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PMC:7344504 / 8153-9126 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T20 690-694 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
224 221-228 Species denotes patient Tax:9606
225 286-298 Species denotes A. fumigatus Tax:746128
226 422-434 Species denotes A. fumigatus Tax:746128
227 841-848 Species denotes patient Tax:9606
228 311-323 Chemical denotes itraconazole MESH:D017964
229 328-340 Chemical denotes voriconazole MESH:D065819
230 460-474 Chemical denotes amphotericin B MESH:D000666
231 485-498 Chemical denotes anidulafungin MESH:D000077612
232 503-513 Chemical denotes micafungin MESH:D000077551
233 527-539 Chemical denotes itraconazole MESH:D017964
234 549-561 Chemical denotes voriconazole MESH:D065819
235 573-585 Chemical denotes posaconazole MESH:C101425
236 596-608 Chemical denotes Voriconazole MESH:D065819
237 644-658 Chemical denotes amphotericin B MESH:D000666
238 777-782 Chemical denotes azole MESH:D001393
239 724-728 Mutation denotes L98H p.L98H

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T53 232-233 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T54 286-287 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T55 422-423 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T56 473-474 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T57 657-658 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T58 690-694 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T59 717-718 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T60 802-804 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T62 311-323 Chemical denotes itraconazole http://purl.obolibrary.org/obo/CHEBI_6076
T63 328-340 Chemical denotes voriconazole http://purl.obolibrary.org/obo/CHEBI_10023
T64 460-474 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T65 485-498 Chemical denotes anidulafungin http://purl.obolibrary.org/obo/CHEBI_55346
T66 503-513 Chemical denotes micafungin http://purl.obolibrary.org/obo/CHEBI_600520
T67 527-539 Chemical denotes itraconazole http://purl.obolibrary.org/obo/CHEBI_6076
T68 549-561 Chemical denotes voriconazole http://purl.obolibrary.org/obo/CHEBI_10023
T69 573-585 Chemical denotes posaconazole http://purl.obolibrary.org/obo/CHEBI_64355
T70 644-658 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T71 777-782 Chemical denotes azole http://purl.obolibrary.org/obo/CHEBI_68452

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T70 0-104 Sentence denotes The respiratory situation improved marginally in the subsequent 7 days but declined steadily thereafter.
T71 105-271 Sentence denotes Pressure support and pressure control ventilation were alternated between days 12 and 19 and attempts to return the patient to a supine position failed several times.
T72 272-408 Sentence denotes After 7 days, A. fumigatus grew on the itraconazole and voriconazole wells of the second VIPcheck on day 19 (tracheal aspirate culture).
T73 409-595 Sentence denotes MICs of this A. fumigatus isolate were as follows: amphotericin B 0.5 mg/L, anidulafungin and micafungin <0.016 mg/L, itraconazole 16 mg/L, voriconazole 2 mg/L and posaconazole 0.5 mg/L.
T74 596-671 Sentence denotes Voriconazole treatment was changed to liposomal amphotericin B 200 mg q24h.
T75 672-794 Sentence denotes Subsequent cyp51A gene sequencing identified a TR34/L98H mutation, probably responsible for the observed azole resistance.
T76 795-943 Sentence denotes On day 22, ventilation and oxygenation of the patient deteriorated further without further treatment options and therapy was discontinued on day 23.
T77 944-973 Sentence denotes An autopsy was not performed.