PMC:7335494 / 93395-94362 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T678","span":{"begin":80,"end":87},"obj":"Body_part"},{"id":"T679","span":{"begin":182,"end":189},"obj":"Body_part"},{"id":"T680","span":{"begin":480,"end":487},"obj":"Body_part"},{"id":"T681","span":{"begin":632,"end":639},"obj":"Body_part"},{"id":"T682","span":{"begin":843,"end":848},"obj":"Body_part"},{"id":"T683","span":{"begin":854,"end":857},"obj":"Body_part"}],"attributes":[{"id":"A678","pred":"fma_id","subj":"T678","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A679","pred":"fma_id","subj":"T679","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A680","pred":"fma_id","subj":"T680","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A681","pred":"fma_id","subj":"T681","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A682","pred":"fma_id","subj":"T682","obj":"http://purl.org/sig/ont/fma/fma86579"},{"id":"A683","pred":"fma_id","subj":"T683","obj":"http://purl.org/sig/ont/fma/fma82785"}],"text":"Flavonoid-rich products have also been discussed for their beneficial effect on insulin resistance-related metabolic complications possibly via the upregulation of genes involved in insulin sensitivity (Engin et al., 2018). In a recent review, the beneficial effect of flavonoid-rich products in a cross-sectional study including 1997 females aged 18–76 years, the correlation between the total flavonoid intake as well as their subclasses (assessed from food questionnaires) and insulin resistance/inflammation was evaluated. Results showed higher anthocyanin and flavone intake were associated with significantly lower peripheral insulin resistance and CRP concentrations (Jennings et al., 2014). In a randomized controlled dietary study, results showed that consuming a high anthocyanins diet is associated with the reduction of CRP, IL-6, IL-12, and LPS concentrations indicating a positive effect on the long term cardiometabolic risk (Kolehmainen et al., 2012)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T248","span":{"begin":499,"end":511},"obj":"Disease"}],"attributes":[{"id":"A248","pred":"mondo_id","subj":"T248","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"Flavonoid-rich products have also been discussed for their beneficial effect on insulin resistance-related metabolic complications possibly via the upregulation of genes involved in insulin sensitivity (Engin et al., 2018). In a recent review, the beneficial effect of flavonoid-rich products in a cross-sectional study including 1997 females aged 18–76 years, the correlation between the total flavonoid intake as well as their subclasses (assessed from food questionnaires) and insulin resistance/inflammation was evaluated. Results showed higher anthocyanin and flavone intake were associated with significantly lower peripheral insulin resistance and CRP concentrations (Jennings et al., 2014). In a randomized controlled dietary study, results showed that consuming a high anthocyanins diet is associated with the reduction of CRP, IL-6, IL-12, and LPS concentrations indicating a positive effect on the long term cardiometabolic risk (Kolehmainen et al., 2012)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T966","span":{"begin":80,"end":87},"obj":"http://purl.obolibrary.org/obo/PR_000009054"},{"id":"T967","span":{"begin":164,"end":169},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T968","span":{"begin":182,"end":189},"obj":"http://purl.obolibrary.org/obo/PR_000009054"},{"id":"T969","span":{"begin":217,"end":221},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T970","span":{"begin":227,"end":228},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T971","span":{"begin":296,"end":297},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T972","span":{"begin":335,"end":342},"obj":"http://purl.obolibrary.org/obo/UBERON_0003100"},{"id":"T973","span":{"begin":348,"end":350},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T974","span":{"begin":480,"end":487},"obj":"http://purl.obolibrary.org/obo/PR_000009054"},{"id":"T975","span":{"begin":632,"end":639},"obj":"http://purl.obolibrary.org/obo/PR_000009054"},{"id":"T976","span":{"begin":702,"end":703},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T977","span":{"begin":771,"end":772},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T978","span":{"begin":884,"end":885},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Flavonoid-rich products have also been discussed for their beneficial effect on insulin resistance-related metabolic complications possibly via the upregulation of genes involved in insulin sensitivity (Engin et al., 2018). In a recent review, the beneficial effect of flavonoid-rich products in a cross-sectional study including 1997 females aged 18–76 years, the correlation between the total flavonoid intake as well as their subclasses (assessed from food questionnaires) and insulin resistance/inflammation was evaluated. Results showed higher anthocyanin and flavone intake were associated with significantly lower peripheral insulin resistance and CRP concentrations (Jennings et al., 2014). In a randomized controlled dietary study, results showed that consuming a high anthocyanins diet is associated with the reduction of CRP, IL-6, IL-12, and LPS concentrations indicating a positive effect on the long term cardiometabolic risk (Kolehmainen et al., 2012)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1278","span":{"begin":0,"end":9},"obj":"Chemical"},{"id":"T1279","span":{"begin":80,"end":87},"obj":"Chemical"},{"id":"T1280","span":{"begin":182,"end":189},"obj":"Chemical"},{"id":"T1281","span":{"begin":269,"end":278},"obj":"Chemical"},{"id":"T1283","span":{"begin":395,"end":404},"obj":"Chemical"},{"id":"T1285","span":{"begin":480,"end":487},"obj":"Chemical"},{"id":"T1286","span":{"begin":549,"end":560},"obj":"Chemical"},{"id":"T1287","span":{"begin":565,"end":572},"obj":"Chemical"},{"id":"T1288","span":{"begin":632,"end":639},"obj":"Chemical"},{"id":"T1289","span":{"begin":778,"end":790},"obj":"Chemical"},{"id":"T1291","span":{"begin":837,"end":839},"obj":"Chemical"},{"id":"T18572","span":{"begin":843,"end":845},"obj":"Chemical"},{"id":"T1295","span":{"begin":854,"end":857},"obj":"Chemical"}],"attributes":[{"id":"A1278","pred":"chebi_id","subj":"T1278","obj":"http://purl.obolibrary.org/obo/CHEBI_47916"},{"id":"A1279","pred":"chebi_id","subj":"T1279","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"},{"id":"A1280","pred":"chebi_id","subj":"T1280","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"},{"id":"A1281","pred":"chebi_id","subj":"T1281","obj":"http://purl.obolibrary.org/obo/CHEBI_47916"},{"id":"A1282","pred":"chebi_id","subj":"T1281","obj":"http://purl.obolibrary.org/obo/CHEBI_72544"},{"id":"A1283","pred":"chebi_id","subj":"T1283","obj":"http://purl.obolibrary.org/obo/CHEBI_47916"},{"id":"A1284","pred":"chebi_id","subj":"T1283","obj":"http://purl.obolibrary.org/obo/CHEBI_72544"},{"id":"A1285","pred":"chebi_id","subj":"T1285","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"},{"id":"A1286","pred":"chebi_id","subj":"T1286","obj":"http://purl.obolibrary.org/obo/CHEBI_38697"},{"id":"A1287","pred":"chebi_id","subj":"T1287","obj":"http://purl.obolibrary.org/obo/CHEBI_42491"},{"id":"A1288","pred":"chebi_id","subj":"T1288","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"},{"id":"A1289","pred":"chebi_id","subj":"T1289","obj":"http://purl.obolibrary.org/obo/CHEBI_35218"},{"id":"A1290","pred":"chebi_id","subj":"T1289","obj":"http://purl.obolibrary.org/obo/CHEBI_38697"},{"id":"A1291","pred":"chebi_id","subj":"T1291","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A1292","pred":"chebi_id","subj":"T1291","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A1293","pred":"chebi_id","subj":"T18572","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A1294","pred":"chebi_id","subj":"T18572","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A1295","pred":"chebi_id","subj":"T1295","obj":"http://purl.obolibrary.org/obo/CHEBI_16412"},{"id":"A1296","pred":"chebi_id","subj":"T1295","obj":"http://purl.obolibrary.org/obo/CHEBI_52603"},{"id":"A1297","pred":"chebi_id","subj":"T1295","obj":"http://purl.obolibrary.org/obo/CHEBI_89981"}],"text":"Flavonoid-rich products have also been discussed for their beneficial effect on insulin resistance-related metabolic complications possibly via the upregulation of genes involved in insulin sensitivity (Engin et al., 2018). In a recent review, the beneficial effect of flavonoid-rich products in a cross-sectional study including 1997 females aged 18–76 years, the correlation between the total flavonoid intake as well as their subclasses (assessed from food questionnaires) and insulin resistance/inflammation was evaluated. Results showed higher anthocyanin and flavone intake were associated with significantly lower peripheral insulin resistance and CRP concentrations (Jennings et al., 2014). In a randomized controlled dietary study, results showed that consuming a high anthocyanins diet is associated with the reduction of CRP, IL-6, IL-12, and LPS concentrations indicating a positive effect on the long term cardiometabolic risk (Kolehmainen et al., 2012)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T275","span":{"begin":499,"end":511},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"Flavonoid-rich products have also been discussed for their beneficial effect on insulin resistance-related metabolic complications possibly via the upregulation of genes involved in insulin sensitivity (Engin et al., 2018). In a recent review, the beneficial effect of flavonoid-rich products in a cross-sectional study including 1997 females aged 18–76 years, the correlation between the total flavonoid intake as well as their subclasses (assessed from food questionnaires) and insulin resistance/inflammation was evaluated. Results showed higher anthocyanin and flavone intake were associated with significantly lower peripheral insulin resistance and CRP concentrations (Jennings et al., 2014). In a randomized controlled dietary study, results showed that consuming a high anthocyanins diet is associated with the reduction of CRP, IL-6, IL-12, and LPS concentrations indicating a positive effect on the long term cardiometabolic risk (Kolehmainen et al., 2012)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T557","span":{"begin":0,"end":223},"obj":"Sentence"},{"id":"T558","span":{"begin":224,"end":526},"obj":"Sentence"},{"id":"T559","span":{"begin":527,"end":698},"obj":"Sentence"},{"id":"T560","span":{"begin":699,"end":967},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Flavonoid-rich products have also been discussed for their beneficial effect on insulin resistance-related metabolic complications possibly via the upregulation of genes involved in insulin sensitivity (Engin et al., 2018). In a recent review, the beneficial effect of flavonoid-rich products in a cross-sectional study including 1997 females aged 18–76 years, the correlation between the total flavonoid intake as well as their subclasses (assessed from food questionnaires) and insulin resistance/inflammation was evaluated. Results showed higher anthocyanin and flavone intake were associated with significantly lower peripheral insulin resistance and CRP concentrations (Jennings et al., 2014). In a randomized controlled dietary study, results showed that consuming a high anthocyanins diet is associated with the reduction of CRP, IL-6, IL-12, and LPS concentrations indicating a positive effect on the long term cardiometabolic risk (Kolehmainen et al., 2012)."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T153","span":{"begin":80,"end":98},"obj":"Phenotype"},{"id":"T154","span":{"begin":480,"end":498},"obj":"Phenotype"},{"id":"T155","span":{"begin":632,"end":650},"obj":"Phenotype"}],"attributes":[{"id":"A153","pred":"hp_id","subj":"T153","obj":"http://purl.obolibrary.org/obo/HP_0000855"},{"id":"A154","pred":"hp_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/HP_0000855"},{"id":"A155","pred":"hp_id","subj":"T155","obj":"http://purl.obolibrary.org/obo/HP_0000855"}],"text":"Flavonoid-rich products have also been discussed for their beneficial effect on insulin resistance-related metabolic complications possibly via the upregulation of genes involved in insulin sensitivity (Engin et al., 2018). In a recent review, the beneficial effect of flavonoid-rich products in a cross-sectional study including 1997 females aged 18–76 years, the correlation between the total flavonoid intake as well as their subclasses (assessed from food questionnaires) and insulin resistance/inflammation was evaluated. Results showed higher anthocyanin and flavone intake were associated with significantly lower peripheral insulin resistance and CRP concentrations (Jennings et al., 2014). In a randomized controlled dietary study, results showed that consuming a high anthocyanins diet is associated with the reduction of CRP, IL-6, IL-12, and LPS concentrations indicating a positive effect on the long term cardiometabolic risk (Kolehmainen et al., 2012)."}

{"project":"MyTest","denotations":[{"id":"32640331-29288757-30721052","span":{"begin":217,"end":221},"obj":"29288757"},{"id":"32640331-24336456-30721053","span":{"begin":692,"end":696},"obj":"24336456"},{"id":"32640331-22961907-30721054","span":{"begin":961,"end":965},"obj":"22961907"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Flavonoid-rich products have also been discussed for their beneficial effect on insulin resistance-related metabolic complications possibly via the upregulation of genes involved in insulin sensitivity (Engin et al., 2018). In a recent review, the beneficial effect of flavonoid-rich products in a cross-sectional study including 1997 females aged 18–76 years, the correlation between the total flavonoid intake as well as their subclasses (assessed from food questionnaires) and insulin resistance/inflammation was evaluated. Results showed higher anthocyanin and flavone intake were associated with significantly lower peripheral insulin resistance and CRP concentrations (Jennings et al., 2014). In a randomized controlled dietary study, results showed that consuming a high anthocyanins diet is associated with the reduction of CRP, IL-6, IL-12, and LPS concentrations indicating a positive effect on the long term cardiometabolic risk (Kolehmainen et al., 2012)."}

{"project":"2_test","denotations":[{"id":"32640331-29288757-30721052","span":{"begin":217,"end":221},"obj":"29288757"},{"id":"32640331-24336456-30721053","span":{"begin":692,"end":696},"obj":"24336456"},{"id":"32640331-22961907-30721054","span":{"begin":961,"end":965},"obj":"22961907"}],"text":"Flavonoid-rich products have also been discussed for their beneficial effect on insulin resistance-related metabolic complications possibly via the upregulation of genes involved in insulin sensitivity (Engin et al., 2018). In a recent review, the beneficial effect of flavonoid-rich products in a cross-sectional study including 1997 females aged 18–76 years, the correlation between the total flavonoid intake as well as their subclasses (assessed from food questionnaires) and insulin resistance/inflammation was evaluated. Results showed higher anthocyanin and flavone intake were associated with significantly lower peripheral insulin resistance and CRP concentrations (Jennings et al., 2014). In a randomized controlled dietary study, results showed that consuming a high anthocyanins diet is associated with the reduction of CRP, IL-6, IL-12, and LPS concentrations indicating a positive effect on the long term cardiometabolic risk (Kolehmainen et al., 2012)."}