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PMC:7346000 / 90-1700 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
25 166-174 Species denotes patients Tax:9606
26 1016-1024 Species denotes patients Tax:9606
27 1321-1331 Species denotes SARS-CoV-2 Tax:2697049
28 12-21 Species denotes influenza Tax:11309
29 821-834 Chemical denotes galactomannan MESH:C012990
30 1278-1284 Chemical denotes azoles MESH:D001393
31 1374-1388 Chemical denotes amphotericin B MESH:D000666
32 1418-1423 Chemical denotes azole MESH:D001393
33 23-45 Disease denotes coronavirus disease-19 MESH:C000657245
34 47-55 Disease denotes COVID-19 MESH:C000657245
35 70-105 Disease denotes acute respiratory distress syndrome MESH:D012128
36 107-111 Disease denotes ARDS MESH:D012128
37 188-211 Disease denotes pulmonary aspergillosis MESH:D055732
38 230-238 Disease denotes COVID-19 MESH:C000657245
39 250-273 Disease denotes pulmonary aspergillosis MESH:D055732
40 374-382 Disease denotes COVID-19 MESH:C000657245
41 399-451 Disease denotes pulmonary epithelial damage and inflammatory disease MESH:D008171
42 493-516 Disease denotes pulmonary aspergillosis MESH:D055732
43 912-925 Disease denotes aspergillosis MESH:D001228
44 1007-1015 Disease denotes COVID-19 MESH:C000657245
45 1286-1299 Disease denotes renal tropism MESH:D007674

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T4 12-21 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T5 47-55 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T6 70-105 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T7 76-105 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T8 107-111 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T9 198-211 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T10 230-238 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T11 260-273 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T12 275-279 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T13 374-382 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T14 431-451 Disease denotes inflammatory disease http://purl.obolibrary.org/obo/MONDO_0021166
T15 503-516 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T16 751-755 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T17 912-925 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T18 1007-1015 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T19 1169-1173 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T20 1201-1205 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T21 1321-1329 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 113-116 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T2 218-220 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T3 409-419 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T4 593-603 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T5 660-661 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 835-842 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T7 902-907 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T8 1387-1388 http://purl.obolibrary.org/obo/CLO_0001021 denotes B

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 607-616 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T2 821-834 Chemical denotes galactomannan http://purl.obolibrary.org/obo/CHEBI_27680
T3 1224-1228 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T4 1229-1233 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T5 1278-1284 Chemical denotes azoles http://purl.obolibrary.org/obo/CHEBI_68452
T6 1374-1388 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T7 1418-1423 Chemical denotes azole http://purl.obolibrary.org/obo/CHEBI_68452
T8 1485-1501 Chemical denotes antifungal drugs http://purl.obolibrary.org/obo/CHEBI_35718|http://purl.obolibrary.org/obo/CHEBI_86327
T10 1496-1501 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 724-736 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T2 1292-1299 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 821-834 GlycoEpitope denotes galactomannan http://www.glycoepitope.jp/epitopes/EP0510

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 76-96 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T3 0-307 Sentence denotes Like severe influenza, coronavirus disease-19 (COVID-19) resulting in acute respiratory distress syndrome (ARDS) has emerged as an important disease that predisposes patients to secondary pulmonary aspergillosis, with 35 cases of COVID-19 associated pulmonary aspergillosis (CAPA) published until June 2020.
T4 308-517 Sentence denotes The release of danger-associated molecular patterns during severe COVID-19 results in both pulmonary epithelial damage and inflammatory disease, which are predisposing risk factors for pulmonary aspergillosis.
T5 518-737 Sentence denotes Moreover, collateral effects of host recognition pathways required for the activation of antiviral immunity may, paradoxically, contribute to a highly permissive inflammatory environment that favors fungal pathogenesis.
T6 738-1065 Sentence denotes Diagnosis of CAPA remains challenging, mainly because bronchoalveolar lavage fluid galactomannan testing and culture, which represent the most sensitive diagnostic tests for aspergillosis in the ICU, are hindered by the fact that bronchoscopies are rarely performed in COVID-19 patients due to the risk of disease transmission.
T7 1066-1174 Sentence denotes Similarly, autopsies are rarely performed, which may result in an underestimation of the prevalence of CAPA.
T8 1175-1435 Sentence denotes Finally, the treatment of CAPA is complicated by drug–drug interactions associated with broad spectrum azoles, renal tropism and damage caused by SARS-CoV-2, which may challenge the use of liposomal amphotericin B, as well as the emergence of azole-resistance.
T9 1436-1610 Sentence denotes This clinical reality creates an urgency for new antifungal drugs currently in advanced clinical development with more promising pharmacokinetic and pharmacodynamic profiles.