PMC:7335653 / 53-1785
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T1 | 538-551 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
| T2 | 648-653 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T3 | 663-672 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T4 | 674-685 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T5 | 687-698 | Body_part | denotes | eosinophils | http://purl.org/sig/ont/fma/fma62861 |
| T6 | 700-711 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
| T7 | 717-728 | Body_part | denotes | lymphocytes | http://purl.org/sig/ont/fma/fma62863 |
| T8 | 762-771 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T9 | 801-805 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T10 | 898-902 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T11 | 1126-1131 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T12 | 1176-1183 | Body_part | denotes | hormone | http://purl.org/sig/ont/fma/fma12278 |
| T13 | 1357-1366 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T14 | 1376-1380 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 538-551 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
| T2 | 898-902 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T6 | 130-138 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T7 | 175-203 | Disease | denotes | Hypersensitivity Pneumonitis | http://purl.obolibrary.org/obo/MONDO_0004553|http://purl.obolibrary.org/obo/MONDO_0017853 |
| T9 | 175-191 | Disease | denotes | Hypersensitivity | http://purl.obolibrary.org/obo/MONDO_0000605|http://purl.obolibrary.org/obo/MONDO_0005271 |
| T11 | 297-303 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
| T12 | 309-317 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T13 | 338-363 | Disease | denotes | hypersensitivity reaction | http://purl.obolibrary.org/obo/MONDO_0000605 |
| T14 | 338-354 | Disease | denotes | hypersensitivity | http://purl.obolibrary.org/obo/MONDO_0005271 |
| T15 | 367-375 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T16 | 378-387 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T17 | 784-796 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T18 | 823-835 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T19 | 1052-1060 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T20 | 1066-1094 | Disease | denotes | hypersensitivity pneumonitis | http://purl.obolibrary.org/obo/MONDO_0004553|http://purl.obolibrary.org/obo/MONDO_0017853 |
| T22 | 1066-1082 | Disease | denotes | hypersensitivity | http://purl.obolibrary.org/obo/MONDO_0000605|http://purl.obolibrary.org/obo/MONDO_0005271 |
| T24 | 1083-1094 | Disease | denotes | pneumonitis | http://purl.obolibrary.org/obo/MONDO_0043905 |
| T25 | 1096-1098 | Disease | denotes | HP | http://purl.obolibrary.org/obo/MONDO_0004553 |
| T26 | 1304-1306 | Disease | denotes | HP | http://purl.obolibrary.org/obo/MONDO_0004553 |
| T27 | 1495-1511 | Disease | denotes | hypersensitivity | http://purl.obolibrary.org/obo/MONDO_0000605|http://purl.obolibrary.org/obo/MONDO_0005271 |
| T29 | 1617-1626 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2 | 140-141 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T3 | 336-337 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T4 | 538-551 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
| T5 | 607-608 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T6 | 636-641 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T7 | 648-653 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T8 | 663-672 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T9 | 801-805 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T10 | 880-885 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T11 | 898-902 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T12 | 898-902 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T13 | 1064-1065 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T14 | 1096-1098 | http://purl.obolibrary.org/obo/CLO_0003797 | denotes | HP |
| T15 | 1096-1098 | http://purl.obolibrary.org/obo/PR_000008725 | denotes | HP |
| T16 | 1120-1131 | http://purl.obolibrary.org/obo/CLO_0053065 | denotes | human cells |
| T17 | 1257-1260 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T18 | 1304-1306 | http://purl.obolibrary.org/obo/CLO_0003797 | denotes | HP |
| T19 | 1304-1306 | http://purl.obolibrary.org/obo/PR_000008725 | denotes | HP |
| T20 | 1311-1312 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T21 | 1417-1419 | http://purl.obolibrary.org/obo/CLO_0001302 | denotes | 34 |
| T22 | 1713-1714 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1 | 226-234 | Chemical | denotes | steroids | http://purl.obolibrary.org/obo/CHEBI_35341 |
| T2 | 953-965 | Chemical | denotes | prednisolone | http://purl.obolibrary.org/obo/CHEBI_8378 |
| T3 | 967-969 | Chemical | denotes | PD | http://purl.obolibrary.org/obo/CHEBI_74756|http://purl.obolibrary.org/obo/CHEBI_8378 |
| T5 | 1096-1098 | Chemical | denotes | HP | http://purl.obolibrary.org/obo/CHEBI_74055 |
| T6 | 1176-1183 | Chemical | denotes | hormone | http://purl.obolibrary.org/obo/CHEBI_24621 |
| T7 | 1184-1198 | Chemical | denotes | glucocorticoid | http://purl.obolibrary.org/obo/CHEBI_24261 |
| T8 | 1254-1256 | Chemical | denotes | PD | http://purl.obolibrary.org/obo/CHEBI_74756|http://purl.obolibrary.org/obo/CHEBI_8378 |
| T10 | 1295-1299 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T11 | 1304-1306 | Chemical | denotes | HP | http://purl.obolibrary.org/obo/CHEBI_74055 |
| T12 | 1376-1378 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T14 | 1382-1384 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T16 | 1406-1415 | Chemical | denotes | biomarker | http://purl.obolibrary.org/obo/CHEBI_59163 |
| T17 | 1451-1453 | Chemical | denotes | PD | http://purl.obolibrary.org/obo/CHEBI_74756|http://purl.obolibrary.org/obo/CHEBI_8378 |
| T19 | 1543-1561 | Chemical | denotes | methylprednisolone | http://purl.obolibrary.org/obo/CHEBI_6888 |
| T20 | 1575-1577 | Chemical | denotes | PD | http://purl.obolibrary.org/obo/CHEBI_74756|http://purl.obolibrary.org/obo/CHEBI_8378 |
| T22 | 1729-1731 | Chemical | denotes | PD | http://purl.obolibrary.org/obo/CHEBI_74756|http://purl.obolibrary.org/obo/CHEBI_8378 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2 | 175-191 | http://purl.obolibrary.org/obo/GO_0002524 | denotes | Hypersensitivity |
| T3 | 338-354 | http://purl.obolibrary.org/obo/GO_0002524 | denotes | hypersensitivity |
| T4 | 784-796 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T5 | 801-811 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | cell death |
| T6 | 823-835 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T7 | 1066-1082 | http://purl.obolibrary.org/obo/GO_0002524 | denotes | hypersensitivity |
| T8 | 1105-1116 | http://purl.obolibrary.org/obo/GO_0042592 | denotes | Homeostasis |
| T9 | 1152-1161 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T10 | 1495-1511 | http://purl.obolibrary.org/obo/GO_0002524 | denotes | hypersensitivity |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T2 | 175-203 | Phenotype | denotes | Hypersensitivity Pneumonitis | http://purl.obolibrary.org/obo/HP_0006516 |
| T3 | 297-303 | Phenotype | denotes | asthma | http://purl.obolibrary.org/obo/HP_0002099 |
| T4 | 338-354 | Phenotype | denotes | hypersensitivity | http://purl.obolibrary.org/obo/HP_0041092 |
| T5 | 1066-1094 | Phenotype | denotes | hypersensitivity pneumonitis | http://purl.obolibrary.org/obo/HP_0006516 |
| T6 | 1096-1098 | Phenotype | denotes | HP | http://purl.obolibrary.org/obo/HP_0006516 |
| T7 | 1304-1306 | Phenotype | denotes | HP | http://purl.obolibrary.org/obo/HP_0006516 |
| T8 | 1495-1511 | Phenotype | denotes | hypersensitivity | http://purl.obolibrary.org/obo/HP_0041092 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2 | 0-13 | Sentence | denotes | Dear Editors: |
| T3 | 14-139 | Sentence | denotes | I appreciate your interest in our study, and would like to share clinical experiences regarding the article titled “COVID-19: |
| T4 | 140-308 | Sentence | denotes | A Clinical Syndrome Manifesting as Hypersensitivity Pneumonitis,” in which the use of steroids was demonstrated to not be efficacious, albeit the underlying asthma [1]. |
| T5 | 309-388 | Sentence | denotes | COVID-19 can be defined as a hypersensitivity reaction by SARS-CoV-2 infection. |
| T6 | 389-480 | Sentence | denotes | Its exact pathophysiology may be unraveled in future through extensive scientific evidence. |
| T7 | 481-642 | Sentence | denotes | Its clinical manifestations are greatly diverse, and the immune system (including innate and adaptive immunity) seems to play a major role in clearing the virus. |
| T8 | 643-812 | Sentence | denotes | Many cells, such as monocytes, macrophages, eosinophils, neutrophils, and lymphocytes might contribute to the surge of cytokines that induce inflammation and cell death. |
| T9 | 813-915 | Sentence | denotes | Excessive inflammation can promote the extracellular spread of the virus and lead to lung destruction. |
| T10 | 916-1104 | Sentence | denotes | We have suggested in our report that prednisolone (PD) could be important for treatment of this condition; based on the hypothesis that COVID-19 is a hypersensitivity pneumonitis (HP) [2]. |
| T11 | 1105-1253 | Sentence | denotes | Homeostasis of human cells is regulated by the secretion of the stress hormone glucocorticoid, to varying degrees, under different external stimuli. |
| T12 | 1254-1323 | Sentence | denotes | PD has been the most effective and safer drug for HP for a long time. |
| T13 | 1324-1421 | Sentence | denotes | It can strongly suppress several cytokines, such as IL-1, IL-6, TNF-α, and type-2 biomarker [34]. |
| T14 | 1422-1566 | Sentence | denotes | Further, the short course of PD does not lower the overall immunity, and hypersensitivity reactions are less common than methylprednisolone [5]. |
| T15 | 1567-1732 | Sentence | denotes | If oral PD is administered at an earlier stage of infection, fewer side effects will develop, since the inflammatory cascade might be overcome at a lower dose of PD. |