PMC:7335494 / 8063-8799 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7335494","sourcedb":"PMC","sourceid":"7335494","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7335494","text":"Regulation of cellular pathways under the influence of pro-inflammatory stimuli (Keap1 – Kelch-like ECH-associated protein 1; Cul3 – Cullin 3; Nrf2 – Nuclear factor erythroid 2-related factor 2; IKK – IκB kinase; NF-κB – Nuclear factor kappa-light-chain-enhancer of activated B cells heterodimer, consisting of p50, p65 and IkBα proteins; STAT3 – Signal transducer and activator of transcription 3; ERK/MAPK – mitogen-activated protein kinases; JNK – c-Jun N-terminal kinases; MEK – Mitogen-activated protein kinases kinase; HIFα – Hypoxia-inducible factor α; HIFβ – Hypoxia-inducible factor β; AP1 – Activator protein 1, with its associated proteins cFOS - and cJUN; Maf – Transcription factor Maf; ARE – antioxidant response element).","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T30","span":{"begin":115,"end":122},"obj":"Body_part"},{"id":"T31","span":{"begin":278,"end":283},"obj":"Body_part"},{"id":"T32","span":{"begin":329,"end":337},"obj":"Body_part"},{"id":"T33","span":{"begin":428,"end":435},"obj":"Body_part"},{"id":"T34","span":{"begin":501,"end":508},"obj":"Body_part"},{"id":"T35","span":{"begin":611,"end":618},"obj":"Body_part"},{"id":"T36","span":{"begin":642,"end":650},"obj":"Body_part"}],"attributes":[{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A31","pred":"fma_id","subj":"T31","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A32","pred":"fma_id","subj":"T32","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A33","pred":"fma_id","subj":"T33","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A34","pred":"fma_id","subj":"T34","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A35","pred":"fma_id","subj":"T35","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A36","pred":"fma_id","subj":"T36","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T62","span":{"begin":203,"end":204},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T63","span":{"begin":217,"end":218},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T64","span":{"begin":266,"end":275},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T65","span":{"begin":276,"end":283},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T66","span":{"begin":347,"end":353},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T67","span":{"begin":369,"end":378},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T68","span":{"begin":418,"end":427},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T69","span":{"begin":491,"end":500},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T70","span":{"begin":601,"end":610},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T71","span":{"begin":651,"end":655},"obj":"http://purl.obolibrary.org/obo/OGG_3000002353"}],"attributes":[{"subj":"T62","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T63","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T64","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T67","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T68","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T69","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T70","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T71","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T69","span":{"begin":115,"end":122},"obj":"Chemical"},{"id":"T70","span":{"begin":213,"end":215},"obj":"Chemical"},{"id":"T73","span":{"begin":329,"end":337},"obj":"Chemical"},{"id":"T74","span":{"begin":410,"end":417},"obj":"Chemical"},{"id":"T75","span":{"begin":428,"end":435},"obj":"Chemical"},{"id":"T76","span":{"begin":477,"end":480},"obj":"Chemical"},{"id":"T77","span":{"begin":501,"end":508},"obj":"Chemical"},{"id":"T78","span":{"begin":595,"end":598},"obj":"Chemical"},{"id":"T79","span":{"begin":611,"end":618},"obj":"Chemical"},{"id":"T80","span":{"begin":642,"end":650},"obj":"Chemical"},{"id":"T81","span":{"begin":706,"end":717},"obj":"Chemical"}],"attributes":[{"id":"A69","pred":"chebi_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A70","pred":"chebi_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A71","pred":"chebi_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A72","pred":"chebi_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"},{"id":"A73","pred":"chebi_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A74","pred":"chebi_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/CHEBI_52290"},{"id":"A75","pred":"chebi_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A76","pred":"chebi_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/CHEBI_28398"},{"id":"A77","pred":"chebi_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A78","pred":"chebi_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/CHEBI_62519"},{"id":"A79","pred":"chebi_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A80","pred":"chebi_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A81","pred":"chebi_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/CHEBI_22586"},{"subj":"T69","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T70","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T73","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T75","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T76","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T77","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T81","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T35","span":{"begin":0,"end":10},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T36","span":{"begin":382,"end":395},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T37","span":{"begin":403,"end":407},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T38","span":{"begin":674,"end":694},"obj":"http://purl.obolibrary.org/obo/GO_0000981"}],"attributes":[{"subj":"T35","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T16","span":{"begin":532,"end":539},"obj":"Phenotype"},{"id":"T17","span":{"begin":567,"end":574},"obj":"Phenotype"}],"attributes":[{"id":"A16","pred":"hp_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/HP_0012418"},{"id":"A17","pred":"hp_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/HP_0012418"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T127","span":{"begin":81,"end":86},"obj":"PR:000009277"},{"id":"T128","span":{"begin":89,"end":124},"obj":"PR:000009277"},{"id":"T129","span":{"begin":126,"end":130},"obj":"PR:000006048"},{"id":"T130","span":{"begin":133,"end":141},"obj":"PR:000006048"},{"id":"T131","span":{"begin":143,"end":147},"obj":"PR:000011170"},{"id":"T132","span":{"begin":150,"end":157},"obj":"GO:0005634;PR:000011170"},{"id":"T133","span":{"begin":158,"end":164},"obj":"PR:000011170"},{"id":"T134","span":{"begin":165,"end":174},"obj":"PR:000011170;CL:0000764"},{"id":"T135","span":{"begin":175,"end":193},"obj":"PR:000011170"},{"id":"T136","span":{"begin":201,"end":211},"obj":"PR:000001775"},{"id":"T137","span":{"begin":213,"end":215},"obj":"GO:0005883"},{"id":"T138","span":{"begin":254,"end":262},"obj":"SO:0000165"},{"id":"T139","span":{"begin":266,"end":275},"obj":"CL:0002627"},{"id":"T140","span":{"begin":276,"end":283},"obj":"CL:0000236"},{"id":"T141","span":{"begin":311,"end":314},"obj":"PR:Q43731"},{"id":"T142","span":{"begin":316,"end":319},"obj":"PR:Q9FJR1"},{"id":"T143","span":{"begin":324,"end":328},"obj":"PR:000003293"},{"id":"T144","span":{"begin":339,"end":344},"obj":"PR:000002089"},{"id":"T145","span":{"begin":347,"end":397},"obj":"PR:000002089"},{"id":"T146","span":{"begin":410,"end":417},"obj":"CHEBI:52290;CHEBI:52290"},{"id":"T147","span":{"begin":595,"end":598},"obj":"PR:000009232"},{"id":"T148","span":{"begin":601,"end":620},"obj":"PR:000009232"},{"id":"T149","span":{"begin":695,"end":698},"obj":"PR:000010045"}],"attributes":[{"subj":"T127","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T128","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T129","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T130","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T131","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T132","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T133","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T134","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T135","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T136","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T137","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T138","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T139","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T140","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T141","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T142","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T143","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T144","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T145","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T146","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T147","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T148","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T149","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#eaec93","default":true},{"id":"LitCovid-PD-CLO","color":"#d493ec"},{"id":"LitCovid-PD-CHEBI","color":"#93ecba"},{"id":"LitCovid-PD-GO-BP","color":"#eca093"},{"id":"LitCovid-PD-HP","color":"#939fec"},{"id":"LitCovid-PMC-OGER-BB","color":"#b9ec93"}]}]}}