PMC:7335494 / 82166-83622 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7335494","sourcedb":"PMC","sourceid":"7335494","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7335494","text":"Another study tested the effects induced by a mixture of four main catechins found in green tea (epicatechin – EC, epigallocatechin – EGC, epigallocatechin gallate – EGCG, epicatechin gallate – GCG), as well as each one alone, on neutrophils isolated from healthy subjects. The catechin compounds induced anti-inflammatory effect (reduction of IL-1β and IL-6, TNF-α, HOCl synthesis and mieloperoxisase), together with the stimulation of antioxidant enzyme activities and Nrf2, along calcium release as well as increased phagocytic capacity, thus proving anti-inflammatory and immunomodulatory actions (Marinovic et al., 2015). In a separate study, EGCG reduced ICAM-1, NF-ĸB and IĸB expressions and reduced ROS levels upon TNF-α-induced inflammation in human retinal pigment epithelial cells. The results suggest the possible therapeutic involvement of EGCG in blocking TNF-α-mediated eye inflammation (Thichanpiang and Wongprasert, 2015). Moreover, in a study evaluating the effect of epicatechin and catechin on arachidonic acid-activated platelets and, respectively, on platelet-HUVEC interaction, the tested compounds induced a reduction of sICAM1, sVCAM1, and sE-selectin levels, as well as an increase of NO bioavailability, proving an anti-inflammatory effect and the ability to counteract endothelial dysfunction, but only when platelets were harvested from peripheral artery disease patients and not from healthy subjects (Carnevale et al., 2014).","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T603","span":{"begin":230,"end":241},"obj":"Body_part"},{"id":"T604","span":{"begin":344,"end":348},"obj":"Body_part"},{"id":"T605","span":{"begin":661,"end":665},"obj":"Body_part"},{"id":"T606","span":{"begin":759,"end":791},"obj":"Body_part"},{"id":"T607","span":{"begin":786,"end":791},"obj":"Body_part"},{"id":"T608","span":{"begin":885,"end":888},"obj":"Body_part"},{"id":"T609","span":{"begin":1041,"end":1050},"obj":"Body_part"},{"id":"T610","span":{"begin":1073,"end":1081},"obj":"Body_part"},{"id":"T611","span":{"begin":1168,"end":1176},"obj":"Body_part"},{"id":"T612","span":{"begin":1336,"end":1345},"obj":"Body_part"},{"id":"T613","span":{"begin":1377,"end":1383},"obj":"Body_part"}],"attributes":[{"id":"A603","pred":"fma_id","subj":"T603","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A604","pred":"fma_id","subj":"T604","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A605","pred":"fma_id","subj":"T605","obj":"http://purl.org/sig/ont/fma/fma67857"},{"id":"A606","pred":"fma_id","subj":"T606","obj":"http://purl.org/sig/ont/fma/fma75802"},{"id":"A607","pred":"fma_id","subj":"T607","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A608","pred":"fma_id","subj":"T608","obj":"http://purl.org/sig/ont/fma/fma54448"},{"id":"A609","pred":"fma_id","subj":"T609","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A610","pred":"fma_id","subj":"T610","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A611","pred":"fma_id","subj":"T611","obj":"http://purl.org/sig/ont/fma/fma61795"},{"id":"A612","pred":"fma_id","subj":"T612","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A613","pred":"fma_id","subj":"T613","obj":"http://purl.org/sig/ont/fma/fma50720"},{"subj":"T603","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T604","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T605","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T606","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T607","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T608","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T609","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T610","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T611","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T612","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T613","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T98","span":{"begin":885,"end":888},"obj":"Body_part"},{"id":"T99","span":{"begin":1377,"end":1383},"obj":"Body_part"}],"attributes":[{"id":"A98","pred":"uberon_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/UBERON_0000970"},{"id":"A99","pred":"uberon_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"subj":"T98","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T99","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T234","span":{"begin":134,"end":137},"obj":"Disease"},{"id":"T235","span":{"begin":737,"end":749},"obj":"Disease"},{"id":"T236","span":{"begin":889,"end":901},"obj":"Disease"},{"id":"T237","span":{"begin":1366,"end":1391},"obj":"Disease"},{"id":"T238","span":{"begin":1377,"end":1391},"obj":"Disease"}],"attributes":[{"id":"A234","pred":"mondo_id","subj":"T234","obj":"http://purl.obolibrary.org/obo/MONDO_0001060"},{"id":"A235","pred":"mondo_id","subj":"T235","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A236","pred":"mondo_id","subj":"T236","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A237","pred":"mondo_id","subj":"T237","obj":"http://purl.obolibrary.org/obo/MONDO_0005386"},{"id":"A238","pred":"mondo_id","subj":"T238","obj":"http://purl.obolibrary.org/obo/MONDO_0000473"},{"subj":"T234","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T235","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T236","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T237","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T238","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T858","span":{"begin":14,"end":20},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T859","span":{"begin":44,"end":45},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T860","span":{"begin":111,"end":113},"obj":"http://purl.obolibrary.org/obo/CLO_0002878"},{"id":"T861","span":{"begin":456,"end":466},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T862","span":{"begin":520,"end":530},"obj":"http://purl.obolibrary.org/obo/CL_0000234"},{"id":"T863","span":{"begin":630,"end":631},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T864","span":{"begin":753,"end":758},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T865","span":{"begin":767,"end":791},"obj":"http://purl.obolibrary.org/obo/CL_0000529"},{"id":"T866","span":{"begin":885,"end":888},"obj":"http://www.ebi.ac.uk/efo/EFO_0000827"},{"id":"T867","span":{"begin":953,"end":954},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T868","span":{"begin":1031,"end":1040},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T869","span":{"begin":1082,"end":1087},"obj":"http://purl.obolibrary.org/obo/CLO_0004307"},{"id":"T870","span":{"begin":1105,"end":1111},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T871","span":{"begin":1130,"end":1131},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T872","span":{"begin":1377,"end":1383},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"id":"T873","span":{"begin":1377,"end":1383},"obj":"http://www.ebi.ac.uk/efo/EFO_0000814"}],"attributes":[{"subj":"T858","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T859","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T860","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T861","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T862","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T863","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T864","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T865","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T866","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T867","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T868","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T869","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T870","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T871","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T872","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T873","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1109","span":{"begin":46,"end":53},"obj":"Chemical"},{"id":"T1110","span":{"begin":67,"end":76},"obj":"Chemical"},{"id":"T1111","span":{"begin":156,"end":163},"obj":"Chemical"},{"id":"T1112","span":{"begin":166,"end":170},"obj":"Chemical"},{"id":"T1113","span":{"begin":184,"end":191},"obj":"Chemical"},{"id":"T1114","span":{"begin":278,"end":286},"obj":"Chemical"},{"id":"T1115","span":{"begin":344,"end":346},"obj":"Chemical"},{"id":"T1117","span":{"begin":354,"end":356},"obj":"Chemical"},{"id":"T1119","span":{"begin":367,"end":371},"obj":"Chemical"},{"id":"T1120","span":{"begin":437,"end":448},"obj":"Chemical"},{"id":"T1121","span":{"begin":483,"end":490},"obj":"Chemical"},{"id":"T1123","span":{"begin":648,"end":652},"obj":"Chemical"},{"id":"T1124","span":{"begin":669,"end":671},"obj":"Chemical"},{"id":"T1127","span":{"begin":707,"end":710},"obj":"Chemical"},{"id":"T1128","span":{"begin":759,"end":766},"obj":"Chemical"},{"id":"T1129","span":{"begin":853,"end":857},"obj":"Chemical"},{"id":"T1130","span":{"begin":1002,"end":1010},"obj":"Chemical"},{"id":"T1131","span":{"begin":1014,"end":1030},"obj":"Chemical"},{"id":"T1132","span":{"begin":1026,"end":1030},"obj":"Chemical"}],"attributes":[{"id":"A1109","pred":"chebi_id","subj":"T1109","obj":"http://purl.obolibrary.org/obo/CHEBI_60004"},{"id":"A1110","pred":"chebi_id","subj":"T1110","obj":"http://purl.obolibrary.org/obo/CHEBI_23053"},{"id":"A1111","pred":"chebi_id","subj":"T1111","obj":"http://purl.obolibrary.org/obo/CHEBI_16918"},{"id":"A1112","pred":"chebi_id","subj":"T1112","obj":"http://purl.obolibrary.org/obo/CHEBI_4806"},{"id":"A1113","pred":"chebi_id","subj":"T1113","obj":"http://purl.obolibrary.org/obo/CHEBI_16918"},{"id":"A1114","pred":"chebi_id","subj":"T1114","obj":"http://purl.obolibrary.org/obo/CHEBI_23053"},{"id":"A1115","pred":"chebi_id","subj":"T1115","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A1116","pred":"chebi_id","subj":"T1115","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A1117","pred":"chebi_id","subj":"T1117","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A1118","pred":"chebi_id","subj":"T1117","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A1119","pred":"chebi_id","subj":"T1119","obj":"http://purl.obolibrary.org/obo/CHEBI_24757"},{"id":"A1120","pred":"chebi_id","subj":"T1120","obj":"http://purl.obolibrary.org/obo/CHEBI_22586"},{"id":"A1121","pred":"chebi_id","subj":"T1121","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A1122","pred":"chebi_id","subj":"T1121","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A1123","pred":"chebi_id","subj":"T1123","obj":"http://purl.obolibrary.org/obo/CHEBI_4806"},{"id":"A1124","pred":"chebi_id","subj":"T1124","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A1125","pred":"chebi_id","subj":"T1124","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A1126","pred":"chebi_id","subj":"T1124","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"},{"id":"A1127","pred":"chebi_id","subj":"T1127","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A1128","pred":"chebi_id","subj":"T1128","obj":"http://purl.obolibrary.org/obo/CHEBI_15035"},{"id":"A1129","pred":"chebi_id","subj":"T1129","obj":"http://purl.obolibrary.org/obo/CHEBI_4806"},{"id":"A1130","pred":"chebi_id","subj":"T1130","obj":"http://purl.obolibrary.org/obo/CHEBI_23053"},{"id":"A1131","pred":"chebi_id","subj":"T1131","obj":"http://purl.obolibrary.org/obo/CHEBI_15843"},{"id":"A1132","pred":"chebi_id","subj":"T1132","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"subj":"T1109","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1110","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1111","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1112","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1113","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1114","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1115","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1117","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1119","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1120","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1121","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1123","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1124","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1127","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1128","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1129","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1130","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1131","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1132","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T260","span":{"begin":372,"end":381},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T261","span":{"begin":737,"end":749},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T262","span":{"begin":889,"end":901},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"attributes":[{"subj":"T260","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T261","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T262","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T499","span":{"begin":0,"end":273},"obj":"Sentence"},{"id":"T500","span":{"begin":274,"end":626},"obj":"Sentence"},{"id":"T501","span":{"begin":627,"end":792},"obj":"Sentence"},{"id":"T502","span":{"begin":793,"end":939},"obj":"Sentence"},{"id":"T503","span":{"begin":940,"end":1456},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T499","pred":"source","obj":"LitCovid-sentences"},{"subj":"T500","pred":"source","obj":"LitCovid-sentences"},{"subj":"T501","pred":"source","obj":"LitCovid-sentences"},{"subj":"T502","pred":"source","obj":"LitCovid-sentences"},{"subj":"T503","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T136","span":{"begin":1297,"end":1320},"obj":"Phenotype"},{"id":"T137","span":{"begin":1366,"end":1391},"obj":"Phenotype"}],"attributes":[{"id":"A136","pred":"hp_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/HP_0032654"},{"id":"A137","pred":"hp_id","subj":"T137","obj":"http://purl.obolibrary.org/obo/HP_0004950"},{"subj":"T136","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T137","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"MyTest","denotations":[{"id":"32640331-25644976-30721026","span":{"begin":933,"end":937},"obj":"25644976"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"32640331-25644976-30721026","pred":"source","obj":"MyTest"}]},{"project":"2_test","denotations":[{"id":"32640331-25644976-30721026","span":{"begin":933,"end":937},"obj":"25644976"}],"attributes":[{"subj":"32640331-25644976-30721026","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93ece1","default":true},{"id":"LitCovid-PD-UBERON","color":"#ecc793"},{"id":"LitCovid-PD-MONDO","color":"#ad93ec"},{"id":"LitCovid-PD-CLO","color":"#93ec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93ac"},{"id":"LitCovid-PD-GO-BP","color":"#93c7ec"},{"id":"LitCovid-sentences","color":"#e1ec93"},{"id":"LitCovid-PD-HP","color":"#dd93ec"},{"id":"MyTest","color":"#93ecc3"},{"id":"2_test","color":"#eca993"}]}]}}