PMC:7346000 / 9471-10723
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T31 | 12-16 | Body_part | denotes | body | http://purl.org/sig/ont/fma/fma256135 |
| T32 | 238-247 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T33 | 429-433 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T34 | 454-467 | Body_part | denotes | T-lymphocytes | http://purl.org/sig/ont/fma/fma62870 |
| T35 | 644-654 | Body_part | denotes | lymphocyte | http://purl.org/sig/ont/fma/fma62863 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 309 | 257-260 | Gene | denotes | TNF | Gene:7124 |
| 310 | 95-103 | Species | denotes | patients | Tax:9606 |
| 311 | 279-287 | Species | denotes | patients | Tax:9606 |
| 312 | 524-532 | Species | denotes | patients | Tax:9606 |
| 313 | 851-859 | Species | denotes | patients | Tax:9606 |
| 314 | 1014-1024 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 315 | 116-136 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 316 | 344-354 | Disease | denotes | infections | MESH:D007239 |
| 317 | 538-546 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 318 | 732-747 | Disease | denotes | lymphocytopenia | MESH:D008231 |
| 319 | 826-847 | Disease | denotes | invasive mold disease | MESH:D009361 |
| 320 | 1141-1145 | Disease | denotes | ARDS | MESH:D012128 |
| 321 | 1217-1237 | Disease | denotes | secondary infections | MESH:D060085 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T104 | 116-124 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T105 | 127-136 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T106 | 168-172 | Disease | denotes | CAPA | http://purl.obolibrary.org/obo/MONDO_0007163 |
| T107 | 344-354 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T108 | 502-520 | Disease | denotes | immune dysfunction | http://purl.obolibrary.org/obo/MONDO_0005046 |
| T109 | 538-546 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T110 | 732-747 | Disease | denotes | lymphocytopenia | http://purl.obolibrary.org/obo/MONDO_0003783 |
| T111 | 1014-1022 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T112 | 1141-1145 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T113 | 1227-1237 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T114 | 1247-1251 | Disease | denotes | CAPA | http://purl.obolibrary.org/obo/MONDO_0007163 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T75 | 356-358 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T76 | 429-433 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T77 | 548-550 | http://purl.obolibrary.org/obo/CLO_0001313 | denotes | 36 |
| T78 | 773-774 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T23 | 588-601 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune |
| T24 | 994-1010 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
| T25 | 1048-1065 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
| T26 | 1048-1065 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T17 | 109-136 | Phenotype | denotes | severe SARS-CoV-2 infection | http://purl.obolibrary.org/obo/HP_0033141 |
| T18 | 732-747 | Phenotype | denotes | lymphocytopenia | http://purl.obolibrary.org/obo/HP_0001888 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T52 | 0-173 | Sentence | denotes | An emerging body of evidence supports therefore an increased systemic inflammatory reaction in patients with severe SARS-CoV-2 infection who are more likely to develop CAPA. |
| T53 | 174-360 | Sentence | denotes | In this regard, increased levels of circulating proinflammatory cytokines, such as TNF, were observed in patients requiring intensive care, compared to those with milder infections [35]. |
| T54 | 361-552 | Sentence | denotes | Other studies, however, have also unveiled marked defects in immune cell populations, namely T-lymphocytes, as another factor explaining the immune dysfunction in patients with COVID-19 [36]. |
| T55 | 553-708 | Sentence | denotes | This suggests that while sustained innate immune function leads to hyperinflammation [37], lymphocyte numbers decline, and their function may be defective. |
| T56 | 709-896 | Sentence | denotes | In this regard, severe lymphocytopenia was among the factors in a risk score model that predicted the development of invasive mold disease in patients with hematological malignances [38]. |
| T57 | 897-1252 | Sentence | denotes | It is thus reasonable to speculate that in elderly individuals or with co-morbidities, defective immune responses to SARS-CoV-2 may allow unrestricted viral replication which, in turn, elicits hyperinflammation and severe complications such as ARDS [39], besides establishing favorable conditions for the acquisition of secondary infections, such as CAPA. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32599813-31986264-60095088 | 356-358 | 31986264 | denotes | 35 |
| 32599813-32161940-60095089 | 548-550 | 32161940 | denotes | 36 |
| 32599813-32320677-60095090 | 639-641 | 32320677 | denotes | 37 |
| 32599813-30974130-60095091 | 892-894 | 30974130 | denotes | 38 |
| 32599813-32437659-60095092 | 1147-1149 | 32437659 | denotes | 39 |