PMC:7340597 / 28579-29390 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T150","span":{"begin":288,"end":293},"obj":"Body_part"}],"attributes":[{"id":"A150","pred":"fma_id","subj":"T150","obj":"http://purl.org/sig/ont/fma/fma9576"}],"text":"5 Conclusion\nWe report late pulmonary pathological findings of COVID-19 ARDS to be heterogeneous and non-typical when compared to non-COVID-19 ARDS patients. The predominant histologic pattern in our case series mainly consists of OP and not DAD. A concordance with specific findings on chest CT is suggested. The absence of histology proven aspergillosis provides further discussion on the presence of CAPA. Based on these late postmortem histopathologic findings, we suggest that the empiric use of corticosteroid therapy in COVID-19 related ARDS should be reconsidered in selected patients. Further research on the late phase of COVID19 in relation to the presence of different histologic patterns, it's concordance with radiology and the presence of COVID19 associated pulmonary aspergillosis is warranted."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T91","span":{"begin":288,"end":293},"obj":"Body_part"}],"attributes":[{"id":"A91","pred":"uberon_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/UBERON_0001443"}],"text":"5 Conclusion\nWe report late pulmonary pathological findings of COVID-19 ARDS to be heterogeneous and non-typical when compared to non-COVID-19 ARDS patients. The predominant histologic pattern in our case series mainly consists of OP and not DAD. A concordance with specific findings on chest CT is suggested. The absence of histology proven aspergillosis provides further discussion on the presence of CAPA. Based on these late postmortem histopathologic findings, we suggest that the empiric use of corticosteroid therapy in COVID-19 related ARDS should be reconsidered in selected patients. Further research on the late phase of COVID19 in relation to the presence of different histologic patterns, it's concordance with radiology and the presence of COVID19 associated pulmonary aspergillosis is warranted."}

{"project":"LitCovid-PubTator","denotations":[{"id":"664","span":{"begin":149,"end":157},"obj":"Species"},{"id":"665","span":{"begin":585,"end":593},"obj":"Species"},{"id":"666","span":{"begin":64,"end":72},"obj":"Disease"},{"id":"667","span":{"begin":73,"end":77},"obj":"Disease"},{"id":"668","span":{"begin":135,"end":143},"obj":"Disease"},{"id":"669","span":{"begin":144,"end":148},"obj":"Disease"},{"id":"670","span":{"begin":343,"end":356},"obj":"Disease"},{"id":"671","span":{"begin":528,"end":536},"obj":"Disease"},{"id":"672","span":{"begin":545,"end":549},"obj":"Disease"},{"id":"673","span":{"begin":633,"end":640},"obj":"Disease"},{"id":"674","span":{"begin":755,"end":762},"obj":"Disease"},{"id":"675","span":{"begin":774,"end":797},"obj":"Disease"}],"attributes":[{"id":"A664","pred":"tao:has_database_id","subj":"664","obj":"Tax:9606"},{"id":"A665","pred":"tao:has_database_id","subj":"665","obj":"Tax:9606"},{"id":"A666","pred":"tao:has_database_id","subj":"666","obj":"MESH:C000657245"},{"id":"A667","pred":"tao:has_database_id","subj":"667","obj":"MESH:D012128"},{"id":"A668","pred":"tao:has_database_id","subj":"668","obj":"MESH:C000657245"},{"id":"A669","pred":"tao:has_database_id","subj":"669","obj":"MESH:D012128"},{"id":"A670","pred":"tao:has_database_id","subj":"670","obj":"MESH:D001228"},{"id":"A671","pred":"tao:has_database_id","subj":"671","obj":"MESH:C000657245"},{"id":"A672","pred":"tao:has_database_id","subj":"672","obj":"MESH:D012128"},{"id":"A673","pred":"tao:has_database_id","subj":"673","obj":"MESH:C000657245"},{"id":"A674","pred":"tao:has_database_id","subj":"674","obj":"MESH:C000657245"},{"id":"A675","pred":"tao:has_database_id","subj":"675","obj":"MESH:D055732"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"5 Conclusion\nWe report late pulmonary pathological findings of COVID-19 ARDS to be heterogeneous and non-typical when compared to non-COVID-19 ARDS patients. The predominant histologic pattern in our case series mainly consists of OP and not DAD. A concordance with specific findings on chest CT is suggested. The absence of histology proven aspergillosis provides further discussion on the presence of CAPA. Based on these late postmortem histopathologic findings, we suggest that the empiric use of corticosteroid therapy in COVID-19 related ARDS should be reconsidered in selected patients. Further research on the late phase of COVID19 in relation to the presence of different histologic patterns, it's concordance with radiology and the presence of COVID19 associated pulmonary aspergillosis is warranted."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T259","span":{"begin":64,"end":72},"obj":"Disease"},{"id":"T260","span":{"begin":73,"end":77},"obj":"Disease"},{"id":"T261","span":{"begin":135,"end":143},"obj":"Disease"},{"id":"T262","span":{"begin":144,"end":148},"obj":"Disease"},{"id":"T263","span":{"begin":232,"end":234},"obj":"Disease"},{"id":"T264","span":{"begin":343,"end":356},"obj":"Disease"},{"id":"T265","span":{"begin":404,"end":408},"obj":"Disease"},{"id":"T266","span":{"begin":528,"end":536},"obj":"Disease"},{"id":"T267","span":{"begin":545,"end":549},"obj":"Disease"},{"id":"T268","span":{"begin":633,"end":640},"obj":"Disease"},{"id":"T269","span":{"begin":755,"end":762},"obj":"Disease"},{"id":"T270","span":{"begin":784,"end":797},"obj":"Disease"}],"attributes":[{"id":"A259","pred":"mondo_id","subj":"T259","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A260","pred":"mondo_id","subj":"T260","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A261","pred":"mondo_id","subj":"T261","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A262","pred":"mondo_id","subj":"T262","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A263","pred":"mondo_id","subj":"T263","obj":"http://purl.obolibrary.org/obo/MONDO_0015265"},{"id":"A264","pred":"mondo_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/MONDO_0005657"},{"id":"A265","pred":"mondo_id","subj":"T265","obj":"http://purl.obolibrary.org/obo/MONDO_0007163"},{"id":"A266","pred":"mondo_id","subj":"T266","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A267","pred":"mondo_id","subj":"T267","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A268","pred":"mondo_id","subj":"T268","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A269","pred":"mondo_id","subj":"T269","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A270","pred":"mondo_id","subj":"T270","obj":"http://purl.obolibrary.org/obo/MONDO_0005657"}],"text":"5 Conclusion\nWe report late pulmonary pathological findings of COVID-19 ARDS to be heterogeneous and non-typical when compared to non-COVID-19 ARDS patients. The predominant histologic pattern in our case series mainly consists of OP and not DAD. A concordance with specific findings on chest CT is suggested. The absence of histology proven aspergillosis provides further discussion on the presence of CAPA. Based on these late postmortem histopathologic findings, we suggest that the empiric use of corticosteroid therapy in COVID-19 related ARDS should be reconsidered in selected patients. Further research on the late phase of COVID19 in relation to the presence of different histologic patterns, it's concordance with radiology and the presence of COVID19 associated pulmonary aspergillosis is warranted."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T252","span":{"begin":248,"end":249},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T253","span":{"begin":288,"end":293},"obj":"http://www.ebi.ac.uk/efo/EFO_0000965"}],"text":"5 Conclusion\nWe report late pulmonary pathological findings of COVID-19 ARDS to be heterogeneous and non-typical when compared to non-COVID-19 ARDS patients. The predominant histologic pattern in our case series mainly consists of OP and not DAD. A concordance with specific findings on chest CT is suggested. The absence of histology proven aspergillosis provides further discussion on the presence of CAPA. Based on these late postmortem histopathologic findings, we suggest that the empiric use of corticosteroid therapy in COVID-19 related ARDS should be reconsidered in selected patients. Further research on the late phase of COVID19 in relation to the presence of different histologic patterns, it's concordance with radiology and the presence of COVID19 associated pulmonary aspergillosis is warranted."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T131","span":{"begin":502,"end":516},"obj":"Chemical"}],"attributes":[{"id":"A131","pred":"chebi_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"}],"text":"5 Conclusion\nWe report late pulmonary pathological findings of COVID-19 ARDS to be heterogeneous and non-typical when compared to non-COVID-19 ARDS patients. The predominant histologic pattern in our case series mainly consists of OP and not DAD. A concordance with specific findings on chest CT is suggested. The absence of histology proven aspergillosis provides further discussion on the presence of CAPA. Based on these late postmortem histopathologic findings, we suggest that the empiric use of corticosteroid therapy in COVID-19 related ARDS should be reconsidered in selected patients. Further research on the late phase of COVID19 in relation to the presence of different histologic patterns, it's concordance with radiology and the presence of COVID19 associated pulmonary aspergillosis is warranted."}

{"project":"LitCovid-sentences","denotations":[{"id":"T230","span":{"begin":0,"end":13},"obj":"Sentence"},{"id":"T231","span":{"begin":14,"end":158},"obj":"Sentence"},{"id":"T232","span":{"begin":159,"end":247},"obj":"Sentence"},{"id":"T233","span":{"begin":248,"end":310},"obj":"Sentence"},{"id":"T234","span":{"begin":311,"end":409},"obj":"Sentence"},{"id":"T235","span":{"begin":410,"end":594},"obj":"Sentence"},{"id":"T236","span":{"begin":595,"end":811},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"5 Conclusion\nWe report late pulmonary pathological findings of COVID-19 ARDS to be heterogeneous and non-typical when compared to non-COVID-19 ARDS patients. The predominant histologic pattern in our case series mainly consists of OP and not DAD. A concordance with specific findings on chest CT is suggested. The absence of histology proven aspergillosis provides further discussion on the presence of CAPA. Based on these late postmortem histopathologic findings, we suggest that the empiric use of corticosteroid therapy in COVID-19 related ARDS should be reconsidered in selected patients. Further research on the late phase of COVID19 in relation to the presence of different histologic patterns, it's concordance with radiology and the presence of COVID19 associated pulmonary aspergillosis is warranted."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T435","span":{"begin":29,"end":38},"obj":"UBERON:0002048"},{"id":"T436","span":{"begin":64,"end":72},"obj":"SP_7"},{"id":"T437","span":{"begin":135,"end":143},"obj":"SP_7"},{"id":"T438","span":{"begin":288,"end":293},"obj":"UBERON:0001443"},{"id":"T439","span":{"begin":430,"end":440},"obj":"GO:0016265"},{"id":"T440","span":{"begin":502,"end":516},"obj":"CHEBI:50858;CHEBI:50858"},{"id":"T441","span":{"begin":528,"end":536},"obj":"SP_7"},{"id":"T442","span":{"begin":633,"end":640},"obj":"SP_7"},{"id":"T443","span":{"begin":755,"end":762},"obj":"SP_7"},{"id":"T444","span":{"begin":774,"end":783},"obj":"UBERON:0002048"},{"id":"T53347","span":{"begin":774,"end":783},"obj":"UBERON:0002048"},{"id":"T38538","span":{"begin":29,"end":38},"obj":"UBERON:0002048"},{"id":"T75291","span":{"begin":64,"end":72},"obj":"SP_7"},{"id":"T46959","span":{"begin":135,"end":143},"obj":"SP_7"},{"id":"T12903","span":{"begin":288,"end":293},"obj":"UBERON:0001443"},{"id":"T33307","span":{"begin":430,"end":440},"obj":"GO:0016265"},{"id":"T59699","span":{"begin":502,"end":516},"obj":"CHEBI:50858;CHEBI:50858"},{"id":"T52737","span":{"begin":528,"end":536},"obj":"SP_7"},{"id":"T52895","span":{"begin":633,"end":640},"obj":"SP_7"},{"id":"T55272","span":{"begin":755,"end":762},"obj":"SP_7"},{"id":"T20603","span":{"begin":774,"end":783},"obj":"UBERON:0002048"}],"text":"5 Conclusion\nWe report late pulmonary pathological findings of COVID-19 ARDS to be heterogeneous and non-typical when compared to non-COVID-19 ARDS patients. The predominant histologic pattern in our case series mainly consists of OP and not DAD. A concordance with specific findings on chest CT is suggested. The absence of histology proven aspergillosis provides further discussion on the presence of CAPA. Based on these late postmortem histopathologic findings, we suggest that the empiric use of corticosteroid therapy in COVID-19 related ARDS should be reconsidered in selected patients. Further research on the late phase of COVID19 in relation to the presence of different histologic patterns, it's concordance with radiology and the presence of COVID19 associated pulmonary aspergillosis is warranted."}