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LitCovid-PD-FMA-UBERON

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T77","span":{"begin":237,"end":242},"obj":"Body_part"},{"id":"T78","span":{"begin":1251,"end":1256},"obj":"Body_part"},{"id":"T79","span":{"begin":1312,"end":1317},"obj":"Body_part"},{"id":"T80","span":{"begin":1576,"end":1582},"obj":"Body_part"},{"id":"T81","span":{"begin":1669,"end":1675},"obj":"Body_part"}],"attributes":[{"id":"A77","pred":"uberon_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"id":"A78","pred":"uberon_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"id":"A79","pred":"uberon_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"id":"A80","pred":"uberon_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A81","pred":"uberon_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"Tested compound(s) Animal model Main anti-inflammatory findings References\nn-3 PUFA (fish oil or mix fish and olive oil or flaxseed oil) TNBS colitis ↓IL-1β; IL-12p70; ↓IL-6; ↓TNFα; ↑PGE3,↑ TXB3; ↑ LTB5 Bosco et al. (2013)\nTNBS colitis ↓colon iNOS, ↓COX-2 expression, ↓IL-6, ↓LTB4, ↓TNFα production Charpentier et al. (2018)\nDSS colitis ↓TNF-α; ↓ COX-2; ↑anti-inflammatory PG; Sharma et al. (2019)\nCarrageenan induced inflammation ↓TNF-α; ↓ IL-6 Zadeh-Ardabili and Rad (2019)\nSTZ- diabetic rats ↑ gene expression PPRγ; ↓ NF-κB activity Ghadge et al. (2016)\nSTZ- diabetic rats ↓TNF-α; ↓ IL-6 Lee et al. (2019)\nSTZ-NIC diabetic rats ↑ PPAR-α only by flaxseed oil; both (flaxseed oil and fish oil):↑ D5 and D6 desaturases; ↓TNF-α; ↓ IL-6; Devarshi et al. (2013)\nSTZ-NIC diabetic rats ↑ renal SOD-1; ↑ GPx-1 expression; ↑ CAT; ↓ renal AGEs formation ↓AGE protein expression; ↓ IL-6; ↓ NF-κB expression Jangale et al. (2016)\nSTZ-NIC diabetic rats ↓ IL-1β; ↓TNFα; ↓IL-6; ↓IL-17 A; ↓MDA Zhu et al. (2020)\nWistar rats ↓ IL-6; ↓ TNF-α; ↓IL- 10 receptor Pimentel et al. (2013)\nC57BL/6 mice ↓ NF-κB expression; ↓ IL-6; ↓ TNF-α Bargut et al. (2015)\nEPA monogliceride DSS colitis ↓PMN infiltration; ↓ NF-κB activity; ↓IL-1β; ↓TNF-α; ↓ IL-6; ↓expression of COX2 in colon Morin et al. (2016)\nALA TNBS colitis ↓ IP-8, ↓ LTB4, ↓ colon NF-κB DNA binding activity Hassan et al. (2010)\nEPA vs. DHA high-fructose fed C57BL/6J mice ↓ TNF-alpha and IL-6 gene expressions; ↓MCP-1 pERK and NFkB protein expressions Bargut et al. (2017)\nEPA free fatty acid APCMin/+ FAP model ↓ COX-2 expression; ↑ EPA tissue uptake; ↓ lipid peroxidation Fini et al. (2010)\nCAC model C57BL/6J mouse ↓PGE2; ↑ EPA tissue uptake Piazzi et al. (2014)\nEndogenous conversion n-6 into n-3 PUFA CAC modelFat-1 mouse ↓ COX-2 expression; ↓ NF-κB activity; ↓PGE2 Han et al. (2016)\nChronic arthritisFat-1 mouse vs WT mouse ↓ IL-17; ↑mRNA expression of Foxp3 (in Fat-1 mouse) Kim et al. (2018)\nAT-RvD1 DSS colitis/TNBS colitis ↓PMN infiltration; ↓ NF-κB activity and mRNA expression; ↓IL-1β; ↓MIP-2; ↓mRNA expression of VCAM-1, ICAM-1 Bento et al. (2011)\nAdjuvant-induced arthritis ↓TNF-α; IL-1β Lima-Garcia et al. (2011)\nRvD2 DSS colitis ↓IL-1β; ↓ murine KC (IL-8 human homolog) Campbell et al. (2010)\nTNBS colitis ↓PMN infiltration; ↓ NF-κB activity and mRNA expression; ↓IL-1β; ↓MIP-2; ↓mRNA expression of VCAM-1, ICAM-1 Bento et al. (2011)\nRvE1 DSS colitis ↓PMN infiltration; ↓TNF-α; ↓mRNA expression of IL-6, TNFα, IL-1β Ishida et al. (2010)\nCollagen-induced arthritis No statistical significant effect on TNF-α de Molon et al. (2019)\nRvD5 DSS colitis ↓PMN infiltration; ↓TNF-α; ↓ IL-6; ↓IL-1β; Gobbetti et al. (2017)\nMaR1 DSS colitis/TNBS colitis ↓PMN infiltration; ↓ NF-κB activity; ↓IL-1β; ↓TNF-α; ↓ IL-6; ↓mRNA expression of ICAM-1 Marcon et al. (2013)\nPD1 DSS colitis ↓PMN infiltration; ↓IL-1β only partially Gobbetti et al. (2017)"}

LitCovid-PD-MONDO

LitCovid-PD-CLO

LitCovid-PD-CHEBI

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T211","span":{"begin":418,"end":430},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T212","span":{"begin":497,"end":512},"obj":"http://purl.obolibrary.org/obo/GO_0010467"},{"id":"T213","span":{"begin":789,"end":794},"obj":"http://purl.obolibrary.org/obo/GO_0004784"},{"id":"T214","span":{"begin":836,"end":845},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T215","span":{"begin":1431,"end":1447},"obj":"http://purl.obolibrary.org/obo/GO_0010467"},{"id":"T216","span":{"begin":1583,"end":1589},"obj":"http://purl.obolibrary.org/obo/GO_0098739"},{"id":"T217","span":{"begin":1583,"end":1589},"obj":"http://purl.obolibrary.org/obo/GO_0098657"},{"id":"T218","span":{"begin":1676,"end":1682},"obj":"http://purl.obolibrary.org/obo/GO_0098739"},{"id":"T219","span":{"begin":1676,"end":1682},"obj":"http://purl.obolibrary.org/obo/GO_0098657"}],"text":"Tested compound(s) Animal model Main anti-inflammatory findings References\nn-3 PUFA (fish oil or mix fish and olive oil or flaxseed oil) TNBS colitis ↓IL-1β; IL-12p70; ↓IL-6; ↓TNFα; ↑PGE3,↑ TXB3; ↑ LTB5 Bosco et al. (2013)\nTNBS colitis ↓colon iNOS, ↓COX-2 expression, ↓IL-6, ↓LTB4, ↓TNFα production Charpentier et al. (2018)\nDSS colitis ↓TNF-α; ↓ COX-2; ↑anti-inflammatory PG; Sharma et al. (2019)\nCarrageenan induced inflammation ↓TNF-α; ↓ IL-6 Zadeh-Ardabili and Rad (2019)\nSTZ- diabetic rats ↑ gene expression PPRγ; ↓ NF-κB activity Ghadge et al. (2016)\nSTZ- diabetic rats ↓TNF-α; ↓ IL-6 Lee et al. (2019)\nSTZ-NIC diabetic rats ↑ PPAR-α only by flaxseed oil; both (flaxseed oil and fish oil):↑ D5 and D6 desaturases; ↓TNF-α; ↓ IL-6; Devarshi et al. (2013)\nSTZ-NIC diabetic rats ↑ renal SOD-1; ↑ GPx-1 expression; ↑ CAT; ↓ renal AGEs formation ↓AGE protein expression; ↓ IL-6; ↓ NF-κB expression Jangale et al. (2016)\nSTZ-NIC diabetic rats ↓ IL-1β; ↓TNFα; ↓IL-6; ↓IL-17 A; ↓MDA Zhu et al. (2020)\nWistar rats ↓ IL-6; ↓ TNF-α; ↓IL- 10 receptor Pimentel et al. (2013)\nC57BL/6 mice ↓ NF-κB expression; ↓ IL-6; ↓ TNF-α Bargut et al. (2015)\nEPA monogliceride DSS colitis ↓PMN infiltration; ↓ NF-κB activity; ↓IL-1β; ↓TNF-α; ↓ IL-6; ↓expression of COX2 in colon Morin et al. (2016)\nALA TNBS colitis ↓ IP-8, ↓ LTB4, ↓ colon NF-κB DNA binding activity Hassan et al. (2010)\nEPA vs. DHA high-fructose fed C57BL/6J mice ↓ TNF-alpha and IL-6 gene expressions; ↓MCP-1 pERK and NFkB protein expressions Bargut et al. (2017)\nEPA free fatty acid APCMin/+ FAP model ↓ COX-2 expression; ↑ EPA tissue uptake; ↓ lipid peroxidation Fini et al. (2010)\nCAC model C57BL/6J mouse ↓PGE2; ↑ EPA tissue uptake Piazzi et al. (2014)\nEndogenous conversion n-6 into n-3 PUFA CAC modelFat-1 mouse ↓ COX-2 expression; ↓ NF-κB activity; ↓PGE2 Han et al. (2016)\nChronic arthritisFat-1 mouse vs WT mouse ↓ IL-17; ↑mRNA expression of Foxp3 (in Fat-1 mouse) Kim et al. (2018)\nAT-RvD1 DSS colitis/TNBS colitis ↓PMN infiltration; ↓ NF-κB activity and mRNA expression; ↓IL-1β; ↓MIP-2; ↓mRNA expression of VCAM-1, ICAM-1 Bento et al. (2011)\nAdjuvant-induced arthritis ↓TNF-α; IL-1β Lima-Garcia et al. (2011)\nRvD2 DSS colitis ↓IL-1β; ↓ murine KC (IL-8 human homolog) Campbell et al. (2010)\nTNBS colitis ↓PMN infiltration; ↓ NF-κB activity and mRNA expression; ↓IL-1β; ↓MIP-2; ↓mRNA expression of VCAM-1, ICAM-1 Bento et al. (2011)\nRvE1 DSS colitis ↓PMN infiltration; ↓TNF-α; ↓mRNA expression of IL-6, TNFα, IL-1β Ishida et al. (2010)\nCollagen-induced arthritis No statistical significant effect on TNF-α de Molon et al. (2019)\nRvD5 DSS colitis ↓PMN infiltration; ↓TNF-α; ↓ IL-6; ↓IL-1β; Gobbetti et al. (2017)\nMaR1 DSS colitis/TNBS colitis ↓PMN infiltration; ↓ NF-κB activity; ↓IL-1β; ↓TNF-α; ↓ IL-6; ↓mRNA expression of ICAM-1 Marcon et al. (2013)\nPD1 DSS colitis ↓PMN infiltration; ↓IL-1β only partially Gobbetti et al. (2017)"}

LitCovid-sentences

LitCovid-PD-HP

MyTest

2_test

PMC:7335494 / 62660-65545 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:7335494 / 62660-65545 JSON TXT