PMC:7340249 / 4046-5947 JSONTXT

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Attention to donor epidemiological risk factors may help to weaken the risk of donor transmitted infection.2\nIn donors not known to have COVID-19 (asymptomatic AND no history of close contact with a diagnosed case of COVID-19), we recommend to sustain good hygiene and avoid crowded residences for at least 28 days before donation, and we would test for COVID-19 by RT-PCR one day before the initiation of conditioning regimen in the recipient.\nIn donors suspected to have COVID-19 (symptomatic OR history of close contact with a diagnosed case of COVID-19), we would check for COVID-19 test by RT-PCR and chest CT scan.\nIn donors with a history of close contact with a diagnosed case of COVID-19, if the RT-PCR test for COVID-19 is negative and the chest CT scan is normal, the donor would be considered eligible for the donation if 14 days have passed from the mentioned last contact and one negative RT-PCR test obtained before starting conditioning regimen.\nIf the RT-PCR test for COVID-19 is positive OR the chest CT scan is suspicious of COVID-19, the donor would be considered ineligible to donate for at least three months after the complete resolution of symptoms.\nIf HSCT is urgent and there are no suitable alternative donors available, re-consider the donor’s eligibility; if at least 28 days have passed from the complete resolution of symptoms AND there is no history of severe respiratory disease, and one negative RT-PCR test could be obtained before starting conditioning regimen, the donor would be considered eligible for donation.\nAs harvesting stem cells from bone marrow requires anaesthesia and referring the donor to the general operation room, in which the donor may be exposed to COVID-19, we prefer to choose peripheral blood as the source of stem cells, for the time 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