PMC:7341831 / 3071-4211 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T6","span":{"begin":102,"end":108},"obj":"Body_part"},{"id":"T7","span":{"begin":548,"end":559},"obj":"Body_part"},{"id":"T8","span":{"begin":591,"end":605},"obj":"Body_part"}],"attributes":[{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma7182"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma61799"}],"text":"A 71-year-old male patient with prior history of hypertension, type II diabetes mellitus, and chronic kidney disease was admitted to the Hospital e Pronto-Socorro Delphina Rinaldi Abdel Aziz, a referral unit for the treatment of patients with COVID-19 in Manaus. The patient was transferred from another hospital, where he had already been diagnosed with COVID-19 by RT-qPCR. Upon admission into the ICU, he was placed under orotracheal intubation, received high-dose vasoactive drugs, was hemodynamically unstable, and presented cyanosis and cold extremities. He was administered high-flow norepinephrine (1.41 µg/kg/min) and placed on invasive mechanical ventilation under aspiration of an orotracheal tube with high parameters (positive end-expiratory pressure [PEEP] 8/FiO2 60%/respiratory rate 26; volume 360). The PaO2/FiO2 ratio was 86.6. The patient received oseltamivir (75 mg twice daily) and chloroquine (450 mg twice on the first day) via a nasoenteral tube, IV azithromycin (500 mg/day), IV ceftriaxone (2g/day), IV furosemide (20mg TID), and prophylactic subcutaneous enoxaparin (40 mg/day). No corticosteroid drugs were used."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T5","span":{"begin":102,"end":108},"obj":"Body_part"},{"id":"T6","span":{"begin":704,"end":708},"obj":"Body_part"},{"id":"T7","span":{"begin":965,"end":969},"obj":"Body_part"}],"attributes":[{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0000025"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0000025"}],"text":"A 71-year-old male patient with prior history of hypertension, type II diabetes mellitus, and chronic kidney disease was admitted to the Hospital e Pronto-Socorro Delphina Rinaldi Abdel Aziz, a referral unit for the treatment of patients with COVID-19 in Manaus. The patient was transferred from another hospital, where he had already been diagnosed with COVID-19 by RT-qPCR. Upon admission into the ICU, he was placed under orotracheal intubation, received high-dose vasoactive drugs, was hemodynamically unstable, and presented cyanosis and cold extremities. He was administered high-flow norepinephrine (1.41 µg/kg/min) and placed on invasive mechanical ventilation under aspiration of an orotracheal tube with high parameters (positive end-expiratory pressure [PEEP] 8/FiO2 60%/respiratory rate 26; volume 360). The PaO2/FiO2 ratio was 86.6. The patient received oseltamivir (75 mg twice daily) and chloroquine (450 mg twice on the first day) via a nasoenteral tube, IV azithromycin (500 mg/day), IV ceftriaxone (2g/day), IV furosemide (20mg TID), and prophylactic subcutaneous enoxaparin (40 mg/day). No corticosteroid drugs were used."}

{"project":"LitCovid-PubTator","denotations":[{"id":"115","span":{"begin":19,"end":26},"obj":"Species"},{"id":"116","span":{"begin":229,"end":237},"obj":"Species"},{"id":"117","span":{"begin":267,"end":274},"obj":"Species"},{"id":"118","span":{"begin":850,"end":857},"obj":"Species"},{"id":"119","span":{"begin":591,"end":605},"obj":"Chemical"},{"id":"120","span":{"begin":867,"end":878},"obj":"Chemical"},{"id":"121","span":{"begin":903,"end":914},"obj":"Chemical"},{"id":"122","span":{"begin":974,"end":986},"obj":"Chemical"},{"id":"123","span":{"begin":1004,"end":1015},"obj":"Chemical"},{"id":"124","span":{"begin":1029,"end":1039},"obj":"Chemical"},{"id":"125","span":{"begin":1082,"end":1092},"obj":"Chemical"},{"id":"126","span":{"begin":49,"end":61},"obj":"Disease"},{"id":"127","span":{"begin":63,"end":88},"obj":"Disease"},{"id":"128","span":{"begin":94,"end":116},"obj":"Disease"},{"id":"129","span":{"begin":243,"end":251},"obj":"Disease"},{"id":"130","span":{"begin":355,"end":363},"obj":"Disease"},{"id":"131","span":{"begin":530,"end":559},"obj":"Disease"}],"attributes":[{"id":"A115","pred":"tao:has_database_id","subj":"115","obj":"Tax:9606"},{"id":"A116","pred":"tao:has_database_id","subj":"116","obj":"Tax:9606"},{"id":"A117","pred":"tao:has_database_id","subj":"117","obj":"Tax:9606"},{"id":"A118","pred":"tao:has_database_id","subj":"118","obj":"Tax:9606"},{"id":"A119","pred":"tao:has_database_id","subj":"119","obj":"MESH:D009638"},{"id":"A120","pred":"tao:has_database_id","subj":"120","obj":"MESH:D053139"},{"id":"A121","pred":"tao:has_database_id","subj":"121","obj":"MESH:D002738"},{"id":"A122","pred":"tao:has_database_id","subj":"122","obj":"MESH:D017963"},{"id":"A123","pred":"tao:has_database_id","subj":"123","obj":"MESH:D002443"},{"id":"A124","pred":"tao:has_database_id","subj":"124","obj":"MESH:D005665"},{"id":"A125","pred":"tao:has_database_id","subj":"125","obj":"MESH:D017984"},{"id":"A126","pred":"tao:has_database_id","subj":"126","obj":"MESH:D006973"},{"id":"A127","pred":"tao:has_database_id","subj":"127","obj":"MESH:D003924"},{"id":"A128","pred":"tao:has_database_id","subj":"128","obj":"MESH:D051436"},{"id":"A129","pred":"tao:has_database_id","subj":"129","obj":"MESH:C000657245"},{"id":"A130","pred":"tao:has_database_id","subj":"130","obj":"MESH:C000657245"},{"id":"A131","pred":"tao:has_database_id","subj":"131","obj":"MESH:D003490"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"A 71-year-old male patient with prior history of hypertension, type II diabetes mellitus, and chronic kidney disease was admitted to the Hospital e Pronto-Socorro Delphina Rinaldi Abdel Aziz, a referral unit for the treatment of patients with COVID-19 in Manaus. The patient was transferred from another hospital, where he had already been diagnosed with COVID-19 by RT-qPCR. Upon admission into the ICU, he was placed under orotracheal intubation, received high-dose vasoactive drugs, was hemodynamically unstable, and presented cyanosis and cold extremities. He was administered high-flow norepinephrine (1.41 µg/kg/min) and placed on invasive mechanical ventilation under aspiration of an orotracheal tube with high parameters (positive end-expiratory pressure [PEEP] 8/FiO2 60%/respiratory rate 26; volume 360). The PaO2/FiO2 ratio was 86.6. The patient received oseltamivir (75 mg twice daily) and chloroquine (450 mg twice on the first day) via a nasoenteral tube, IV azithromycin (500 mg/day), IV ceftriaxone (2g/day), IV furosemide (20mg TID), and prophylactic subcutaneous enoxaparin (40 mg/day). No corticosteroid drugs were used."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T38","span":{"begin":49,"end":61},"obj":"Disease"},{"id":"T39","span":{"begin":63,"end":88},"obj":"Disease"},{"id":"T40","span":{"begin":71,"end":79},"obj":"Disease"},{"id":"T41","span":{"begin":94,"end":116},"obj":"Disease"},{"id":"T42","span":{"begin":102,"end":116},"obj":"Disease"},{"id":"T44","span":{"begin":243,"end":251},"obj":"Disease"},{"id":"T45","span":{"begin":320,"end":322},"obj":"Disease"},{"id":"T46","span":{"begin":355,"end":363},"obj":"Disease"},{"id":"T47","span":{"begin":405,"end":407},"obj":"Disease"}],"attributes":[{"id":"A38","pred":"mondo_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/MONDO_0005044"},{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0005148"},{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0005015"},{"id":"A41","pred":"mondo_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/MONDO_0005300"},{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0001343"},{"id":"A43","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0005240"},{"id":"A44","pred":"mondo_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A45","pred":"mondo_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/MONDO_0017319"},{"id":"A46","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A47","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0017319"}],"text":"A 71-year-old male patient with prior history of hypertension, type II diabetes mellitus, and chronic kidney disease was admitted to the Hospital e Pronto-Socorro Delphina Rinaldi Abdel Aziz, a referral unit for the treatment of patients with COVID-19 in Manaus. The patient was transferred from another hospital, where he had already been diagnosed with COVID-19 by RT-qPCR. Upon admission into the ICU, he was placed under orotracheal intubation, received high-dose vasoactive drugs, was hemodynamically unstable, and presented cyanosis and cold extremities. He was administered high-flow norepinephrine (1.41 µg/kg/min) and placed on invasive mechanical ventilation under aspiration of an orotracheal tube with high parameters (positive end-expiratory pressure [PEEP] 8/FiO2 60%/respiratory rate 26; volume 360). The PaO2/FiO2 ratio was 86.6. The patient received oseltamivir (75 mg twice daily) and chloroquine (450 mg twice on the first day) via a nasoenteral tube, IV azithromycin (500 mg/day), IV ceftriaxone (2g/day), IV furosemide (20mg TID), and prophylactic subcutaneous enoxaparin (40 mg/day). No corticosteroid drugs were used."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T18","span":{"begin":0,"end":1},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T19","span":{"begin":2,"end":4},"obj":"http://purl.obolibrary.org/obo/CLO_0054055"},{"id":"T20","span":{"begin":14,"end":18},"obj":"http://purl.obolibrary.org/obo/UBERON_0003101"},{"id":"T21","span":{"begin":14,"end":18},"obj":"http://www.ebi.ac.uk/efo/EFO_0000970"},{"id":"T22","span":{"begin":102,"end":108},"obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"T23","span":{"begin":102,"end":108},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T24","span":{"begin":102,"end":108},"obj":"http://www.ebi.ac.uk/efo/EFO_0000929"},{"id":"T25","span":{"begin":192,"end":193},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T26","span":{"begin":548,"end":559},"obj":"http://www.ebi.ac.uk/efo/EFO_0000876"},{"id":"T27","span":{"begin":704,"end":708},"obj":"http://purl.obolibrary.org/obo/UBERON_0000025"},{"id":"T28","span":{"begin":951,"end":952},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T29","span":{"begin":965,"end":969},"obj":"http://purl.obolibrary.org/obo/UBERON_0000025"}],"text":"A 71-year-old male patient with prior history of hypertension, type II diabetes mellitus, and chronic kidney disease was admitted to the Hospital e Pronto-Socorro Delphina Rinaldi Abdel Aziz, a referral unit for the treatment of patients with COVID-19 in Manaus. The patient was transferred from another hospital, where he had already been diagnosed with COVID-19 by RT-qPCR. Upon admission into the ICU, he was placed under orotracheal intubation, received high-dose vasoactive drugs, was hemodynamically unstable, and presented cyanosis and cold extremities. He was administered high-flow norepinephrine (1.41 µg/kg/min) and placed on invasive mechanical ventilation under aspiration of an orotracheal tube with high parameters (positive end-expiratory pressure [PEEP] 8/FiO2 60%/respiratory rate 26; volume 360). The PaO2/FiO2 ratio was 86.6. The patient received oseltamivir (75 mg twice daily) and chloroquine (450 mg twice on the first day) via a nasoenteral tube, IV azithromycin (500 mg/day), IV ceftriaxone (2g/day), IV furosemide (20mg TID), and prophylactic subcutaneous enoxaparin (40 mg/day). No corticosteroid drugs were used."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T29","span":{"begin":14,"end":18},"obj":"Chemical"},{"id":"T30","span":{"begin":68,"end":70},"obj":"Chemical"},{"id":"T31","span":{"begin":479,"end":484},"obj":"Chemical"},{"id":"T32","span":{"begin":591,"end":605},"obj":"Chemical"},{"id":"T34","span":{"begin":765,"end":769},"obj":"Chemical"},{"id":"T36","span":{"begin":867,"end":878},"obj":"Chemical"},{"id":"T37","span":{"begin":903,"end":914},"obj":"Chemical"},{"id":"T38","span":{"begin":971,"end":973},"obj":"Chemical"},{"id":"T39","span":{"begin":974,"end":986},"obj":"Chemical"},{"id":"T40","span":{"begin":1001,"end":1003},"obj":"Chemical"},{"id":"T41","span":{"begin":1004,"end":1015},"obj":"Chemical"},{"id":"T42","span":{"begin":1026,"end":1028},"obj":"Chemical"},{"id":"T43","span":{"begin":1029,"end":1039},"obj":"Chemical"},{"id":"T44","span":{"begin":1109,"end":1123},"obj":"Chemical"},{"id":"T45","span":{"begin":1124,"end":1129},"obj":"Chemical"}],"attributes":[{"id":"A29","pred":"chebi_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/CHEBI_30780"},{"id":"A30","pred":"chebi_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A31","pred":"chebi_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A32","pred":"chebi_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/CHEBI_18357"},{"id":"A33","pred":"chebi_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/CHEBI_33569"},{"id":"A34","pred":"chebi_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/CHEBI_53359"},{"id":"A35","pred":"chebi_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/CHEBI_60683"},{"id":"A36","pred":"chebi_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/CHEBI_7798"},{"id":"A37","pred":"chebi_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A38","pred":"chebi_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_74327"},{"id":"A39","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_2955"},{"id":"A40","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_74327"},{"id":"A41","pred":"chebi_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/CHEBI_29007"},{"id":"A42","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_74327"},{"id":"A43","pred":"chebi_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/CHEBI_47426"},{"id":"A44","pred":"chebi_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"},{"id":"A45","pred":"chebi_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"A 71-year-old male patient with prior history of hypertension, type II diabetes mellitus, and chronic kidney disease was admitted to the Hospital e Pronto-Socorro Delphina Rinaldi Abdel Aziz, a referral unit for the treatment of patients with COVID-19 in Manaus. The patient was transferred from another hospital, where he had already been diagnosed with COVID-19 by RT-qPCR. Upon admission into the ICU, he was placed under orotracheal intubation, received high-dose vasoactive drugs, was hemodynamically unstable, and presented cyanosis and cold extremities. He was administered high-flow norepinephrine (1.41 µg/kg/min) and placed on invasive mechanical ventilation under aspiration of an orotracheal tube with high parameters (positive end-expiratory pressure [PEEP] 8/FiO2 60%/respiratory rate 26; volume 360). The PaO2/FiO2 ratio was 86.6. The patient received oseltamivir (75 mg twice daily) and chloroquine (450 mg twice on the first day) via a nasoenteral tube, IV azithromycin (500 mg/day), IV ceftriaxone (2g/day), IV furosemide (20mg TID), and prophylactic subcutaneous enoxaparin (40 mg/day). No corticosteroid drugs were used."}

{"project":"LitCovid-sentences","denotations":[{"id":"T31","span":{"begin":0,"end":262},"obj":"Sentence"},{"id":"T32","span":{"begin":263,"end":375},"obj":"Sentence"},{"id":"T33","span":{"begin":376,"end":560},"obj":"Sentence"},{"id":"T34","span":{"begin":561,"end":815},"obj":"Sentence"},{"id":"T35","span":{"begin":816,"end":845},"obj":"Sentence"},{"id":"T36","span":{"begin":846,"end":1105},"obj":"Sentence"},{"id":"T37","span":{"begin":1106,"end":1140},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"A 71-year-old male patient with prior history of hypertension, type II diabetes mellitus, and chronic kidney disease was admitted to the Hospital e Pronto-Socorro Delphina Rinaldi Abdel Aziz, a referral unit for the treatment of patients with COVID-19 in Manaus. The patient was transferred from another hospital, where he had already been diagnosed with COVID-19 by RT-qPCR. Upon admission into the ICU, he was placed under orotracheal intubation, received high-dose vasoactive drugs, was hemodynamically unstable, and presented cyanosis and cold extremities. He was administered high-flow norepinephrine (1.41 µg/kg/min) and placed on invasive mechanical ventilation under aspiration of an orotracheal tube with high parameters (positive end-expiratory pressure [PEEP] 8/FiO2 60%/respiratory rate 26; volume 360). The PaO2/FiO2 ratio was 86.6. The patient received oseltamivir (75 mg twice daily) and chloroquine (450 mg twice on the first day) via a nasoenteral tube, IV azithromycin (500 mg/day), IV ceftriaxone (2g/day), IV furosemide (20mg TID), and prophylactic subcutaneous enoxaparin (40 mg/day). No corticosteroid drugs were used."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T15","span":{"begin":49,"end":61},"obj":"Phenotype"},{"id":"T16","span":{"begin":63,"end":88},"obj":"Phenotype"},{"id":"T17","span":{"begin":94,"end":116},"obj":"Phenotype"},{"id":"T18","span":{"begin":530,"end":538},"obj":"Phenotype"},{"id":"T19","span":{"begin":675,"end":685},"obj":"Phenotype"}],"attributes":[{"id":"A15","pred":"hp_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"id":"A16","pred":"hp_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/HP_0005978"},{"id":"A17","pred":"hp_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/HP_0012622"},{"id":"A18","pred":"hp_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/HP_0000961"},{"id":"A19","pred":"hp_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/HP_0002835"}],"text":"A 71-year-old male patient with prior history of hypertension, type II diabetes mellitus, and chronic kidney disease was admitted to the Hospital e Pronto-Socorro Delphina Rinaldi Abdel Aziz, a referral unit for the treatment of patients with COVID-19 in Manaus. The patient was transferred from another hospital, where he had already been diagnosed with COVID-19 by RT-qPCR. Upon admission into the ICU, he was placed under orotracheal intubation, received high-dose vasoactive drugs, was hemodynamically unstable, and presented cyanosis and cold extremities. He was administered high-flow norepinephrine (1.41 µg/kg/min) and placed on invasive mechanical ventilation under aspiration of an orotracheal tube with high parameters (positive end-expiratory pressure [PEEP] 8/FiO2 60%/respiratory rate 26; volume 360). The PaO2/FiO2 ratio was 86.6. The patient received oseltamivir (75 mg twice daily) and chloroquine (450 mg twice on the first day) via a nasoenteral tube, IV azithromycin (500 mg/day), IV ceftriaxone (2g/day), IV furosemide (20mg TID), and prophylactic subcutaneous enoxaparin (40 mg/day). No corticosteroid drugs were used."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T47","span":{"begin":102,"end":108},"obj":"UBERON:0002113"},{"id":"T48","span":{"begin":243,"end":251},"obj":"SP_7"},{"id":"T49","span":{"begin":355,"end":363},"obj":"SP_7"},{"id":"T50","span":{"begin":425,"end":436},"obj":"UBERON:0006060"},{"id":"T51","span":{"begin":479,"end":484},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T52","span":{"begin":704,"end":708},"obj":"UBERON:0000025"},{"id":"T53","span":{"begin":773,"end":777},"obj":"CHEBI:16526;CHEBI:16526"},{"id":"T54","span":{"begin":782,"end":793},"obj":"UBERON:0001004"},{"id":"T55","span":{"begin":867,"end":878},"obj":"CHEBI:7798;CHEBI:7798"},{"id":"T56","span":{"begin":903,"end":914},"obj":"CHEBI:3638;CHEBI:3638;DG_10"},{"id":"T57","span":{"begin":974,"end":986},"obj":"CHEBI:2955;CHEBI:2955;DG_6"},{"id":"T58","span":{"begin":1004,"end":1015},"obj":"CHEBI:29007;CHEBI:29007"},{"id":"T59","span":{"begin":1029,"end":1039},"obj":"CHEBI:47426;CHEBI:47426"},{"id":"T60","span":{"begin":1109,"end":1123},"obj":"CHEBI:50858;CHEBI:50858"},{"id":"T61","span":{"begin":1124,"end":1129},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T98313","span":{"begin":102,"end":108},"obj":"UBERON:0002113"},{"id":"T14556","span":{"begin":243,"end":251},"obj":"SP_7"},{"id":"T45329","span":{"begin":355,"end":363},"obj":"SP_7"},{"id":"T62007","span":{"begin":425,"end":436},"obj":"UBERON:0006060"},{"id":"T81053","span":{"begin":479,"end":484},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T84418","span":{"begin":704,"end":708},"obj":"UBERON:0000025"},{"id":"T13632","span":{"begin":773,"end":777},"obj":"CHEBI:16526;CHEBI:16526"},{"id":"T35862","span":{"begin":782,"end":793},"obj":"UBERON:0001004"},{"id":"T24320","span":{"begin":867,"end":878},"obj":"CHEBI:7798;CHEBI:7798"},{"id":"T83491","span":{"begin":903,"end":914},"obj":"CHEBI:3638;CHEBI:3638;DG_10"},{"id":"T9292","span":{"begin":974,"end":986},"obj":"CHEBI:2955;CHEBI:2955;DG_6"},{"id":"T19984","span":{"begin":1004,"end":1015},"obj":"CHEBI:29007;CHEBI:29007"},{"id":"T4490","span":{"begin":1029,"end":1039},"obj":"CHEBI:47426;CHEBI:47426"},{"id":"T37947","span":{"begin":1109,"end":1123},"obj":"CHEBI:50858;CHEBI:50858"},{"id":"T19256","span":{"begin":1124,"end":1129},"obj":"CHEBI:23888;CHEBI:23888"}],"text":"A 71-year-old male patient with prior history of hypertension, type II diabetes mellitus, and chronic kidney disease was admitted to the Hospital e Pronto-Socorro Delphina Rinaldi Abdel Aziz, a referral unit for the treatment of patients with COVID-19 in Manaus. The patient was transferred from another hospital, where he had already been diagnosed with COVID-19 by RT-qPCR. Upon admission into the ICU, he was placed under orotracheal intubation, received high-dose vasoactive drugs, was hemodynamically unstable, and presented cyanosis and cold extremities. He was administered high-flow norepinephrine (1.41 µg/kg/min) and placed on invasive mechanical ventilation under aspiration of an orotracheal tube with high parameters (positive end-expiratory pressure [PEEP] 8/FiO2 60%/respiratory rate 26; volume 360). The PaO2/FiO2 ratio was 86.6. The patient received oseltamivir (75 mg twice daily) and chloroquine (450 mg twice on the first day) via a nasoenteral tube, IV azithromycin (500 mg/day), IV ceftriaxone (2g/day), IV furosemide (20mg TID), and prophylactic subcutaneous enoxaparin (40 mg/day). No corticosteroid drugs were used."}