PMC:7346000 / 9651-10229 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T32","span":{"begin":58,"end":67},"obj":"Body_part"},{"id":"T33","span":{"begin":249,"end":253},"obj":"Body_part"},{"id":"T34","span":{"begin":274,"end":287},"obj":"Body_part"},{"id":"T35","span":{"begin":464,"end":474},"obj":"Body_part"}],"attributes":[{"id":"A32","pred":"fma_id","subj":"T32","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A33","pred":"fma_id","subj":"T33","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A34","pred":"fma_id","subj":"T34","obj":"http://purl.org/sig/ont/fma/fma62870"},{"id":"A35","pred":"fma_id","subj":"T35","obj":"http://purl.org/sig/ont/fma/fma62863"}],"text":"s regard, increased levels of circulating proinflammatory cytokines, such as TNF, were observed in patients requiring intensive care, compared to those with milder infections [35]. Other studies, however, have also unveiled marked defects in immune cell populations, namely T-lymphocytes, as another factor explaining the immune dysfunction in patients with COVID-19 [36]. This suggests that while sustained innate immune function leads to hyperinflammation [37], lymphocyte numbers decline, and their function may be defective. In this regard, severe lymphocytopenia was among "}

{"project":"LitCovid-PubTator","denotations":[{"id":"309","span":{"begin":77,"end":80},"obj":"Gene"},{"id":"311","span":{"begin":99,"end":107},"obj":"Species"},{"id":"312","span":{"begin":344,"end":352},"obj":"Species"},{"id":"316","span":{"begin":164,"end":174},"obj":"Disease"},{"id":"317","span":{"begin":358,"end":366},"obj":"Disease"},{"id":"318","span":{"begin":552,"end":567},"obj":"Disease"}],"attributes":[{"id":"A309","pred":"tao:has_database_id","subj":"309","obj":"Gene:7124"},{"id":"A311","pred":"tao:has_database_id","subj":"311","obj":"Tax:9606"},{"id":"A312","pred":"tao:has_database_id","subj":"312","obj":"Tax:9606"},{"id":"A316","pred":"tao:has_database_id","subj":"316","obj":"MESH:D007239"},{"id":"A317","pred":"tao:has_database_id","subj":"317","obj":"MESH:C000657245"},{"id":"A318","pred":"tao:has_database_id","subj":"318","obj":"MESH:D008231"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"s regard, increased levels of circulating proinflammatory cytokines, such as TNF, were observed in patients requiring intensive care, compared to those with milder infections [35]. Other studies, however, have also unveiled marked defects in immune cell populations, namely T-lymphocytes, as another factor explaining the immune dysfunction in patients with COVID-19 [36]. This suggests that while sustained innate immune function leads to hyperinflammation [37], lymphocyte numbers decline, and their function may be defective. In this regard, severe lymphocytopenia was among "}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T107","span":{"begin":164,"end":174},"obj":"Disease"},{"id":"T108","span":{"begin":322,"end":340},"obj":"Disease"},{"id":"T109","span":{"begin":358,"end":366},"obj":"Disease"},{"id":"T110","span":{"begin":552,"end":567},"obj":"Disease"}],"attributes":[{"id":"A107","pred":"mondo_id","subj":"T107","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A108","pred":"mondo_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/MONDO_0005046"},{"id":"A109","pred":"mondo_id","subj":"T109","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A110","pred":"mondo_id","subj":"T110","obj":"http://purl.obolibrary.org/obo/MONDO_0003783"}],"text":"s regard, increased levels of circulating proinflammatory cytokines, such as TNF, were observed in patients requiring intensive care, compared to those with milder infections [35]. Other studies, however, have also unveiled marked defects in immune cell populations, namely T-lymphocytes, as another factor explaining the immune dysfunction in patients with COVID-19 [36]. This suggests that while sustained innate immune function leads to hyperinflammation [37], lymphocyte numbers decline, and their function may be defective. In this regard, severe lymphocytopenia was among "}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T75","span":{"begin":176,"end":178},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"},{"id":"T76","span":{"begin":249,"end":253},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T77","span":{"begin":368,"end":370},"obj":"http://purl.obolibrary.org/obo/CLO_0001313"}],"text":"s regard, increased levels of circulating proinflammatory cytokines, such as TNF, were observed in patients requiring intensive care, compared to those with milder infections [35]. Other studies, however, have also unveiled marked defects in immune cell populations, namely T-lymphocytes, as another factor explaining the immune dysfunction in patients with COVID-19 [36]. This suggests that while sustained innate immune function leads to hyperinflammation [37], lymphocyte numbers decline, and their function may be defective. In this regard, severe lymphocytopenia was among "}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T23","span":{"begin":408,"end":421},"obj":"http://purl.obolibrary.org/obo/GO_0045087"}],"text":"s regard, increased levels of circulating proinflammatory cytokines, such as TNF, were observed in patients requiring intensive care, compared to those with milder infections [35]. Other studies, however, have also unveiled marked defects in immune cell populations, namely T-lymphocytes, as another factor explaining the immune dysfunction in patients with COVID-19 [36]. This suggests that while sustained innate immune function leads to hyperinflammation [37], lymphocyte numbers decline, and their function may be defective. In this regard, severe lymphocytopenia was among "}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T18","span":{"begin":552,"end":567},"obj":"Phenotype"}],"attributes":[{"id":"A18","pred":"hp_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/HP_0001888"}],"text":"s regard, increased levels of circulating proinflammatory cytokines, such as TNF, were observed in patients requiring intensive care, compared to those with milder infections [35]. Other studies, however, have also unveiled marked defects in immune cell populations, namely T-lymphocytes, as another factor explaining the immune dysfunction in patients with COVID-19 [36]. This suggests that while sustained innate immune function leads to hyperinflammation [37], lymphocyte numbers decline, and their function may be defective. In this regard, severe lymphocytopenia was among "}

{"project":"LitCovid-sentences","denotations":[{"id":"T54","span":{"begin":181,"end":372},"obj":"Sentence"},{"id":"T55","span":{"begin":373,"end":528},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"s regard, increased levels of circulating proinflammatory cytokines, such as TNF, were observed in patients requiring intensive care, compared to those with milder infections [35]. Other studies, however, have also unveiled marked defects in immune cell populations, namely T-lymphocytes, as another factor explaining the immune dysfunction in patients with COVID-19 [36]. This suggests that while sustained innate immune function leads to hyperinflammation [37], lymphocyte numbers decline, and their function may be defective. In this regard, severe lymphocytopenia was among "}

{"project":"2_test","denotations":[{"id":"32599813-31986264-60095088","span":{"begin":176,"end":178},"obj":"31986264"},{"id":"32599813-32161940-60095089","span":{"begin":368,"end":370},"obj":"32161940"},{"id":"32599813-32320677-60095090","span":{"begin":459,"end":461},"obj":"32320677"}],"text":"s regard, increased levels of circulating proinflammatory cytokines, such as TNF, were observed in patients requiring intensive care, compared to those with milder infections [35]. Other studies, however, have also unveiled marked defects in immune cell populations, namely T-lymphocytes, as another factor explaining the immune dysfunction in patients with COVID-19 [36]. This suggests that while sustained innate immune function leads to hyperinflammation [37], lymphocyte numbers decline, and their function may be defective. In this regard, severe lymphocytopenia was among "}