PMC:7340597 / 27128-27941 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7340597","sourcedb":"PMC","sourceid":"7340597","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7340597","text":"To our surprise, none of the lung biopsies showed any presence of invasive aspergillosis. Lack of evidence for invasive pulmonary aspergillosis in our patients with probable CAPA raises the question whether patients with suspected CAPA truly develop invasive aspergillosis and require antifungal therapy. For instance, the three deaths in the CAPA report from France were attributed to bacterial septic shock, and not to aspergillosis. Although in our patients adequate antifungal treatment could be an explanation for the absence of histologic fungal features, we find this improbable as respiratory conditions deteriorated despite treatment. Further research on the presence of CAPA, its case definition and the necessity for antifungal treatment and (relative) contraindication for steroid treatment is needed.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T147","span":{"begin":29,"end":33},"obj":"Body_part"}],"attributes":[{"id":"A147","pred":"fma_id","subj":"T147","obj":"http://purl.org/sig/ont/fma/fma7195"},{"subj":"T147","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T88","span":{"begin":29,"end":33},"obj":"Body_part"}],"attributes":[{"id":"A88","pred":"uberon_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"subj":"T88","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"637","span":{"begin":151,"end":159},"obj":"Species"},{"id":"638","span":{"begin":207,"end":215},"obj":"Species"},{"id":"639","span":{"begin":452,"end":460},"obj":"Species"},{"id":"640","span":{"begin":785,"end":792},"obj":"Chemical"},{"id":"641","span":{"begin":66,"end":88},"obj":"Disease"},{"id":"642","span":{"begin":111,"end":143},"obj":"Disease"},{"id":"643","span":{"begin":250,"end":272},"obj":"Disease"},{"id":"644","span":{"begin":329,"end":335},"obj":"Disease"},{"id":"645","span":{"begin":396,"end":408},"obj":"Disease"},{"id":"646","span":{"begin":421,"end":434},"obj":"Disease"},{"id":"647","span":{"begin":589,"end":624},"obj":"Disease"}],"attributes":[{"id":"A637","pred":"tao:has_database_id","subj":"637","obj":"Tax:9606"},{"id":"A638","pred":"tao:has_database_id","subj":"638","obj":"Tax:9606"},{"id":"A639","pred":"tao:has_database_id","subj":"639","obj":"Tax:9606"},{"id":"A640","pred":"tao:has_database_id","subj":"640","obj":"MESH:D013256"},{"id":"A641","pred":"tao:has_database_id","subj":"641","obj":"MESH:D055744"},{"id":"A642","pred":"tao:has_database_id","subj":"642","obj":"MESH:D055744"},{"id":"A643","pred":"tao:has_database_id","subj":"643","obj":"MESH:D055744"},{"id":"A644","pred":"tao:has_database_id","subj":"644","obj":"MESH:D003643"},{"id":"A645","pred":"tao:has_database_id","subj":"645","obj":"MESH:D012772"},{"id":"A646","pred":"tao:has_database_id","subj":"646","obj":"MESH:D001228"},{"id":"A647","pred":"tao:has_database_id","subj":"647","obj":"MESH:D012131"},{"subj":"637","pred":"source","obj":"LitCovid-PubTator"},{"subj":"638","pred":"source","obj":"LitCovid-PubTator"},{"subj":"639","pred":"source","obj":"LitCovid-PubTator"},{"subj":"640","pred":"source","obj":"LitCovid-PubTator"},{"subj":"641","pred":"source","obj":"LitCovid-PubTator"},{"subj":"642","pred":"source","obj":"LitCovid-PubTator"},{"subj":"643","pred":"source","obj":"LitCovid-PubTator"},{"subj":"644","pred":"source","obj":"LitCovid-PubTator"},{"subj":"645","pred":"source","obj":"LitCovid-PubTator"},{"subj":"646","pred":"source","obj":"LitCovid-PubTator"},{"subj":"647","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T246","span":{"begin":66,"end":88},"obj":"Disease"},{"id":"T247","span":{"begin":75,"end":88},"obj":"Disease"},{"id":"T248","span":{"begin":130,"end":143},"obj":"Disease"},{"id":"T249","span":{"begin":174,"end":178},"obj":"Disease"},{"id":"T250","span":{"begin":231,"end":235},"obj":"Disease"},{"id":"T251","span":{"begin":250,"end":272},"obj":"Disease"},{"id":"T252","span":{"begin":259,"end":272},"obj":"Disease"},{"id":"T253","span":{"begin":343,"end":347},"obj":"Disease"},{"id":"T254","span":{"begin":421,"end":434},"obj":"Disease"},{"id":"T255","span":{"begin":680,"end":684},"obj":"Disease"}],"attributes":[{"id":"A246","pred":"mondo_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/MONDO_0000240"},{"id":"A247","pred":"mondo_id","subj":"T247","obj":"http://purl.obolibrary.org/obo/MONDO_0005657"},{"id":"A248","pred":"mondo_id","subj":"T248","obj":"http://purl.obolibrary.org/obo/MONDO_0005657"},{"id":"A249","pred":"mondo_id","subj":"T249","obj":"http://purl.obolibrary.org/obo/MONDO_0007163"},{"id":"A250","pred":"mondo_id","subj":"T250","obj":"http://purl.obolibrary.org/obo/MONDO_0007163"},{"id":"A251","pred":"mondo_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/MONDO_0000240"},{"id":"A252","pred":"mondo_id","subj":"T252","obj":"http://purl.obolibrary.org/obo/MONDO_0005657"},{"id":"A253","pred":"mondo_id","subj":"T253","obj":"http://purl.obolibrary.org/obo/MONDO_0007163"},{"id":"A254","pred":"mondo_id","subj":"T254","obj":"http://purl.obolibrary.org/obo/MONDO_0005657"},{"id":"A255","pred":"mondo_id","subj":"T255","obj":"http://purl.obolibrary.org/obo/MONDO_0007163"},{"subj":"T246","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T247","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T248","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T249","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T250","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T251","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T252","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T253","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T254","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T255","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T246","span":{"begin":29,"end":33},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T247","span":{"begin":29,"end":33},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"}],"attributes":[{"subj":"T246","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T247","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T127","span":{"begin":285,"end":295},"obj":"Chemical"},{"id":"T128","span":{"begin":470,"end":480},"obj":"Chemical"},{"id":"T129","span":{"begin":728,"end":738},"obj":"Chemical"},{"id":"T130","span":{"begin":785,"end":792},"obj":"Chemical"}],"attributes":[{"id":"A127","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_35718"},{"id":"A128","pred":"chebi_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/CHEBI_35718"},{"id":"A129","pred":"chebi_id","subj":"T129","obj":"http://purl.obolibrary.org/obo/CHEBI_35718"},{"id":"A130","pred":"chebi_id","subj":"T130","obj":"http://purl.obolibrary.org/obo/CHEBI_35341"},{"subj":"T127","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T128","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T129","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T130","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T68","span":{"begin":111,"end":143},"obj":"Phenotype"},{"id":"T69","span":{"begin":403,"end":408},"obj":"Phenotype"}],"attributes":[{"id":"A68","pred":"hp_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/HP_0020103"},{"id":"A69","pred":"hp_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/HP_0031273"},{"subj":"T68","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T69","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T222","span":{"begin":0,"end":89},"obj":"Sentence"},{"id":"T223","span":{"begin":90,"end":304},"obj":"Sentence"},{"id":"T224","span":{"begin":305,"end":435},"obj":"Sentence"},{"id":"T225","span":{"begin":436,"end":643},"obj":"Sentence"},{"id":"T226","span":{"begin":644,"end":813},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T222","pred":"source","obj":"LitCovid-sentences"},{"subj":"T223","pred":"source","obj":"LitCovid-sentences"},{"subj":"T224","pred":"source","obj":"LitCovid-sentences"},{"subj":"T225","pred":"source","obj":"LitCovid-sentences"},{"subj":"T226","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T422","span":{"begin":29,"end":33},"obj":"UBERON:0002048"},{"id":"T423","span":{"begin":120,"end":129},"obj":"UBERON:0002048"},{"id":"T424","span":{"begin":329,"end":335},"obj":"GO:0016265"},{"id":"T425","span":{"begin":386,"end":395},"obj":"NCBITaxon:2"},{"id":"T426","span":{"begin":589,"end":600},"obj":"UBERON:0001004"},{"id":"T427","span":{"begin":785,"end":792},"obj":"CHEBI:35341;CHEBI:35341"},{"id":"T45354","span":{"begin":29,"end":33},"obj":"UBERON:0002048"},{"id":"T56788","span":{"begin":120,"end":129},"obj":"UBERON:0002048"},{"id":"T54417","span":{"begin":329,"end":335},"obj":"GO:0016265"},{"id":"T81328","span":{"begin":386,"end":395},"obj":"NCBITaxon:2"},{"id":"T86074","span":{"begin":589,"end":600},"obj":"UBERON:0001004"},{"id":"T651","span":{"begin":785,"end":792},"obj":"CHEBI:35341;CHEBI:35341"}],"attributes":[{"subj":"T422","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T423","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T424","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T425","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T426","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T427","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T45354","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T56788","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T54417","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T81328","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T86074","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T651","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#a2ec93","default":true},{"id":"LitCovid-PD-UBERON","color":"#ec93bc"},{"id":"LitCovid-PubTator","color":"#93d6ec"},{"id":"LitCovid-PD-MONDO","color":"#ece793"},{"id":"LitCovid-PD-CLO","color":"#cd93ec"},{"id":"LitCovid-PD-CHEBI","color":"#93ecb3"},{"id":"LitCovid-PD-HP","color":"#ec9993"},{"id":"LitCovid-sentences","color":"#93a6ec"},{"id":"LitCovid-PMC-OGER-BB","color":"#c0ec93"}]}]}}