PMC:7335631 / 8596-9262
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7335631","sourcedb":"PMC","sourceid":"7335631","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7335631","text":"Among all the proteins present in the novel RNA virus, some accessory proteins such as ORF6, ORF7b, ORF8, ORF10 contain the least number of missense mutation as reported in various studies [[14], [15], [16]]. And same is true for E-protein. We find 15 among 3617 (0.414%) of the SARS-CoV2 genome contains eight different types of mutations in TMD and C-terminus of the envelope protein. Mutated E-protein might affect replication and propagation of the SARS-CoV2 as has been observed in cases of SARS-CoV and MERS-CoV in mouse model [17]. Potential studies have also shown that vaccine against the E-protein mutated viruses can reduce the infectivity in mouse model.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T89","span":{"begin":14,"end":22},"obj":"Body_part"},{"id":"T90","span":{"begin":44,"end":47},"obj":"Body_part"},{"id":"T91","span":{"begin":70,"end":78},"obj":"Body_part"},{"id":"T92","span":{"begin":232,"end":239},"obj":"Body_part"},{"id":"T93","span":{"begin":289,"end":295},"obj":"Body_part"},{"id":"T94","span":{"begin":378,"end":385},"obj":"Body_part"},{"id":"T95","span":{"begin":397,"end":404},"obj":"Body_part"},{"id":"T96","span":{"begin":600,"end":607},"obj":"Body_part"}],"attributes":[{"id":"A89","pred":"fma_id","subj":"T89","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A90","pred":"fma_id","subj":"T90","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A91","pred":"fma_id","subj":"T91","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A92","pred":"fma_id","subj":"T92","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A93","pred":"fma_id","subj":"T93","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A94","pred":"fma_id","subj":"T94","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A95","pred":"fma_id","subj":"T95","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A96","pred":"fma_id","subj":"T96","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T89","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T90","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T91","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T92","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T93","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T94","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T95","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T96","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T65","span":{"begin":279,"end":283},"obj":"Disease"},{"id":"T66","span":{"begin":343,"end":346},"obj":"Disease"},{"id":"T69","span":{"begin":453,"end":457},"obj":"Disease"},{"id":"T70","span":{"begin":496,"end":504},"obj":"Disease"}],"attributes":[{"id":"A65","pred":"mondo_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A66","pred":"mondo_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/MONDO_0005473"},{"id":"A67","pred":"mondo_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/MONDO_0008040"},{"id":"A68","pred":"mondo_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/MONDO_0010870"},{"id":"A69","pred":"mondo_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A70","pred":"mondo_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T69","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T70","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T35","span":{"begin":48,"end":53},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T36","span":{"begin":466,"end":469},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T37","span":{"begin":521,"end":526},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T38","span":{"begin":616,"end":623},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T39","span":{"begin":654,"end":659},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"}],"attributes":[{"subj":"T35","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T114","span":{"begin":14,"end":22},"obj":"Chemical"},{"id":"T115","span":{"begin":70,"end":78},"obj":"Chemical"},{"id":"T116","span":{"begin":232,"end":239},"obj":"Chemical"},{"id":"T117","span":{"begin":378,"end":385},"obj":"Chemical"},{"id":"T118","span":{"begin":397,"end":404},"obj":"Chemical"},{"id":"T119","span":{"begin":600,"end":607},"obj":"Chemical"}],"attributes":[{"id":"A114","pred":"chebi_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A115","pred":"chebi_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A116","pred":"chebi_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A117","pred":"chebi_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A118","pred":"chebi_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A119","pred":"chebi_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T114","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T115","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T116","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T117","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T118","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T119","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T11","span":{"begin":343,"end":346},"obj":"Phenotype"}],"attributes":[{"id":"A11","pred":"hp_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/HP_0005534"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T84","span":{"begin":0,"end":208},"obj":"Sentence"},{"id":"T85","span":{"begin":209,"end":240},"obj":"Sentence"},{"id":"T86","span":{"begin":241,"end":386},"obj":"Sentence"},{"id":"T87","span":{"begin":387,"end":538},"obj":"Sentence"},{"id":"T88","span":{"begin":539,"end":666},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T84","pred":"source","obj":"LitCovid-sentences"},{"subj":"T85","pred":"source","obj":"LitCovid-sentences"},{"subj":"T86","pred":"source","obj":"LitCovid-sentences"},{"subj":"T87","pred":"source","obj":"LitCovid-sentences"},{"subj":"T88","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32640274-15963240-44882430","span":{"begin":197,"end":199},"obj":"15963240"}],"attributes":[{"subj":"32640274-15963240-44882430","pred":"source","obj":"2_test"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T176","span":{"begin":44,"end":47},"obj":"BV_22"},{"id":"T177","span":{"begin":48,"end":53},"obj":"BV_22;NCBITaxon:10239"},{"id":"T178","span":{"begin":230,"end":239},"obj":"PG_2"},{"id":"T179","span":{"begin":279,"end":288},"obj":"SP_7"},{"id":"T180","span":{"begin":289,"end":295},"obj":"SO:0001026"},{"id":"T181","span":{"begin":369,"end":377},"obj":"GO:0031975"},{"id":"T182","span":{"begin":395,"end":404},"obj":"PG_2"},{"id":"T183","span":{"begin":418,"end":429},"obj":"GO:0006260"},{"id":"T184","span":{"begin":453,"end":462},"obj":"SP_7"},{"id":"T185","span":{"begin":496,"end":504},"obj":"SP_10"},{"id":"T186","span":{"begin":509,"end":517},"obj":"SP_9"},{"id":"T187","span":{"begin":521,"end":526},"obj":"NCBITaxon:10088"},{"id":"T188","span":{"begin":598,"end":607},"obj":"PG_2"},{"id":"T189","span":{"begin":616,"end":623},"obj":"NCBITaxon:10239"},{"id":"T190","span":{"begin":654,"end":659},"obj":"NCBITaxon:10088"},{"id":"T84244","span":{"begin":369,"end":377},"obj":"GO:0031975"},{"id":"T70978","span":{"begin":44,"end":47},"obj":"BV_22"},{"id":"T9831","span":{"begin":48,"end":53},"obj":"BV_22;NCBITaxon:10239"},{"id":"T24285","span":{"begin":230,"end":239},"obj":"PG_2"},{"id":"T63046","span":{"begin":279,"end":288},"obj":"SP_7"},{"id":"T43426","span":{"begin":289,"end":295},"obj":"SO:0001026"},{"id":"T56524","span":{"begin":369,"end":377},"obj":"GO:0031975"},{"id":"T98494","span":{"begin":395,"end":404},"obj":"PG_2"},{"id":"T452","span":{"begin":418,"end":429},"obj":"GO:0006260"},{"id":"T2987","span":{"begin":453,"end":462},"obj":"SP_7"},{"id":"T35672","span":{"begin":496,"end":504},"obj":"SP_10"},{"id":"T31631","span":{"begin":509,"end":517},"obj":"SP_9"},{"id":"T71628","span":{"begin":521,"end":526},"obj":"NCBITaxon:10088"},{"id":"T6891","span":{"begin":598,"end":607},"obj":"PG_2"},{"id":"T35723","span":{"begin":616,"end":623},"obj":"NCBITaxon:10239"},{"id":"T41846","span":{"begin":654,"end":659},"obj":"NCBITaxon:10088"}],"attributes":[{"subj":"T176","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T177","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T178","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T179","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T180","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T181","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T182","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T183","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T184","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T185","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T186","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T187","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T188","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T189","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T190","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T84244","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T70978","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T9831","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T24285","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T63046","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T43426","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T56524","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T98494","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T452","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T2987","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T35672","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T31631","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T71628","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T6891","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T35723","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T41846","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#99ec93","default":true},{"id":"LitCovid-PD-MONDO","color":"#ec93b3"},{"id":"LitCovid-PD-CLO","color":"#93cdec"},{"id":"LitCovid-PD-CHEBI","color":"#e7ec93"},{"id":"LitCovid-PD-HP","color":"#d693ec"},{"id":"LitCovid-sentences","color":"#93ecbc"},{"id":"2_test","color":"#eca293"},{"id":"LitCovid-PMC-OGER-BB","color":"#939dec"}]}]}}