PMC:7335494 / 5635-6083 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T19","span":{"begin":43,"end":52},"obj":"Body_part"},{"id":"T20","span":{"begin":61,"end":65},"obj":"Body_part"}],"attributes":[{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma86583"}],"text":"fect of inflammatory stimuli (for instance cytokines – IL-8, IL-1β, IL-6, or TNF-α, UV exposure, etc), the heterodimer dissociates, IκBα is degraded, and the two components, p50 and p65, translocate into the nucleus binding the promoter regions from different genes that are involved in initiating several cellular pathways linked to chronic diseases, tumorigenesis, angiogenesis and metastasis. Among the genes regulated by NF-κB are the ones for "}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T32","span":{"begin":55,"end":59},"obj":"http://purl.obolibrary.org/obo/CLO_0053704"},{"id":"T33","span":{"begin":134,"end":135},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T34","span":{"begin":260,"end":265},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T35","span":{"begin":406,"end":411},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T36","span":{"begin":429,"end":447},"obj":"http://purl.obolibrary.org/obo/UBERON_0001474"},{"id":"T37","span":{"begin":429,"end":443},"obj":"http://www.ebi.ac.uk/efo/EFO_0000298"}],"text":"fect of inflammatory stimuli (for instance cytokines – IL-8, IL-1β, IL-6, or TNF-α, UV exposure, etc), the heterodimer dissociates, IκBα is degraded, and the two components, p50 and p65, translocate into the nucleus binding the promoter regions from different genes that are involved in initiating several cellular pathways linked to chronic diseases, tumorigenesis, angiogenesis and metastasis. Among the genes regulated by NF-κB are the ones for "}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T35","span":{"begin":55,"end":57},"obj":"Chemical"},{"id":"T37","span":{"begin":61,"end":63},"obj":"Chemical"},{"id":"T39","span":{"begin":68,"end":70},"obj":"Chemical"},{"id":"T41","span":{"begin":208,"end":215},"obj":"Chemical"},{"id":"T42","span":{"begin":425,"end":427},"obj":"Chemical"}],"attributes":[{"id":"A35","pred":"chebi_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A36","pred":"chebi_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A37","pred":"chebi_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A38","pred":"chebi_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A39","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A40","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A41","pred":"chebi_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/CHEBI_33252"},{"id":"A42","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A43","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A44","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"}],"text":"fect of inflammatory stimuli (for instance cytokines – IL-8, IL-1β, IL-6, or TNF-α, UV exposure, etc), the heterodimer dissociates, IκBα is degraded, and the two components, p50 and p65, translocate into the nucleus binding the promoter regions from different genes that are involved in initiating several cellular pathways linked to chronic diseases, tumorigenesis, angiogenesis and metastasis. Among the genes regulated by NF-κB are the ones for "}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T21","span":{"begin":367,"end":379},"obj":"http://purl.obolibrary.org/obo/GO_0001525"}],"text":"fect of inflammatory stimuli (for instance cytokines – IL-8, IL-1β, IL-6, or TNF-α, UV exposure, etc), the heterodimer dissociates, IκBα is degraded, and the two components, p50 and p65, translocate into the nucleus binding the promoter regions from different genes that are involved in initiating several cellular pathways linked to chronic diseases, tumorigenesis, angiogenesis and metastasis. Among the genes regulated by NF-κB are the ones for "}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T74","span":{"begin":55,"end":59},"obj":"PR:000001395"},{"id":"T75","span":{"begin":61,"end":66},"obj":"PR:000001136"},{"id":"T76","span":{"begin":68,"end":72},"obj":"PR:000001393"},{"id":"T77","span":{"begin":77,"end":82},"obj":"PR:000000134"},{"id":"T78","span":{"begin":132,"end":136},"obj":"PR:000003293"},{"id":"T79","span":{"begin":174,"end":177},"obj":"PR:Q43731"},{"id":"T80","span":{"begin":182,"end":185},"obj":"PR:Q9FJR1"},{"id":"T81","span":{"begin":208,"end":215},"obj":"GO:0005634"},{"id":"T82","span":{"begin":228,"end":236},"obj":"SO:0000167"},{"id":"T83","span":{"begin":260,"end":265},"obj":"SO:0000704"},{"id":"T84","span":{"begin":367,"end":379},"obj":"GO:0001525"},{"id":"T85","span":{"begin":406,"end":411},"obj":"SO:0000704"},{"id":"T86","span":{"begin":412,"end":421},"obj":"GO:0065007"},{"id":"T87","span":{"begin":425,"end":427},"obj":"GO:0005883"}],"text":"fect of inflammatory stimuli (for instance cytokines – IL-8, IL-1β, IL-6, or TNF-α, UV exposure, etc), the heterodimer dissociates, IκBα is degraded, and the two components, p50 and p65, translocate into the nucleus binding the promoter regions from different genes that are involved in initiating several cellular pathways linked to chronic diseases, tumorigenesis, angiogenesis and metastasis. Among the genes regulated by NF-κB are the ones for "}