> top > docs > PMC:7346000 > spans > 1702-29443 > annotations

PMC:7346000 / 1702-29443 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 791-795 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T2 2450-2466 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T3 2461-2466 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T4 2479-2490 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T5 2525-2532 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T6 2706-2713 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T7 2769-2773 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T8 2902-2906 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T9 3125-3130 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T10 3420-3425 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T11 3657-3670 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T12 4022-4027 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T13 4140-4144 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T14 4311-4315 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T15 4492-4501 Body_part denotes stem-cell http://purl.org/sig/ont/fma/fma63368
T16 4497-4501 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T17 5158-5163 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T18 5567-5576 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T19 5671-5675 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T20 5880-5884 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T21 5959-5963 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T22 6176-6189 Body_part denotes interleukin-1 http://purl.org/sig/ont/fma/fma86583
T23 6319-6323 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T24 6599-6603 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T25 6769-6773 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T26 6899-6903 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T27 6953-6958 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T28 7016-7032 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T29 7027-7032 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T30 7180-7188 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T31 7781-7785 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T32 8007-8016 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T33 8198-8202 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T34 8223-8236 Body_part denotes T-lymphocytes http://purl.org/sig/ont/fma/fma62870
T35 8413-8423 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T36 10931-10935 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T37 11158-11162 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T38 11267-11275 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T39 11387-11391 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T40 11912-11920 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T41 12231-12234 Body_part denotes gut http://purl.org/sig/ont/fma/fma7199
T42 12551-12564 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T43 12817-12822 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T44 12984-12989 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T45 13075-13079 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T46 13374-13380 Body_part denotes throat http://purl.org/sig/ont/fma/fma228738
T47 14627-14650 Body_part denotes upper respiratory tract http://purl.org/sig/ont/fma/fma45661
T48 16461-16466 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T49 16740-16763 Body_part denotes upper respiratory tract http://purl.org/sig/ont/fma/fma45661
T50 17642-17647 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T51 18566-18571 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T52 18658-18663 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T53 19462-19468 Body_part denotes sputum http://purl.org/sig/ont/fma/fma312401
T54 19613-19618 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T55 19687-19693 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T56 20150-20155 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T57 20331-20336 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T58 20394-20399 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T59 22307-22313 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T60 25713-25720 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T61 25845-25849 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T62 26834-26838 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T63 27177-27182 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 791-795 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T2 2902-2906 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T3 3168-3192 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T4 3657-3670 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T5 4140-4144 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T6 10931-10935 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T7 11158-11162 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T8 11387-11391 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T9 12551-12564 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T10 12817-12822 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T11 12984-12989 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T12 13075-13079 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T13 13374-13380 Body_part denotes throat http://purl.obolibrary.org/obo/UBERON_0000341
T14 14627-14650 Body_part denotes upper respiratory tract http://purl.obolibrary.org/obo/UBERON_0001557
T15 14633-14650 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T16 16461-16466 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T17 16740-16763 Body_part denotes upper respiratory tract http://purl.obolibrary.org/obo/UBERON_0001557
T18 16746-16763 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T19 17642-17647 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T20 18566-18571 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T21 18658-18663 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T22 19462-19468 Body_part denotes sputum http://purl.obolibrary.org/obo/UBERON_0007311
T23 19613-19618 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T24 19687-19693 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T25 20150-20155 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T26 20331-20336 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T27 20394-20399 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T28 22307-22313 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T29 25713-25720 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T30 25725-25732 Body_part denotes bronchi http://purl.obolibrary.org/obo/UBERON_0002185
T31 25845-25849 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T32 26834-26838 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T33 27177-27182 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
64 206-227 Species denotes Aspergillus fumigatus Tax:746128
65 303-309 Species denotes humans Tax:9606
66 880-888 Species denotes patients Tax:9606
67 86-97 Species denotes Aspergillus Tax:746128
68 170-181 Species denotes Aspergillus Tax:746128
69 572-583 Species denotes Aspergillus Tax:746128
70 16-42 Disease denotes Invasive fungal infections MESH:D000072742
71 289-299 Disease denotes infections MESH:D007239
72 321-353 Disease denotes invasive pulmonary aspergillosis MESH:D055744
73 369-392 Disease denotes pulmonary aspergillosis MESH:D055732
74 400-439 Disease denotes allergic bronchopulmonary aspergillosis MESH:D001229
75 448-470 Disease denotes chronic rhinosinusitis MESH:D002908
76 472-485 Disease denotes fungal asthma MESH:D001249
77 491-513 Disease denotes Aspergillus bronchitis MESH:D001991
78 609-618 Disease denotes mortality MESH:D003643
79 791-802 Disease denotes lung damage MESH:D008171
80 894-932 Disease denotes chronic obstructive pulmonary diseases MESH:D029424
81 934-938 Disease denotes COPD MESH:D029424
105 1019-1027 Species denotes patients Tax:9606
106 1441-1449 Species denotes patients Tax:9606
107 1550-1558 Species denotes patients Tax:9606
108 1009-1018 Species denotes influenza Tax:11309
109 1273-1282 Species denotes influenza Tax:11309
110 1665-1676 Species denotes Aspergillus Tax:746128
111 1824-1833 Species denotes influenza Tax:11309
112 1051-1086 Disease denotes acute respiratory distress syndrome MESH:D012128
113 1088-1092 Disease denotes ARDS MESH:D012128
114 1187-1196 Disease denotes mortality MESH:D003643
115 1365-1387 Disease denotes coronavirus disease-19 MESH:C000657245
116 1403-1411 Disease denotes COVID-19 MESH:C000657245
117 1417-1425 Disease denotes infected MESH:D007239
118 1484-1490 Disease denotes deaths MESH:D003643
119 1528-1536 Disease denotes COVID-19 MESH:C000657245
120 1571-1575 Disease denotes ARDS MESH:D012128
121 1626-1636 Disease denotes infections MESH:D007239
122 1711-1724 Disease denotes co-infections MESH:D060085
123 1767-1780 Disease denotes co-infections MESH:D060085
124 1903-1912 Disease denotes mortality MESH:D003643
125 1954-1962 Disease denotes COVID-19 MESH:C000657245
126 2029-2037 Disease denotes COVID-19 MESH:C000657245
127 2049-2072 Disease denotes pulmonary aspergillosis MESH:D055732
144 2540-2571 Gene denotes angiotensin-converting enzyme 2 Gene:59272
145 2573-2577 Gene denotes ACE2 Gene:59272
146 2661-2668 Gene denotes TMPRSS2 Gene:7113
147 2778-2782 Gene denotes ACE2 Gene:59272
148 2827-2831 Gene denotes ACE2 Gene:59272
149 2996-2999 Gene denotes ACE Gene:1636
150 3204-3214 Gene denotes kallikrein Gene:9622
151 2338-2348 Species denotes SARS-CoV-2 Tax:2697049
152 2399-2417 Species denotes SARS coronaviruses Tax:694009
153 2419-2429 Species denotes SARS-CoV-2 Tax:2697049
154 2806-2816 Species denotes SARS virus Tax:694009
155 3104-3114 Species denotes SARS-CoV-2 Tax:2697049
156 2323-2332 Disease denotes infection MESH:D007239
157 2902-2913 Disease denotes lung injury MESH:D055370
158 2917-2921 Disease denotes ARDS MESH:D012128
159 3029-3033 Disease denotes ARDS MESH:D012128
175 3694-3704 Species denotes SARS-CoV-2 Tax:2697049
176 3765-3778 Species denotes coronaviruses Tax:11118
177 4806-4814 Species denotes patients Tax:9606
178 3513-3524 Species denotes Aspergillus Tax:746128
179 3283-3294 Disease denotes Viral entry
180 3299-3308 Disease denotes infection MESH:D007239
181 3743-3753 Disease denotes infections MESH:D007239
182 3868-3872 Disease denotes ARDS MESH:D012128
183 4140-4151 Disease denotes lung injury MESH:D055370
184 4219-4231 Disease denotes inflammation MESH:D007249
185 4235-4250 Disease denotes fungal diseases MESH:D009181
186 4437-4450 Disease denotes aspergillosis MESH:D001228
187 4609-4618 Disease denotes infection MESH:D007239
188 4759-4771 Disease denotes inflammation MESH:D007249
189 4797-4805 Disease denotes COVID-19 MESH:C000657245
223 5121-5125 Gene denotes ACE2 Gene:59272
224 5195-5199 Gene denotes TLR4 Gene:7099
225 5204-5208 Gene denotes TLR3 Gene:7098
226 5239-5244 Gene denotes MyD88 Gene:4615
227 5249-5253 Gene denotes TRIF Gene:148022
228 5380-5384 Gene denotes TLR4 Gene:7099
229 5385-5390 Gene denotes MyD88 Gene:17874
230 5391-5395 Gene denotes TRIF Gene:148022
231 5420-5430 Gene denotes fibrinogen Gene:2244
232 5671-5676 Gene denotes IL-1β Gene:3552
233 5880-5884 Gene denotes IL-1 Gene:3552
234 5959-5963 Gene denotes IL-1 Gene:3552
235 6319-6323 Gene denotes IL-1 Gene:3552
236 6599-6603 Gene denotes IL-1 Gene:3552
237 5168-5176 Species denotes SARS-CoV Tax:694009
238 5455-5465 Species denotes SARS-CoV-2 Tax:2697049
239 5629-5637 Species denotes SARS-CoV Tax:694009
240 5791-5799 Species denotes patients Tax:9606
241 6100-6108 Species denotes patients Tax:9606
242 6280-6288 Species denotes patients Tax:9606
243 5348-5359 Species denotes Aspergillus Tax:746128
244 6542-6553 Species denotes Aspergillus Tax:746128
245 5109-5119 Disease denotes infections MESH:D007239
246 5782-5790 Disease denotes COVID-19 MESH:C000657245
247 6091-6099 Disease denotes COVID-19 MESH:C000657245
248 6114-6158 Disease denotes secondary hemophagocytic lymphohistiocytosis MESH:D051359
249 6265-6279 Disease denotes acute leukemia MESH:D015470
250 6294-6302 Disease denotes COVID-19 MESH:C000657245
251 6381-6393 Disease denotes inflammation MESH:D007249
252 6402-6431 Disease denotes chronic granulomatous disease MESH:D006105
253 6441-6456 Disease denotes cystic fibrosis MESH:D003550
254 6513-6522 Disease denotes infection MESH:D007239
255 6627-6647 Disease denotes SARS-CoV-2 infection MESH:C000657245
276 6769-6773 Gene denotes IL-1 Gene:3552
277 6795-6799 Gene denotes IL-6 Gene:3569
278 6991-6995 Gene denotes IL-6 Gene:3569
279 7696-7700 Gene denotes IL-6 Gene:3569
280 7058-7070 Species denotes A. fumigatus Tax:746128
281 7106-7114 Species denotes patients Tax:9606
282 7208-7216 Species denotes patients Tax:9606
283 7234-7241 Species denotes patient Tax:9606
284 7261-7269 Species denotes patients Tax:9606
285 7759-7767 Species denotes patients Tax:9606
286 7321-7332 Chemical denotes tocilizumab MESH:C502936
287 6856-6864 Disease denotes COVID-19 MESH:C000657245
288 7043-7052 Disease denotes infection MESH:D007239
289 7120-7132 Disease denotes co-infection MESH:D060085
290 7199-7207 Disease denotes COVID-19 MESH:C000657245
291 7252-7260 Disease denotes COVID-19 MESH:C000657245
292 7275-7279 Disease denotes ARDS MESH:D012128
293 7567-7582 Disease denotes IL-6 deficiency MESH:C535750
294 7609-7622 Disease denotes aspergillosis MESH:D001228
295 7750-7758 Disease denotes COVID-19 MESH:C000657245
309 8026-8029 Gene denotes TNF Gene:7124
310 7864-7872 Species denotes patients Tax:9606
311 8048-8056 Species denotes patients Tax:9606
312 8293-8301 Species denotes patients Tax:9606
313 8620-8628 Species denotes patients Tax:9606
314 8783-8793 Species denotes SARS-CoV-2 Tax:2697049
315 7885-7905 Disease denotes SARS-CoV-2 infection MESH:C000657245
316 8113-8123 Disease denotes infections MESH:D007239
317 8307-8315 Disease denotes COVID-19 MESH:C000657245
318 8501-8516 Disease denotes lymphocytopenia MESH:D008231
319 8595-8616 Disease denotes invasive mold disease MESH:D009361
320 8910-8914 Disease denotes ARDS MESH:D012128
321 8986-9006 Disease denotes secondary infections MESH:D060085
324 9310-9318 Species denotes patients Tax:9606
325 9172-9181 Species denotes influenza Tax:11309
337 9491-9499 Species denotes patients Tax:9606
338 9938-9946 Species denotes patients Tax:9606
339 10118-10126 Species denotes patients Tax:9606
340 10198-10206 Species denotes patients Tax:9606
341 9522-9530 Disease denotes COVID-19 MESH:C000657245
342 9748-9754 Disease denotes Cancer MESH:D009369
343 9755-9781 Disease denotes Invasive Fungal Infections MESH:D000072742
344 9826-9833 Disease denotes Allergy MESH:D004342
345 9838-9857 Disease denotes Infectious Diseases MESH:D003141
346 9977-9989 Disease denotes malignancies MESH:D009369
347 10212-10220 Disease denotes COVID-19 MESH:C000657245
358 10757-10765 Species denotes patients Tax:9606
359 10670-10679 Species denotes influenza Tax:11309
360 10847-10856 Species denotes influenza Tax:11309
361 10691-10714 Disease denotes pulmonary aspergillosis MESH:D055732
362 10748-10756 Disease denotes COVID-19 MESH:C000657245
363 10787-10810 Disease denotes pulmonary aspergillosis MESH:D055732
364 10931-10942 Disease denotes lung damage MESH:D008171
365 10964-10972 Disease denotes COVID-19 MESH:C000657245
366 11020-11024 Disease denotes ARDS MESH:D012128
367 11158-11170 Disease denotes lung defects MESH:D008171
377 11224-11242 Disease denotes pulmonary fibrosis MESH:D011658
378 11315-11323 Disease denotes toxicity MESH:D064420
379 11365-11372 Disease denotes hypoxia MESH:D000860
380 11381-11398 Disease denotes acute lung injury MESH:D055371
381 11460-11478 Disease denotes pulmonary fibrosis MESH:D011658
382 11553-11561 Disease denotes COVID-19 MESH:C000657245
383 11689-11704 Disease denotes viral infection MESH:D001102
384 11826-11830 Disease denotes ARDS MESH:D012128
385 12004-12024 Disease denotes secondary infections MESH:D060085
392 12104-12112 Species denotes patients Tax:9606
393 12184-12192 Species denotes patients Tax:9606
394 12225-12230 Species denotes human Tax:9606
395 12231-12245 Species denotes gut microbiome Tax:749906
396 12175-12183 Disease denotes COVID-19 MESH:C000657245
397 12515-12541 Disease denotes invasive fungal infections MESH:D000072742
415 12650-12658 Species denotes patients Tax:9606
416 13140-13148 Species denotes patients Tax:9606
417 12641-12649 Disease denotes COVID-19 MESH:C000657245
418 12729-12741 Disease denotes hypertension MESH:D006973
419 12756-12764 Disease denotes diabetes MESH:D003920
420 12778-12785 Disease denotes obesity MESH:D009765
421 12799-12803 Disease denotes COPD MESH:D029424
422 12817-12831 Disease denotes heart diseases MESH:D006331
423 12845-12865 Disease denotes hypercholesterinemia
424 12883-12889 Disease denotes asthma MESH:D001249
425 12961-12973 Disease denotes hypertension MESH:D006973
426 12984-12998 Disease denotes heart diseases MESH:D006331
427 13004-13012 Disease denotes diabetes MESH:D003920
428 13034-13043 Disease denotes infection MESH:D007239
429 13075-13086 Disease denotes lung damage MESH:D008171
430 13097-13101 Disease denotes COPD MESH:D029424
431 13105-13111 Disease denotes asthma MESH:D001249
455 13278-13286 Species denotes patients Tax:9606
456 13361-13369 Species denotes patients Tax:9606
457 13553-13561 Species denotes patients Tax:9606
458 13583-13591 Species denotes patients Tax:9606
459 13755-13763 Species denotes patients Tax:9606
460 13860-13868 Species denotes patients Tax:9606
461 14469-14477 Species denotes patients Tax:9606
462 13240-13251 Species denotes Aspergillus Tax:746128
463 13419-13430 Species denotes Aspergillus Tax:746128
464 14595-14606 Species denotes Aspergillus Tax:746128
465 14654-14665 Species denotes Aspergillus Tax:746128
466 14287-14300 Chemical denotes galactomannan MESH:C012990
467 13252-13262 Disease denotes infections MESH:D007239
468 13269-13277 Disease denotes COVID-19 MESH:C000657245
469 13344-13352 Disease denotes COVID-19 MESH:C000657245
470 13457-13482 Disease denotes Aspergillus co-infections MESH:D060085
471 13567-13575 Disease denotes COVID-19 MESH:C000657245
472 13851-13859 Disease denotes COVID-19 MESH:C000657245
473 13887-13904 Disease denotes fungal infections MESH:D009181
474 13988-13998 Disease denotes infections MESH:D007239
475 14191-14214 Disease denotes pulmonary aspergillosis MESH:D055732
476 14483-14491 Disease denotes COVID-19 MESH:C000657245
477 14666-14675 Disease denotes infection MESH:D007239
518 15676-15684 Species denotes patients Tax:9606
519 15772-15780 Species denotes patients Tax:9606
520 15907-15915 Species denotes children Tax:9606
521 16296-16303 Species denotes patient Tax:9606
522 16378-16390 Species denotes A. fumigatus Tax:746128
523 16857-16865 Species denotes patients Tax:9606
524 16898-16910 Species denotes A. fumigatus Tax:746128
525 17104-17116 Species denotes A. fumigatus Tax:746128
526 17324-17336 Species denotes A. fumigatus Tax:746128
527 17749-17756 Species denotes patient Tax:9606
528 17816-17828 Species denotes A. fumigatus Tax:746128
529 17963-17972 Species denotes A. flavus Tax:5059
530 15883-15892 Species denotes influenza Tax:11309
531 16696-16707 Species denotes Aspergillus Tax:746128
532 17863-17874 Species denotes Aspergillus Tax:746128
533 16467-16480 Chemical denotes galactomannan MESH:C012990
534 16776-16781 Chemical denotes azole MESH:D001393
535 16880-16885 Chemical denotes azole MESH:D001393
536 17065-17070 Chemical denotes azole MESH:D001393
537 17088-17093 Chemical denotes Azole MESH:D001393
538 17204-17209 Chemical denotes azole MESH:D001393
539 17308-17313 Chemical denotes azole MESH:D001393
540 17346-17358 Chemical denotes itraconazole MESH:D017964
541 17360-17372 Chemical denotes voriconazole MESH:D065819
542 17378-17390 Chemical denotes posaconazole MESH:C101425
543 17629-17641 Chemical denotes voriconazole MESH:D065819
544 17722-17734 Chemical denotes voriconazole MESH:D065819
545 17738-17743 Chemical denotes l-AmB
546 14823-14831 Disease denotes COVID-19 MESH:C000657245
547 14843-14847 Disease denotes ARDS MESH:D012128
548 15321-15330 Disease denotes mortality MESH:D003643
549 15424-15433 Disease denotes mortality MESH:D003643
550 15763-15771 Disease denotes COVID-19 MESH:C000657245
551 15796-15800 Disease denotes ARDS MESH:D012128
552 15855-15859 Disease denotes ARDS MESH:D012128
553 15869-15877 Disease denotes infected MESH:D007239
554 16101-16110 Disease denotes mortality MESH:D003643
555 16825-16834 Disease denotes mortality MESH:D003643
556 16866-16874 Disease denotes infected MESH:D007239
557 17474-17478 Mutation denotes L98H p.L98H
568 18350-18361 Species denotes Aspergillus Tax:746128
569 18641-18652 Species denotes Aspergillus Tax:746128
570 18692-18703 Species denotes Aspergillus Tax:746128
571 18782-18793 Species denotes Aspergillus Tax:746128
572 18513-18526 Chemical denotes Galactomannan MESH:C012990
573 18528-18530 Chemical denotes GM MESH:C012990
574 18669-18680 Chemical denotes -β-d-glucan
575 18682-18685 Chemical denotes BDG
576 18704-18717 Chemical denotes galactomannan MESH:C012990
577 18758-18766 Disease denotes Oklahoma MESH:C537147
584 19286-19294 Species denotes patients Tax:9606
585 19773-19781 Species denotes patients Tax:9606
586 19235-19246 Species denotes Aspergillus Tax:746128
587 19159-19161 Chemical denotes GM MESH:C012990
588 19492-19494 Chemical denotes GM MESH:C012990
589 19619-19621 Chemical denotes GM MESH:C012990
598 19978-19986 Species denotes patients Tax:9606
599 20034-20042 Species denotes patients Tax:9606
600 20062-20072 Species denotes SARS-CoV-2 Tax:2697049
601 19841-19843 Chemical denotes GM MESH:C012990
602 20312-20314 Chemical denotes GM MESH:C012990
603 20400-20403 Chemical denotes BDG
604 19992-20000 Disease denotes COVID-19 MESH:C000657245
605 20001-20010 Disease denotes infection MESH:D007239
607 20460-20464 Chemical denotes CAPA
657 21078-21085 Gene denotes CYP2C19 Gene:1557
658 21087-21093 Gene denotes CYP2C9 Gene:1559
659 21099-21105 Gene denotes CYP3A4 Gene:1576
660 21441-21447 Gene denotes CYP3A4 Gene:1576
661 21805-21811 Gene denotes CYP3A4 Gene:1576
662 22203-22211 Species denotes patients Tax:9606
663 22224-22234 Species denotes SARS-CoV-2 Tax:2697049
664 22526-22544 Species denotes feline coronavirus Tax:12663
665 23661-23669 Species denotes patients Tax:9606
666 22971-22982 Species denotes Aspergillus Tax:746128
667 23106-23117 Species denotes Aspergillus Tax:746128
668 23964-23975 Species denotes Aspergillus Tax:746128
669 20725-20737 Chemical denotes voriconazole MESH:D065819
670 21018-21030 Chemical denotes voriconazole MESH:D065819
671 21107-21119 Chemical denotes voriconazole MESH:D065819
672 21303-21321 Chemical denotes hydroxychloroquine MESH:D006886
673 21323-21333 Chemical denotes atazanavir MESH:D000069446
674 21335-21354 Chemical denotes lopinavir/ritonavir MESH:C558899
675 21399-21409 Chemical denotes remdesivir MESH:C000606551
676 21523-21536 Chemical denotes Isavuconazole MESH:C508735
677 21551-21565 Chemical denotes amphotericin B MESH:D000666
678 21652-21664 Chemical denotes voriconazole MESH:D065819
679 21666-21679 Chemical denotes isavuconazole MESH:C508735
680 21914-21927 Chemical denotes isavuconazole MESH:C508735
681 21938-21950 Chemical denotes voriconazole MESH:D065819
682 21970-21984 Chemical denotes amphotericin B MESH:D000666
683 22333-22345 Chemical denotes itraconazole MESH:D017964
684 22470-22481 Chemical denotes cholesterol MESH:D002784
685 22638-22650 Chemical denotes itraconazole MESH:D017964
686 22796-22805 Chemical denotes triazoles MESH:D014230
687 23335-23347 Chemical denotes fosmanogepix
688 23352-23360 Chemical denotes olorofim MESH:C000626907
689 23772-23781 Chemical denotes triazoles MESH:D014230
690 23806-23820 Chemical denotes amphotericin B MESH:D000666
691 23920-23932 Chemical denotes echinocandin MESH:D054714
692 20554-20562 Disease denotes COVID-19 MESH:C000657245
693 20693-20715 Disease denotes hematologic malignancy MESH:D019337
694 20940-20954 Disease denotes hepatotoxicity MESH:D056486
695 21273-21281 Disease denotes COVID-19 MESH:C000657245
696 21757-21767 Disease denotes toxicities MESH:D064420
697 22058-22077 Disease denotes renal insufficiency MESH:D051437
698 22212-22220 Disease denotes infected MESH:D007239
699 22251-22264 Disease denotes renal tropism MESH:D007674
700 22307-22320 Disease denotes kidney injury MESH:D058186
701 22374-22396 Disease denotes invasive aspergillosis MESH:D055744
702 22703-22711 Disease denotes COVID-19 MESH:C000657245
703 22899-22921 Disease denotes invasive aspergillosis MESH:D055744
704 23445-23453 Disease denotes toxicity MESH:D064420
705 23630-23638 Disease denotes COVID-19 MESH:C000657245
731 24142-24164 Species denotes Acinetobacter baumanii Tax:470
732 24767-24775 Species denotes patients Tax:9606
733 24849-24870 Species denotes human metapneumovirus Tax:162145
734 25103-25111 Species denotes patients Tax:9606
735 25506-25516 Species denotes SARS-CoV-2 Tax:2697049
736 25904-25914 Species denotes SARS-CoV-2 Tax:2697049
737 26016-26024 Species denotes patients Tax:9606
738 24191-24202 Species denotes Aspergillus Tax:746128
739 24660-24671 Species denotes Aspergillus Tax:746128
740 24080-24106 Disease denotes viral secondary infections MESH:D001102
741 24110-24123 Disease denotes co-infections MESH:D060085
742 24131-24140 Disease denotes mortality MESH:D003643
743 24403-24416 Disease denotes co-infections MESH:D060085
744 24512-24521 Disease denotes infection MESH:D007239
745 24752-24766 Disease denotes critically ill MESH:D016638
746 24820-24824 Disease denotes ARDS MESH:D012128
747 24831-24843 Disease denotes Co-infection MESH:D060085
748 24985-24993 Disease denotes COVID-19 MESH:C000657245
749 25075-25090 Disease denotes viral infection MESH:D001102
750 25094-25102 Disease denotes COVID-19 MESH:C000657245
751 25149-25157 Disease denotes COVID-19 MESH:C000657245
752 25165-25180 Disease denotes viral infection MESH:D001102
753 25443-25451 Disease denotes COVID-19 MESH:C000657245
754 25713-25720 Disease denotes trachea MESH:C557675
755 25797-25826 Disease denotes Aspergillus tracheobronchitis MESH:D001228
760 26278-26288 Species denotes SARS-CoV-2 Tax:2697049
761 26103-26128 Disease denotes Aspergillus co-infections MESH:D060085
762 26423-26433 Disease denotes infections MESH:D007239
763 26441-26449 Disease denotes COVID-19 MESH:C000657245
774 26998-27006 Species denotes patients Tax:9606
775 27441-27449 Species denotes patients Tax:9606
776 26700-26708 Disease denotes COVID-19 MESH:C000657245
777 26834-26845 Disease denotes lung damage MESH:D008171
778 26860-26868 Disease denotes COVID-19 MESH:C000657245
779 26982-26994 Disease denotes co-infection MESH:D060085
780 27019-27027 Disease denotes COVID-19 MESH:C000657245
781 27110-27118 Disease denotes COVID-19 MESH:C000657245
782 27432-27440 Disease denotes COVID-19 MESH:C000657245
783 27553-27562 Disease denotes mortality MESH:D003643

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T22 25-42 Disease denotes fungal infections http://purl.obolibrary.org/obo/MONDO_0002041
T23 289-302 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T24 340-353 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T25 379-392 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T26 400-439 Disease denotes allergic bronchopulmonary aspergillosis http://purl.obolibrary.org/obo/MONDO_0015243
T27 400-408 Disease denotes allergic http://purl.obolibrary.org/obo/MONDO_0004980
T28 426-439 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T29 441-445 Disease denotes ABPA http://purl.obolibrary.org/obo/MONDO_0015243
T30 448-470 Disease denotes chronic rhinosinusitis http://purl.obolibrary.org/obo/MONDO_0006031
T31 479-485 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T32 503-513 Disease denotes bronchitis http://purl.obolibrary.org/obo/MONDO_0003781
T33 894-932 Disease denotes chronic obstructive pulmonary diseases http://purl.obolibrary.org/obo/MONDO_0005002
T34 914-932 Disease denotes pulmonary diseases http://purl.obolibrary.org/obo/MONDO_0005275
T35 934-938 Disease denotes COPD http://purl.obolibrary.org/obo/MONDO_0005002
T36 1009-1018 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T37 1051-1086 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T38 1057-1086 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T39 1088-1092 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T40 1273-1282 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T41 1403-1411 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T42 1528-1536 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T43 1571-1575 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T44 1626-1636 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T45 1714-1724 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T46 1770-1780 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T47 1824-1833 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T48 1954-1962 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T49 2029-2037 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T50 2059-2072 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T51 2074-2078 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T52 2244-2248 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T53 2323-2332 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T54 2338-2346 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T55 2399-2403 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T56 2419-2427 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T57 2514-2518 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T58 2806-2810 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T59 2896-2913 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T61 2907-2913 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T62 2917-2921 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T63 3029-3033 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T64 3104-3112 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T65 3263-3267 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T66 3299-3308 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T67 3694-3702 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T68 3743-3753 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T69 3868-3872 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T70 3890-3894 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T71 4145-4151 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T72 4219-4231 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T73 4437-4450 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T74 4609-4618 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T75 4759-4771 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T76 4797-4805 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T77 4887-4891 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T78 5109-5119 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T79 5168-5176 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T80 5455-5463 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T81 5629-5637 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T82 5782-5790 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T83 6091-6099 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T84 6114-6158 Disease denotes secondary hemophagocytic lymphohistiocytosis http://purl.obolibrary.org/obo/MONDO_0015542
T85 6124-6158 Disease denotes hemophagocytic lymphohistiocytosis http://purl.obolibrary.org/obo/MONDO_0015540
T86 6265-6279 Disease denotes acute leukemia http://purl.obolibrary.org/obo/MONDO_0010643
T87 6271-6279 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059
T88 6294-6302 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T89 6381-6393 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T90 6402-6431 Disease denotes chronic granulomatous disease http://purl.obolibrary.org/obo/MONDO_0018305
T91 6441-6456 Disease denotes cystic fibrosis http://purl.obolibrary.org/obo/MONDO_0009061
T92 6513-6522 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T93 6627-6635 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T94 6638-6647 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T95 6856-6864 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T96 7043-7052 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T97 7123-7132 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T98 7199-7207 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T99 7252-7260 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T100 7275-7279 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T101 7533-7537 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T102 7609-7622 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T103 7750-7758 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T104 7885-7893 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T105 7896-7905 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T106 7937-7941 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T107 8113-8123 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T108 8271-8289 Disease denotes immune dysfunction http://purl.obolibrary.org/obo/MONDO_0005046
T109 8307-8315 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T110 8501-8516 Disease denotes lymphocytopenia http://purl.obolibrary.org/obo/MONDO_0003783
T111 8783-8791 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T112 8910-8914 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T113 8996-9006 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T114 9016-9020 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T115 9062-9066 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T116 9172-9181 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T117 9389-9393 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T118 9522-9530 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T119 9748-9754 Disease denotes Cancer http://purl.obolibrary.org/obo/MONDO_0004992
T120 9826-9833 Disease denotes Allergy http://purl.obolibrary.org/obo/MONDO_0005271
T121 9838-9848 Disease denotes Infectious http://purl.obolibrary.org/obo/MONDO_0005550
T122 9858-9865 Disease denotes Mycoses http://purl.obolibrary.org/obo/MONDO_0002041
T123 10212-10220 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T124 10592-10596 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T125 10670-10679 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T126 10701-10714 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T127 10748-10756 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T128 10797-10810 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T129 10847-10856 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T130 10964-10972 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T131 11020-11024 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T132 11224-11242 Disease denotes pulmonary fibrosis http://purl.obolibrary.org/obo/MONDO_0002771
T133 11381-11398 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T135 11392-11398 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T136 11460-11478 Disease denotes pulmonary fibrosis http://purl.obolibrary.org/obo/MONDO_0002771
T137 11553-11561 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T138 11649-11653 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T139 11689-11704 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T140 11695-11704 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T141 11726-11730 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T142 11826-11830 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T143 12014-12024 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T144 12175-12183 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T145 12524-12541 Disease denotes fungal infections http://purl.obolibrary.org/obo/MONDO_0002041
T146 12641-12649 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T147 12670-12674 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T148 12689-12693 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T149 12729-12741 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T150 12756-12764 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T151 12778-12785 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T152 12799-12803 Disease denotes COPD http://purl.obolibrary.org/obo/MONDO_0005002
T153 12817-12831 Disease denotes heart diseases http://purl.obolibrary.org/obo/MONDO_0005267
T154 12883-12889 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T155 12961-12973 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T156 12975-12998 Disease denotes coronary heart diseases http://purl.obolibrary.org/obo/MONDO_0005010
T157 13004-13012 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T158 13034-13043 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T159 13097-13101 Disease denotes COPD http://purl.obolibrary.org/obo/MONDO_0005002
T160 13105-13111 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T161 13174-13178 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T162 13252-13262 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T163 13269-13277 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T164 13344-13352 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T165 13472-13482 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T166 13567-13575 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T167 13851-13859 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T168 13887-13904 Disease denotes fungal infections http://purl.obolibrary.org/obo/MONDO_0002041
T169 13981-13998 Disease denotes fungal infections http://purl.obolibrary.org/obo/MONDO_0002041
T170 14163-14167 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T171 14201-14214 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T172 14483-14491 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T173 14666-14675 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T174 14812-14816 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T175 14823-14831 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T176 14843-14847 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T177 14913-14917 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T178 15037-15041 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T179 15234-15238 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T180 15763-15771 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T181 15796-15800 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T182 15855-15859 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T183 15883-15892 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T184 15992-15996 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T185 16508-16512 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T186 17279-17283 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T187 18038-18042 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T188 18091-18095 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T189 19036-19040 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T190 19992-20000 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T191 20001-20010 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T192 20062-20070 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T193 20460-20464 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T194 20554-20562 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T195 20693-20715 Disease denotes hematologic malignancy http://purl.obolibrary.org/obo/MONDO_0002334|http://purl.obolibrary.org/obo/MONDO_0044881
T197 21273-21281 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T198 22058-22077 Disease denotes renal insufficiency http://purl.obolibrary.org/obo/MONDO_0001106
T199 22224-22232 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T200 22314-22320 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T201 22374-22396 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T202 22383-22396 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T203 22703-22711 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T204 22899-22921 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T205 22908-22921 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T206 23630-23638 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T207 24096-24106 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T208 24113-24123 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T209 24166-24186 Disease denotes Klebsiella pneumonia http://purl.obolibrary.org/obo/MONDO_0030602
T210 24177-24186 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T211 24386-24390 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T212 24406-24416 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T213 24512-24521 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T214 24820-24824 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T215 24834-24843 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T216 24924-24928 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T217 24985-24993 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T218 25075-25090 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T219 25081-25090 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T220 25094-25102 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T221 25149-25157 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T222 25165-25180 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T223 25171-25180 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T224 25443-25451 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T225 25506-25514 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T226 25809-25826 Disease denotes tracheobronchitis http://purl.obolibrary.org/obo/MONDO_0021925
T227 25904-25912 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T228 26118-26128 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T229 26278-26286 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T230 26416-26433 Disease denotes fungal infections http://purl.obolibrary.org/obo/MONDO_0002041
T231 26441-26449 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T232 26700-26708 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T233 26777-26781 Disease denotes CAPA http://purl.obolibrary.org/obo/MONDO_0007163
T234 26860-26868 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T235 26985-26994 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T236 27019-27027 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T237 27110-27118 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T238 27432-27440 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T9 273-274 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 303-309 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T11 394-397 http://purl.obolibrary.org/obo/CLO_0002599 denotes CPA
T12 632-633 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T13 791-795 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T14 791-795 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T15 958-961 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T16 981-982 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T17 1237-1247 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T18 1413-1416 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T19 1495-1498 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T20 1647-1655 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T21 2081-2089 http://purl.obolibrary.org/obo/CLO_0009985 denotes focusing
T22 2258-2259 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T23 2450-2460 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T24 2461-2475 http://purl.obolibrary.org/obo/CL_0000000 denotes cells and type
T25 2590-2592 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T26 2611-2613 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T27 2614-2616 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T28 2614-2616 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T29 2682-2692 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T30 2769-2773 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T31 2804-2805 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T32 2811-2816 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T33 2902-2906 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T34 2902-2906 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T35 3000-3008 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T36 3125-3130 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T37 3420-3425 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T38 3456-3465 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T39 3657-3670 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T40 3976-3982 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T41 4022-4027 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T42 4058-4065 http://purl.obolibrary.org/obo/SO_0000418 denotes signals
T43 4140-4144 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T44 4140-4144 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T45 4452-4454 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T46 4492-4501 http://purl.obolibrary.org/obo/CL_0000034 denotes stem-cell
T47 4556-4557 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T48 4584-4593 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T49 4893-4894 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T50 4987-4997 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T51 5158-5163 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T52 5225-5235 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T53 5263-5272 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T54 5371-5379 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T55 5432-5434 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T56 5481-5482 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T57 5509-5518 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T58 5595-5605 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T59 5754-5755 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T60 5851-5852 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T61 6176-6189 http://purl.obolibrary.org/obo/PR_000001091 denotes interleukin-1
T62 6347-6350 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T63 6433-6435 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T64 6526-6538 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T65 6655-6656 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T66 6683-6684 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T67 6899-6903 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T68 6953-6958 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T69 7016-7026 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T70 7027-7032 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T71 7058-7059 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T72 7226-7227 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T73 7550-7556 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T74 7624-7626 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T75 8125-8127 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T76 8198-8202 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T77 8317-8319 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T78 8542-8543 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T79 9156-9163 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T80 9602-9606 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T81 9705-9717 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T82 9907-9912 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T83 10235-10238 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T84 10348-10350 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T85 10931-10935 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T86 10931-10935 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T87 10974-10976 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T88 11158-11162 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T89 11158-11162 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T90 11282-11291 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T91 11345-11351 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T92 11387-11391 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T93 11387-11391 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T94 11529-11530 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T95 11759-11761 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T96 12225-12230 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T97 12231-12234 http://purl.obolibrary.org/obo/UBERON_0001007 denotes gut
T98 12231-12234 http://purl.obolibrary.org/obo/UBERON_0001555 denotes gut
T99 12231-12234 http://www.ebi.ac.uk/efo/EFO_0000834 denotes gut
T100 12249-12250 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T101 12283-12291 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T102 12312-12320 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T103 12551-12564 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T104 12686-12688 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T105 12746-12748 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T106 12768-12770 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T107 12789-12791 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T108 12807-12809 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T109 12817-12822 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T110 12817-12822 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T111 12817-12822 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T112 12817-12822 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T113 12835-12837 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T114 12869-12871 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T115 12873-12875 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T116 12893-12895 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T117 12984-12989 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T118 12984-12989 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T119 12984-12989 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T120 12984-12989 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T121 13075-13079 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T122 13075-13079 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T123 13399-13405 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T124 13796-13798 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T125 13840-13842 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T126 13873-13875 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T127 14301-14308 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T128 14373-14374 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T129 14607-14619 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colonization
T130 14865-14867 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T131 14941-14942 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T132 15231-15233 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T133 15274-15275 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T134 15345-15347 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T135 15348-15350 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T136 15371-15377 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T137 15379-15382 http://purl.obolibrary.org/obo/CLO_0001382 denotes 4/8
T138 15401-15405 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T139 15401-15405 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T140 15407-15409 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T141 15410-15412 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T142 16146-16147 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T143 16321-16322 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T144 16378-16379 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T145 16481-16485 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T146 16565-16566 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T147 16816-16817 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T148 16898-16899 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T149 16984-16991 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T150 17104-17105 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T151 17277-17278 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T152 17324-17325 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T153 17401-17406 http://purl.obolibrary.org/obo/CLO_0001002 denotes 16, 2
T154 17446-17447 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T155 17738-17743 http://purl.obolibrary.org/obo/NCBITaxon_9940 denotes l-AmB
T156 17816-17817 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T157 17963-17964 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T158 18139-18147 http://purl.obolibrary.org/obo/CLO_0001658 denotes actively
T159 18480-18487 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T160 18600-18605 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T161 18816-18822 http://purl.obolibrary.org/obo/OBI_0000968 denotes device
T162 18829-18833 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T163 18989-18991 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T164 19148-19149 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T165 19274-19276 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T166 19310-19311 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T167 19333-19334 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T168 19414-19416 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T169 19485-19486 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T170 19495-19503 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test was
T171 19531-19532 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T172 19564-19565 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T173 19634-19635 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T174 19717-19719 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T175 19766-19769 http://purl.obolibrary.org/obo/CLO_0053733 denotes 1/1
T176 19844-19851 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T177 19964-19969 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T178 20024-20025 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T179 20073-20078 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T180 20137-20144 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T181 20150-20155 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T182 20150-20155 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T183 20242-20245 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T184 20280-20282 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T185 20594-20595 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T186 21425-21426 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T187 21508-21516 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T188 21564-21565 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T189 21686-21687 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T190 21899-21900 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T191 21983-21984 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T192 21988-21989 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T193 22241-22244 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T194 22287-22288 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T195 22307-22313 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T196 22307-22313 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T197 22307-22313 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T198 22401-22404 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T199 22442-22450 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T200 22468-22469 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T201 22524-22525 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T202 22602-22605 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T203 22954-22962 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T204 23089-23097 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T205 23819-23820 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T206 23822-23824 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T207 23947-23955 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T208 23990-23991 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T209 24333-24335 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T210 24454-24455 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T211 24688-24695 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T212 24728-24729 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T213 24777-24779 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T214 24849-24854 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T215 24871-24874 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T216 24994-24998 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T217 25112-25115 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T218 25358-25369 http://purl.obolibrary.org/obo/OBI_0000968 denotes instruments
T219 25845-25849 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T220 26451-26453 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T221 26823-26833 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T222 26834-26838 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T223 26834-26838 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T224 26888-26889 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T225 27177-27182 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T226 27177-27182 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T227 27485-27486 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T228 27707-27708 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T11 355-358 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T13 521-524 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T15 824-839 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T16 1115-1118 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T18 1324-1327 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T20 2476-2478 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T21 2525-2532 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T22 2540-2551 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T23 2614-2616 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T24 2706-2713 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T25 3174-3185 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T26 3976-3992 Chemical denotes signal molecules http://purl.obolibrary.org/obo/CHEBI_62488
T27 3983-3992 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T28 4279-4310 Chemical denotes advanced glycation end-products http://purl.obolibrary.org/obo/CHEBI_84123
T29 4661-4664 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T31 5001-5010 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T32 5671-5673 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T34 5880-5882 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T36 5959-5961 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T38 6199-6209 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T39 6319-6321 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T41 6599-6601 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T43 6769-6771 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T45 6795-6797 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T47 6991-6993 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T49 7296-7298 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T51 7310-7320 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T52 7321-7332 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T53 7567-7569 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T55 7696-7698 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T57 7701-7712 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T58 7717-7727 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T59 9439-9442 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T61 9885-9888 Chemical denotes MSG http://purl.obolibrary.org/obo/CHEBI_64220|http://purl.obolibrary.org/obo/CHEBI_64243
T63 10020-10023 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T65 10316-10319 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T67 10376-10379 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T69 10425-10428 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T71 10485-10487 Chemical denotes IA http://purl.obolibrary.org/obo/CHEBI_74062
T72 10857-10860 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T74 10990-11005 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T75 11063-11074 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T76 11305-11313 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T77 11333-11338 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T78 11524-11527 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T80 11594-11608 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T81 11785-11800 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T82 11841-11856 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T83 12083-12093 Chemical denotes antibiotic http://purl.obolibrary.org/obo/CHEBI_33281
T84 12129-12140 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T85 12378-12389 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T86 13160-13163 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T88 13614-13617 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T90 13683-13686 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T92 13722-13725 Chemical denotes MSG http://purl.obolibrary.org/obo/CHEBI_64220|http://purl.obolibrary.org/obo/CHEBI_64243
T94 14287-14300 Chemical denotes galactomannan http://purl.obolibrary.org/obo/CHEBI_27680
T95 14321-14325 Chemical denotes gold http://purl.obolibrary.org/obo/CHEBI_29287|http://purl.obolibrary.org/obo/CHEBI_30050
T97 14462-14465 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T99 15401-15405 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T100 16467-16480 Chemical denotes galactomannan http://purl.obolibrary.org/obo/CHEBI_27680
T101 16624-16634 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T102 16776-16781 Chemical denotes azole http://purl.obolibrary.org/obo/CHEBI_68452
T103 16880-16885 Chemical denotes azole http://purl.obolibrary.org/obo/CHEBI_68452
T104 16958-16968 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T105 17011-17021 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T106 17065-17070 Chemical denotes azole http://purl.obolibrary.org/obo/CHEBI_68452
T107 17204-17209 Chemical denotes azole http://purl.obolibrary.org/obo/CHEBI_68452
T108 17308-17313 Chemical denotes azole http://purl.obolibrary.org/obo/CHEBI_68452
T109 17346-17358 Chemical denotes itraconazole http://purl.obolibrary.org/obo/CHEBI_6076
T110 17360-17372 Chemical denotes voriconazole http://purl.obolibrary.org/obo/CHEBI_10023
T111 17378-17390 Chemical denotes posaconazole http://purl.obolibrary.org/obo/CHEBI_64355
T112 17556-17559 Chemical denotes MIC http://purl.obolibrary.org/obo/CHEBI_59059
T113 17629-17641 Chemical denotes voriconazole http://purl.obolibrary.org/obo/CHEBI_10023
T114 17722-17734 Chemical denotes voriconazole http://purl.obolibrary.org/obo/CHEBI_10023
T115 18470-18479 Chemical denotes biomarker http://purl.obolibrary.org/obo/CHEBI_59163
T116 18528-18530 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T117 18674-18680 Chemical denotes glucan http://purl.obolibrary.org/obo/CHEBI_37163
T118 18704-18717 Chemical denotes galactomannan http://purl.obolibrary.org/obo/CHEBI_27680
T119 18738-18741 Chemical denotes LFA http://purl.obolibrary.org/obo/CHEBI_139482
T120 18824-18827 Chemical denotes LFD http://purl.obolibrary.org/obo/CHEBI_73571
T121 19159-19161 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T122 19165-19168 Chemical denotes LFD http://purl.obolibrary.org/obo/CHEBI_73571
T123 19492-19494 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T124 19619-19621 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T125 19726-19729 Chemical denotes LFD http://purl.obolibrary.org/obo/CHEBI_73571
T126 19841-19843 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T127 20312-20314 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T128 20432-20434 Chemical denotes IA http://purl.obolibrary.org/obo/CHEBI_74062
T129 20530-20540 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T130 20574-20577 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T132 20659-20669 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T133 20725-20737 Chemical denotes voriconazole http://purl.obolibrary.org/obo/CHEBI_10023
T134 20787-20790 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T136 20883-20887 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T137 20961-20965 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T138 20966-20970 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T139 21018-21030 Chemical denotes voriconazole http://purl.obolibrary.org/obo/CHEBI_10023
T140 21107-21119 Chemical denotes voriconazole http://purl.obolibrary.org/obo/CHEBI_10023
T141 21133-21138 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T142 21177-21181 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T143 21182-21186 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T144 21303-21321 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T145 21323-21333 Chemical denotes atazanavir http://purl.obolibrary.org/obo/CHEBI_37924
T146 21335-21354 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T147 21335-21344 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T148 21345-21354 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T149 21399-21409 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T150 21551-21565 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T151 21619-21622 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T153 21652-21664 Chemical denotes voriconazole http://purl.obolibrary.org/obo/CHEBI_10023
T154 21666-21679 Chemical denotes isavuconazole http://purl.obolibrary.org/obo/CHEBI_85979
T155 21857-21861 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T156 21862-21866 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T157 21914-21927 Chemical denotes isavuconazole http://purl.obolibrary.org/obo/CHEBI_85979
T158 21938-21950 Chemical denotes voriconazole http://purl.obolibrary.org/obo/CHEBI_10023
T159 21970-21984 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T160 22143-22159 Chemical denotes antifungal agent http://purl.obolibrary.org/obo/CHEBI_35718
T161 22333-22345 Chemical denotes itraconazole http://purl.obolibrary.org/obo/CHEBI_6076
T162 22432-22441 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T163 22470-22481 Chemical denotes cholesterol http://purl.obolibrary.org/obo/CHEBI_16113
T164 22492-22501 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T165 22638-22650 Chemical denotes itraconazole http://purl.obolibrary.org/obo/CHEBI_6076
T166 22723-22726 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T168 22762-22766 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T169 22767-22771 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T170 22796-22805 Chemical denotes triazoles http://purl.obolibrary.org/obo/CHEBI_35727
T171 22833-22846 Chemical denotes echinocandins http://purl.obolibrary.org/obo/CHEBI_57248
T172 22943-22953 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T173 23036-23040 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T174 23041-23045 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T175 23190-23201 Chemical denotes antifungals http://purl.obolibrary.org/obo/CHEBI_35718
T176 23251-23261 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T177 23280-23290 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T178 23418-23422 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T179 23423-23427 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T180 23521-23532 Chemical denotes antifungals http://purl.obolibrary.org/obo/CHEBI_35718
T181 23650-23653 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T183 23772-23781 Chemical denotes triazoles http://purl.obolibrary.org/obo/CHEBI_35727
T184 23806-23820 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T185 23850-23860 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T186 23920-23932 Chemical denotes echinocandin http://purl.obolibrary.org/obo/CHEBI_57248
T187 24672-24679 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T188 24831-24833 Chemical denotes Co http://purl.obolibrary.org/obo/CHEBI_27638
T189 26622-26632 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T190 26924-26927 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T192 26946-26949 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T194 27130-27133 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T196 27170-27173 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T198 27330-27333 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T200 27378-27388 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T201 27523-27526 Chemical denotes IPA http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802
T203 27621-27637 Chemical denotes antifungal drugs http://purl.obolibrary.org/obo/CHEBI_35718|http://purl.obolibrary.org/obo/CHEBI_86327
T205 27632-27637 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T206 27683-27694 Chemical denotes antifungals http://purl.obolibrary.org/obo/CHEBI_35718
T207 27720-27730 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T3 2228-2240 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T4 2368-2380 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T5 3150-3160 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T6 3319-3334 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T7 3406-3419 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T8 3456-3474 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T9 3456-3465 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T10 3976-3992 http://purl.obolibrary.org/obo/GO_0048018 denotes signal molecules
T11 4107-4128 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T12 4219-4231 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T13 4399-4420 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T14 4584-4593 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T15 4719-4731 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T16 4759-4771 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T17 5263-5272 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18 5509-5527 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T19 5509-5518 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T20 5818-5833 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T21 6381-6393 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T22 6747-6759 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T23 8357-8370 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T24 8763-8779 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T25 8817-8834 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T26 8817-8834 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T27 9423-9435 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T28 11689-11704 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T29 11883-11899 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T30 19744-19753 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T31 21462-21472 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T32 21498-21516 http://purl.obolibrary.org/obo/GO_0051345 denotes hydrolase activity
T33 22257-22264 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T34 22470-22491 http://purl.obolibrary.org/obo/GO_0030301 denotes cholesterol transport
T35 22482-22491 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T36 25075-25090 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T37 25165-25180 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T2 14287-14300 GlycoEpitope denotes galactomannan http://www.glycoepitope.jp/epitopes/EP0510
T3 16467-16480 GlycoEpitope denotes galactomannan http://www.glycoepitope.jp/epitopes/EP0510
T4 18513-18526 GlycoEpitope denotes Galactomannan http://www.glycoepitope.jp/epitopes/EP0510
T5 18528-18530 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T6 18704-18717 GlycoEpitope denotes galactomannan http://www.glycoepitope.jp/epitopes/EP0510
T7 19159-19161 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T8 19492-19494 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T9 19619-19621 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T10 19841-19843 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510
T11 20312-20314 GlycoEpitope denotes GM http://www.glycoepitope.jp/epitopes/EP0510

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T2 16-42 Phenotype denotes Invasive fungal infections http://purl.obolibrary.org/obo/HP_0020101
T3 321-353 Phenotype denotes invasive pulmonary aspergillosis http://purl.obolibrary.org/obo/HP_0020103
T4 355-358 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T5 479-485 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T6 503-513 Phenotype denotes bronchitis http://purl.obolibrary.org/obo/HP_0012387
T7 521-524 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T8 894-932 Phenotype denotes chronic obstructive pulmonary diseases http://purl.obolibrary.org/obo/HP_0006510
T9 934-938 Phenotype denotes COPD http://purl.obolibrary.org/obo/HP_0006510
T10 1057-1077 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T11 1115-1118 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T12 1324-1327 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T13 2896-2913 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T14 4661-4664 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T15 6265-6279 Phenotype denotes acute leukemia http://purl.obolibrary.org/obo/HP_0002488
T16 6495-6522 Phenotype denotes susceptibility to infection http://purl.obolibrary.org/obo/HP_0002719
T17 7878-7905 Phenotype denotes severe SARS-CoV-2 infection http://purl.obolibrary.org/obo/HP_0033141
T18 8501-8516 Phenotype denotes lymphocytopenia http://purl.obolibrary.org/obo/HP_0001888
T19 9439-9442 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T20 9748-9754 Phenotype denotes Cancer http://purl.obolibrary.org/obo/HP_0002664
T21 9755-9781 Phenotype denotes Invasive Fungal Infections http://purl.obolibrary.org/obo/HP_0020101
T22 9826-9833 Phenotype denotes Allergy http://purl.obolibrary.org/obo/HP_0012393
T23 10020-10023 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T24 10316-10319 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T25 10376-10379 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T26 10425-10428 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T27 10857-10860 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T28 11224-11242 Phenotype denotes pulmonary fibrosis http://purl.obolibrary.org/obo/HP_0002206
T29 11267-11281 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T30 11365-11372 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T31 11381-11398 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T32 11460-11478 Phenotype denotes pulmonary fibrosis http://purl.obolibrary.org/obo/HP_0002206
T33 11524-11527 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T34 11912-11926 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T35 12515-12541 Phenotype denotes invasive fungal infections http://purl.obolibrary.org/obo/HP_0020101
T36 12729-12741 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T37 12778-12785 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T38 12799-12803 Phenotype denotes COPD http://purl.obolibrary.org/obo/HP_0006510
T39 12883-12889 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T40 12961-12973 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T41 13097-13101 Phenotype denotes COPD http://purl.obolibrary.org/obo/HP_0006510
T42 13105-13111 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T43 13160-13163 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T44 13614-13617 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T45 13683-13686 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T46 14462-14465 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T47 20574-20577 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T48 20787-20790 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T49 21619-21622 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T50 22058-22077 Phenotype denotes renal insufficiency http://purl.obolibrary.org/obo/HP_0000083
T51 22723-22726 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T52 23650-23653 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T53 24177-24186 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T54 26788-26808 Phenotype denotes Immune dysregulation http://purl.obolibrary.org/obo/HP_0002958
T55 26924-26927 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T56 26946-26949 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T57 27130-27133 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T58 27170-27173 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T59 27330-27333 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103
T60 27523-27526 Phenotype denotes IPA http://purl.obolibrary.org/obo/HP_0020103

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T10 0-2 Sentence denotes 1.
T11 3-15 Sentence denotes Introduction
T12 16-169 Sentence denotes Invasive fungal infections caused by various fungal genera, including Aspergillus, complicate and endanger lives of millions of individuals annually [1].
T13 170-520 Sentence denotes Aspergillus genera, most frequently Aspergillus fumigatus, are ubiquitous in the environment and cause a wide range of infections in humans, including invasive pulmonary aspergillosis (IPA), chronic pulmonary aspergillosis (CPA), allergic bronchopulmonary aspergillosis (ABPA), chronic rhinosinusitis, fungal asthma, and Aspergillus bronchitis [2,3].
T14 521-944 Sentence denotes IPA, the most severe manifestation of disease from Aspergillus, is associated with high mortality rates and is a prominent complication among those with profound immunosuppression, such as those undergoing hematopoietic transplantation, as well as those with structural lung damage who receive systemic corticosteroids for their underlying condition, such as patients with chronic obstructive pulmonary diseases (COPD) [2].
T15 945-1203 Sentence denotes Recently, it has been reported that a relatively high number of influenza patients presenting with severe acute respiratory distress syndrome (ARDS) also rapidly develop IPA, which is associated with increased duration of hospitalization and mortality [4,5].
T16 1204-1334 Sentence denotes Corticosteroid use and pulmonary epithelial damages caused by severe influenza are the main risk factors for developing IPA [4,5].
T17 1335-1491 Sentence denotes The recent global pandemic of coronavirus disease-19, also known as COVID-19, has infected over 6 million patients worldwide, with more than 360,000 deaths.
T18 1492-1838 Sentence denotes It has been shown that up to 40% of COVID-19 hospitalized patients can develop ARDS [6], and thereby become susceptible to acquire co-infections caused by bacteria and also Aspergillus spp. [7,8], although frequency of co-infections seems to vary between centers and overall co-infections may occur less frequently than with severe influenza [9].
T19 1839-1968 Sentence denotes Once they occur, these superinfections are associated with high mortality rates and may prolong the acute phase of COVID-19 [10].
T20 1969-2189 Sentence denotes In this comprehensive review, we discuss various aspects of COVID-19 associated pulmonary aspergillosis (CAPA), focusing specifically on immunology, risk factors, prevalence, diagnosis, treatment, and current challenges.
T21 2191-2193 Sentence denotes 2.
T22 2194-2204 Sentence denotes Immunology
T23 2205-2381 Sentence denotes Dissecting the complex pathogenesis of CAPA requires a molecular understanding of the physiological processes whereby infection with SARS-CoV-2 facilitates fungal pathogenesis.
T24 2382-2594 Sentence denotes Similar to other SARS coronaviruses, SARS-CoV-2 targets and invades epithelial cells and type II pneumocytes through binding of the SARS spike protein to the angiotensin-converting enzyme 2 (ACE2) receptors [11].
T25 2595-2783 Sentence denotes Cleavage of the S1/S2 domain by the type 2 transmembrane protease TMPRSS2 leads to the activation of the spike protein [12], thereby facilitating viral entry into the target cell via ACE2.
T26 2784-2927 Sentence denotes Besides its role as a SARS virus receptor, ACE2 was also demonstrated to be required for protection from severe acute lung injury in ARDS [13].
T27 2928-3066 Sentence denotes In support of this, an insertion/deletion polymorphism that affects ACE activity was associated with ARDS susceptibility and outcome [14].
T28 3067-3282 Sentence denotes Whether the preceding interaction of SARS-CoV-2 with host cells, by disrupting the regulation of the renin-angiotensin system and or the kallikrein-kinin system, contributes to the development of CAPA, is not known.
T29 3283-3426 Sentence denotes Viral entry and infection elicit an immune response, which is initiated by the establishment of an inflammatory cascade by innate immune cells.
T30 3427-3705 Sentence denotes Although the receptor(s) and signaling pathways involved in the immune recognition of Aspergillus and the downstream production of inflammatory mediators are relatively well characterized [15], not much is known regarding how the immune system senses and responds to SARS-CoV-2.
T31 3706-3895 Sentence denotes Based on the available knowledge for infections with other coronaviruses, two possible mechanisms can be anticipated and are likely to explain the development of ARDS and consequently CAPA.
T32 3896-4157 Sentence denotes The first involves the release of danger-associated molecular patterns (DAMPs), signal molecules released by dying or damaged cells that act as endogenous danger signals to promote and exacerbate the immune and inflammatory response leading to lung injury [16].
T33 4158-4256 Sentence denotes It is noteworthy that DAMPs have also been shown to regulate inflammation in fungal diseases [17].
T34 4257-4456 Sentence denotes The DAMP/receptor for advanced glycation end-products axis was found to integrate with Toll-like receptors (TLRs) to generate and amplify the inflammatory response in experimental aspergillosis [18].
T35 4457-4670 Sentence denotes Moreover, recipients of allogeneic stem-cell transplantation harboring genetic variants underlying a hyperactivation of danger signaling in response to infection displayed an increased risk of developing IPA [19].
T36 4671-4892 Sentence denotes This emerging concept could help explain fungal pathogenesis in conditions of exuberant inflammation such as that observed in COVID-19 patients and highlights DAMP targeting as potential immunomodulatory strategy in CAPA.
T37 4893-5120 Sentence denotes A second possibility involves the collateral effects of recognition pathways required for the activation of antiviral immunity that may, paradoxically, contribute to an inflammatory environment that favors secondary infections.
T38 5121-5295 Sentence denotes ACE2 is not well expressed on immune cells and SARS-CoV are recognized by TLR4 and TLR3, leading to the activation of MyD88- or TRIF-mediated signaling, respectively [20,21].
T39 5296-5436 Sentence denotes Of note, this may be potentiated in the presence of Aspergillus spp. which activate TLR4/MyD88/TRIF through the cleavage of fibrinogen [22].
T40 5437-5577 Sentence denotes It is likely that SARS-CoV-2 may elicit, to a large extent, overlapping signaling pathways towards the production of inflammatory cytokines.
T41 5578-5753 Sentence denotes In addition, the activation of the inflammasome by SARS-CoV and the consequent production of IL-1β is an event that contributes further to the hyperinflammatory response [23].
T42 5754-5937 Sentence denotes A transcriptome analysis of COVID-19 patients revealed an early immune response characterized by a marked upregulation of the IL-1 pathway, even after respiratory function nadir [24].
T43 5938-6224 Sentence denotes The possibility that IL-1 and related pro-inflammatory pathways could serve as therapeutic targets was demonstrated by the favorable responses in severe COVID-19 patients with secondary hemophagocytic lymphohistiocytosis treated with the interleukin-1 receptor antagonist anakinra [25].
T44 6225-6308 Sentence denotes Similar findings were also disclosed in acute leukemia patients with COVID-19 [26].
T45 6309-6554 Sentence denotes Likewise, IL-1 blockade with anakinra has also been found to ameliorate inflammation in both chronic granulomatous disease [27] and cystic fibrosis [28], and in either case, to restrain susceptibility to infection or colonization by Aspergillus.
T46 6555-6760 Sentence denotes Therefore, the early hyperactivation of the IL-1 pathway induced by the SARS-CoV-2 infection may be a major factor establishing a highly permissive inflammatory environment that favors fungal pathogenesis.
T47 6761-6964 Sentence denotes Besides IL-1, increased levels of IL-6 have also been consistently reported in severe cases of COVID-19 [29,30], with an impact on immune cell function and the anti-viral mechanisms of immune cells [31].
T48 6965-7222 Sentence denotes An enhanced production of IL-6 is also observed in epithelial cells following infection with A. fumigatus, suggesting that, at least in some patients, the co-infection may contribute to the increased levels of this cytokine in severe COVID-19 patients [32].
T49 7223-7450 Sentence denotes In a large patient series of COVID-19 patients with ARDS, the use of the IL-6 receptor antagonist tocilizumab was recently reported to promote rapid and sustained responses associated with significant clinical improvement [33].
T50 7451-7628 Sentence denotes However, such clinical approach could paradoxically enhance the predisposition to CAPA, similar to animal models of IL-6 deficiency subjected to experimental aspergillosis [34].
T51 7629-7768 Sentence denotes For this reason, ongoing trials are addressing the combined use of IL-6 antagonists and antifungal prophylaxis in severe COVID-19 patients.
T52 7769-7942 Sentence denotes An emerging body of evidence supports therefore an increased systemic inflammatory reaction in patients with severe SARS-CoV-2 infection who are more likely to develop CAPA.
T53 7943-8129 Sentence denotes In this regard, increased levels of circulating proinflammatory cytokines, such as TNF, were observed in patients requiring intensive care, compared to those with milder infections [35].
T54 8130-8321 Sentence denotes Other studies, however, have also unveiled marked defects in immune cell populations, namely T-lymphocytes, as another factor explaining the immune dysfunction in patients with COVID-19 [36].
T55 8322-8477 Sentence denotes This suggests that while sustained innate immune function leads to hyperinflammation [37], lymphocyte numbers decline, and their function may be defective.
T56 8478-8665 Sentence denotes In this regard, severe lymphocytopenia was among the factors in a risk score model that predicted the development of invasive mold disease in patients with hematological malignances [38].
T57 8666-9021 Sentence denotes It is thus reasonable to speculate that in elderly individuals or with co-morbidities, defective immune responses to SARS-CoV-2 may allow unrestricted viral replication which, in turn, elicits hyperinflammation and severe complications such as ARDS [39], besides establishing favorable conditions for the acquisition of secondary infections, such as CAPA.
T58 9022-9357 Sentence denotes While there is much to be learned about CAPA, our current understanding of the pathophysiology of other coinfections with respiratory viruses such as influenza [40] provides an important framework towards the effective design of immunotherapeutic approaches and the identification of the patients that could benefit the most from them.
T59 9359-9361 Sentence denotes 3.
T60 9362-9405 Sentence denotes Risk Factors Implicated in CAPA Development
T61 9406-9650 Sentence denotes Importantly, the pathogenesis of IPA differs between neutropenic and non-neutropenic patients, including those with COVID-19, impacting clinical presentation, radiological findings and diagnostic test results in the mycology laboratory [41,42].
T62 9651-10229 Sentence denotes Despite these important differences, revised European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) definitions [43] focus primarily on neutropenic patients with underlying hematological malignancies and “typical” presentation of IPA and have been shown to have limited applicability and inferior performance in non-neutropenic patients who frequently do not fulfil radiological and host criteria, including patients with COVID-19 [41,44].
T63 10230-10570 Sentence denotes This has resulted in the creation of an alternative clinical algorithm for diagnosing IPA in the ICU setting in 2012 [41], which defines putative IPA and is now the standard of care for defining IPA in the ICU [4,45], where highly reliable definitions of IA are still missing (work on improved definitions is currently in progress [45,46]).
T64 10571-10721 Sentence denotes Rapid development of CAPA few days following ICU admission [47] resembles the observation made for influenza-associated pulmonary aspergillosis [4,5].
T65 10722-10883 Sentence denotes Risk factors predisposing COVID-19 patients to develop secondary pulmonary aspergillosis are similar to those identified for influenza-IPA superinfections [4,5].
T66 10884-11185 Sentence denotes The most important risk factors include severe lung damage during the course of COVID-19 [48], the use of corticosteroids in those with ARDS, the widespread use of broad-spectrum antibiotics in intensive care units [49], and the presence of comorbidities such as structural lung defects [47,50,51,52].
T67 11186-11440 Sentence denotes There are some reports revealing that pulmonary fibrosis can be triggered by the cytokine storm activated by the viral antigens, toxicity posed by drugs, high airway pressure and hypoxia-induced acute lung injury secondary to mechanical ventilation [53].
T68 11441-11705 Sentence denotes While interstitial pulmonary fibrosis per se does not predispose to development of IPA, a small subset of these COVID-19 survivors may require long term corticosteroid treatment, which may predispose them to CAPA years after the acute phase of the viral infection.
T69 11706-11811 Sentence denotes Overall, 29% of the CAPA cases published to date (10/35) had received systemic corticosteroids (Table 1).
T70 11812-12031 Sentence denotes In those with ARDS, systemic corticosteroids are used to alleviate the immune responses and prevent cytokine storm [6,54,55,56], but may at the same time increase vulnerability for developing secondary infections [4,5].
T71 12032-12214 Sentence denotes Although detailed case series have not reported on antibiotic use among patients, broad-spectrum antibiotics are presumed to be used in 75% of COVID-19 patients admitted to ICU [49].
T72 12215-12590 Sentence denotes Since the human gut microbiome is a highly complicated structure of bacteria and fungi, although bacteria are the most diverse constituents, the administration of antibiotics results in perturbation of microbiome steady-state composition, which allows fungi to thrive, and may predispose the host to invasive fungal infections once the immune system becomes impaired [65,66].
T73 12591-12675 Sentence denotes Underlying medical conditions may also predispose COVID-19 patients to develop CAPA.
T74 12676-12954 Sentence denotes Among the 35 CAPA cases published to date (Table 1), hypertension (17/35; 49%), diabetes (9/35; 26%), obesity (8/35; 23%), COPD (5/35; 14%), heart diseases (5/35; 14%), hypercholesterinemia (4/35; 11%), and asthma (3/35; 9%) were among the most prevalent comorbidities observed.
T75 12955-13169 Sentence denotes While hypertension, coronary heart diseases, and diabetes increase the risk of infection overall [67,68,69], structural lung damage caused by COPD or asthma may particularly predispose patients to develop IPA [70].
T76 13171-13173 Sentence denotes 4.
T77 13174-13189 Sentence denotes CAPA Prevalence
T78 13190-13287 Sentence denotes Several studies from China reported high rates of Aspergillus infections among COVID-19 patients.
T79 13288-13487 Sentence denotes In one study from the Jiangsu province in China, 60/257 COVID-19 (23.3%) patients had throat swab samples that tested positive for Aspergillus spp. and were reported as Aspergillus co-infections [8].
T80 13488-13800 Sentence denotes In another Chinese study from the Zhejiang province 8 of the 104 patients with COVID-19 (7.7%) patients were reported to have IPA although questions remain regarding criteria used for diagnosing IPA in this study (authors state EORTC/MSG criteria were used but all 8 patients seemingly lacked host factors) [71].
T81 13801-13936 Sentence denotes Another study from China reported that 27% of the COVID-19 patients (13/48) developed fungal infections but lacked further details [7].
T82 13937-14047 Sentence denotes In other reports from China, lower rates of fungal infections were reported ranging between 3.2–5% [54,55,72].
T83 14048-14168 Sentence denotes None of those studies have used specific definitions and standardized diagnostic algorithms to identify and define CAPA.
T84 14169-14369 Sentence denotes In fact, diagnosis of pulmonary aspergillosis is challenging with culture exhibiting limited sensitivity [73,74], and galactomannan testing—the current gold standard—is rarely available in China [75].
T85 14370-14676 Sentence denotes As a result, some of these reported rates are likely an underestimate of the real burden of IPA in patients with COVID-19 requiring ICU admission, while other rates may be an overestimation due to potentially misinterpreting Aspergillus colonization in the upper respiratory tract as Aspergillus infection.
T86 14677-14893 Sentence denotes More recently, several studies and case-series from Europe (France, Germany, Belgium, and the Netherlands) have reported high rates of CAPA among COVID-19 cases with ARDS, ranging from 20–35% (Table 1) [47,50,51,52].
T87 14894-15011 Sentence denotes The development of CAPA was fairly rapid, with a median of 6 days and range of 3–28 days after ICU admission [47,52].
T88 15012-15224 Sentence denotes Moreover, two additional CAPA cases have been reported from Germany [61] and single cases have also been reported from the Netherlands [62], Austria [60], Italy [59], Australia [63], and France [57,58] (Table 1).
T89 15225-15308 Sentence denotes Among 35 CAPA cases reported to date, there were a total of 5 proven cases [52,59].
T90 15309-15419 Sentence denotes The overall mortality rate was 63% (22/35), among whom 4 were female (4/8; 50%) and 14 were male (18/27; 67%).
T91 15420-15544 Sentence denotes The mortality in case series reported from France, Germany, Belgium and Netherlands ranged between 44.5–66.7% [47,50,51,52].
T92 15545-15734 Sentence denotes Of particular importance was the 100% fatality rate of those with underlying diseases reported from the Netherlands, while the two patients without underlying conditions both survived [47].
T93 15735-15960 Sentence denotes Noteworthy is the fact that COVID-19 patients presented with ARDS typically fall into the elderly category [6], whereas ARDS in those infected with influenza involves both children <5 years old and elderly >65 years old [76].
T94 15961-16117 Sentence denotes The difficulties in diagnosing CAPA, which are outlined in more detail in the next section of this review, may also contribute to increased mortality rates.
T95 16118-16317 Sentence denotes The most notable example is a study from France [57], where both culture and serology assays were negative for the initial respiratory samples and became only positive after the patient expired [57].
T96 16318-16507 Sentence denotes In a case from Italy, initial BALF culture was positive for A. fumigatus but the treatment was delayed for two days and only started after the serum galactomannan test became positive [59].
T97 16508-16561 Sentence denotes CAPA was later confirmed by autopsy examination [59].
T98 16562-16769 Sentence denotes As a result, authors encouraged prompt initiation of systemic antifungal therapy immediately after obtaining positive results even if Aspergillus is detected in samples from the upper respiratory tract [59].
T99 16770-17087 Sentence denotes Since azole resistance can be associated with a higher mortality rate when compared to patients infected with azole susceptible A. fumigatus isolates, it is of paramount importance to use antifungal susceptibility testing to inform targeted antifungal treatment, especially in regions with high azole resistance [77].
T100 17088-17303 Sentence denotes Azole-resistant A. fumigatus isolates were also persistently recovered from tracheal aspirates during the course of azole treatment in the most recent study from the Netherlands implicated a CAPA case for whom [62].
T101 17304-17542 Sentence denotes The azole-resistant A. fumigatus isolate (itraconazole, voriconazole, and posaconazole MICs were 16, 2, and 0.5 µg/mL, respectively) harbored a well-known mutation, TR34/L98H [62], presumed to have been acquired from the environment [77].
T102 17543-17806 Sentence denotes The in vitro MIC value of the isolate obtained at day 19 (2 mg/L) was higher than the voriconazole serum trough concentration measured on day 17 (1.43 mg/L) and despite switching voriconazole to l-AmB, the patient died due to deteriorating health conditions [62].
T103 17807-17984 Sentence denotes Overall, A. fumigatus appeared to be the most prevalent Aspergillus spp. isolated among respiratory samples with positive culture (26/29; 90%), followed by A. flavus (2/29; 7%).
T104 17986-17988 Sentence denotes 5.
T105 17989-18042 Sentence denotes Diagnostic Workup for Accurate Identification of CAPA
T106 18043-18287 Sentence denotes The optimal diagnostic algorithm for diagnosing CAPA is currently unknown, and this question is actively being investigated in an ongoing multinational explorative trial in conjunction with the European Confederation of Medical Mycology (ECMM).
T107 18288-18582 Sentence denotes The most common methods to date include attempting to recover Aspergillus spp. on culture media of bronchoalveolar fluid (BALF) and tracheal aspirate, as well as utilizing serologic biomarker testing such as the conventional Galactomannan (GM) from BALF, tracheal aspirate, and serum specimens.
T108 18583-18877 Sentence denotes Other diagnostic tests that may prove useful also include Aspergillus PCR, serum (1→3)-β-d-glucan (BDG), the Aspergillus galactomannan lateral flow assay (LFA) (IMMY, Norman, Oklahoma, USA), and the Aspergillus-specific lateral-flow device (LFD) test (OLM Diagnostics, Newcastle Upon Tyne, UK).
T109 18878-19210 Sentence denotes In published cases and case series from Germany [50,61], France [51,57,58], Italy [59], Austria [60], Belgium [52], Australia [63], and the Netherlands [47], CAPA was most commonly mycologically diagnosed by either culture from BALF or tracheal aspirate and/or based on a positive GM or LFD from BALF or tracheal aspirate (Table 1).
T110 19211-19469 Sentence denotes Across published cases, Aspergillus culture was positive in 29/35 (83%) of patients; of those with a positive culture and a reported source, 16/29 (55%) were recovered from—often undirected—BALF, 12/29 (41%) from tracheal aspirate, and 1/29 (3%) from sputum.
T111 19470-19652 Sentence denotes In those where a BALF GM test was performed, 14/23 (61%) had a titer ≥1.5 ODI and 16/23 (70%) a titer ≥0.5 ODI, while 6/28 (21%) of those with serum GM results had a titer > 0.5 ODI.
T112 19653-19782 Sentence denotes PCR from respiratory specimens or tissue was positive in 10/14 (71%) and LFD from tracheal secretion positive in 1/1 of patients.
T113 19783-19916 Sentence denotes Thus, BALF and tracheal aspirate culture and conventional GM testing from BALF appear to be the most promising diagnostic modalities.
T114 19917-20079 Sentence denotes Still, bronchoscopy can potentially aerosolize virus [78] in patients with COVID-19 infection, thus posing a risk to patients and personnel from SARS-CoV-2 virus.
T115 20080-20455 Sentence denotes In many centers, the role of bronchoscopy is limited and testing from blood samples may be safer and more optimal and allow also for twice weekly screening which has been implemented in many centers [52], although the low levels of GM positivity from serum in these reports is discouraging, and the sensitivity of serum BDG, which is less specific for IA, was only 44% (4/9).
T116 20457-20459 Sentence denotes 6.
T117 20460-20491 Sentence denotes CAPA Treatment—Current Paradigm
T118 20492-20680 Sentence denotes While it is currently unknown whether antifungal treatment of COVID-19 associated IPA translates into a survival benefit, diagnosis should in most cases trigger early antifungal treatment.
T119 20681-20799 Sentence denotes Outside the hematologic malignancy setting, voriconazole remains the recommended first-line treatment for IPA [79,80].
T120 20800-21055 Sentence denotes However, besides its narrow therapeutic window and the requirement for therapeutic drug monitoring to ensure efficacy and prevent neuro and hepatotoxicity [81], drug–drug interactions may particularly limit the use of voriconazole in the ICU setting [82].
T121 21056-21216 Sentence denotes Being metabolized via CYP2C19, CYP2C9, and CYP3A4, voriconazole is among the drugs most frequently associated with major drug–drug interactions in the ICU [83].
T122 21217-21522 Sentence denotes Furthermore, it may show interactions with experimental COVID-19 therapies, including hydroxychloroquine, atazanavir, lopinavir/ritonavir and last but not least—although weaker—with remdesivir, which is also a substrate for CYP3A4, although its metabolism is primarily mediated by hydrolase activity [84].
T123 21523-21639 Sentence denotes Isavuconazole and liposomal amphotericin B are the primary alternative options for treatment of IPA in the ICU [79].
T124 21640-21768 Sentence denotes Compared to voriconazole, isavuconazole shows a more favorable pharmacokinetic profile, and is associated with fewer toxicities.
T125 21769-21959 Sentence denotes However, it is also metabolized via CYP3A4 and could therefore be problematic, although drug–drug interactions are generally less a problem with isavuconazole than with voriconazole [85,86].
T126 21960-22160 Sentence denotes Liposomal amphotericin B is a broadly effective alternative treatment option, however, in the ICU renal insufficiency often complicates initiation or requires discontinuation of this antifungal agent.
T127 22161-22326 Sentence denotes This concern is particularly relevant for patients infected by SARS-CoV-2 which has shown renal tropism and been described as a frequent cause of kidney injury [87].
T128 22327-22556 Sentence denotes While itraconazole is now rarely used to treat invasive aspergillosis, it has been shown to exhibit some antiviral activity, specifically as a cholesterol transport inhibitor, and was effective in a feline coronavirus model [88].
T129 22557-22806 Sentence denotes In addition, its novel oral SUBA formulation has great bioavailability [89], and itraconazole may therefore be an alternative option for treating COVID-19 associated IPA, although it shares the problem of drug–drug interactions with other triazoles.
T130 22807-23130 Sentence denotes While currently available echinocandins are not considered first-line treatment options for invasive aspergillosis due to their limited antifungal activity against Aspergillus spp., they are generally well tolerated with limited drug–drug interactions and show at least fungistatic activity against Aspergillus hyphae [90].
T131 23131-23275 Sentence denotes Furthermore, they synergistic interactions with some other antifungals, making them an excellent choice for combination antifungal therapy [90].
T132 23276-23595 Sentence denotes New antifungal classes currently under development, namely fosmanogepix and olorofim [91], may have equal efficacy without the same burden of drug–drug interactions and toxicity, and may therefore overcome the limitations of currently available antifungals and become the preferred treatment options in the near future.
T133 23596-24007 Sentence denotes If the reported high incidence of COVID-19 associated IPA in ICU patients is confirmed in larger studies, there may be justification for prophylaxis trials, for which not only triazoles and nebulized liposomal amphotericin B [52], but also another novel antifungal currently under development, rezafungin (i.e., once weekly echinocandin with improved activity against Aspergillus spp.), may be a candidate [92].
T134 24009-24011 Sentence denotes 7.
T135 24012-24057 Sentence denotes The Current Challenges and How to Tackle Them
T136 24058-24141 Sentence denotes Bacterial, fungal and viral secondary infections or co-infections affect mortality.
T137 24142-24283 Sentence denotes Acinetobacter baumanii, Klebsiella pneumonia and Aspergillus species are important nosocomial pathogens [93] complicating the disease course.
T138 24284-24391 Sentence denotes Studies from France [51], Germany [50], Belgium [52], and the Netherlands [47], underline the role of CAPA.
T139 24392-24490 Sentence denotes Diagnosing co-infections is complex and rapid diagnosis plays a crucial role in this setting [49].
T140 24491-24659 Sentence denotes Close monitoring for infection development is needed, as well as longitudinal sampling throughout the disease course using culture dependent and independent techniques.
T141 24660-24830 Sentence denotes Aspergillus antigen and PCR testing of respiratory fluids should be a routine procedure for critically ill patients [94], specifically for those suffering from ARDS [50].
T142 24831-24941 Sentence denotes Co-infection with human metapneumovirus has been reported in two of five cases in the German CAPA series [50].
T143 24942-25130 Sentence denotes It is unknown whether hospitals caring for COVID-19 test comprehensive respiratory pathogen panels, and to date no analysis of mixed viral infection in COVID-19 patients has been reported.
T144 25131-25268 Sentence denotes In the context of COVID-19, mixed viral infection may be misinterpreted as presence of innocent bystanders and thus remain underreported.
T145 25269-25382 Sentence denotes With bronchoalveolar lavage and autopsy regarded as high-risk procedures, key diagnostic instruments are lacking.
T146 25383-25541 Sentence denotes Autopsy studies are key to understanding pathophysiology of COVID-19 [95] and are critically enlighten interaction between SARS-CoV-2 and different pathogens.
T147 25542-25698 Sentence denotes With availability of lower respiratory samples, normally obtained by BALF, the quality of microbiological and virological work up would be greatly improved.
T148 25699-25827 Sentence denotes Inspection of trachea and bronchi is achieved by bronchoscopy, which is critical to find possible Aspergillus tracheobronchitis.
T149 25828-26049 Sentence denotes Thus, physicians face the dilemma of taking the hazard of aerosolization of SARS-CoV-2, risking transmission versus the endeavor of facilitating the optimal diagnosis and treatment to the patients entrusted to their care.
T150 26050-26159 Sentence denotes To this day, our understanding of the true impact of Aspergillus co-infections remains frustratingly limited.
T151 26160-26299 Sentence denotes Therefore, guidance on proper management of these high-risk procedures to prevent transmission and super spreading of SARS-CoV-2 is needed.
T152 26300-26519 Sentence denotes The European Confederation of Medical Mycology initiated national multicenter studies aiming to explore the risk of fungal infections during COVID-19 [94] and is currently working on diagnostic and treatment algorithms.
T153 26520-26643 Sentence denotes Key goals are to improve the outcome by avoiding misdiagnosis and by initiation of early and targeted antifungal treatment.
T154 26645-26647 Sentence denotes 8.
T155 26648-26667 Sentence denotes Future Perspectives
T156 26668-26787 Sentence denotes We anticipate that autopsies of COVID-19 fatalities will increase and likely prove the clinical relevance of CAPA [96].
T157 26788-26945 Sentence denotes Immune dysregulation together with epithelial lung damage stemming from COVID-19 immunopathology is a likely mechanism predisposing for IPA development [97].
T158 26946-27091 Sentence denotes IPA will be recognized as important co-infection in patients with severe COVID-19, but incidence will likely vary between different ICU settings.
T159 27092-27334 Sentence denotes In settings where COVID-19 associated IPA occurs most commonly, screening for IPA in blood and true BALF samples (i.e., obtained via bronchoscopy) will be implemented followed by preemptive treatment in those with mycological evidence of IPA.
T160 27335-27563 Sentence denotes In other high-incidence settings, clinical antifungal prophylaxis trials will be conducted among COVID-19 patients admitted to the ICU aiming to show a decrease in putative [4] and proven IPA cases, as well as overall mortality.
T161 27564-27741 Sentence denotes Treatment trials will compare efficacy and safety of new antifungal drugs currently under development with established antifungals, initiating a new era of antifungal treatment.

2_test

Id Subject Object Predicate Lexical cue
32599813-23253612-60095058 166-167 23253612 denotes 1
32599813-25354514-60095059 515-516 25354514 denotes 2
32599813-31296304-60095060 517-518 31296304 denotes 3
32599813-25354514-60095061 941-942 25354514 denotes 2
32599813-30076119-60095062 1198-1199 30076119 denotes 4
32599813-22895826-60095063 1200-1201 22895826 denotes 5
32599813-30076119-60095064 1329-1330 30076119 denotes 4
32599813-22895826-60095065 1331-1332 22895826 denotes 5
32599813-16007097-60095066 2590-2592 16007097 denotes 11
32599813-21325420-60095067 2715-2717 21325420 denotes 12
32599813-16001071-60095068 2923-2925 16001071 denotes 13
32599813-12204859-60095069 3062-3064 12204859 denotes 14
32599813-28919635-60095070 3616-3618 28919635 denotes 15
32599813-23097158-60095071 4153-4155 23097158 denotes 16
32599813-22973279-60095072 4252-4254 22973279 denotes 17
32599813-21423669-60095073 4452-4454 21423669 denotes 18
32599813-22114731-60095074 4666-4668 22114731 denotes 19
32599813-26015500-60095075 5288-5290 26015500 denotes 20
32599813-19079579-60095076 5291-5293 19079579 denotes 21
32599813-23950537-60095077 5432-5434 23950537 denotes 22
32599813-31231549-60095078 5749-5751 31231549 denotes 23
32599813-32359396-60095079 5933-5935 32359396 denotes 24
32599813-32411313-60095080 6220-6222 32411313 denotes 25
32599813-32438450-60095081 6304-6306 32438450 denotes 26
32599813-24550444-60095082 6433-6435 24550444 denotes 27
32599813-26972847-60095083 6458-6460 26972847 denotes 28
32599813-32428990-60095084 6869-6871 32428990 denotes 30
32599813-10479157-60095085 7218-7220 10479157 denotes 32
32599813-32376398-60095086 7446-7448 32376398 denotes 33
32599813-11494166-60095087 7624-7626 11494166 denotes 34
32599813-31986264-60095088 8125-8127 31986264 denotes 35
32599813-32161940-60095089 8317-8319 32161940 denotes 36
32599813-32320677-60095090 8408-8410 32320677 denotes 37
32599813-30974130-60095091 8661-8663 30974130 denotes 38
32599813-32437659-60095092 8916-8918 32437659 denotes 39
32599813-28387526-60095093 9183-9185 28387526 denotes 40
32599813-30565352-60095094 9643-9645 30565352 denotes 41
32599813-31802125-60095095 9903-9905 31802125 denotes 43
32599813-30565352-60095096 10222-10224 30565352 denotes 41
32599813-22517788-60095097 10225-10227 22517788 denotes 44
32599813-30565352-60095098 10348-10350 30565352 denotes 41
32599813-30076119-60095099 10441-10442 30076119 denotes 4
32599813-32330523-60095100 10443-10445 32330523 denotes 45
32599813-32330523-60095101 10562-10564 32330523 denotes 45
32599813-30426598-60095102 10565-10567 30426598 denotes 46
32599813-30076119-60095103 10716-10717 30076119 denotes 4
32599813-22895826-60095104 10718-10719 22895826 denotes 5
32599813-30076119-60095105 10878-10879 30076119 denotes 4
32599813-22895826-60095106 10880-10881 22895826 denotes 5
32599813-32043983-60095107 10974-10976 32043983 denotes 48
32599813-32339350-60095108 11175-11177 32339350 denotes 50
32599813-32488446-60095109 11181-11183 32488446 denotes 52
32599813-32242738-60095110 11933-11935 32242738 denotes 55
32599813-30076119-60095111 12026-12027 30076119 denotes 4
32599813-22895826-60095112 12028-12029 22895826 denotes 5
32599813-30987351-60095113 12583-12585 30987351 denotes 65
32599813-31222314-60095114 12586-12588 31222314 denotes 66
32599813-30104296-60095115 13053-13055 30104296 denotes 67
32599813-9259669-60095116 13056-13058 9259669 denotes 68
32599813-30879371-60095117 13059-13061 30879371 denotes 69
32599813-15882191-60095118 13165-13167 15882191 denotes 70
32599813-32503617-60095119 13796-13798 32503617 denotes 71
32599813-32242738-60095120 14040-14042 32242738 denotes 55
32599813-32311650-60095121 14043-14045 32311650 denotes 72
32599813-31569472-60095122 14275-14277 31569472 denotes 73
32599813-29036605-60095123 14365-14367 29036605 denotes 75
32599813-32339350-60095124 14883-14885 32339350 denotes 50
32599813-32488446-60095125 14889-14891 32488446 denotes 52
32599813-32488446-60095126 15007-15009 32488446 denotes 52
32599813-32517166-60095127 15148-15150 32517166 denotes 62
32599813-32470620-60095128 15174-15176 32470620 denotes 59
32599813-32488446-60095129 15301-15303 32488446 denotes 52
32599813-32470620-60095130 15304-15306 32470620 denotes 59
32599813-32339350-60095131 15534-15536 32339350 denotes 50
32599813-32488446-60095132 15540-15542 32488446 denotes 52
32599813-31324202-60095133 15956-15958 31324202 denotes 76
32599813-32470620-60095134 16503-16505 32470620 denotes 59
32599813-32470620-60095135 16557-16559 32470620 denotes 59
32599813-32470620-60095136 16765-16767 32470620 denotes 59
32599813-30580035-60095137 17083-17085 30580035 denotes 77
32599813-32517166-60095138 17299-17301 32517166 denotes 62
32599813-32517166-60095139 17480-17482 32517166 denotes 62
32599813-30580035-60095140 17538-17540 30580035 denotes 77
32599813-32517166-60095141 17802-17804 32517166 denotes 62
32599813-32339350-60095142 18927-18929 32339350 denotes 50
32599813-32470620-60095143 18961-18963 32470620 denotes 59
32599813-32488446-60095144 18989-18991 32488446 denotes 52
32599813-32488446-60095145 20280-20282 32488446 denotes 52
32599813-27365388-60095146 20792-20794 27365388 denotes 79
32599813-29544767-60095147 20795-20797 29544767 denotes 80
32599813-23629724-60095148 20956-20958 23629724 denotes 81
32599813-30816967-60095149 21051-21053 30816967 denotes 82
32599813-26603290-60095150 21212-21214 26603290 denotes 83
32599813-32284951-60095151 21518-21520 32284951 denotes 84
32599813-27365388-60095152 21635-21637 27365388 denotes 79
32599813-29112326-60095153 21955-21957 29112326 denotes 86
32599813-30658691-60095154 22552-22554 30658691 denotes 88
32599813-31360992-60095155 22629-22631 31360992 denotes 89
32599813-31138565-60095156 23126-23128 31138565 denotes 90
32599813-31138565-60095157 23271-23273 31138565 denotes 90
32599813-31649174-60095158 23362-23364 31649174 denotes 91
32599813-32488446-60095159 23822-23824 32488446 denotes 52
32599813-30032217-60095160 24003-24005 30032217 denotes 92
32599813-32339350-60095161 24319-24321 32339350 denotes 50
32599813-32488446-60095162 24333-24335 32488446 denotes 52
32599813-31905234-60095163 24777-24779 31905234 denotes 94
32599813-32339350-60095164 24826-24828 32339350 denotes 50
32599813-32339350-60095165 24937-24939 32339350 denotes 50
32599813-32437596-60095166 25453-25455 32437596 denotes 95
32599813-31905234-60095167 26451-26453 31905234 denotes 94
32599813-30076119-60095168 27509-27510 30076119 denotes 4