PMC:7346000 / 28347-29443 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7346000","sourcedb":"PMC","sourceid":"7346000","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7346000","text":"8. Future Perspectives\nWe anticipate that autopsies of COVID-19 fatalities will increase and likely prove the clinical relevance of CAPA [96]. Immune dysregulation together with epithelial lung damage stemming from COVID-19 immunopathology is a likely mechanism predisposing for IPA development [97]. IPA will be recognized as important co-infection in patients with severe COVID-19, but incidence will likely vary between different ICU settings. In settings where COVID-19 associated IPA occurs most commonly, screening for IPA in blood and true BALF samples (i.e., obtained via bronchoscopy) will be implemented followed by preemptive treatment in those with mycological evidence of IPA. In other high-incidence settings, clinical antifungal prophylaxis trials will be conducted among COVID-19 patients admitted to the ICU aiming to show a decrease in putative [4] and proven IPA cases, as well as overall mortality. Treatment trials will compare efficacy and safety of new antifungal drugs currently under development with established antifungals, initiating a new era of antifungal treatment.","divisions":[{"label":"title","span":{"begin":0,"end":22}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T62","span":{"begin":189,"end":193},"obj":"Body_part"},{"id":"T63","span":{"begin":532,"end":537},"obj":"Body_part"}],"attributes":[{"id":"A62","pred":"fma_id","subj":"T62","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A63","pred":"fma_id","subj":"T63","obj":"http://purl.org/sig/ont/fma/fma9670"},{"subj":"T62","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T63","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T32","span":{"begin":189,"end":193},"obj":"Body_part"},{"id":"T33","span":{"begin":532,"end":537},"obj":"Body_part"}],"attributes":[{"id":"A32","pred":"uberon_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A33","pred":"uberon_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"774","span":{"begin":353,"end":361},"obj":"Species"},{"id":"775","span":{"begin":796,"end":804},"obj":"Species"},{"id":"776","span":{"begin":55,"end":63},"obj":"Disease"},{"id":"777","span":{"begin":189,"end":200},"obj":"Disease"},{"id":"778","span":{"begin":215,"end":223},"obj":"Disease"},{"id":"779","span":{"begin":337,"end":349},"obj":"Disease"},{"id":"780","span":{"begin":374,"end":382},"obj":"Disease"},{"id":"781","span":{"begin":465,"end":473},"obj":"Disease"},{"id":"782","span":{"begin":787,"end":795},"obj":"Disease"},{"id":"783","span":{"begin":908,"end":917},"obj":"Disease"}],"attributes":[{"id":"A774","pred":"tao:has_database_id","subj":"774","obj":"Tax:9606"},{"id":"A775","pred":"tao:has_database_id","subj":"775","obj":"Tax:9606"},{"id":"A776","pred":"tao:has_database_id","subj":"776","obj":"MESH:C000657245"},{"id":"A777","pred":"tao:has_database_id","subj":"777","obj":"MESH:D008171"},{"id":"A778","pred":"tao:has_database_id","subj":"778","obj":"MESH:C000657245"},{"id":"A779","pred":"tao:has_database_id","subj":"779","obj":"MESH:D060085"},{"id":"A780","pred":"tao:has_database_id","subj":"780","obj":"MESH:C000657245"},{"id":"A781","pred":"tao:has_database_id","subj":"781","obj":"MESH:C000657245"},{"id":"A782","pred":"tao:has_database_id","subj":"782","obj":"MESH:C000657245"},{"id":"A783","pred":"tao:has_database_id","subj":"783","obj":"MESH:D003643"},{"subj":"774","pred":"source","obj":"LitCovid-PubTator"},{"subj":"775","pred":"source","obj":"LitCovid-PubTator"},{"subj":"776","pred":"source","obj":"LitCovid-PubTator"},{"subj":"777","pred":"source","obj":"LitCovid-PubTator"},{"subj":"778","pred":"source","obj":"LitCovid-PubTator"},{"subj":"779","pred":"source","obj":"LitCovid-PubTator"},{"subj":"780","pred":"source","obj":"LitCovid-PubTator"},{"subj":"781","pred":"source","obj":"LitCovid-PubTator"},{"subj":"782","pred":"source","obj":"LitCovid-PubTator"},{"subj":"783","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T232","span":{"begin":55,"end":63},"obj":"Disease"},{"id":"T233","span":{"begin":132,"end":136},"obj":"Disease"},{"id":"T234","span":{"begin":215,"end":223},"obj":"Disease"},{"id":"T235","span":{"begin":340,"end":349},"obj":"Disease"},{"id":"T236","span":{"begin":374,"end":382},"obj":"Disease"},{"id":"T237","span":{"begin":465,"end":473},"obj":"Disease"},{"id":"T238","span":{"begin":787,"end":795},"obj":"Disease"}],"attributes":[{"id":"A232","pred":"mondo_id","subj":"T232","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A233","pred":"mondo_id","subj":"T233","obj":"http://purl.obolibrary.org/obo/MONDO_0007163"},{"id":"A234","pred":"mondo_id","subj":"T234","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A235","pred":"mondo_id","subj":"T235","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A236","pred":"mondo_id","subj":"T236","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A237","pred":"mondo_id","subj":"T237","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A238","pred":"mondo_id","subj":"T238","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T232","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T233","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T234","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T235","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T236","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T237","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T238","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T221","span":{"begin":178,"end":188},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T222","span":{"begin":189,"end":193},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T223","span":{"begin":189,"end":193},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T224","span":{"begin":243,"end":244},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T225","span":{"begin":532,"end":537},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T226","span":{"begin":532,"end":537},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T227","span":{"begin":840,"end":841},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T228","span":{"begin":1062,"end":1063},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T221","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T222","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T223","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T224","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T225","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T226","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T227","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T228","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T190","span":{"begin":279,"end":282},"obj":"Chemical"},{"id":"T192","span":{"begin":301,"end":304},"obj":"Chemical"},{"id":"T194","span":{"begin":485,"end":488},"obj":"Chemical"},{"id":"T196","span":{"begin":525,"end":528},"obj":"Chemical"},{"id":"T198","span":{"begin":685,"end":688},"obj":"Chemical"},{"id":"T200","span":{"begin":733,"end":743},"obj":"Chemical"},{"id":"T201","span":{"begin":878,"end":881},"obj":"Chemical"},{"id":"T203","span":{"begin":976,"end":992},"obj":"Chemical"},{"id":"T205","span":{"begin":987,"end":992},"obj":"Chemical"},{"id":"T206","span":{"begin":1038,"end":1049},"obj":"Chemical"},{"id":"T207","span":{"begin":1075,"end":1085},"obj":"Chemical"}],"attributes":[{"id":"A190","pred":"chebi_id","subj":"T190","obj":"http://purl.obolibrary.org/obo/CHEBI_17824"},{"id":"A191","pred":"chebi_id","subj":"T190","obj":"http://purl.obolibrary.org/obo/CHEBI_30802"},{"id":"A192","pred":"chebi_id","subj":"T192","obj":"http://purl.obolibrary.org/obo/CHEBI_17824"},{"id":"A193","pred":"chebi_id","subj":"T192","obj":"http://purl.obolibrary.org/obo/CHEBI_30802"},{"id":"A194","pred":"chebi_id","subj":"T194","obj":"http://purl.obolibrary.org/obo/CHEBI_17824"},{"id":"A195","pred":"chebi_id","subj":"T194","obj":"http://purl.obolibrary.org/obo/CHEBI_30802"},{"id":"A196","pred":"chebi_id","subj":"T196","obj":"http://purl.obolibrary.org/obo/CHEBI_17824"},{"id":"A197","pred":"chebi_id","subj":"T196","obj":"http://purl.obolibrary.org/obo/CHEBI_30802"},{"id":"A198","pred":"chebi_id","subj":"T198","obj":"http://purl.obolibrary.org/obo/CHEBI_17824"},{"id":"A199","pred":"chebi_id","subj":"T198","obj":"http://purl.obolibrary.org/obo/CHEBI_30802"},{"id":"A200","pred":"chebi_id","subj":"T200","obj":"http://purl.obolibrary.org/obo/CHEBI_35718"},{"id":"A201","pred":"chebi_id","subj":"T201","obj":"http://purl.obolibrary.org/obo/CHEBI_17824"},{"id":"A202","pred":"chebi_id","subj":"T201","obj":"http://purl.obolibrary.org/obo/CHEBI_30802"},{"id":"A203","pred":"chebi_id","subj":"T203","obj":"http://purl.obolibrary.org/obo/CHEBI_35718"},{"id":"A204","pred":"chebi_id","subj":"T203","obj":"http://purl.obolibrary.org/obo/CHEBI_86327"},{"id":"A205","pred":"chebi_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A206","pred":"chebi_id","subj":"T206","obj":"http://purl.obolibrary.org/obo/CHEBI_35718"},{"id":"A207","pred":"chebi_id","subj":"T207","obj":"http://purl.obolibrary.org/obo/CHEBI_35718"},{"subj":"T190","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T192","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T194","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T196","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T198","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T200","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T201","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T203","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T205","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T206","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T207","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T54","span":{"begin":143,"end":163},"obj":"Phenotype"},{"id":"T55","span":{"begin":279,"end":282},"obj":"Phenotype"},{"id":"T56","span":{"begin":301,"end":304},"obj":"Phenotype"},{"id":"T57","span":{"begin":485,"end":488},"obj":"Phenotype"},{"id":"T58","span":{"begin":525,"end":528},"obj":"Phenotype"},{"id":"T59","span":{"begin":685,"end":688},"obj":"Phenotype"},{"id":"T60","span":{"begin":878,"end":881},"obj":"Phenotype"}],"attributes":[{"id":"A54","pred":"hp_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/HP_0002958"},{"id":"A55","pred":"hp_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/HP_0020103"},{"id":"A56","pred":"hp_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/HP_0020103"},{"id":"A57","pred":"hp_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/HP_0020103"},{"id":"A58","pred":"hp_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/HP_0020103"},{"id":"A59","pred":"hp_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/HP_0020103"},{"id":"A60","pred":"hp_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/HP_0020103"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T154","span":{"begin":0,"end":2},"obj":"Sentence"},{"id":"T155","span":{"begin":3,"end":22},"obj":"Sentence"},{"id":"T156","span":{"begin":23,"end":142},"obj":"Sentence"},{"id":"T157","span":{"begin":143,"end":300},"obj":"Sentence"},{"id":"T158","span":{"begin":301,"end":446},"obj":"Sentence"},{"id":"T159","span":{"begin":447,"end":689},"obj":"Sentence"},{"id":"T160","span":{"begin":690,"end":918},"obj":"Sentence"},{"id":"T161","span":{"begin":919,"end":1096},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T154","pred":"source","obj":"LitCovid-sentences"},{"subj":"T155","pred":"source","obj":"LitCovid-sentences"},{"subj":"T156","pred":"source","obj":"LitCovid-sentences"},{"subj":"T157","pred":"source","obj":"LitCovid-sentences"},{"subj":"T158","pred":"source","obj":"LitCovid-sentences"},{"subj":"T159","pred":"source","obj":"LitCovid-sentences"},{"subj":"T160","pred":"source","obj":"LitCovid-sentences"},{"subj":"T161","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32599813-30076119-60095168","span":{"begin":864,"end":865},"obj":"30076119"}],"attributes":[{"subj":"32599813-30076119-60095168","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#98ec93","default":true},{"id":"LitCovid-PD-UBERON","color":"#ec93b2"},{"id":"LitCovid-PubTator","color":"#93ccec"},{"id":"LitCovid-PD-MONDO","color":"#e6ec93"},{"id":"LitCovid-PD-CLO","color":"#d893ec"},{"id":"LitCovid-PD-CHEBI","color":"#93ecbd"},{"id":"LitCovid-PD-HP","color":"#eca393"},{"id":"LitCovid-sentences","color":"#939cec"},{"id":"2_test","color":"#b6ec93"}]}]}}