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LitCovid-PD-FMA-UBERON

LitCovid-PD-UBERON

LitCovid-PubTator

LitCovid-PD-MONDO

LitCovid-PD-CLO

LitCovid-PD-CHEBI

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T39","span":{"begin":448,"end":453},"obj":"http://purl.obolibrary.org/obo/GO_0030431"},{"id":"T40","span":{"begin":1292,"end":1301},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T41","span":{"begin":1436,"end":1445},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T42","span":{"begin":2155,"end":2164},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T43","span":{"begin":3425,"end":3434},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T44","span":{"begin":5287,"end":5296},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T45","span":{"begin":5349,"end":5358},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T46","span":{"begin":5493,"end":5502},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T47","span":{"begin":5651,"end":5660},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T48","span":{"begin":5951,"end":5956},"obj":"http://purl.obolibrary.org/obo/GO_0030431"}],"text":"Table 1 Clinical characteristics of COVID-19 patients with pulmonary aspergillosis published before 10 June 2020.\nCountry (Prevalence) COHORT [Ref] Age/Sex Underlying Conditions CAPA Classification Local/Systemic Corticosteroid Use GM (ODI)/Serum BDG (pg/mL)/qPCR Species (Voriconazole Susceptibility Pattern) Treatment # Outcome\nGermany (5/19; 26.3%)ARDS [50] 62/F Cholecystectomy for cholecystitis, arterial hypertension, obesity with sleep apnea, hypercholesterolemia, ex-smoker, COPD (GOLD 2) Putative Inhaled steroids for COPD GM Serum negative GM BALF\u003e 2.5 qPCR BALF = Positive Aspergillus fumigatus (S) culture from BALF VCZ Died\n70/M Vertebral disc prolapse left L4/5, flavectomy and nucleotomy, Ex-smoker Putative No GM Serum = 0.7 GM BALF\u003e 2.5 qPCR BALF = Positive A. fumigatus by PCR; negative culture ISA Died\n54/M Arterial hypertension, diabetes mellitus, aneurysm coiling right A. vertebralis Putative Intravenous corticosteroid therapy 0.4 mg/kg/d, total of 13 days) GM Serum negative GM BALF\u003e 2.5 qPCR BALF = Positive A. fumigatus (S) culture from tracheal aspirate CASPO→ VCZ Alive\n73/M Arterial hypertension, bullous emphysema, smoker, COPD (GOLD 3), Previous Hepatitis B Putative Inhaled steroids for COPD GM Serum negative qPCR tracheal secretion = Positive A. fumigatus (S) culture from tracheal aspirate VCZ Died\n54/F None Putative No GM Serum = 1.3 and 2.7 qPCR tracheal secretion = Negative Negative culture CASPO→ VCZ Alive\nFrance (9/27; 33.3%)ARDS * [51] 53/M Hypertension, obesity, ischemic heart disease Putative Dexamethasone iv 20 mg once daily from day 1 to day 5, followed by 10 mg once daily from day 6 to day 10 GM Serum = 0.13 GM BALF = 0.89 BDG = 523 qPCR = Negative Negative culture None Alive\n59/F Hypertension, obesity, diabetes Putative No GM Serum = 0.04 GM BALF = 0.03 qPCR = Negative A. fumigatus, culture from BALF None Alive\n69/F Hypertension, obesity Putative Dexamethasone iv 20 mg once daily from day 1 to day 5, followed by 10 mg once daily from day 6 to day 10 GM Serum = 0.04 BDG = 7.8 qPCR BALF = 23.9 A. fumigatus, culture from tracheal secretion None Alive\n63/F Hypertension, diabetes, ischemic heart disease Putative Dexamethasone iv 20 mg once daily from day 1 to day 5, followed by 10 mg once daily from day 6 to day 10 GM Serum = 0.51GM BALF = 0.15 BDG = 63 Negative culture None Died\n43/M Asthma with steroid use history Putative No GM Serum = 0.04 GM BALF = 0.12 BDG = 7 qPCR = Negative A. fumigatus, culture from BALF None Alive\n79/M Hypertension Putative Dexamethasone iv 20 mg once daily from day 1 to day 5, followed by 10 mg once daily from day 6 to day 10 GM Serum = 0.02 GM BALF = 0.05 BDG = 23 qPCR BALF = 34.5 A. fumigatus, culture from BALF None Alive\n77/M Hypertension, asthma Putative Dexamethasone iv 20 mg once daily from day 1 to day 5, followed by 10 mg once daily from day 6 to day 10 GM Serum = 0.37 GM BALF = 3.91 BDG = 135 qPCR BALF = 29 A. fumigatus, culture from BALF VCZ Died\n75/F Hypertension, diabetes Putative Dexamethasone iv 20 mg once daily from day 1 to day 5, followed by 10 mg once daily from day 6 to day 10 GM Serum = 0.37 GM BALF = 0.36 BDG = 450 qPCR BALF = 31.7 A. fumigatus, culture from BALF CASPO Died\n47/M Multiple myeloma with steroid therapy Probable No GM Serum = 0.09 BDG = 14 A. fumigatus, culture from tracheal secretion None Died\nNetherlands (6/31; 19.4%)ARDS [47] 83/M Cardiomyopathy Possible Prednisolone 0ꞏ13mg/kg/day for 28 dayspre-admission GM Serum = 0.4 A. fumigatus, culture from tracheal aspirate VCZ + ANID (5/6) L-AmB (1/6) Died\n67/M COPD (GOLD 3), Post RTx NSCLC 2014 Possible Prednisolone 0ꞏ37mg/kg/day for 2 dayspre-admission NA A. fumigatus, culture from tracheal aspirate Died\n75/M COPD (GOLD 2a) Probable No GM BALF = 4.0 A. fumigatus, culture from BALF Died\n43/M None Probable No GM Serum = 0.1 GM BALF = 3.8 NA Alive\n57/M Bronchial asthma Probable Fluticasone 1ꞏ94 mcg/kg/day for 1 month pre-admission GM Serum = 0.1 GM BALF = 1.6 A. fumigatus. culture from BALF Died\n58/M None Possible No NA Aspergillus spp. (S), culture from sputum Alive\nBelgium (7/20; 35%)ARDS [52] 86/M Hypercholesterinemia NA No GM serum = 0.1 A. flavus culture from tracheal aspirate None Died\n38/M Obesity, hypercholesterinemia Proven No GM serum = 0.3 GM BALF \u003e 2.8 A. fumigatus culture from BALF VCZ, ISA Alive\n62/M Diabetes Proven No GM serum = 0.2 GM BALF = 2 A. fumigatus culture from BALF VCZ Died\n73/M Diabetes, obesity, hypertension, hypercholesterinemia Proven No GM serum= 0.1 GM BALF \u003e 2.8 A. fumigatus culture from BALF VCZ Alive\n77/M Diabetes, chronic kidney disease, hypertension, pemphigus foliaceus Proven Yes, ND GM serum = 0.1 GM BALF = 2.79 A. fumigatus culture from BALF VCZ Alive\n55/M HIV, hypertension, hypercholesterinemia NA No GM serum = 0.80 GM BALF = 0.69 Negative culture VCZ, ISA Died\n75/M Acute myeloid leukemia NA No GM BALF = 2.63 A. fumigatus culture from BALF VCZ Died\nFrance (1)ARDS [57] 74/M Myelodysplastic syndrome, CD8 + T-cell lymphocytosis, Hashimoto’s thyroiditis, hypertension, benign prostatic hypertrophy Putative No First GM on tracheal secretion = Negative First qPCR = Positive Second GM tracheal secretion = NA Second qPCR = Positive Direct smear of the second sample = branched septate hyphae A. fumigatus, culture of the second tracheal secretion None Died\nFrance (1/5; 20%)Mixed ICU [58] 80/M Thyroid cancer (patient presented with ARDS) Putative NA No A. flavus, culture from tracheal secretion VCZ→ ISA Died\nItaly (1)ARDS [59] 73/M Diabetes, hypertension, obesity, hyperthyroidism, atrial fibrillation Proven No GM Serum = 8.6 qPCR from paraffin block tissue = Positive A. fumigatus, culture from BALF L-AmB → ISA Died\nAustria (1)ARDS [60] 70/M COPD (GOLD 2), obstructive sleep apnea syndrome, insulin-dependent type 2 diabetes with end organ damage, arterial hypertension, coronary heart disease, and obesity Putative Inhaled Budesonide (400 mg per day) GM Serum = Negative BDG = Negative LFD Positive from endotracheal aspiration A. fumigatus, culture from endotracheal aspiration VCZ Died\nGermany (2)ARDS [61] 80/M Suspected pulmonary fibrosis ND No GM Serum = 1.5 GM BALF = 6.3 A. fumigatus, culture from BALF L-AmB Died\n70/M None ND No GM Serum = Negative GM BALF = 6.1 A. fumigatus, culture from BALF L-AmB Died\nNetherlands (1)ARDS [62] 74/F Polyarthritis, reflux, stopped smoking 20 years ago Putative No GM serum = Persistently \u003c 0.5 GM tracheal aspirate = \u003e3 BDG serum = 1590 A. fumigatus, culture from tracheal aspirate (R)TR34/L98HICZ = 16µg/mL, VCZ = 2µg/mL, and POSA = 0.5µg/ml VCZ + CASPO→ Oral VCZ→ L-AmB Died\nAustralia (1) ARDS [63] 66/F Hypertension, osteopenia, ex-smoker (20 pack years) Putative No N/A A. fumigatus culture from tracheal aspirate (3x) VCZ + Therapeutic Drug monitoring Alive\n* All serum qPCR remained negative. # All dosages are standard dosages (e.g., VCZ 6 mg/kg bid Day 1, and 4 mg/kg bid starting Day 2) [64]. ARDS: acute respiratory distress syndrome; NA: not applicable; ND: not determined; BALF: bronchoalveolar lavage fluid; BDG: beta-D-Glucan; COPD: chronic obstructive pulmonary disease; GM; galactomannan; GOLD: global initiative for chronic obstructive lung disease; NSCLC: non-small-cell lung cancer; ODI: optical density index; RTx: radio therapy; LFD: lateral flow device; qPCR: quantitative real-time PCR; VCZ: voriconazole; ISA: isavuconazole; CASPO: caspofungin; ANID: anidulafungin; L-AmB: liposomal amphotericin B; ICZ: itraconazole; POSA = posaconazole."}

LitCovid-PD-GlycoEpitope

LitCovid-PD-HP

LitCovid-sentences

PMC:7346000 / 31788-39514 JSONTXT

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PMC:7346000 / 31788-39514 JSON TXT