PMC:7346000 / 11061-14871
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T36 | 1572-1576 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T37 | 1799-1803 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T38 | 1908-1916 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T39 | 2028-2032 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T40 | 2553-2561 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T41 | 2872-2875 | Body_part | denotes | gut | http://purl.org/sig/ont/fma/fma7199 |
| T42 | 3192-3205 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
| T43 | 3458-3463 | Body_part | denotes | heart | http://purl.org/sig/ont/fma/fma7088 |
| T44 | 3625-3630 | Body_part | denotes | heart | http://purl.org/sig/ont/fma/fma7088 |
| T45 | 3716-3720 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T6 | 1572-1576 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T7 | 1799-1803 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T8 | 2028-2032 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T9 | 3192-3205 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
| T10 | 3458-3463 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948 |
| T11 | 3625-3630 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948 |
| T12 | 3716-3720 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 337 | 132-140 | Species | denotes | patients | Tax:9606 |
| 338 | 579-587 | Species | denotes | patients | Tax:9606 |
| 339 | 759-767 | Species | denotes | patients | Tax:9606 |
| 340 | 839-847 | Species | denotes | patients | Tax:9606 |
| 341 | 163-171 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 342 | 389-395 | Disease | denotes | Cancer | MESH:D009369 |
| 343 | 396-422 | Disease | denotes | Invasive Fungal Infections | MESH:D000072742 |
| 344 | 467-474 | Disease | denotes | Allergy | MESH:D004342 |
| 345 | 479-498 | Disease | denotes | Infectious Diseases | MESH:D003141 |
| 346 | 618-630 | Disease | denotes | malignancies | MESH:D009369 |
| 347 | 853-861 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 358 | 1398-1406 | Species | denotes | patients | Tax:9606 |
| 359 | 1311-1320 | Species | denotes | influenza | Tax:11309 |
| 360 | 1488-1497 | Species | denotes | influenza | Tax:11309 |
| 361 | 1332-1355 | Disease | denotes | pulmonary aspergillosis | MESH:D055732 |
| 362 | 1389-1397 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 363 | 1428-1451 | Disease | denotes | pulmonary aspergillosis | MESH:D055732 |
| 364 | 1572-1583 | Disease | denotes | lung damage | MESH:D008171 |
| 365 | 1605-1613 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 366 | 1661-1665 | Disease | denotes | ARDS | MESH:D012128 |
| 367 | 1799-1811 | Disease | denotes | lung defects | MESH:D008171 |
| 377 | 1865-1883 | Disease | denotes | pulmonary fibrosis | MESH:D011658 |
| 378 | 1956-1964 | Disease | denotes | toxicity | MESH:D064420 |
| 379 | 2006-2013 | Disease | denotes | hypoxia | MESH:D000860 |
| 380 | 2022-2039 | Disease | denotes | acute lung injury | MESH:D055371 |
| 381 | 2101-2119 | Disease | denotes | pulmonary fibrosis | MESH:D011658 |
| 382 | 2194-2202 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 383 | 2330-2345 | Disease | denotes | viral infection | MESH:D001102 |
| 384 | 2467-2471 | Disease | denotes | ARDS | MESH:D012128 |
| 385 | 2645-2665 | Disease | denotes | secondary infections | MESH:D060085 |
| 392 | 2745-2753 | Species | denotes | patients | Tax:9606 |
| 393 | 2825-2833 | Species | denotes | patients | Tax:9606 |
| 394 | 2866-2871 | Species | denotes | human | Tax:9606 |
| 395 | 2872-2886 | Species | denotes | gut microbiome | Tax:749906 |
| 396 | 2816-2824 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 397 | 3156-3182 | Disease | denotes | invasive fungal infections | MESH:D000072742 |
| 415 | 3291-3299 | Species | denotes | patients | Tax:9606 |
| 416 | 3781-3789 | Species | denotes | patients | Tax:9606 |
| 417 | 3282-3290 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 418 | 3370-3382 | Disease | denotes | hypertension | MESH:D006973 |
| 419 | 3397-3405 | Disease | denotes | diabetes | MESH:D003920 |
| 420 | 3419-3426 | Disease | denotes | obesity | MESH:D009765 |
| 421 | 3440-3444 | Disease | denotes | COPD | MESH:D029424 |
| 422 | 3458-3472 | Disease | denotes | heart diseases | MESH:D006331 |
| 423 | 3486-3506 | Disease | denotes | hypercholesterinemia | |
| 424 | 3524-3530 | Disease | denotes | asthma | MESH:D001249 |
| 425 | 3602-3614 | Disease | denotes | hypertension | MESH:D006973 |
| 426 | 3625-3639 | Disease | denotes | heart diseases | MESH:D006331 |
| 427 | 3645-3653 | Disease | denotes | diabetes | MESH:D003920 |
| 428 | 3675-3684 | Disease | denotes | infection | MESH:D007239 |
| 429 | 3716-3727 | Disease | denotes | lung damage | MESH:D008171 |
| 430 | 3738-3742 | Disease | denotes | COPD | MESH:D029424 |
| 431 | 3746-3752 | Disease | denotes | asthma | MESH:D001249 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T117 | 30-34 | Disease | denotes | CAPA | http://purl.obolibrary.org/obo/MONDO_0007163 |
| T118 | 163-171 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T119 | 389-395 | Disease | denotes | Cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T120 | 467-474 | Disease | denotes | Allergy | http://purl.obolibrary.org/obo/MONDO_0005271 |
| T121 | 479-489 | Disease | denotes | Infectious | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T122 | 499-506 | Disease | denotes | Mycoses | http://purl.obolibrary.org/obo/MONDO_0002041 |
| T123 | 853-861 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T124 | 1233-1237 | Disease | denotes | CAPA | http://purl.obolibrary.org/obo/MONDO_0007163 |
| T125 | 1311-1320 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T126 | 1342-1355 | Disease | denotes | aspergillosis | http://purl.obolibrary.org/obo/MONDO_0005657 |
| T127 | 1389-1397 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T128 | 1438-1451 | Disease | denotes | aspergillosis | http://purl.obolibrary.org/obo/MONDO_0005657 |
| T129 | 1488-1497 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T130 | 1605-1613 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T131 | 1661-1665 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T132 | 1865-1883 | Disease | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0002771 |
| T133 | 2022-2039 | Disease | denotes | acute lung injury | http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796 |
| T135 | 2033-2039 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T136 | 2101-2119 | Disease | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0002771 |
| T137 | 2194-2202 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T138 | 2290-2294 | Disease | denotes | CAPA | http://purl.obolibrary.org/obo/MONDO_0007163 |
| T139 | 2330-2345 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T140 | 2336-2345 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T141 | 2367-2371 | Disease | denotes | CAPA | http://purl.obolibrary.org/obo/MONDO_0007163 |
| T142 | 2467-2471 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T143 | 2655-2665 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T144 | 2816-2824 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T145 | 3165-3182 | Disease | denotes | fungal infections | http://purl.obolibrary.org/obo/MONDO_0002041 |
| T146 | 3282-3290 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T147 | 3311-3315 | Disease | denotes | CAPA | http://purl.obolibrary.org/obo/MONDO_0007163 |
| T148 | 3330-3334 | Disease | denotes | CAPA | http://purl.obolibrary.org/obo/MONDO_0007163 |
| T149 | 3370-3382 | Disease | denotes | hypertension | http://purl.obolibrary.org/obo/MONDO_0005044 |
| T150 | 3397-3405 | Disease | denotes | diabetes | http://purl.obolibrary.org/obo/MONDO_0005015 |
| T151 | 3419-3426 | Disease | denotes | obesity | http://purl.obolibrary.org/obo/MONDO_0011122 |
| T152 | 3440-3444 | Disease | denotes | COPD | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T153 | 3458-3472 | Disease | denotes | heart diseases | http://purl.obolibrary.org/obo/MONDO_0005267 |
| T154 | 3524-3530 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
| T155 | 3602-3614 | Disease | denotes | hypertension | http://purl.obolibrary.org/obo/MONDO_0005044 |
| T156 | 3616-3639 | Disease | denotes | coronary heart diseases | http://purl.obolibrary.org/obo/MONDO_0005010 |
| T157 | 3645-3653 | Disease | denotes | diabetes | http://purl.obolibrary.org/obo/MONDO_0005015 |
| T158 | 3675-3684 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T159 | 3738-3742 | Disease | denotes | COPD | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T160 | 3746-3752 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T80 | 243-247 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | test |
| T81 | 346-358 | http://purl.obolibrary.org/obo/OBI_0000245 | denotes | Organization |
| T82 | 548-553 | http://purl.obolibrary.org/obo/CLO_0009985 | denotes | focus |
| T83 | 876-879 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T84 | 989-991 | http://purl.obolibrary.org/obo/CLO_0053794 | denotes | 41 |
| T85 | 1572-1576 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T86 | 1572-1576 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T87 | 1615-1617 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
| T88 | 1799-1803 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T89 | 1799-1803 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T90 | 1923-1932 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T91 | 1986-1992 | http://purl.obolibrary.org/obo/UBERON_0001005 | denotes | airway |
| T92 | 2028-2032 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T93 | 2028-2032 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T94 | 2170-2171 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T95 | 2400-2402 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T96 | 2866-2871 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T97 | 2872-2875 | http://purl.obolibrary.org/obo/UBERON_0001007 | denotes | gut |
| T98 | 2872-2875 | http://purl.obolibrary.org/obo/UBERON_0001555 | denotes | gut |
| T99 | 2872-2875 | http://www.ebi.ac.uk/efo/EFO_0000834 | denotes | gut |
| T100 | 2890-2891 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T101 | 2924-2932 | http://purl.obolibrary.org/obo/NCBITaxon_2 | denotes | bacteria |
| T102 | 2953-2961 | http://purl.obolibrary.org/obo/NCBITaxon_2 | denotes | bacteria |
| T103 | 3192-3205 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
| T104 | 3327-3329 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T105 | 3387-3389 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T106 | 3409-3411 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T107 | 3430-3432 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T108 | 3448-3450 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T109 | 3458-3463 | http://purl.obolibrary.org/obo/UBERON_0000948 | denotes | heart |
| T110 | 3458-3463 | http://purl.obolibrary.org/obo/UBERON_0007100 | denotes | heart |
| T111 | 3458-3463 | http://purl.obolibrary.org/obo/UBERON_0015228 | denotes | heart |
| T112 | 3458-3463 | http://www.ebi.ac.uk/efo/EFO_0000815 | denotes | heart |
| T113 | 3476-3478 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T114 | 3510-3512 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T115 | 3514-3516 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T116 | 3534-3536 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T117 | 3625-3630 | http://purl.obolibrary.org/obo/UBERON_0000948 | denotes | heart |
| T118 | 3625-3630 | http://purl.obolibrary.org/obo/UBERON_0007100 | denotes | heart |
| T119 | 3625-3630 | http://purl.obolibrary.org/obo/UBERON_0015228 | denotes | heart |
| T120 | 3625-3630 | http://www.ebi.ac.uk/efo/EFO_0000815 | denotes | heart |
| T121 | 3716-3720 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T122 | 3716-3720 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T59 | 80-83 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T61 | 526-529 | Chemical | denotes | MSG | http://purl.obolibrary.org/obo/CHEBI_64220|http://purl.obolibrary.org/obo/CHEBI_64243 |
| T63 | 661-664 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T65 | 957-960 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T67 | 1017-1020 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T69 | 1066-1069 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T71 | 1126-1128 | Chemical | denotes | IA | http://purl.obolibrary.org/obo/CHEBI_74062 |
| T72 | 1498-1501 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T74 | 1631-1646 | Chemical | denotes | corticosteroids | http://purl.obolibrary.org/obo/CHEBI_50858 |
| T75 | 1704-1715 | Chemical | denotes | antibiotics | http://purl.obolibrary.org/obo/CHEBI_33281 |
| T76 | 1946-1954 | Chemical | denotes | antigens | http://purl.obolibrary.org/obo/CHEBI_59132 |
| T77 | 1974-1979 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T78 | 2165-2168 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
| T80 | 2235-2249 | Chemical | denotes | corticosteroid | http://purl.obolibrary.org/obo/CHEBI_50858 |
| T81 | 2426-2441 | Chemical | denotes | corticosteroids | http://purl.obolibrary.org/obo/CHEBI_50858 |
| T82 | 2482-2497 | Chemical | denotes | corticosteroids | http://purl.obolibrary.org/obo/CHEBI_50858 |
| T83 | 2724-2734 | Chemical | denotes | antibiotic | http://purl.obolibrary.org/obo/CHEBI_33281 |
| T84 | 2770-2781 | Chemical | denotes | antibiotics | http://purl.obolibrary.org/obo/CHEBI_33281 |
| T85 | 3019-3030 | Chemical | denotes | antibiotics | http://purl.obolibrary.org/obo/CHEBI_33281 |
| T86 | 3801-3804 | Chemical | denotes | IPA | http://purl.obolibrary.org/obo/CHEBI_17824|http://purl.obolibrary.org/obo/CHEBI_30802 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T27 | 64-76 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
| T28 | 2330-2345 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
| T29 | 2524-2540 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T19 | 80-83 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T20 | 389-395 | Phenotype | denotes | Cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T21 | 396-422 | Phenotype | denotes | Invasive Fungal Infections | http://purl.obolibrary.org/obo/HP_0020101 |
| T22 | 467-474 | Phenotype | denotes | Allergy | http://purl.obolibrary.org/obo/HP_0012393 |
| T23 | 661-664 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T24 | 957-960 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T25 | 1017-1020 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T26 | 1066-1069 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T27 | 1498-1501 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T28 | 1865-1883 | Phenotype | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/HP_0002206 |
| T29 | 1908-1922 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T30 | 2006-2013 | Phenotype | denotes | hypoxia | http://purl.obolibrary.org/obo/HP_0012418 |
| T31 | 2022-2039 | Phenotype | denotes | acute lung injury | http://www.orpha.net/ORDO/Orphanet_178320 |
| T32 | 2101-2119 | Phenotype | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/HP_0002206 |
| T33 | 2165-2168 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
| T34 | 2553-2567 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T35 | 3156-3182 | Phenotype | denotes | invasive fungal infections | http://purl.obolibrary.org/obo/HP_0020101 |
| T36 | 3370-3382 | Phenotype | denotes | hypertension | http://purl.obolibrary.org/obo/HP_0000822 |
| T37 | 3419-3426 | Phenotype | denotes | obesity | http://purl.obolibrary.org/obo/HP_0001513 |
| T38 | 3440-3444 | Phenotype | denotes | COPD | http://purl.obolibrary.org/obo/HP_0006510 |
| T39 | 3524-3530 | Phenotype | denotes | asthma | http://purl.obolibrary.org/obo/HP_0002099 |
| T40 | 3602-3614 | Phenotype | denotes | hypertension | http://purl.obolibrary.org/obo/HP_0000822 |
| T41 | 3738-3742 | Phenotype | denotes | COPD | http://purl.obolibrary.org/obo/HP_0006510 |
| T42 | 3746-3752 | Phenotype | denotes | asthma | http://purl.obolibrary.org/obo/HP_0002099 |
| T43 | 3801-3804 | Phenotype | denotes | IPA | http://purl.obolibrary.org/obo/HP_0020103 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T59 | 0-2 | Sentence | denotes | 3. |
| T60 | 3-46 | Sentence | denotes | Risk Factors Implicated in CAPA Development |
| T61 | 47-291 | Sentence | denotes | Importantly, the pathogenesis of IPA differs between neutropenic and non-neutropenic patients, including those with COVID-19, impacting clinical presentation, radiological findings and diagnostic test results in the mycology laboratory [41,42]. |
| T62 | 292-870 | Sentence | denotes | Despite these important differences, revised European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) definitions [43] focus primarily on neutropenic patients with underlying hematological malignancies and “typical” presentation of IPA and have been shown to have limited applicability and inferior performance in non-neutropenic patients who frequently do not fulfil radiological and host criteria, including patients with COVID-19 [41,44]. |
| T63 | 871-1211 | Sentence | denotes | This has resulted in the creation of an alternative clinical algorithm for diagnosing IPA in the ICU setting in 2012 [41], which defines putative IPA and is now the standard of care for defining IPA in the ICU [4,45], where highly reliable definitions of IA are still missing (work on improved definitions is currently in progress [45,46]). |
| T64 | 1212-1362 | Sentence | denotes | Rapid development of CAPA few days following ICU admission [47] resembles the observation made for influenza-associated pulmonary aspergillosis [4,5]. |
| T65 | 1363-1524 | Sentence | denotes | Risk factors predisposing COVID-19 patients to develop secondary pulmonary aspergillosis are similar to those identified for influenza-IPA superinfections [4,5]. |
| T66 | 1525-1826 | Sentence | denotes | The most important risk factors include severe lung damage during the course of COVID-19 [48], the use of corticosteroids in those with ARDS, the widespread use of broad-spectrum antibiotics in intensive care units [49], and the presence of comorbidities such as structural lung defects [47,50,51,52]. |
| T67 | 1827-2081 | Sentence | denotes | There are some reports revealing that pulmonary fibrosis can be triggered by the cytokine storm activated by the viral antigens, toxicity posed by drugs, high airway pressure and hypoxia-induced acute lung injury secondary to mechanical ventilation [53]. |
| T68 | 2082-2346 | Sentence | denotes | While interstitial pulmonary fibrosis per se does not predispose to development of IPA, a small subset of these COVID-19 survivors may require long term corticosteroid treatment, which may predispose them to CAPA years after the acute phase of the viral infection. |
| T69 | 2347-2452 | Sentence | denotes | Overall, 29% of the CAPA cases published to date (10/35) had received systemic corticosteroids (Table 1). |
| T70 | 2453-2672 | Sentence | denotes | In those with ARDS, systemic corticosteroids are used to alleviate the immune responses and prevent cytokine storm [6,54,55,56], but may at the same time increase vulnerability for developing secondary infections [4,5]. |
| T71 | 2673-2855 | Sentence | denotes | Although detailed case series have not reported on antibiotic use among patients, broad-spectrum antibiotics are presumed to be used in 75% of COVID-19 patients admitted to ICU [49]. |
| T72 | 2856-3231 | Sentence | denotes | Since the human gut microbiome is a highly complicated structure of bacteria and fungi, although bacteria are the most diverse constituents, the administration of antibiotics results in perturbation of microbiome steady-state composition, which allows fungi to thrive, and may predispose the host to invasive fungal infections once the immune system becomes impaired [65,66]. |
| T73 | 3232-3316 | Sentence | denotes | Underlying medical conditions may also predispose COVID-19 patients to develop CAPA. |
| T74 | 3317-3595 | Sentence | denotes | Among the 35 CAPA cases published to date (Table 1), hypertension (17/35; 49%), diabetes (9/35; 26%), obesity (8/35; 23%), COPD (5/35; 14%), heart diseases (5/35; 14%), hypercholesterinemia (4/35; 11%), and asthma (3/35; 9%) were among the most prevalent comorbidities observed. |
| T75 | 3596-3810 | Sentence | denotes | While hypertension, coronary heart diseases, and diabetes increase the risk of infection overall [67,68,69], structural lung damage caused by COPD or asthma may particularly predispose patients to develop IPA [70]. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32599813-30565352-60095094 | 284-286 | 30565352 | denotes | 41 |
| 32599813-31802125-60095095 | 544-546 | 31802125 | denotes | 43 |
| 32599813-30565352-60095096 | 863-865 | 30565352 | denotes | 41 |
| 32599813-22517788-60095097 | 866-868 | 22517788 | denotes | 44 |
| 32599813-30565352-60095098 | 989-991 | 30565352 | denotes | 41 |
| 32599813-30076119-60095099 | 1082-1083 | 30076119 | denotes | 4 |
| 32599813-32330523-60095100 | 1084-1086 | 32330523 | denotes | 45 |
| 32599813-32330523-60095101 | 1203-1205 | 32330523 | denotes | 45 |
| 32599813-30426598-60095102 | 1206-1208 | 30426598 | denotes | 46 |
| 32599813-30076119-60095103 | 1357-1358 | 30076119 | denotes | 4 |
| 32599813-22895826-60095104 | 1359-1360 | 22895826 | denotes | 5 |
| 32599813-30076119-60095105 | 1519-1520 | 30076119 | denotes | 4 |
| 32599813-22895826-60095106 | 1521-1522 | 22895826 | denotes | 5 |
| 32599813-32043983-60095107 | 1615-1617 | 32043983 | denotes | 48 |
| 32599813-32339350-60095108 | 1816-1818 | 32339350 | denotes | 50 |
| 32599813-32488446-60095109 | 1822-1824 | 32488446 | denotes | 52 |
| 32599813-32242738-60095110 | 2574-2576 | 32242738 | denotes | 55 |
| 32599813-30076119-60095111 | 2667-2668 | 30076119 | denotes | 4 |
| 32599813-22895826-60095112 | 2669-2670 | 22895826 | denotes | 5 |
| 32599813-30987351-60095113 | 3224-3226 | 30987351 | denotes | 65 |
| 32599813-31222314-60095114 | 3227-3229 | 31222314 | denotes | 66 |
| 32599813-30104296-60095115 | 3694-3696 | 30104296 | denotes | 67 |
| 32599813-9259669-60095116 | 3697-3699 | 9259669 | denotes | 68 |
| 32599813-30879371-60095117 | 3700-3702 | 30879371 | denotes | 69 |
| 32599813-15882191-60095118 | 3806-3808 | 15882191 | denotes | 70 |