PMC:7346000 / 715-1568 JSONTXT

Annnotations TAB JSON ListView MergeView

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7346000","sourcedb":"PMC","sourceid":"7346000","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7346000","text":" may, paradoxically, contribute to a highly permissive inflammatory environment that favors fungal pathogenesis. Diagnosis of CAPA remains challenging, mainly because bronchoalveolar lavage fluid galactomannan testing and culture, which represent the most sensitive diagnostic tests for aspergillosis in the ICU, are hindered by the fact that bronchoscopies are rarely performed in COVID-19 patients due to the risk of disease transmission. Similarly, autopsies are rarely performed, which may result in an underestimation of the prevalence of CAPA. Finally, the treatment of CAPA is complicated by drug–drug interactions associated with broad spectrum azoles, renal tropism and damage caused by SARS-CoV-2, which may challenge the use of liposomal amphotericin B, as well as the emergence of azole-resistance. This clinical reality creates an urgency f","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"26","span":{"begin":391,"end":399},"obj":"Species"},{"id":"27","span":{"begin":696,"end":706},"obj":"Species"},{"id":"29","span":{"begin":196,"end":209},"obj":"Chemical"},{"id":"30","span":{"begin":653,"end":659},"obj":"Chemical"},{"id":"31","span":{"begin":749,"end":763},"obj":"Chemical"},{"id":"32","span":{"begin":793,"end":798},"obj":"Chemical"},{"id":"43","span":{"begin":287,"end":300},"obj":"Disease"},{"id":"44","span":{"begin":382,"end":390},"obj":"Disease"},{"id":"45","span":{"begin":661,"end":674},"obj":"Disease"}],"attributes":[{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"Tax:9606"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"Tax:2697049"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"MESH:C012990"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"MESH:D001393"},{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"MESH:D000666"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"MESH:D001393"},{"id":"A43","pred":"tao:has_database_id","subj":"43","obj":"MESH:D001228"},{"id":"A44","pred":"tao:has_database_id","subj":"44","obj":"MESH:C000657245"},{"id":"A45","pred":"tao:has_database_id","subj":"45","obj":"MESH:D007674"},{"subj":"26","pred":"source","obj":"LitCovid-PubTator"},{"subj":"27","pred":"source","obj":"LitCovid-PubTator"},{"subj":"29","pred":"source","obj":"LitCovid-PubTator"},{"subj":"30","pred":"source","obj":"LitCovid-PubTator"},{"subj":"31","pred":"source","obj":"LitCovid-PubTator"},{"subj":"32","pred":"source","obj":"LitCovid-PubTator"},{"subj":"43","pred":"source","obj":"LitCovid-PubTator"},{"subj":"44","pred":"source","obj":"LitCovid-PubTator"},{"subj":"45","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T16","span":{"begin":126,"end":130},"obj":"Disease"},{"id":"T17","span":{"begin":287,"end":300},"obj":"Disease"},{"id":"T18","span":{"begin":382,"end":390},"obj":"Disease"},{"id":"T19","span":{"begin":544,"end":548},"obj":"Disease"},{"id":"T20","span":{"begin":576,"end":580},"obj":"Disease"},{"id":"T21","span":{"begin":696,"end":704},"obj":"Disease"}],"attributes":[{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0007163"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0005657"},{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0007163"},{"id":"A20","pred":"mondo_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/MONDO_0007163"},{"id":"A21","pred":"mondo_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T5","span":{"begin":35,"end":36},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T6","span":{"begin":210,"end":217},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T7","span":{"begin":277,"end":282},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T8","span":{"begin":762,"end":763},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"}],"attributes":[{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T2","span":{"begin":196,"end":209},"obj":"Chemical"},{"id":"T3","span":{"begin":599,"end":603},"obj":"Chemical"},{"id":"T4","span":{"begin":604,"end":608},"obj":"Chemical"},{"id":"T5","span":{"begin":653,"end":659},"obj":"Chemical"},{"id":"T6","span":{"begin":749,"end":763},"obj":"Chemical"},{"id":"T7","span":{"begin":793,"end":798},"obj":"Chemical"}],"attributes":[{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_27680"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_68452"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_2682"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_68452"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":99,"end":111},"obj":"http://purl.obolibrary.org/obo/GO_0009405"},{"id":"T2","span":{"begin":667,"end":674},"obj":"http://purl.obolibrary.org/obo/GO_0009606"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T1","span":{"begin":196,"end":209},"obj":"GlycoEpitope"}],"attributes":[{"id":"A1","pred":"glyco_epitope_db_id","subj":"T1","obj":"http://www.glycoepitope.jp/epitopes/EP0510"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-GlycoEpitope"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T6","span":{"begin":113,"end":440},"obj":"Sentence"},{"id":"T7","span":{"begin":441,"end":549},"obj":"Sentence"},{"id":"T8","span":{"begin":550,"end":810},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T6","pred":"source","obj":"LitCovid-sentences"},{"subj":"T7","pred":"source","obj":"LitCovid-sentences"},{"subj":"T8","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ec9398","default":true},{"id":"LitCovid-PD-MONDO","color":"#93b2ec"},{"id":"LitCovid-PD-CLO","color":"#ccec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93e6"},{"id":"LitCovid-PD-GO-BP","color":"#93ecd8"},{"id":"LitCovid-PD-GlycoEpitope","color":"#ecbe93"},{"id":"LitCovid-sentences","color":"#a493ec"}]}]}}