | http://purl.obolibrary.org/obo/MONDO_0008764 |
| T14 | 718-726 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T15 | 772-775 | Disease | denotes | CRB | http://purl.obolibrary.org/obo/MONDO_0008764 |
| T16 | 833-842 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T17 | 1046-1054 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T18 | 1240-1243 | Disease | denotes | CRB | http://purl.obolibrary.org/obo/MONDO_0008764 |
| T19 | 1288-1291 | Disease | denotes | CRB | http://purl.obolibrary.org/obo/MONDO_0008764 |
| T20 | 1739-1747 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T21 | 1778-1786 | Disease | denotes | diabetes | http://purl.obolibrary.org/obo/MONDO_0005015 |
| T22 | 1839-1847 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T23 | 1894-1902 | Disease | denotes | diabetes | http://purl.obolibrary.org/obo/MONDO_0005015 |
| T24 | 1912-1920 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T25 | 1943-1970 | Disease | denotes | glucose metabolic disorders | http://purl.obolibrary.org/obo/MONDO_0002908 |
| T26 | 1951-1970 | Disease | denotes | metabolic disorders | http://purl.obolibrary.org/obo/MONDO_0005066 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T4 | 254-259 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T5 | 254-259 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T6 | 410-411 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T7 | 481-482 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T8 | 929-934 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T9 | 929-934 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T10 | 968-973 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T11 | 968-973 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T12 | 1089-1092 | http://purl.obolibrary.org/obo/CLO_0053001 | denotes | 114 |
| T13 | 1200-1204 | http://purl.obolibrary.org/obo/UBERON_0003101 | denotes | male |
| T14 | 1200-1204 | http://www.ebi.ac.uk/efo/EFO_0000970 | denotes | male |
| T15 | 1301-1304 | http://purl.obolibrary.org/obo/CLO_0001302 | denotes | 3–4 |
| T16 | 1798-1805 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | testing |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T3 | 260-267 | Chemical | denotes | glucose | http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167 |
| T5 | 1200-1204 | Chemical | denotes | male | http://purl.obolibrary.org/obo/CHEBI_30780 |
| T6 | 1943-1950 | Chemical | denotes | glucose | http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1943-1960 | http://purl.obolibrary.org/obo/GO_0006006 | denotes | glucose metabolic |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 102-111 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T2 | 113-119 | Phenotype | denotes | stroke | http://purl.obolibrary.org/obo/HP_0001297 |
| T3 | 127-148 | Phenotype | denotes | myocardial infarction | http://purl.obolibrary.org/obo/HP_0001658 |
| T4 | 833-842 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T3 | 0-15 | Sentence | denotes | Aims/hypothesis |
| T4 | 16-193 | Sentence | denotes | Hyperglycaemia is associated with an elevated risk of mortality in community-acquired pneumonia, stroke, acute myocardial infarction, trauma and surgery, among other conditions. |
| T5 | 194-387 | Sentence | denotes | In this study, we examined the relationship between fasting blood glucose (FBG) and 28-day mortality in coronavirus disease 2019 (COVID-19) patients not previously diagnosed as having diabetes. |
| T6 | 389-396 | Sentence | denotes | Methods |
| T7 | 397-622 | Sentence | denotes | We conducted a retrospective study involving all consecutive COVID-19 patients with a definitive 28-day outcome and FBG measurement at admission from 24 January 2020 to 10 February 2020 in two hospitals based in Wuhan, China. |
| T8 | 623-771 | Sentence | denotes | Demographic and clinical data, 28-day outcomes, in-hospital complications and CRB-65 scores of COVID-19 patients in the two hospitals were analysed. |
| T9 | 772-1015 | Sentence | denotes | CRB-65 is an effective measure for assessing the severity of pneumonia and is based on four indicators, i.e. confusion, respiratory rate (>30/min), systolic blood pressure (≤90 mmHg) or diastolic blood pressure (≤60 mmHg), and age (≥65 years). |
| T10 | 1017-1024 | Sentence | denotes | Results |
| T11 | 1025-1114 | Sentence | denotes | Six hundred and five COVID-19 patients were enrolled, including 114 who died in hospital. |
| T12 | 1115-1435 | Sentence | denotes | Multivariable Cox regression analysis showed that age (HR 1.02 [95% CI 1.00, 1.04]), male sex (HR 1.75 [95% CI 1.17, 2.60]), CRB-65 score 1–2 (HR 2.68 [95% CI 1.56, 4.59]), CRB-65 score 3–4 (HR 5.25 [95% CI 2.05, 13.43]) and FBG ≥7.0 mmol/l (HR 2.30 [95% CI 1.49, 3.55]) were independent predictors for 28-day mortality. |
| T13 | 1436-1615 | Sentence | denotes | The OR for 28-day in-hospital complications in those with FBG ≥7.0 mmol/l and 6.1–6.9 mmol/l vs <6.1 mmol/l was 3.99 (95% CI 2.71, 5.88) or 2.61 (95% CI 1.64, 4.41), respectively. |
| T14 | 1617-1643 | Sentence | denotes | Conclusions/interpretation |
| T15 | 1644-1787 | Sentence | denotes | FBG ≥7.0 mmol/l at admission is an independent predictor for 28-day mortality in patients with COVID-19 without previous diagnosis of diabetes. |
| T16 | 1788-1971 | Sentence | denotes | Glycaemic testing and control are important to all COVID-19 patients even where they have no pre-existing diabetes, as most COVID-19 patients are prone to glucose metabolic disorders. |
| T17 | 1972-1990 | Sentence | denotes | Graphical abstract |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T4 | 127-137 | UBERON:0002349 | denotes | myocardial |
| T5 | 254-259 | UBERON:0000178 | denotes | blood |
| T6 | 260-267 | CHEBI:17234;CHEBI:17234 | denotes | glucose |
| T7 | 298-309 | NCBITaxon:11118 | denotes | coronavirus |
| T8 | 324-332 | SP_7 | denotes | COVID-19 |
| T9 | 458-466 | SP_7 | denotes | COVID-19 |
| T10 | 701-704 | PR:Q9SA52 | denotes | CRB |
| T11 | 718-726 | SP_7 | denotes | COVID-19 |
| T12 | 772-775 | PR:Q9SA52 | denotes | CRB |
| T13 | 892-903 | UBERON:0001004 | denotes | respiratory |
| T14 | 929-934 | UBERON:0000178 | denotes | blood |
| T15 | 968-973 | UBERON:0000178 | denotes | blood |
| T16 | 1046-1054 | SP_7 | denotes | COVID-19 |
| T17 | 1097-1101 | GO:0016265 | denotes | died |
| T18 | 1288-1291 | PR:Q9SA52 | denotes | CRB |
| T19 | 1739-1747 | SP_7 | denotes | COVID-19 |
| T20 | 1788-1797 | GO:0005977 | denotes | Glycaemic |
| T21 | 1839-1847 | SP_7 | denotes | COVID-19 |
| T22 | 1912-1920 | SP_7 | denotes | COVID-19 |
| T23 | 1943-1950 | CHEBI:17234;CHEBI:17234;GO:0006006 | denotes | glucose |
| T24 | 1951-1960 | GO:0006006 | denotes | metabolic |
| T81012 | 127-137 | UBERON:0002349 | denotes | myocardial |
| T1255 | 254-259 | UBERON:0000178 | denotes | blood |
| T24359 | 260-267 | CHEBI:17234;CHEBI:17234 | denotes | glucose |
| T51614 | 298-309 | NCBITaxon:11118 | denotes | coronavirus |
| T47334 | 324-332 | SP_7 | denotes | COVID-19 |
| T83970 | 458-466 | SP_7 | denotes | COVID-19 |
| T94099 | 701-704 | PR:Q9SA52 | denotes | CRB |
| T61001 | 718-726 | SP_7 | denotes | COVID-19 |
| T70032 | 772-775 | PR:Q9SA52 | denotes | CRB |
| T41750 | 892-903 | UBERON:0001004 | denotes | respiratory |
| T480 | 929-934 | UBERON:0000178 | denotes | blood |
| T31576 | 968-973 | UBERON:0000178 | denotes | blood |
| T71775 | 1046-1054 | SP_7 | denotes | COVID-19 |
| T65767 | 1097-1101 | GO:0016265 | denotes | died |
| T33893 | 1288-1291 | PR:Q9SA52 | denotes | CRB |
| T89896 | 1739-1747 | SP_7 | denotes | COVID-19 |
| T30921 | 1788-1797 | GO:0005977 | denotes | Glycaemic |
| T33879 | 1839-1847 | SP_7 | denotes | COVID-19 |
| T22988 | 1912-1920 | SP_7 | denotes | COVID-19 |
| T96795 | 1943-1950 | CHEBI:17234;CHEBI:17234;GO:0006006 | denotes | glucose |
| T30512 | 1951-1960 | GO:0006006 | denotes | metabolic |