PMC:7346000 / 22919-23224 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"660","span":{"begin":224,"end":230},"obj":"Gene"},{"id":"672","span":{"begin":86,"end":104},"obj":"Chemical"},{"id":"673","span":{"begin":106,"end":116},"obj":"Chemical"},{"id":"674","span":{"begin":118,"end":137},"obj":"Chemical"},{"id":"675","span":{"begin":182,"end":192},"obj":"Chemical"},{"id":"695","span":{"begin":56,"end":64},"obj":"Disease"}],"attributes":[{"id":"A660","pred":"tao:has_database_id","subj":"660","obj":"Gene:1576"},{"id":"A672","pred":"tao:has_database_id","subj":"672","obj":"MESH:D006886"},{"id":"A673","pred":"tao:has_database_id","subj":"673","obj":"MESH:D000069446"},{"id":"A674","pred":"tao:has_database_id","subj":"674","obj":"MESH:C558899"},{"id":"A675","pred":"tao:has_database_id","subj":"675","obj":"MESH:C000606551"},{"id":"A695","pred":"tao:has_database_id","subj":"695","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Furthermore, it may show interactions with experimental COVID-19 therapies, including hydroxychloroquine, atazanavir, lopinavir/ritonavir and last but not least—although weaker—with remdesivir, which is also a substrate for CYP3A4, although its metabolism is primarily mediated by hydrolase activity [84]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T197","span":{"begin":56,"end":64},"obj":"Disease"}],"attributes":[{"id":"A197","pred":"mondo_id","subj":"T197","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Furthermore, it may show interactions with experimental COVID-19 therapies, including hydroxychloroquine, atazanavir, lopinavir/ritonavir and last but not least—although weaker—with remdesivir, which is also a substrate for CYP3A4, although its metabolism is primarily mediated by hydrolase activity [84]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T186","span":{"begin":208,"end":209},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T187","span":{"begin":291,"end":299},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"Furthermore, it may show interactions with experimental COVID-19 therapies, including hydroxychloroquine, atazanavir, lopinavir/ritonavir and last but not least—although weaker—with remdesivir, which is also a substrate for CYP3A4, although its metabolism is primarily mediated by hydrolase activity [84]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T144","span":{"begin":86,"end":104},"obj":"Chemical"},{"id":"T145","span":{"begin":106,"end":116},"obj":"Chemical"},{"id":"T146","span":{"begin":118,"end":137},"obj":"Chemical"},{"id":"T147","span":{"begin":118,"end":127},"obj":"Chemical"},{"id":"T148","span":{"begin":128,"end":137},"obj":"Chemical"},{"id":"T149","span":{"begin":182,"end":192},"obj":"Chemical"}],"attributes":[{"id":"A144","pred":"chebi_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/CHEBI_5801"},{"id":"A145","pred":"chebi_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/CHEBI_37924"},{"id":"A146","pred":"chebi_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/CHEBI_145924"},{"id":"A147","pred":"chebi_id","subj":"T147","obj":"http://purl.obolibrary.org/obo/CHEBI_31781"},{"id":"A148","pred":"chebi_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/CHEBI_45409"},{"id":"A149","pred":"chebi_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/CHEBI_145994"}],"text":"Furthermore, it may show interactions with experimental COVID-19 therapies, including hydroxychloroquine, atazanavir, lopinavir/ritonavir and last but not least—although weaker—with remdesivir, which is also a substrate for CYP3A4, although its metabolism is primarily mediated by hydrolase activity [84]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T31","span":{"begin":245,"end":255},"obj":"http://purl.obolibrary.org/obo/GO_0008152"},{"id":"T32","span":{"begin":281,"end":299},"obj":"http://purl.obolibrary.org/obo/GO_0051345"}],"text":"Furthermore, it may show interactions with experimental COVID-19 therapies, including hydroxychloroquine, atazanavir, lopinavir/ritonavir and last but not least—although weaker—with remdesivir, which is also a substrate for CYP3A4, although its metabolism is primarily mediated by hydrolase activity [84]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T122","span":{"begin":0,"end":305},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Furthermore, it may show interactions with experimental COVID-19 therapies, including hydroxychloroquine, atazanavir, lopinavir/ritonavir and last but not least—although weaker—with remdesivir, which is also a substrate for CYP3A4, although its metabolism is primarily mediated by hydrolase activity [84]."}

{"project":"2_test","denotations":[{"id":"32599813-32284951-60095151","span":{"begin":301,"end":303},"obj":"32284951"}],"text":"Furthermore, it may show interactions with experimental COVID-19 therapies, including hydroxychloroquine, atazanavir, lopinavir/ritonavir and last but not least—although weaker—with remdesivir, which is also a substrate for CYP3A4, although its metabolism is primarily mediated by hydrolase activity [84]."}