PMC:7346000 / 22502-22757 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"670","span":{"begin":218,"end":230},"obj":"Chemical"},{"id":"694","span":{"begin":140,"end":154},"obj":"Disease"}],"attributes":[{"id":"A670","pred":"tao:has_database_id","subj":"670","obj":"MESH:D065819"},{"id":"A694","pred":"tao:has_database_id","subj":"694","obj":"MESH:D056486"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"However, besides its narrow therapeutic window and the requirement for therapeutic drug monitoring to ensure efficacy and prevent neuro and hepatotoxicity [81], drug–drug interactions may particularly limit the use of voriconazole in the ICU setting [82]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T136","span":{"begin":83,"end":87},"obj":"Chemical"},{"id":"T137","span":{"begin":161,"end":165},"obj":"Chemical"},{"id":"T138","span":{"begin":166,"end":170},"obj":"Chemical"},{"id":"T139","span":{"begin":218,"end":230},"obj":"Chemical"}],"attributes":[{"id":"A136","pred":"chebi_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A137","pred":"chebi_id","subj":"T137","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A138","pred":"chebi_id","subj":"T138","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A139","pred":"chebi_id","subj":"T139","obj":"http://purl.obolibrary.org/obo/CHEBI_10023"}],"text":"However, besides its narrow therapeutic window and the requirement for therapeutic drug monitoring to ensure efficacy and prevent neuro and hepatotoxicity [81], drug–drug interactions may particularly limit the use of voriconazole in the ICU setting [82]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T120","span":{"begin":0,"end":255},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"However, besides its narrow therapeutic window and the requirement for therapeutic drug monitoring to ensure efficacy and prevent neuro and hepatotoxicity [81], drug–drug interactions may particularly limit the use of voriconazole in the ICU setting [82]."}

{"project":"2_test","denotations":[{"id":"32599813-23629724-60095148","span":{"begin":156,"end":158},"obj":"23629724"},{"id":"32599813-30816967-60095149","span":{"begin":251,"end":253},"obj":"30816967"}],"text":"However, besides its narrow therapeutic window and the requirement for therapeutic drug monitoring to ensure efficacy and prevent neuro and hepatotoxicity [81], drug–drug interactions may particularly limit the use of voriconazole in the ICU setting [82]."}