PMC:7340597 / 22036-23234 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T124","span":{"begin":648,"end":652},"obj":"Body_part"}],"attributes":[{"id":"A124","pred":"fma_id","subj":"T124","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":"Most plausible explanation for the more common pattern of OP in our study population when compared to previous mentioned studies is the difference in length of hospital and ICU stay correlating with more advanced disease and longer treatment with mechanical ventilation. In the studies mentioned above the mean hospital stay was six days or less and most of the patients did not receive mechanical ventilatory support. In our present series mean hospital stay of 22 days is significant longer and all patients died in the ICU with a mean of 20 days on mechanical ventilation. Secondary OP can be seen in association with many types of non-specific lung injury, including viral infections and drug reactions. OP is reported following severe influenza infections [[20], [21], [22], [23], [24]] and Middle East Respiratory Syndrome [25]. Most recently, Copin et al. reported postmortem biopsies on six patients with COVID and reported in five patients with phenotype H and AFOP histology in contrast to their patient with DAD [26]. Estimated elapsed disease time in the AFOP group was 20 days versus 6 days in the DAD patients. In our opinion this supports the theory that pathology changes over time."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T76","span":{"begin":648,"end":652},"obj":"Body_part"}],"attributes":[{"id":"A76","pred":"uberon_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"Most plausible explanation for the more common pattern of OP in our study population when compared to previous mentioned studies is the difference in length of hospital and ICU stay correlating with more advanced disease and longer treatment with mechanical ventilation. In the studies mentioned above the mean hospital stay was six days or less and most of the patients did not receive mechanical ventilatory support. In our present series mean hospital stay of 22 days is significant longer and all patients died in the ICU with a mean of 20 days on mechanical ventilation. Secondary OP can be seen in association with many types of non-specific lung injury, including viral infections and drug reactions. OP is reported following severe influenza infections [[20], [21], [22], [23], [24]] and Middle East Respiratory Syndrome [25]. Most recently, Copin et al. reported postmortem biopsies on six patients with COVID and reported in five patients with phenotype H and AFOP histology in contrast to their patient with DAD [26]. Estimated elapsed disease time in the AFOP group was 20 days versus 6 days in the DAD patients. In our opinion this supports the theory that pathology changes over time."}

{"project":"LitCovid-PubTator","denotations":[{"id":"508","span":{"begin":362,"end":370},"obj":"Species"},{"id":"509","span":{"begin":501,"end":509},"obj":"Species"},{"id":"510","span":{"begin":899,"end":907},"obj":"Species"},{"id":"511","span":{"begin":940,"end":948},"obj":"Species"},{"id":"512","span":{"begin":1006,"end":1013},"obj":"Species"},{"id":"513","span":{"begin":1115,"end":1123},"obj":"Species"},{"id":"514","span":{"begin":510,"end":514},"obj":"Disease"},{"id":"515","span":{"begin":648,"end":659},"obj":"Disease"},{"id":"516","span":{"begin":671,"end":687},"obj":"Disease"},{"id":"517","span":{"begin":750,"end":760},"obj":"Disease"},{"id":"518","span":{"begin":796,"end":828},"obj":"Disease"},{"id":"519","span":{"begin":913,"end":918},"obj":"Disease"}],"attributes":[{"id":"A508","pred":"tao:has_database_id","subj":"508","obj":"Tax:9606"},{"id":"A509","pred":"tao:has_database_id","subj":"509","obj":"Tax:9606"},{"id":"A510","pred":"tao:has_database_id","subj":"510","obj":"Tax:9606"},{"id":"A511","pred":"tao:has_database_id","subj":"511","obj":"Tax:9606"},{"id":"A512","pred":"tao:has_database_id","subj":"512","obj":"Tax:9606"},{"id":"A513","pred":"tao:has_database_id","subj":"513","obj":"Tax:9606"},{"id":"A514","pred":"tao:has_database_id","subj":"514","obj":"MESH:D003643"},{"id":"A515","pred":"tao:has_database_id","subj":"515","obj":"MESH:D055370"},{"id":"A516","pred":"tao:has_database_id","subj":"516","obj":"MESH:D001102"},{"id":"A517","pred":"tao:has_database_id","subj":"517","obj":"MESH:D007239"},{"id":"A518","pred":"tao:has_database_id","subj":"518","obj":"MESH:D018352"},{"id":"A519","pred":"tao:has_database_id","subj":"519","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Most plausible explanation for the more common pattern of OP in our study population when compared to previous mentioned studies is the difference in length of hospital and ICU stay correlating with more advanced disease and longer treatment with mechanical ventilation. In the studies mentioned above the mean hospital stay was six days or less and most of the patients did not receive mechanical ventilatory support. In our present series mean hospital stay of 22 days is significant longer and all patients died in the ICU with a mean of 20 days on mechanical ventilation. Secondary OP can be seen in association with many types of non-specific lung injury, including viral infections and drug reactions. OP is reported following severe influenza infections [[20], [21], [22], [23], [24]] and Middle East Respiratory Syndrome [25]. Most recently, Copin et al. reported postmortem biopsies on six patients with COVID and reported in five patients with phenotype H and AFOP histology in contrast to their patient with DAD [26]. Estimated elapsed disease time in the AFOP group was 20 days versus 6 days in the DAD patients. In our opinion this supports the theory that pathology changes over time."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T187","span":{"begin":58,"end":60},"obj":"Disease"},{"id":"T188","span":{"begin":586,"end":588},"obj":"Disease"},{"id":"T189","span":{"begin":653,"end":659},"obj":"Disease"},{"id":"T190","span":{"begin":671,"end":687},"obj":"Disease"},{"id":"T191","span":{"begin":708,"end":710},"obj":"Disease"},{"id":"T192","span":{"begin":740,"end":749},"obj":"Disease"},{"id":"T193","span":{"begin":750,"end":760},"obj":"Disease"}],"attributes":[{"id":"A187","pred":"mondo_id","subj":"T187","obj":"http://purl.obolibrary.org/obo/MONDO_0015265"},{"id":"A188","pred":"mondo_id","subj":"T188","obj":"http://purl.obolibrary.org/obo/MONDO_0015265"},{"id":"A189","pred":"mondo_id","subj":"T189","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A190","pred":"mondo_id","subj":"T190","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A191","pred":"mondo_id","subj":"T191","obj":"http://purl.obolibrary.org/obo/MONDO_0015265"},{"id":"A192","pred":"mondo_id","subj":"T192","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A193","pred":"mondo_id","subj":"T193","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Most plausible explanation for the more common pattern of OP in our study population when compared to previous mentioned studies is the difference in length of hospital and ICU stay correlating with more advanced disease and longer treatment with mechanical ventilation. In the studies mentioned above the mean hospital stay was six days or less and most of the patients did not receive mechanical ventilatory support. In our present series mean hospital stay of 22 days is significant longer and all patients died in the ICU with a mean of 20 days on mechanical ventilation. Secondary OP can be seen in association with many types of non-specific lung injury, including viral infections and drug reactions. OP is reported following severe influenza infections [[20], [21], [22], [23], [24]] and Middle East Respiratory Syndrome [25]. Most recently, Copin et al. reported postmortem biopsies on six patients with COVID and reported in five patients with phenotype H and AFOP histology in contrast to their patient with DAD [26]. Estimated elapsed disease time in the AFOP group was 20 days versus 6 days in the DAD patients. In our opinion this supports the theory that pathology changes over time."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T198","span":{"begin":463,"end":465},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T199","span":{"begin":531,"end":532},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T200","span":{"begin":648,"end":652},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T201","span":{"begin":648,"end":652},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T202","span":{"begin":775,"end":777},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"}],"text":"Most plausible explanation for the more common pattern of OP in our study population when compared to previous mentioned studies is the difference in length of hospital and ICU stay correlating with more advanced disease and longer treatment with mechanical ventilation. In the studies mentioned above the mean hospital stay was six days or less and most of the patients did not receive mechanical ventilatory support. In our present series mean hospital stay of 22 days is significant longer and all patients died in the ICU with a mean of 20 days on mechanical ventilation. Secondary OP can be seen in association with many types of non-specific lung injury, including viral infections and drug reactions. OP is reported following severe influenza infections [[20], [21], [22], [23], [24]] and Middle East Respiratory Syndrome [25]. Most recently, Copin et al. reported postmortem biopsies on six patients with COVID and reported in five patients with phenotype H and AFOP histology in contrast to their patient with DAD [26]. Estimated elapsed disease time in the AFOP group was 20 days versus 6 days in the DAD patients. In our opinion this supports the theory that pathology changes over time."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T110","span":{"begin":692,"end":696},"obj":"Chemical"},{"id":"T111","span":{"begin":1072,"end":1077},"obj":"Chemical"}],"attributes":[{"id":"A110","pred":"chebi_id","subj":"T110","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A111","pred":"chebi_id","subj":"T111","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"}],"text":"Most plausible explanation for the more common pattern of OP in our study population when compared to previous mentioned studies is the difference in length of hospital and ICU stay correlating with more advanced disease and longer treatment with mechanical ventilation. In the studies mentioned above the mean hospital stay was six days or less and most of the patients did not receive mechanical ventilatory support. In our present series mean hospital stay of 22 days is significant longer and all patients died in the ICU with a mean of 20 days on mechanical ventilation. Secondary OP can be seen in association with many types of non-specific lung injury, including viral infections and drug reactions. OP is reported following severe influenza infections [[20], [21], [22], [23], [24]] and Middle East Respiratory Syndrome [25]. Most recently, Copin et al. reported postmortem biopsies on six patients with COVID and reported in five patients with phenotype H and AFOP histology in contrast to their patient with DAD [26]. Estimated elapsed disease time in the AFOP group was 20 days versus 6 days in the DAD patients. In our opinion this supports the theory that pathology changes over time."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T5","span":{"begin":671,"end":687},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"Most plausible explanation for the more common pattern of OP in our study population when compared to previous mentioned studies is the difference in length of hospital and ICU stay correlating with more advanced disease and longer treatment with mechanical ventilation. In the studies mentioned above the mean hospital stay was six days or less and most of the patients did not receive mechanical ventilatory support. In our present series mean hospital stay of 22 days is significant longer and all patients died in the ICU with a mean of 20 days on mechanical ventilation. Secondary OP can be seen in association with many types of non-specific lung injury, including viral infections and drug reactions. OP is reported following severe influenza infections [[20], [21], [22], [23], [24]] and Middle East Respiratory Syndrome [25]. Most recently, Copin et al. reported postmortem biopsies on six patients with COVID and reported in five patients with phenotype H and AFOP histology in contrast to their patient with DAD [26]. Estimated elapsed disease time in the AFOP group was 20 days versus 6 days in the DAD patients. In our opinion this supports the theory that pathology changes over time."}

{"project":"LitCovid-sentences","denotations":[{"id":"T188","span":{"begin":0,"end":270},"obj":"Sentence"},{"id":"T189","span":{"begin":271,"end":418},"obj":"Sentence"},{"id":"T190","span":{"begin":419,"end":575},"obj":"Sentence"},{"id":"T191","span":{"begin":576,"end":707},"obj":"Sentence"},{"id":"T192","span":{"begin":708,"end":834},"obj":"Sentence"},{"id":"T193","span":{"begin":835,"end":1028},"obj":"Sentence"},{"id":"T194","span":{"begin":1029,"end":1124},"obj":"Sentence"},{"id":"T195","span":{"begin":1125,"end":1198},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Most plausible explanation for the more common pattern of OP in our study population when compared to previous mentioned studies is the difference in length of hospital and ICU stay correlating with more advanced disease and longer treatment with mechanical ventilation. In the studies mentioned above the mean hospital stay was six days or less and most of the patients did not receive mechanical ventilatory support. In our present series mean hospital stay of 22 days is significant longer and all patients died in the ICU with a mean of 20 days on mechanical ventilation. Secondary OP can be seen in association with many types of non-specific lung injury, including viral infections and drug reactions. OP is reported following severe influenza infections [[20], [21], [22], [23], [24]] and Middle East Respiratory Syndrome [25]. Most recently, Copin et al. reported postmortem biopsies on six patients with COVID and reported in five patients with phenotype H and AFOP histology in contrast to their patient with DAD [26]. Estimated elapsed disease time in the AFOP group was 20 days versus 6 days in the DAD patients. In our opinion this supports the theory that pathology changes over time."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T354","span":{"begin":510,"end":514},"obj":"GO:0016265"},{"id":"T355","span":{"begin":648,"end":652},"obj":"UBERON:0002048"},{"id":"T356","span":{"begin":671,"end":676},"obj":"NCBITaxon:10239"},{"id":"T357","span":{"begin":692,"end":696},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T358","span":{"begin":872,"end":882},"obj":"GO:0016265"},{"id":"T8625","span":{"begin":510,"end":514},"obj":"GO:0016265"},{"id":"T78237","span":{"begin":648,"end":652},"obj":"UBERON:0002048"},{"id":"T1261","span":{"begin":671,"end":676},"obj":"NCBITaxon:10239"},{"id":"T15029","span":{"begin":692,"end":696},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T10447","span":{"begin":872,"end":882},"obj":"GO:0016265"}],"text":"Most plausible explanation for the more common pattern of OP in our study population when compared to previous mentioned studies is the difference in length of hospital and ICU stay correlating with more advanced disease and longer treatment with mechanical ventilation. In the studies mentioned above the mean hospital stay was six days or less and most of the patients did not receive mechanical ventilatory support. In our present series mean hospital stay of 22 days is significant longer and all patients died in the ICU with a mean of 20 days on mechanical ventilation. Secondary OP can be seen in association with many types of non-specific lung injury, including viral infections and drug reactions. OP is reported following severe influenza infections [[20], [21], [22], [23], [24]] and Middle East Respiratory Syndrome [25]. Most recently, Copin et al. reported postmortem biopsies on six patients with COVID and reported in five patients with phenotype H and AFOP histology in contrast to their patient with DAD [26]. Estimated elapsed disease time in the AFOP group was 20 days versus 6 days in the DAD patients. In our opinion this supports the theory that pathology changes over time."}

{"project":"2_test","denotations":[{"id":"32674001-21178022-58631473","span":{"begin":775,"end":777},"obj":"21178022"},{"id":"32674001-27867585-58631474","span":{"begin":830,"end":832},"obj":"27867585"}],"text":"Most plausible explanation for the more common pattern of OP in our study population when compared to previous mentioned studies is the difference in length of hospital and ICU stay correlating with more advanced disease and longer treatment with mechanical ventilation. In the studies mentioned above the mean hospital stay was six days or less and most of the patients did not receive mechanical ventilatory support. In our present series mean hospital stay of 22 days is significant longer and all patients died in the ICU with a mean of 20 days on mechanical ventilation. Secondary OP can be seen in association with many types of non-specific lung injury, including viral infections and drug reactions. OP is reported following severe influenza infections [[20], [21], [22], [23], [24]] and Middle East Respiratory Syndrome [25]. Most recently, Copin et al. reported postmortem biopsies on six patients with COVID and reported in five patients with phenotype H and AFOP histology in contrast to their patient with DAD [26]. Estimated elapsed disease time in the AFOP group was 20 days versus 6 days in the DAD patients. In our opinion this supports the theory that pathology changes over time."}