PMC:7335653
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T1 | 591-604 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
| T2 | 701-706 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T3 | 716-725 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T4 | 727-738 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T5 | 740-751 | Body_part | denotes | eosinophils | http://purl.org/sig/ont/fma/fma62861 |
| T6 | 753-764 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
| T7 | 770-781 | Body_part | denotes | lymphocytes | http://purl.org/sig/ont/fma/fma62863 |
| T8 | 815-824 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T9 | 854-858 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T10 | 951-955 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T11 | 1179-1184 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T12 | 1229-1236 | Body_part | denotes | hormone | http://purl.org/sig/ont/fma/fma12278 |
| T13 | 1410-1419 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T14 | 1429-1433 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 591-604 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
| T2 | 951-955 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 7-15 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T2 | 23-51 | Disease | denotes | Hypersensitivity Pneumonitis | http://purl.obolibrary.org/obo/MONDO_0004553|http://purl.obolibrary.org/obo/MONDO_0017853 |
| T4 | 23-39 | Disease | denotes | Hypersensitivity | http://purl.obolibrary.org/obo/MONDO_0000605|http://purl.obolibrary.org/obo/MONDO_0005271 |
| T6 | 183-191 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T7 | 228-256 | Disease | denotes | Hypersensitivity Pneumonitis | http://purl.obolibrary.org/obo/MONDO_0004553|http://purl.obolibrary.org/obo/MONDO_0017853 |
| T9 | 228-244 | Disease | denotes | Hypersensitivity | http://purl.obolibrary.org/obo/MONDO_0000605|http://purl.obolibrary.org/obo/MONDO_0005271 |
| T11 | 350-356 | Disease | denotes | asthma | http://purl.obolibrary.org/obo/MONDO_0004979 |
| T12 | 362-370 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T13 | 391-416 | Disease | denotes | hypersensitivity reaction | http://purl.obolibrary.org/obo/MONDO_0000605 |
| T14 | 391-407 | Disease | denotes | hypersensitivity | http://purl.obolibrary.org/obo/MONDO_0005271 |
| T15 | 420-428 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T16 | 431-440 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T17 | 837-849 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T18 | 876-888 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T19 | 1105-1113 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T20 | 1119-1147 | Disease | denotes | hypersensitivity pneumonitis | http://purl.obolibrary.org/obo/MONDO_0004553|http://purl.obolibrary.org/obo/MONDO_0017853 |
| T22 | 1119-1135 | Disease | denotes | hypersensitivity | http://purl.obolibrary.org/obo/MONDO_0000605|http://purl.obolibrary.org/obo/MONDO_0005271 |
| T24 | 1136-1147 | Disease | denotes | pneumonitis | http://purl.obolibrary.org/obo/MONDO_0043905 |
| T25 | 1149-1151 | Disease | denotes | HP | http://purl.obolibrary.org/obo/MONDO_0004553 |
| T26 | 1357-1359 | Disease | denotes | HP | http://purl.obolibrary.org/obo/MONDO_0004553 |
| T27 | 1548-1564 | Disease | denotes | hypersensitivity | http://purl.obolibrary.org/obo/MONDO_0000605|http://purl.obolibrary.org/obo/MONDO_0005271 |
| T29 | 1670-1679 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 17-18 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T2 | 193-194 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T3 | 389-390 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T4 | 591-604 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
| T5 | 660-661 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T6 | 689-694 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T7 | 701-706 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T8 | 716-725 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T9 | 854-858 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T10 | 933-938 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T11 | 951-955 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T12 | 951-955 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T13 | 1117-1118 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T14 | 1149-1151 | http://purl.obolibrary.org/obo/CLO_0003797 | denotes | HP |
| T15 | 1149-1151 | http://purl.obolibrary.org/obo/PR_000008725 | denotes | HP |
| T16 | 1173-1184 | http://purl.obolibrary.org/obo/CLO_0053065 | denotes | human cells |
| T17 | 1310-1313 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T18 | 1357-1359 | http://purl.obolibrary.org/obo/CLO_0003797 | denotes | HP |
| T19 | 1357-1359 | http://purl.obolibrary.org/obo/PR_000008725 | denotes | HP |
| T20 | 1364-1365 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T21 | 1470-1472 | http://purl.obolibrary.org/obo/CLO_0001302 | denotes | 34 |
| T22 | 1766-1767 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1 | 279-287 | Chemical | denotes | steroids | http://purl.obolibrary.org/obo/CHEBI_35341 |
| T2 | 1006-1018 | Chemical | denotes | prednisolone | http://purl.obolibrary.org/obo/CHEBI_8378 |
| T3 | 1020-1022 | Chemical | denotes | PD | http://purl.obolibrary.org/obo/CHEBI_74756|http://purl.obolibrary.org/obo/CHEBI_8378 |
| T5 | 1149-1151 | Chemical | denotes | HP | http://purl.obolibrary.org/obo/CHEBI_74055 |
| T6 | 1229-1236 | Chemical | denotes | hormone | http://purl.obolibrary.org/obo/CHEBI_24621 |
| T7 | 1237-1251 | Chemical | denotes | glucocorticoid | http://purl.obolibrary.org/obo/CHEBI_24261 |
| T8 | 1307-1309 | Chemical | denotes | PD | http://purl.obolibrary.org/obo/CHEBI_74756|http://purl.obolibrary.org/obo/CHEBI_8378 |
| T10 | 1348-1352 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T11 | 1357-1359 | Chemical | denotes | HP | http://purl.obolibrary.org/obo/CHEBI_74055 |
| T12 | 1429-1431 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T14 | 1435-1437 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T16 | 1459-1468 | Chemical | denotes | biomarker | http://purl.obolibrary.org/obo/CHEBI_59163 |
| T17 | 1504-1506 | Chemical | denotes | PD | http://purl.obolibrary.org/obo/CHEBI_74756|http://purl.obolibrary.org/obo/CHEBI_8378 |
| T19 | 1596-1614 | Chemical | denotes | methylprednisolone | http://purl.obolibrary.org/obo/CHEBI_6888 |
| T20 | 1628-1630 | Chemical | denotes | PD | http://purl.obolibrary.org/obo/CHEBI_74756|http://purl.obolibrary.org/obo/CHEBI_8378 |
| T22 | 1782-1784 | Chemical | denotes | PD | http://purl.obolibrary.org/obo/CHEBI_74756|http://purl.obolibrary.org/obo/CHEBI_8378 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 23-39 | http://purl.obolibrary.org/obo/GO_0002524 | denotes | Hypersensitivity |
| T2 | 228-244 | http://purl.obolibrary.org/obo/GO_0002524 | denotes | Hypersensitivity |
| T3 | 391-407 | http://purl.obolibrary.org/obo/GO_0002524 | denotes | hypersensitivity |
| T4 | 837-849 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T5 | 854-864 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | cell death |
| T6 | 876-888 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T7 | 1119-1135 | http://purl.obolibrary.org/obo/GO_0002524 | denotes | hypersensitivity |
| T8 | 1158-1169 | http://purl.obolibrary.org/obo/GO_0042592 | denotes | Homeostasis |
| T9 | 1205-1214 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T10 | 1548-1564 | http://purl.obolibrary.org/obo/GO_0002524 | denotes | hypersensitivity |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 23-51 | Phenotype | denotes | Hypersensitivity Pneumonitis | http://purl.obolibrary.org/obo/HP_0006516 |
| T2 | 228-256 | Phenotype | denotes | Hypersensitivity Pneumonitis | http://purl.obolibrary.org/obo/HP_0006516 |
| T3 | 350-356 | Phenotype | denotes | asthma | http://purl.obolibrary.org/obo/HP_0002099 |
| T4 | 391-407 | Phenotype | denotes | hypersensitivity | http://purl.obolibrary.org/obo/HP_0041092 |
| T5 | 1119-1147 | Phenotype | denotes | hypersensitivity pneumonitis | http://purl.obolibrary.org/obo/HP_0006516 |
| T6 | 1149-1151 | Phenotype | denotes | HP | http://purl.obolibrary.org/obo/HP_0006516 |
| T7 | 1357-1359 | Phenotype | denotes | HP | http://purl.obolibrary.org/obo/HP_0006516 |
| T8 | 1548-1564 | Phenotype | denotes | hypersensitivity | http://purl.obolibrary.org/obo/HP_0041092 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-51 | Sentence | denotes | Reply: COVID-19, A and Hypersensitivity Pneumonitis |
| T2 | 53-66 | Sentence | denotes | Dear Editors: |
| T3 | 67-192 | Sentence | denotes | I appreciate your interest in our study, and would like to share clinical experiences regarding the article titled “COVID-19: |
| T4 | 193-361 | Sentence | denotes | A Clinical Syndrome Manifesting as Hypersensitivity Pneumonitis,” in which the use of steroids was demonstrated to not be efficacious, albeit the underlying asthma [1]. |
| T5 | 362-441 | Sentence | denotes | COVID-19 can be defined as a hypersensitivity reaction by SARS-CoV-2 infection. |
| T6 | 442-533 | Sentence | denotes | Its exact pathophysiology may be unraveled in future through extensive scientific evidence. |
| T7 | 534-695 | Sentence | denotes | Its clinical manifestations are greatly diverse, and the immune system (including innate and adaptive immunity) seems to play a major role in clearing the virus. |
| T8 | 696-865 | Sentence | denotes | Many cells, such as monocytes, macrophages, eosinophils, neutrophils, and lymphocytes might contribute to the surge of cytokines that induce inflammation and cell death. |
| T9 | 866-968 | Sentence | denotes | Excessive inflammation can promote the extracellular spread of the virus and lead to lung destruction. |
| T10 | 969-1157 | Sentence | denotes | We have suggested in our report that prednisolone (PD) could be important for treatment of this condition; based on the hypothesis that COVID-19 is a hypersensitivity pneumonitis (HP) [2]. |
| T11 | 1158-1306 | Sentence | denotes | Homeostasis of human cells is regulated by the secretion of the stress hormone glucocorticoid, to varying degrees, under different external stimuli. |
| T12 | 1307-1376 | Sentence | denotes | PD has been the most effective and safer drug for HP for a long time. |
| T13 | 1377-1474 | Sentence | denotes | It can strongly suppress several cytokines, such as IL-1, IL-6, TNF-α, and type-2 biomarker [34]. |
| T14 | 1475-1619 | Sentence | denotes | Further, the short course of PD does not lower the overall immunity, and hypersensitivity reactions are less common than methylprednisolone [5]. |
| T15 | 1620-1785 | Sentence | denotes | If oral PD is administered at an earlier stage of infection, fewer side effects will develop, since the inflammatory cascade might be overcome at a lower dose of PD. |
| T16 | 1787-1808 | Sentence | denotes | Conflict of Interest: |
| T17 | 1809-1834 | Sentence | denotes | No conflicts of interest. |