> top > docs > PMC:7346000 > spans > 22194-25709 > annotations

PMC:7346000 / 22194-25709 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T59 1815-1821 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T28 1815-1821 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
657 586-593 Gene denotes CYP2C19 Gene:1557
658 595-601 Gene denotes CYP2C9 Gene:1559
659 607-613 Gene denotes CYP3A4 Gene:1576
660 949-955 Gene denotes CYP3A4 Gene:1576
661 1313-1319 Gene denotes CYP3A4 Gene:1576
662 1711-1719 Species denotes patients Tax:9606
663 1732-1742 Species denotes SARS-CoV-2 Tax:2697049
664 2034-2052 Species denotes feline coronavirus Tax:12663
665 3169-3177 Species denotes patients Tax:9606
666 2479-2490 Species denotes Aspergillus Tax:746128
667 2614-2625 Species denotes Aspergillus Tax:746128
668 3472-3483 Species denotes Aspergillus Tax:746128
669 233-245 Chemical denotes voriconazole MESH:D065819
670 526-538 Chemical denotes voriconazole MESH:D065819
671 615-627 Chemical denotes voriconazole MESH:D065819
672 811-829 Chemical denotes hydroxychloroquine MESH:D006886
673 831-841 Chemical denotes atazanavir MESH:D000069446
674 843-862 Chemical denotes lopinavir/ritonavir MESH:C558899
675 907-917 Chemical denotes remdesivir MESH:C000606551
676 1031-1044 Chemical denotes Isavuconazole MESH:C508735
677 1059-1073 Chemical denotes amphotericin B MESH:D000666
678 1160-1172 Chemical denotes voriconazole MESH:D065819
679 1174-1187 Chemical denotes isavuconazole MESH:C508735
680 1422-1435 Chemical denotes isavuconazole MESH:C508735
681 1446-1458 Chemical denotes voriconazole MESH:D065819
682 1478-1492 Chemical denotes amphotericin B MESH:D000666
683 1841-1853 Chemical denotes itraconazole MESH:D017964
684 1978-1989 Chemical denotes cholesterol MESH:D002784
685 2146-2158 Chemical denotes itraconazole MESH:D017964
686 2304-2313 Chemical denotes triazoles MESH:D014230
687 2843-2855 Chemical denotes fosmanogepix
688 2860-2868 Chemical denotes olorofim MESH:C000626907
689 3280-3289 Chemical denotes triazoles MESH:D014230
690 3314-3328 Chemical denotes amphotericin B MESH:D000666
691 3428-3440 Chemical denotes echinocandin MESH:D054714
692 62-70 Disease denotes COVID-19 MESH:C000657245
693 201-223 Disease denotes hematologic malignancy MESH:D019337
694 448-462 Disease denotes hepatotoxicity MESH:D056486
695 781-789 Disease denotes COVID-19 MESH:C000657245
696 1265-1275 Disease denotes toxicities MESH:D064420
697 1566-1585 Disease denotes renal insufficiency MESH:D051437
698 1720-1728 Disease denotes infected MESH:D007239
699 1759-1772 Disease denotes renal tropism MESH:D007674
700 1815-1828 Disease denotes kidney injury MESH:D058186
701 1882-1904 Disease denotes invasive aspergillosis MESH:D055744
702 2211-2219 Disease denotes COVID-19 MESH:C000657245
703 2407-2429 Disease denotes invasive aspergillosis MESH:D055744
704 2953-2961 Disease denotes toxicity MESH:D064420
705 3138-3146 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T194 62-70 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T195 201-223 Disease denotes hematologic malignancy http://purl.obolibrary.org/obo/MONDO_0002334|http://purl.obolibrary.org/obo/MONDO_0044881
T197 781-789 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T198 1566-1585 Disease denotes renal insufficiency http://purl.obolibrary.org/obo/MONDO_0001106
T199 1732-1740 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T200 1822-1828 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T201 1882-1904 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T202 1891-1904 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T203 2211-2219 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T204 2407-2429 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T205 2416-2429 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T206 3138-3146 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T185 102-103 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T186 933-934 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T187 1016-1024 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T188 1072-1073 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T189 1194-1195 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T190 1407-1408 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T191 1491-1492 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T192 1496-1497 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T193 1749-1752 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T194 1795-1796 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T195 1815-1821 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T196 1815-1821 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T197 1815-1821 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T198 1909-1912 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T199 1950-1958 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T200 1976-1977 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T201 2032-2033 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T202 2110-2113 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T203 2462-2470 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T204 2597-2605 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T205 3327-3328 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T206 3330-3332 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T207 3455-3463 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T208 3498-3499 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T129 38-48 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T130 82-85 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T132 167-177 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T133 233-245 Chemical denotes voriconazole http://purl.obolibrary.org/obo/CHEBI_10023
T134 295-298 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T136 391-395 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T137 469-473 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T138 474-478 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T139 526-538 Chemical denotes voriconazole http://purl.obolibrary.org/obo/CHEBI_10023
T140 615-627 Chemical denotes voriconazole http://purl.obolibrary.org/obo/CHEBI_10023
T141 641-646 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T142 685-689 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T143 690-694 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T144 811-829 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T145 831-841 Chemical denotes atazanavir http://purl.obolibrary.org/obo/CHEBI_37924
T146 843-862 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T147 843-852 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T148 853-862 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T149 907-917 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T150 1059-1073 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T151 1127-1130 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T153 1160-1172 Chemical denotes voriconazole http://purl.obolibrary.org/obo/CHEBI_10023
T154 1174-1187 Chemical denotes isavuconazole http://purl.obolibrary.org/obo/CHEBI_85979
T155 1365-1369 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T156 1370-1374 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T157 1422-1435 Chemical denotes isavuconazole http://purl.obolibrary.org/obo/CHEBI_85979
T158 1446-1458 Chemical denotes voriconazole http://purl.obolibrary.org/obo/CHEBI_10023
T159 1478-1492 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T160 1651-1667 Chemical denotes antifungal agent http://purl.obolibrary.org/obo/CHEBI_35718
T161 1841-1853 Chemical denotes itraconazole http://purl.obolibrary.org/obo/CHEBI_6076
T162 1940-1949 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T163 1978-1989 Chemical denotes cholesterol http://purl.obolibrary.org/obo/CHEBI_16113
T164 2000-2009 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T165 2146-2158 Chemical denotes itraconazole http://purl.obolibrary.org/obo/CHEBI_6076
T166 2231-2234 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T168 2270-2274 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T169 2275-2279 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T170 2304-2313 Chemical denotes triazoles http://purl.obolibrary.org/obo/CHEBI_35727
T171 2341-2354 Chemical denotes echinocandins http://purl.obolibrary.org/obo/CHEBI_57248
T172 2451-2461 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T173 2544-2548 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T174 2549-2553 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T175 2698-2709 Chemical denotes antifungals http://purl.obolibrary.org/obo/CHEBI_35718
T176 2759-2769 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T177 2788-2798 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T178 2926-2930 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T179 2931-2935 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T180 3029-3040 Chemical denotes antifungals http://purl.obolibrary.org/obo/CHEBI_35718
T181 3158-3161 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T183 3280-3289 Chemical denotes triazoles http://purl.obolibrary.org/obo/CHEBI_35727
T184 3314-3328 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T185 3358-3368 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T186 3428-3440 Chemical denotes echinocandin http://purl.obolibrary.org/obo/CHEBI_57248

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T31 970-980 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T32 1006-1024 http://purl.obolibrary.org/obo/GO_0051345 denotes hydrolase activity
T33 1765-1772 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T34 1978-1999 http://purl.obolibrary.org/obo/GO_0030301 denotes cholesterol transport
T35 1990-1999 http://purl.obolibrary.org/obo/GO_0006810 denotes transport

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T47 82-85 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T48 295-298 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T49 1127-1130 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T50 1566-1585 Phenotype denotes renal insufficiency http://purl.obolibrary.org/obo/HP_0000083
T51 2231-2234 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T52 3158-3161 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T118 0-188 Sentence denotes While it is currently unknown whether antifungal treatment of COVID-19 associated IPA translates into a survival benefit, diagnosis should in most cases trigger early antifungal treatment.
T119 189-307 Sentence denotes Outside the hematologic malignancy setting, voriconazole remains the recommended first-line treatment for IPA [79,80].
T120 308-563 Sentence denotes However, besides its narrow therapeutic window and the requirement for therapeutic drug monitoring to ensure efficacy and prevent neuro and hepatotoxicity [81], drug–drug interactions may particularly limit the use of voriconazole in the ICU setting [82].
T121 564-724 Sentence denotes Being metabolized via CYP2C19, CYP2C9, and CYP3A4, voriconazole is among the drugs most frequently associated with major drug–drug interactions in the ICU [83].
T122 725-1030 Sentence denotes Furthermore, it may show interactions with experimental COVID-19 therapies, including hydroxychloroquine, atazanavir, lopinavir/ritonavir and last but not least—although weaker—with remdesivir, which is also a substrate for CYP3A4, although its metabolism is primarily mediated by hydrolase activity [84].
T123 1031-1147 Sentence denotes Isavuconazole and liposomal amphotericin B are the primary alternative options for treatment of IPA in the ICU [79].
T124 1148-1276 Sentence denotes Compared to voriconazole, isavuconazole shows a more favorable pharmacokinetic profile, and is associated with fewer toxicities.
T125 1277-1467 Sentence denotes However, it is also metabolized via CYP3A4 and could therefore be problematic, although drug–drug interactions are generally less a problem with isavuconazole than with voriconazole [85,86].
T126 1468-1668 Sentence denotes Liposomal amphotericin B is a broadly effective alternative treatment option, however, in the ICU renal insufficiency often complicates initiation or requires discontinuation of this antifungal agent.
T127 1669-1834 Sentence denotes This concern is particularly relevant for patients infected by SARS-CoV-2 which has shown renal tropism and been described as a frequent cause of kidney injury [87].
T128 1835-2064 Sentence denotes While itraconazole is now rarely used to treat invasive aspergillosis, it has been shown to exhibit some antiviral activity, specifically as a cholesterol transport inhibitor, and was effective in a feline coronavirus model [88].
T129 2065-2314 Sentence denotes In addition, its novel oral SUBA formulation has great bioavailability [89], and itraconazole may therefore be an alternative option for treating COVID-19 associated IPA, although it shares the problem of drug–drug interactions with other triazoles.
T130 2315-2638 Sentence denotes While currently available echinocandins are not considered first-line treatment options for invasive aspergillosis due to their limited antifungal activity against Aspergillus spp., they are generally well tolerated with limited drug–drug interactions and show at least fungistatic activity against Aspergillus hyphae [90].
T131 2639-2783 Sentence denotes Furthermore, they synergistic interactions with some other antifungals, making them an excellent choice for combination antifungal therapy [90].
T132 2784-3103 Sentence denotes New antifungal classes currently under development, namely fosmanogepix and olorofim [91], may have equal efficacy without the same burden of drug–drug interactions and toxicity, and may therefore overcome the limitations of currently available antifungals and become the preferred treatment options in the near future.
T133 3104-3515 Sentence denotes If the reported high incidence of COVID-19 associated IPA in ICU patients is confirmed in larger studies, there may be justification for prophylaxis trials, for which not only triazoles and nebulized liposomal amphotericin B [52], but also another novel antifungal currently under development, rezafungin (i.e., once weekly echinocandin with improved activity against Aspergillus spp.), may be a candidate [92].

2_test

Id Subject Object Predicate Lexical cue
32599813-27365388-60095146 300-302 27365388 denotes 79
32599813-29544767-60095147 303-305 29544767 denotes 80
32599813-23629724-60095148 464-466 23629724 denotes 81
32599813-30816967-60095149 559-561 30816967 denotes 82
32599813-26603290-60095150 720-722 26603290 denotes 83
32599813-32284951-60095151 1026-1028 32284951 denotes 84
32599813-27365388-60095152 1143-1145 27365388 denotes 79
32599813-29112326-60095153 1463-1465 29112326 denotes 86
32599813-30658691-60095154 2060-2062 30658691 denotes 88
32599813-31360992-60095155 2137-2139 31360992 denotes 89
32599813-31138565-60095156 2634-2636 31138565 denotes 90
32599813-31138565-60095157 2779-2781 31138565 denotes 90
32599813-31649174-60095158 2870-2872 31649174 denotes 91
32599813-32488446-60095159 3330-3332 32488446 denotes 52
32599813-30032217-60095160 3511-3513 30032217 denotes 92