PMC:7346000 / 19745-20579 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7346000","sourcedb":"PMC","sourceid":"7346000","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7346000","text":"The optimal diagnostic algorithm for diagnosing CAPA is currently unknown, and this question is actively being investigated in an ongoing multinational explorative trial in conjunction with the European Confederation of Medical Mycology (ECMM). The most common methods to date include attempting to recover Aspergillus spp. on culture media of bronchoalveolar fluid (BALF) and tracheal aspirate, as well as utilizing serologic biomarker testing such as the conventional Galactomannan (GM) from BALF, tracheal aspirate, and serum specimens. Other diagnostic tests that may prove useful also include Aspergillus PCR, serum (1→3)-β-d-glucan (BDG), the Aspergillus galactomannan lateral flow assay (LFA) (IMMY, Norman, Oklahoma, USA), and the Aspergillus-specific lateral-flow device (LFD) test (OLM Diagnostics, Newcastle Upon Tyne, UK).","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T51","span":{"begin":523,"end":528},"obj":"Body_part"},{"id":"T52","span":{"begin":615,"end":620},"obj":"Body_part"}],"attributes":[{"id":"A51","pred":"fma_id","subj":"T51","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A52","pred":"fma_id","subj":"T52","obj":"http://purl.org/sig/ont/fma/fma63083"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T20","span":{"begin":523,"end":528},"obj":"Body_part"},{"id":"T21","span":{"begin":615,"end":620},"obj":"Body_part"}],"attributes":[{"id":"A20","pred":"uberon_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"568","span":{"begin":307,"end":318},"obj":"Species"},{"id":"569","span":{"begin":598,"end":609},"obj":"Species"},{"id":"570","span":{"begin":649,"end":660},"obj":"Species"},{"id":"571","span":{"begin":739,"end":750},"obj":"Species"},{"id":"572","span":{"begin":470,"end":483},"obj":"Chemical"},{"id":"573","span":{"begin":485,"end":487},"obj":"Chemical"},{"id":"574","span":{"begin":626,"end":637},"obj":"Chemical"},{"id":"575","span":{"begin":639,"end":642},"obj":"Chemical"},{"id":"576","span":{"begin":661,"end":674},"obj":"Chemical"},{"id":"577","span":{"begin":715,"end":723},"obj":"Disease"}],"attributes":[{"id":"A568","pred":"tao:has_database_id","subj":"568","obj":"Tax:746128"},{"id":"A569","pred":"tao:has_database_id","subj":"569","obj":"Tax:746128"},{"id":"A570","pred":"tao:has_database_id","subj":"570","obj":"Tax:746128"},{"id":"A571","pred":"tao:has_database_id","subj":"571","obj":"Tax:746128"},{"id":"A572","pred":"tao:has_database_id","subj":"572","obj":"MESH:C012990"},{"id":"A573","pred":"tao:has_database_id","subj":"573","obj":"MESH:C012990"},{"id":"A576","pred":"tao:has_database_id","subj":"576","obj":"MESH:C012990"},{"id":"A577","pred":"tao:has_database_id","subj":"577","obj":"MESH:C537147"},{"subj":"568","pred":"source","obj":"LitCovid-PubTator"},{"subj":"569","pred":"source","obj":"LitCovid-PubTator"},{"subj":"570","pred":"source","obj":"LitCovid-PubTator"},{"subj":"571","pred":"source","obj":"LitCovid-PubTator"},{"subj":"572","pred":"source","obj":"LitCovid-PubTator"},{"subj":"573","pred":"source","obj":"LitCovid-PubTator"},{"subj":"574","pred":"source","obj":"LitCovid-PubTator"},{"subj":"575","pred":"source","obj":"LitCovid-PubTator"},{"subj":"576","pred":"source","obj":"LitCovid-PubTator"},{"subj":"577","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T188","span":{"begin":48,"end":52},"obj":"Disease"}],"attributes":[{"id":"A188","pred":"mondo_id","subj":"T188","obj":"http://purl.obolibrary.org/obo/MONDO_0007163"},{"subj":"T188","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T158","span":{"begin":96,"end":104},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T159","span":{"begin":437,"end":444},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T160","span":{"begin":557,"end":562},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T161","span":{"begin":773,"end":779},"obj":"http://purl.obolibrary.org/obo/OBI_0000968"},{"id":"T162","span":{"begin":786,"end":790},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"}],"attributes":[{"subj":"T158","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T159","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T160","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T161","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T162","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T115","span":{"begin":427,"end":436},"obj":"Chemical"},{"id":"T116","span":{"begin":485,"end":487},"obj":"Chemical"},{"id":"T117","span":{"begin":631,"end":637},"obj":"Chemical"},{"id":"T118","span":{"begin":661,"end":674},"obj":"Chemical"},{"id":"T119","span":{"begin":695,"end":698},"obj":"Chemical"},{"id":"T120","span":{"begin":781,"end":784},"obj":"Chemical"}],"attributes":[{"id":"A115","pred":"chebi_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/CHEBI_59163"},{"id":"A116","pred":"chebi_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/CHEBI_74120"},{"id":"A117","pred":"chebi_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/CHEBI_37163"},{"id":"A118","pred":"chebi_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/CHEBI_27680"},{"id":"A119","pred":"chebi_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/CHEBI_139482"},{"id":"A120","pred":"chebi_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/CHEBI_73571"},{"subj":"T115","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T116","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T117","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T118","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T119","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T120","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T4","span":{"begin":470,"end":483},"obj":"GlycoEpitope"},{"id":"T5","span":{"begin":485,"end":487},"obj":"GlycoEpitope"},{"id":"T6","span":{"begin":661,"end":674},"obj":"GlycoEpitope"}],"attributes":[{"id":"A4","pred":"glyco_epitope_db_id","subj":"T4","obj":"http://www.glycoepitope.jp/epitopes/EP0510"},{"id":"A5","pred":"glyco_epitope_db_id","subj":"T5","obj":"http://www.glycoepitope.jp/epitopes/EP0510"},{"id":"A6","pred":"glyco_epitope_db_id","subj":"T6","obj":"http://www.glycoepitope.jp/epitopes/EP0510"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-GlycoEpitope"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-GlycoEpitope"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-GlycoEpitope"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T106","span":{"begin":0,"end":244},"obj":"Sentence"},{"id":"T107","span":{"begin":245,"end":539},"obj":"Sentence"},{"id":"T108","span":{"begin":540,"end":834},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T106","pred":"source","obj":"LitCovid-sentences"},{"subj":"T107","pred":"source","obj":"LitCovid-sentences"},{"subj":"T108","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93baec","default":true},{"id":"LitCovid-PD-UBERON","color":"#d4ec93"},{"id":"LitCovid-PubTator","color":"#ea93ec"},{"id":"LitCovid-PD-MONDO","color":"#93ecd0"},{"id":"LitCovid-PD-CLO","color":"#ecb693"},{"id":"LitCovid-PD-CHEBI","color":"#9b93ec"},{"id":"LitCovid-PD-GlycoEpitope","color":"#a4ec93"},{"id":"LitCovid-sentences","color":"#ec93be"}]}]}}