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LitCovid_Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 2170-2177 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 635-641 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T2 1108-1113 Body_part denotes Organ http://purl.org/sig/ont/fma/fma67498
T3 1151-1158 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T4 2093-2098 Body_part denotes urine http://purl.org/sig/ont/fma/fma12274
T5 2170-2177 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1108-1113 Body_part denotes Organ http://purl.obolibrary.org/obo/UBERON_0000062
T2 2093-2098 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 43-51 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T2 478-489 Disease denotes common cold http://purl.obolibrary.org/obo/MONDO_0005709
T3 510-534 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T4 536-544 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 580-627 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T6 580-613 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T7 702-713 Disease denotes common cold http://purl.obolibrary.org/obo/MONDO_0005709
T8 840-865 Disease denotes acute respiratory failure http://purl.obolibrary.org/obo/MONDO_0001208|http://purl.obolibrary.org/obo/MONDO_0021113
T10 1997-2005 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T11 2205-2209 Disease denotes G6PD http://purl.obolibrary.org/obo/MONDO_0005775
T12 2225-2242 Disease denotes genetic condition http://purl.obolibrary.org/obo/MONDO_0003847
T13 2270-2274 Disease denotes G6PD http://purl.obolibrary.org/obo/MONDO_0005775
T14 2293-2309 Disease denotes hemolytic anemia http://purl.obolibrary.org/obo/MONDO_0003664
T15 2303-2309 Disease denotes anemia http://purl.obolibrary.org/obo/MONDO_0002280
T16 2433-2441 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 20-21 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 309-317 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T3 327-330 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T4 559-560 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 670-675 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T6 1108-1113 http://purl.obolibrary.org/obo/UBERON_0003103 denotes Organ
T7 1576-1577 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 2040-2041 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T9 2223-2224 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 7-16 Chemical denotes Vitamin C http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290
T4 7-14 Chemical denotes Vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T5 218-224 Chemical denotes copper http://purl.obolibrary.org/obo/CHEBI_28694|http://purl.obolibrary.org/obo/CHEBI_30052
T7 232-236 Chemical denotes iron http://purl.obolibrary.org/obo/CHEBI_18248
T8 1151-1158 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T9 1437-1446 Chemical denotes Vitamin C http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290
T12 1437-1444 Chemical denotes Vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T13 1448-1462 Chemical denotes hydrocortisone http://purl.obolibrary.org/obo/CHEBI_17650
T14 1467-1475 Chemical denotes thiamine http://purl.obolibrary.org/obo/CHEBI_18385|http://purl.obolibrary.org/obo/CHEBI_26948|http://purl.obolibrary.org/obo/CHEBI_33283
T17 1612-1626 Chemical denotes hydrocortisone http://purl.obolibrary.org/obo/CHEBI_17650
T18 1632-1640 Chemical denotes thiamine http://purl.obolibrary.org/obo/CHEBI_18385|http://purl.obolibrary.org/obo/CHEBI_26948|http://purl.obolibrary.org/obo/CHEBI_33283
T21 1816-1830 Chemical denotes hydrocortisone http://purl.obolibrary.org/obo/CHEBI_17650
T22 2042-2063 Chemical denotes water-soluble vitamin http://purl.obolibrary.org/obo/CHEBI_27314
T23 2042-2047 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T24 2056-2063 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T25 2170-2177 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167
T27 2180-2189 Chemical denotes phosphate http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 2125-2134 http://purl.obolibrary.org/obo/GO_0009058 denotes formation

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 822-828 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T2 846-865 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T3 1500-1505 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T4 1569-1574 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T5 1981-1995 Phenotype denotes abdominal pain http://purl.obolibrary.org/obo/HP_0002027
T6 1997-2005 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T7 2014-2020 Phenotype denotes nausea http://purl.obolibrary.org/obo/HP_0002018
T8 2138-2150 Phenotype denotes renal stones http://purl.obolibrary.org/obo/HP_0000787
T9 2293-2309 Phenotype denotes hemolytic anemia http://purl.obolibrary.org/obo/HP_0001878

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-6 Sentence denotes Reply:
T2 7-51 Sentence denotes Vitamin C as a Possible Therapy for COVID-19
T3 53-65 Sentence denotes Dear Editor:
T4 66-114 Sentence denotes We appreciate the comment from Hemilä et al [1].
T5 115-254 Sentence denotes Previous studies based on in-vitro experiments have identified that high dosage intravenous Vit-C with copper and/or iron is virucidal [2].
T6 255-360 Sentence denotes However, despite these studies, the in-vivo virucidal activity of Vit-C has not been confirmed in detail.
T7 361-500 Sentence denotes Previously, your meta-analyses of clinical trial data showed that regular Vit-C intake shortened the duration of the common cold by 8% [3].
T8 501-718 Sentence denotes However, coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus (severe acute respiratory syndrome coronavirus 2) whose genome sequence differs from other human coronaviruses causing the common cold [4].
T9 719-902 Sentence denotes Moreover, two recent clinical trials have demonstrated no significant difference in the development of sepsis, or severe acute respiratory failure, between Vit-C and non-Vit-C groups.
T10 903-1072 Sentence denotes In the CITRIS-ALI trial, no significant difference was found between the Vit-C (50 mg/kg every 6 hours for 96 hours) and placebo groups in the primary outcomes measured.
T11 1073-1206 Sentence denotes These included modified Sequential Organ Failure Assessment score, C-reactive protein levels, and thrombomodulin levels at 168 hours.
T12 1207-1432 Sentence denotes However, secondary outcome measures did differ between the groups with 28-day all-cause mortality significantly lower and intensive care unit-free days significantly shorter in the placebo groups than in the Vit-C groups [5].
T13 1433-1851 Sentence denotes The Vitamin C, hydrocortisone and thiamine in patients with septic shock (VITAMINS) trial also reported that among patients with septic shock, a combination of intravenous Vit-C, hydrocortisone, and thiamine did not significantly improve the primary outcome measure (duration of time alive and free of vasopressor administration over 7 days) compared with that after the intravenous hydrocortisone treatment alone [6].
T14 1852-2021 Sentence denotes Although Vit-C generally exhibits low toxicity, taking >2 g of Vit-C per day may cause adverse gastrointestinal events including abdominal pain, diarrhea, and/or nausea.
T15 2022-2155 Sentence denotes Although Vit-C is a water-soluble vitamin, with excess excreted in the urine, it can contribute to the formation of renal stones [7].
T16 2156-2352 Sentence denotes Additionally, glucose-6-phosphate dehydrogenase (G6PD) deficiency, a genetic condition that results in inadequate G6PD levels, can cause hemolytic anemia following intravenous Vit-C treatment [8].
T17 2353-2459 Sentence denotes Currently, multiple clinical trials investigating the effect of Vit-C on severe COVID-19 are on going [9].
T18 2460-2610 Sentence denotes However, this therapy can only be considered, and therefore incorporated into treatment guidelines, based on sufficient confirmatory research results.
T19 2611-2641 Sentence denotes For now, we will have to wait.
T20 2643-2664 Sentence denotes Conflict of Interest:
T21 2665-2690 Sentence denotes No conflicts of interest.
T22 2691-2712 Sentence denotes Author Contributions:
T23 2713-2741 Sentence denotes Conceptualization: SBK, JSY.
T24 2742-2766 Sentence denotes Data curation: SBK, JSY.
T25 2767-2793 Sentence denotes Formal analysis: SBK, JSY.
T26 2794-2813 Sentence denotes Investigation: SBK.
T27 2814-2831 Sentence denotes Methodology: SBK.
T28 2832-2860 Sentence denotes Project administration: JSY.
T29 2861-2876 Sentence denotes Resources: SBK.
T30 2877-2891 Sentence denotes Software: SBK.
T31 2892-2909 Sentence denotes Supervision: JSY.
T32 2910-2926 Sentence denotes Validation: JSY.
T33 2927-2946 Sentence denotes Visualization: SBK.
T34 2947-2977 Sentence denotes Writing - original draft: SBK.
T35 2978-3010 Sentence denotes Writing - review & editing: JSY.