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LitCovid-PD-FMA-UBERON

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T61","span":{"begin":667,"end":671},"obj":"Body_part"},{"id":"T62","span":{"begin":2836,"end":2841},"obj":"Body_part"}],"attributes":[{"id":"A61","pred":"uberon_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/UBERON_0000974"},{"id":"A62","pred":"uberon_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"}],"text":"Table 4 Recent reports concerning Mediterranean diet and inflammation.\nDesign Population Intervention Effects Reference\nFeeding study 25 subjects One-meal intervention:➢ Tocopherol-enriched Mediterranean meal\n➢ Western high-fat meal ↓ expression of inflammation-related genes De Lorenzo et al. (2017)\nControlled feeding study 35 men and 27 women ➢ 4-week MD intervention MD induced the same type of response regarding hs-CRP both in males and females Bedard et al. (2015)\nRandomized Controlled Trial 1142 subjects 12-month diet intervention:➢ MD-like NU-AGE diet + vitamin D3 (10 μg/day)\n➢ Control group Slowed the decline of bone mineral density only in the femoral neck in subjects with osteoporosis Jennings et al. (2018)\nRandomized Controlled Trial 20 elderly subjects 4-week diet intervention:➢ MD + coenzyme Q10 (MD-Q10)\n➢ MD\nDiet rich in saturated fatty acids (SFAD) MD, MD-Q10: ↓ expression of p65, IKK-b, MMP-9, IL-1b (versus SFAD)MD-Q: marked decrease of P65 and IKK-b (versus the other diets) Yubero-Serrano et al. (2012)\nRandomized Controlled Trial 20 elderly people 4-week diet intervention:➢ MD + olive oil (MD-O)\n➢ diet rich in saturated fatty acids (SFAD) low-fat, high-carbohydrate diet enriched in n-3 PUFA (LFHC-PUFA) MD-O: ↓ expression of inflammation-related genes (versus SFAD: p65, MCP-1; versus LFHC-PUFA: p65, TNF-α) Camargo et al. (2012)\nRandomized Controlled Crossover Trial 20 elderly subjects isocaloric diets for successive periods of 4 weeks in a crossover design: MD, MD + CoQ, Western diet ↓ AGE, RAGE Lopez-Moreno et al. (2018)\nRandomized Controlled Trial 34 male overweight subjects 4-week diet intervention:➢ Ketogenic MD (KMD)\nKMD + omega-3 (KMD-O3) KMD: ↓ TNF-αKMD-O3: ↓ IL-1β, IL-6, TNF-α, ↑ adiponectin Paoli et al. (2015)\n\u2028\u2028\nControlled feeding study 50 overweight and obese subjects 13-week diet intervention: Caloric restriction, MD + dietary supplementation ↓ CRP (versus baseline) Tripp et al. (2019)\nClinical Trial 90 subjects with abdominal obesity 2-month diet intervention:➢ MD, using olive oil\nControl group MD: ↓ CRP, P-selectin, E-selectin (versus baseline) Rallidis et al. (2017)\nClinical Trial 40 subjects with metabolic syndrome 8-week diet hypocaloric MD intervention ↓ mRNA associated with the regulation of inflammatory genes Marques-Rocha et al. (2016)\nRandomized Controlled Trial 36 subjects with metabolic syndrome 3-month MD intervention ↓ CRP, insulin Bekkouche et al. (2014)\nRandomized Controlled Trial 24 T2DM patients 3-month diet intervention:➢ MD, using olive oil\nLow fat diet (LFD) MD: ↓ IL-6, ICAM-1, ↑ GLP-1 stimulated insulin secretion Ceriello et al. (2014)\nRandomized Controlled Trial 215 T2DM (newly diagnosed) 12-month diet intervention:➢ MD\nLow fat diet (LFD) MD: ↓ CRP (37%), ↑ adiponectin (43%) Maiorino et al. (2016)\nRandomized Controlled Trial 56 coronary heart disease patients 6-month diet intervention:➢ MD\nLow fat diet (LFD) ↓ dietary inflammatory index (including IL-1b, IL-4, IL-6, IL-10, TNF-α, CRP) Mayr et al. (2018)\nRandomized Controlled Trial 164 subjects with high cardiovascular risk 12-month diet intervention:➢ MD + 50 mL extra virgin olive oil (MD-O)\n➢ MD + 30 g nuts (MD-N)\nLow fat diet (LFD) MD-O: ↓ CRP (45%), IL-6 (35%), sICAM-1 (50%), P-selectin (27%)MD-N: ↓ CRP (45%), IL-6 (35%)(versus LFD) Casas et al. (2014)"}

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T146","span":{"begin":57,"end":69},"obj":"Disease"},{"id":"T147","span":{"begin":249,"end":261},"obj":"Disease"},{"id":"T148","span":{"begin":689,"end":701},"obj":"Disease"},{"id":"T149","span":{"begin":1259,"end":1271},"obj":"Disease"},{"id":"T150","span":{"begin":1987,"end":1994},"obj":"Disease"},{"id":"T151","span":{"begin":2164,"end":2182},"obj":"Disease"},{"id":"T152","span":{"begin":2356,"end":2374},"obj":"Disease"},{"id":"T153","span":{"begin":2827,"end":2849},"obj":"Disease"},{"id":"T154","span":{"begin":2836,"end":2849},"obj":"Disease"}],"attributes":[{"id":"A146","pred":"mondo_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A147","pred":"mondo_id","subj":"T147","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A148","pred":"mondo_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/MONDO_0005298"},{"id":"A149","pred":"mondo_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A150","pred":"mondo_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"},{"id":"A151","pred":"mondo_id","subj":"T151","obj":"http://purl.obolibrary.org/obo/MONDO_0004955"},{"id":"A152","pred":"mondo_id","subj":"T152","obj":"http://purl.obolibrary.org/obo/MONDO_0004955"},{"id":"A153","pred":"mondo_id","subj":"T153","obj":"http://purl.obolibrary.org/obo/MONDO_0005010"},{"id":"A154","pred":"mondo_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/MONDO_0005267"}],"text":"Table 4 Recent reports concerning Mediterranean diet and inflammation.\nDesign Population Intervention Effects Reference\nFeeding study 25 subjects One-meal intervention:➢ Tocopherol-enriched Mediterranean meal\n➢ Western high-fat meal ↓ expression of inflammation-related genes De Lorenzo et al. (2017)\nControlled feeding study 35 men and 27 women ➢ 4-week MD intervention MD induced the same type of response regarding hs-CRP both in males and females Bedard et al. (2015)\nRandomized Controlled Trial 1142 subjects 12-month diet intervention:➢ MD-like NU-AGE diet + vitamin D3 (10 μg/day)\n➢ Control group Slowed the decline of bone mineral density only in the femoral neck in subjects with osteoporosis Jennings et al. (2018)\nRandomized Controlled Trial 20 elderly subjects 4-week diet intervention:➢ MD + coenzyme Q10 (MD-Q10)\n➢ MD\nDiet rich in saturated fatty acids (SFAD) MD, MD-Q10: ↓ expression of p65, IKK-b, MMP-9, IL-1b (versus SFAD)MD-Q: marked decrease of P65 and IKK-b (versus the other diets) Yubero-Serrano et al. (2012)\nRandomized Controlled Trial 20 elderly people 4-week diet intervention:➢ MD + olive oil (MD-O)\n➢ diet rich in saturated fatty acids (SFAD) low-fat, high-carbohydrate diet enriched in n-3 PUFA (LFHC-PUFA) MD-O: ↓ expression of inflammation-related genes (versus SFAD: p65, MCP-1; versus LFHC-PUFA: p65, TNF-α) Camargo et al. (2012)\nRandomized Controlled Crossover Trial 20 elderly subjects isocaloric diets for successive periods of 4 weeks in a crossover design: MD, MD + CoQ, Western diet ↓ AGE, RAGE Lopez-Moreno et al. (2018)\nRandomized Controlled Trial 34 male overweight subjects 4-week diet intervention:➢ Ketogenic MD (KMD)\nKMD + omega-3 (KMD-O3) KMD: ↓ TNF-αKMD-O3: ↓ IL-1β, IL-6, TNF-α, ↑ adiponectin Paoli et al. (2015)\n\u2028\u2028\nControlled feeding study 50 overweight and obese subjects 13-week diet intervention: Caloric restriction, MD + dietary supplementation ↓ CRP (versus baseline) Tripp et al. (2019)\nClinical Trial 90 subjects with abdominal obesity 2-month diet intervention:➢ MD, using olive oil\nControl group MD: ↓ CRP, P-selectin, E-selectin (versus baseline) Rallidis et al. (2017)\nClinical Trial 40 subjects with metabolic syndrome 8-week diet hypocaloric MD intervention ↓ mRNA associated with the regulation of inflammatory genes Marques-Rocha et al. (2016)\nRandomized Controlled Trial 36 subjects with metabolic syndrome 3-month MD intervention ↓ CRP, insulin Bekkouche et al. (2014)\nRandomized Controlled Trial 24 T2DM patients 3-month diet intervention:➢ MD, using olive oil\nLow fat diet (LFD) MD: ↓ IL-6, ICAM-1, ↑ GLP-1 stimulated insulin secretion Ceriello et al. (2014)\nRandomized Controlled Trial 215 T2DM (newly diagnosed) 12-month diet intervention:➢ MD\nLow fat diet (LFD) MD: ↓ CRP (37%), ↑ adiponectin (43%) Maiorino et al. (2016)\nRandomized Controlled Trial 56 coronary heart disease patients 6-month diet intervention:➢ MD\nLow fat diet (LFD) ↓ dietary inflammatory index (including IL-1b, IL-4, IL-6, IL-10, TNF-α, CRP) Mayr et al. (2018)\nRandomized Controlled Trial 164 subjects with high cardiovascular risk 12-month diet intervention:➢ MD + 50 mL extra virgin olive oil (MD-O)\n➢ MD + 30 g nuts (MD-N)\nLow fat diet (LFD) MD-O: ↓ CRP (45%), IL-6 (35%), sICAM-1 (50%), P-selectin (27%)MD-N: ↓ CRP (45%), IL-6 (35%)(versus LFD) Casas et al. (2014)"}

LitCovid-PD-CLO

LitCovid-PD-CHEBI

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T142","span":{"begin":57,"end":69},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T143","span":{"begin":249,"end":261},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T144","span":{"begin":1259,"end":1271},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T145","span":{"begin":2250,"end":2260},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T146","span":{"begin":2578,"end":2606},"obj":"http://purl.obolibrary.org/obo/GO_0032024"},{"id":"T147","span":{"begin":2589,"end":2606},"obj":"http://purl.obolibrary.org/obo/GO_0030073"},{"id":"T148","span":{"begin":2597,"end":2606},"obj":"http://purl.obolibrary.org/obo/GO_0046903"}],"text":"Table 4 Recent reports concerning Mediterranean diet and inflammation.\nDesign Population Intervention Effects Reference\nFeeding study 25 subjects One-meal intervention:➢ Tocopherol-enriched Mediterranean meal\n➢ Western high-fat meal ↓ expression of inflammation-related genes De Lorenzo et al. (2017)\nControlled feeding study 35 men and 27 women ➢ 4-week MD intervention MD induced the same type of response regarding hs-CRP both in males and females Bedard et al. (2015)\nRandomized Controlled Trial 1142 subjects 12-month diet intervention:➢ MD-like NU-AGE diet + vitamin D3 (10 μg/day)\n➢ Control group Slowed the decline of bone mineral density only in the femoral neck in subjects with osteoporosis Jennings et al. (2018)\nRandomized Controlled Trial 20 elderly subjects 4-week diet intervention:➢ MD + coenzyme Q10 (MD-Q10)\n➢ MD\nDiet rich in saturated fatty acids (SFAD) MD, MD-Q10: ↓ expression of p65, IKK-b, MMP-9, IL-1b (versus SFAD)MD-Q: marked decrease of P65 and IKK-b (versus the other diets) Yubero-Serrano et al. (2012)\nRandomized Controlled Trial 20 elderly people 4-week diet intervention:➢ MD + olive oil (MD-O)\n➢ diet rich in saturated fatty acids (SFAD) low-fat, high-carbohydrate diet enriched in n-3 PUFA (LFHC-PUFA) MD-O: ↓ expression of inflammation-related genes (versus SFAD: p65, MCP-1; versus LFHC-PUFA: p65, TNF-α) Camargo et al. (2012)\nRandomized Controlled Crossover Trial 20 elderly subjects isocaloric diets for successive periods of 4 weeks in a crossover design: MD, MD + CoQ, Western diet ↓ AGE, RAGE Lopez-Moreno et al. (2018)\nRandomized Controlled Trial 34 male overweight subjects 4-week diet intervention:➢ Ketogenic MD (KMD)\nKMD + omega-3 (KMD-O3) KMD: ↓ TNF-αKMD-O3: ↓ IL-1β, IL-6, TNF-α, ↑ adiponectin Paoli et al. (2015)\n\u2028\u2028\nControlled feeding study 50 overweight and obese subjects 13-week diet intervention: Caloric restriction, MD + dietary supplementation ↓ CRP (versus baseline) Tripp et al. (2019)\nClinical Trial 90 subjects with abdominal obesity 2-month diet intervention:➢ MD, using olive oil\nControl group MD: ↓ CRP, P-selectin, E-selectin (versus baseline) Rallidis et al. (2017)\nClinical Trial 40 subjects with metabolic syndrome 8-week diet hypocaloric MD intervention ↓ mRNA associated with the regulation of inflammatory genes Marques-Rocha et al. (2016)\nRandomized Controlled Trial 36 subjects with metabolic syndrome 3-month MD intervention ↓ CRP, insulin Bekkouche et al. (2014)\nRandomized Controlled Trial 24 T2DM patients 3-month diet intervention:➢ MD, using olive oil\nLow fat diet (LFD) MD: ↓ IL-6, ICAM-1, ↑ GLP-1 stimulated insulin secretion Ceriello et al. (2014)\nRandomized Controlled Trial 215 T2DM (newly diagnosed) 12-month diet intervention:➢ MD\nLow fat diet (LFD) MD: ↓ CRP (37%), ↑ adiponectin (43%) Maiorino et al. (2016)\nRandomized Controlled Trial 56 coronary heart disease patients 6-month diet intervention:➢ MD\nLow fat diet (LFD) ↓ dietary inflammatory index (including IL-1b, IL-4, IL-6, IL-10, TNF-α, CRP) Mayr et al. (2018)\nRandomized Controlled Trial 164 subjects with high cardiovascular risk 12-month diet intervention:➢ MD + 50 mL extra virgin olive oil (MD-O)\n➢ MD + 30 g nuts (MD-N)\nLow fat diet (LFD) MD-O: ↓ CRP (45%), IL-6 (35%), sICAM-1 (50%), P-selectin (27%)MD-N: ↓ CRP (45%), IL-6 (35%)(versus LFD) Casas et al. (2014)"}

LitCovid-sentences

LitCovid-PD-HP

{"project":"LitCovid-PD-HP","denotations":[{"id":"T85","span":{"begin":689,"end":701},"obj":"Phenotype"},{"id":"T86","span":{"begin":1598,"end":1608},"obj":"Phenotype"},{"id":"T87","span":{"begin":1794,"end":1804},"obj":"Phenotype"},{"id":"T88","span":{"begin":1977,"end":1994},"obj":"Phenotype"}],"attributes":[{"id":"A85","pred":"hp_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/HP_0000939"},{"id":"A86","pred":"hp_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/HP_0025502"},{"id":"A87","pred":"hp_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/HP_0025502"},{"id":"A88","pred":"hp_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/HP_0012743"}],"text":"Table 4 Recent reports concerning Mediterranean diet and inflammation.\nDesign Population Intervention Effects Reference\nFeeding study 25 subjects One-meal intervention:➢ Tocopherol-enriched Mediterranean meal\n➢ Western high-fat meal ↓ expression of inflammation-related genes De Lorenzo et al. (2017)\nControlled feeding study 35 men and 27 women ➢ 4-week MD intervention MD induced the same type of response regarding hs-CRP both in males and females Bedard et al. (2015)\nRandomized Controlled Trial 1142 subjects 12-month diet intervention:➢ MD-like NU-AGE diet + vitamin D3 (10 μg/day)\n➢ Control group Slowed the decline of bone mineral density only in the femoral neck in subjects with osteoporosis Jennings et al. (2018)\nRandomized Controlled Trial 20 elderly subjects 4-week diet intervention:➢ MD + coenzyme Q10 (MD-Q10)\n➢ MD\nDiet rich in saturated fatty acids (SFAD) MD, MD-Q10: ↓ expression of p65, IKK-b, MMP-9, IL-1b (versus SFAD)MD-Q: marked decrease of P65 and IKK-b (versus the other diets) Yubero-Serrano et al. (2012)\nRandomized Controlled Trial 20 elderly people 4-week diet intervention:➢ MD + olive oil (MD-O)\n➢ diet rich in saturated fatty acids (SFAD) low-fat, high-carbohydrate diet enriched in n-3 PUFA (LFHC-PUFA) MD-O: ↓ expression of inflammation-related genes (versus SFAD: p65, MCP-1; versus LFHC-PUFA: p65, TNF-α) Camargo et al. (2012)\nRandomized Controlled Crossover Trial 20 elderly subjects isocaloric diets for successive periods of 4 weeks in a crossover design: MD, MD + CoQ, Western diet ↓ AGE, RAGE Lopez-Moreno et al. (2018)\nRandomized Controlled Trial 34 male overweight subjects 4-week diet intervention:➢ Ketogenic MD (KMD)\nKMD + omega-3 (KMD-O3) KMD: ↓ TNF-αKMD-O3: ↓ IL-1β, IL-6, TNF-α, ↑ adiponectin Paoli et al. (2015)\n\u2028\u2028\nControlled feeding study 50 overweight and obese subjects 13-week diet intervention: Caloric restriction, MD + dietary supplementation ↓ CRP (versus baseline) Tripp et al. (2019)\nClinical Trial 90 subjects with abdominal obesity 2-month diet intervention:➢ MD, using olive oil\nControl group MD: ↓ CRP, P-selectin, E-selectin (versus baseline) Rallidis et al. (2017)\nClinical Trial 40 subjects with metabolic syndrome 8-week diet hypocaloric MD intervention ↓ mRNA associated with the regulation of inflammatory genes Marques-Rocha et al. (2016)\nRandomized Controlled Trial 36 subjects with metabolic syndrome 3-month MD intervention ↓ CRP, insulin Bekkouche et al. (2014)\nRandomized Controlled Trial 24 T2DM patients 3-month diet intervention:➢ MD, using olive oil\nLow fat diet (LFD) MD: ↓ IL-6, ICAM-1, ↑ GLP-1 stimulated insulin secretion Ceriello et al. (2014)\nRandomized Controlled Trial 215 T2DM (newly diagnosed) 12-month diet intervention:➢ MD\nLow fat diet (LFD) MD: ↓ CRP (37%), ↑ adiponectin (43%) Maiorino et al. (2016)\nRandomized Controlled Trial 56 coronary heart disease patients 6-month diet intervention:➢ MD\nLow fat diet (LFD) ↓ dietary inflammatory index (including IL-1b, IL-4, IL-6, IL-10, TNF-α, CRP) Mayr et al. (2018)\nRandomized Controlled Trial 164 subjects with high cardiovascular risk 12-month diet intervention:➢ MD + 50 mL extra virgin olive oil (MD-O)\n➢ MD + 30 g nuts (MD-N)\nLow fat diet (LFD) MD-O: ↓ CRP (45%), IL-6 (35%), sICAM-1 (50%), P-selectin (27%)MD-N: ↓ CRP (45%), IL-6 (35%)(versus LFD) Casas et al. (2014)"}

MyTest

{"project":"MyTest","denotations":[{"id":"32640331-27709360-30720878","span":{"begin":295,"end":299},"obj":"27709360"},{"id":"32640331-25962728-30720879","span":{"begin":466,"end":470},"obj":"25962728"},{"id":"32640331-30007343-30720880","span":{"begin":719,"end":723},"obj":"30007343"},{"id":"32640331-22016358-30720881","span":{"begin":1027,"end":1031},"obj":"22016358"},{"id":"32640331-22085595-30720882","span":{"begin":1358,"end":1362},"obj":"22085595"},{"id":"32640331-28329789-30720883","span":{"begin":1556,"end":1560},"obj":"28329789"},{"id":"32640331-25689563-30720884","span":{"begin":1757,"end":1761},"obj":"25689563"},{"id":"32640331-31084538-30720885","span":{"begin":1939,"end":1943},"obj":"31084538"},{"id":"32640331-28361746-30720886","span":{"begin":2126,"end":2130},"obj":"28361746"},{"id":"32640331-26421388-30720887","span":{"begin":2305,"end":2309},"obj":"26421388"},{"id":"32640331-24446153-30720888","span":{"begin":2432,"end":2436},"obj":"24446153"},{"id":"32640331-25407792-30720889","span":{"begin":2624,"end":2628},"obj":"25407792"},{"id":"32640331-26860514-30720890","span":{"begin":2790,"end":2794},"obj":"26860514"},{"id":"32640331-29754829-30720891","span":{"begin":3000,"end":3004},"obj":"29754829"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Table 4 Recent reports concerning Mediterranean diet and inflammation.\nDesign Population Intervention Effects Reference\nFeeding study 25 subjects One-meal intervention:➢ Tocopherol-enriched Mediterranean meal\n➢ Western high-fat meal ↓ expression of inflammation-related genes De Lorenzo et al. (2017)\nControlled feeding study 35 men and 27 women ➢ 4-week MD intervention MD induced the same type of response regarding hs-CRP both in males and females Bedard et al. (2015)\nRandomized Controlled Trial 1142 subjects 12-month diet intervention:➢ MD-like NU-AGE diet + vitamin D3 (10 μg/day)\n➢ Control group Slowed the decline of bone mineral density only in the femoral neck in subjects with osteoporosis Jennings et al. (2018)\nRandomized Controlled Trial 20 elderly subjects 4-week diet intervention:➢ MD + coenzyme Q10 (MD-Q10)\n➢ MD\nDiet rich in saturated fatty acids (SFAD) MD, MD-Q10: ↓ expression of p65, IKK-b, MMP-9, IL-1b (versus SFAD)MD-Q: marked decrease of P65 and IKK-b (versus the other diets) Yubero-Serrano et al. (2012)\nRandomized Controlled Trial 20 elderly people 4-week diet intervention:➢ MD + olive oil (MD-O)\n➢ diet rich in saturated fatty acids (SFAD) low-fat, high-carbohydrate diet enriched in n-3 PUFA (LFHC-PUFA) MD-O: ↓ expression of inflammation-related genes (versus SFAD: p65, MCP-1; versus LFHC-PUFA: p65, TNF-α) Camargo et al. (2012)\nRandomized Controlled Crossover Trial 20 elderly subjects isocaloric diets for successive periods of 4 weeks in a crossover design: MD, MD + CoQ, Western diet ↓ AGE, RAGE Lopez-Moreno et al. (2018)\nRandomized Controlled Trial 34 male overweight subjects 4-week diet intervention:➢ Ketogenic MD (KMD)\nKMD + omega-3 (KMD-O3) KMD: ↓ TNF-αKMD-O3: ↓ IL-1β, IL-6, TNF-α, ↑ adiponectin Paoli et al. (2015)\n\u2028\u2028\nControlled feeding study 50 overweight and obese subjects 13-week diet intervention: Caloric restriction, MD + dietary supplementation ↓ CRP (versus baseline) Tripp et al. (2019)\nClinical Trial 90 subjects with abdominal obesity 2-month diet intervention:➢ MD, using olive oil\nControl group MD: ↓ CRP, P-selectin, E-selectin (versus baseline) Rallidis et al. (2017)\nClinical Trial 40 subjects with metabolic syndrome 8-week diet hypocaloric MD intervention ↓ mRNA associated with the regulation of inflammatory genes Marques-Rocha et al. (2016)\nRandomized Controlled Trial 36 subjects with metabolic syndrome 3-month MD intervention ↓ CRP, insulin Bekkouche et al. (2014)\nRandomized Controlled Trial 24 T2DM patients 3-month diet intervention:➢ MD, using olive oil\nLow fat diet (LFD) MD: ↓ IL-6, ICAM-1, ↑ GLP-1 stimulated insulin secretion Ceriello et al. (2014)\nRandomized Controlled Trial 215 T2DM (newly diagnosed) 12-month diet intervention:➢ MD\nLow fat diet (LFD) MD: ↓ CRP (37%), ↑ adiponectin (43%) Maiorino et al. (2016)\nRandomized Controlled Trial 56 coronary heart disease patients 6-month diet intervention:➢ MD\nLow fat diet (LFD) ↓ dietary inflammatory index (including IL-1b, IL-4, IL-6, IL-10, TNF-α, CRP) Mayr et al. (2018)\nRandomized Controlled Trial 164 subjects with high cardiovascular risk 12-month diet intervention:➢ MD + 50 mL extra virgin olive oil (MD-O)\n➢ MD + 30 g nuts (MD-N)\nLow fat diet (LFD) MD-O: ↓ CRP (45%), IL-6 (35%), sICAM-1 (50%), P-selectin (27%)MD-N: ↓ CRP (45%), IL-6 (35%)(versus LFD) Casas et al. (2014)"}

2_test

{"project":"2_test","denotations":[{"id":"32640331-27709360-30720878","span":{"begin":295,"end":299},"obj":"27709360"},{"id":"32640331-25962728-30720879","span":{"begin":466,"end":470},"obj":"25962728"},{"id":"32640331-30007343-30720880","span":{"begin":719,"end":723},"obj":"30007343"},{"id":"32640331-22016358-30720881","span":{"begin":1027,"end":1031},"obj":"22016358"},{"id":"32640331-22085595-30720882","span":{"begin":1358,"end":1362},"obj":"22085595"},{"id":"32640331-28329789-30720883","span":{"begin":1556,"end":1560},"obj":"28329789"},{"id":"32640331-25689563-30720884","span":{"begin":1757,"end":1761},"obj":"25689563"},{"id":"32640331-31084538-30720885","span":{"begin":1939,"end":1943},"obj":"31084538"},{"id":"32640331-28361746-30720886","span":{"begin":2126,"end":2130},"obj":"28361746"},{"id":"32640331-26421388-30720887","span":{"begin":2305,"end":2309},"obj":"26421388"},{"id":"32640331-24446153-30720888","span":{"begin":2432,"end":2436},"obj":"24446153"},{"id":"32640331-25407792-30720889","span":{"begin":2624,"end":2628},"obj":"25407792"},{"id":"32640331-26860514-30720890","span":{"begin":2790,"end":2794},"obj":"26860514"},{"id":"32640331-29754829-30720891","span":{"begin":3000,"end":3004},"obj":"29754829"}],"text":"Table 4 Recent reports concerning Mediterranean diet and inflammation.\nDesign Population Intervention Effects Reference\nFeeding study 25 subjects One-meal intervention:➢ Tocopherol-enriched Mediterranean meal\n➢ Western high-fat meal ↓ expression of inflammation-related genes De Lorenzo et al. (2017)\nControlled feeding study 35 men and 27 women ➢ 4-week MD intervention MD induced the same type of response regarding hs-CRP both in males and females Bedard et al. (2015)\nRandomized Controlled Trial 1142 subjects 12-month diet intervention:➢ MD-like NU-AGE diet + vitamin D3 (10 μg/day)\n➢ Control group Slowed the decline of bone mineral density only in the femoral neck in subjects with osteoporosis Jennings et al. (2018)\nRandomized Controlled Trial 20 elderly subjects 4-week diet intervention:➢ MD + coenzyme Q10 (MD-Q10)\n➢ MD\nDiet rich in saturated fatty acids (SFAD) MD, MD-Q10: ↓ expression of p65, IKK-b, MMP-9, IL-1b (versus SFAD)MD-Q: marked decrease of P65 and IKK-b (versus the other diets) Yubero-Serrano et al. (2012)\nRandomized Controlled Trial 20 elderly people 4-week diet intervention:➢ MD + olive oil (MD-O)\n➢ diet rich in saturated fatty acids (SFAD) low-fat, high-carbohydrate diet enriched in n-3 PUFA (LFHC-PUFA) MD-O: ↓ expression of inflammation-related genes (versus SFAD: p65, MCP-1; versus LFHC-PUFA: p65, TNF-α) Camargo et al. (2012)\nRandomized Controlled Crossover Trial 20 elderly subjects isocaloric diets for successive periods of 4 weeks in a crossover design: MD, MD + CoQ, Western diet ↓ AGE, RAGE Lopez-Moreno et al. (2018)\nRandomized Controlled Trial 34 male overweight subjects 4-week diet intervention:➢ Ketogenic MD (KMD)\nKMD + omega-3 (KMD-O3) KMD: ↓ TNF-αKMD-O3: ↓ IL-1β, IL-6, TNF-α, ↑ adiponectin Paoli et al. (2015)\n\u2028\u2028\nControlled feeding study 50 overweight and obese subjects 13-week diet intervention: Caloric restriction, MD + dietary supplementation ↓ CRP (versus baseline) Tripp et al. (2019)\nClinical Trial 90 subjects with abdominal obesity 2-month diet intervention:➢ MD, using olive oil\nControl group MD: ↓ CRP, P-selectin, E-selectin (versus baseline) Rallidis et al. (2017)\nClinical Trial 40 subjects with metabolic syndrome 8-week diet hypocaloric MD intervention ↓ mRNA associated with the regulation of inflammatory genes Marques-Rocha et al. (2016)\nRandomized Controlled Trial 36 subjects with metabolic syndrome 3-month MD intervention ↓ CRP, insulin Bekkouche et al. (2014)\nRandomized Controlled Trial 24 T2DM patients 3-month diet intervention:➢ MD, using olive oil\nLow fat diet (LFD) MD: ↓ IL-6, ICAM-1, ↑ GLP-1 stimulated insulin secretion Ceriello et al. (2014)\nRandomized Controlled Trial 215 T2DM (newly diagnosed) 12-month diet intervention:➢ MD\nLow fat diet (LFD) MD: ↓ CRP (37%), ↑ adiponectin (43%) Maiorino et al. (2016)\nRandomized Controlled Trial 56 coronary heart disease patients 6-month diet intervention:➢ MD\nLow fat diet (LFD) ↓ dietary inflammatory index (including IL-1b, IL-4, IL-6, IL-10, TNF-α, CRP) Mayr et al. (2018)\nRandomized Controlled Trial 164 subjects with high cardiovascular risk 12-month diet intervention:➢ MD + 50 mL extra virgin olive oil (MD-O)\n➢ MD + 30 g nuts (MD-N)\nLow fat diet (LFD) MD-O: ↓ CRP (45%), IL-6 (35%), sICAM-1 (50%), P-selectin (27%)MD-N: ↓ CRP (45%), IL-6 (35%)(versus LFD) Casas et al. (2014)"}

LitCovid-PMC-OGER-BB

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T2117","span":{"begin":805,"end":828},"obj":"SP_7"},{"id":"T2118","span":{"begin":863,"end":866},"obj":"NCBITaxon:1"},{"id":"T2119","span":{"begin":1213,"end":1215},"obj":"UBERON:0002405;GO:0006955"},{"id":"T2120","span":{"begin":1248,"end":1255},"obj":"GO:0006955"},{"id":"T2121","span":{"begin":1259,"end":1260},"obj":"NCBITaxon:10239"},{"id":"T2122","span":{"begin":1454,"end":1479},"obj":"GO:0008152"},{"id":"T2123","span":{"begin":1678,"end":1715},"obj":"SP_7"},{"id":"T2124","span":{"begin":1904,"end":1930},"obj":"GO:0065007;CL:0000815"},{"id":"T2125","span":{"begin":1932,"end":1953},"obj":"CL:0000815"},{"id":"T2128","span":{"begin":2528,"end":2579},"obj":"NCBITaxon:1"},{"id":"T2129","span":{"begin":2726,"end":2728},"obj":"UBERON:0002405;CL:0000738"},{"id":"T2130","span":{"begin":2730,"end":2735},"obj":"CL:0000738"},{"id":"T2131","span":{"begin":2898,"end":2937},"obj":"CHEBI:67079;CHEBI:67079"},{"id":"T2132","span":{"begin":2949,"end":2954},"obj":"PR:000001393"},{"id":"T2133","span":{"begin":2975,"end":2980},"obj":"PR:000000134"},{"id":"T2134","span":{"begin":3011,"end":3026},"obj":"CL:0000235;PR:000002123"},{"id":"T2135","span":{"begin":3030,"end":3105},"obj":"PR:000002123"}],"text":"Table 4 Recent reports concerning Mediterranean diet and inflammation.\nDesign Population Intervention Effects Reference\nFeeding study 25 subjects One-meal intervention:➢ Tocopherol-enriched Mediterranean meal\n➢ Western high-fat meal ↓ expression of inflammation-related genes De Lorenzo et al. (2017)\nControlled feeding study 35 men and 27 women ➢ 4-week MD intervention MD induced the same type of response regarding hs-CRP both in males and females Bedard et al. (2015)\nRandomized Controlled Trial 1142 subjects 12-month diet intervention:➢ MD-like NU-AGE diet + vitamin D3 (10 μg/day)\n➢ Control group Slowed the decline of bone mineral density only in the femoral neck in subjects with osteoporosis Jennings et al. (2018)\nRandomized Controlled Trial 20 elderly subjects 4-week diet intervention:➢ MD + coenzyme Q10 (MD-Q10)\n➢ MD\nDiet rich in saturated fatty acids (SFAD) MD, MD-Q10: ↓ expression of p65, IKK-b, MMP-9, IL-1b (versus SFAD)MD-Q: marked decrease of P65 and IKK-b (versus the other diets) Yubero-Serrano et al. (2012)\nRandomized Controlled Trial 20 elderly people 4-week diet intervention:➢ MD + olive oil (MD-O)\n➢ diet rich in saturated fatty acids (SFAD) low-fat, high-carbohydrate diet enriched in n-3 PUFA (LFHC-PUFA) MD-O: ↓ expression of inflammation-related genes (versus SFAD: p65, MCP-1; versus LFHC-PUFA: p65, TNF-α) Camargo et al. (2012)\nRandomized Controlled Crossover Trial 20 elderly subjects isocaloric diets for successive periods of 4 weeks in a crossover design: MD, MD + CoQ, Western diet ↓ AGE, RAGE Lopez-Moreno et al. (2018)\nRandomized Controlled Trial 34 male overweight subjects 4-week diet intervention:➢ Ketogenic MD (KMD)\nKMD + omega-3 (KMD-O3) KMD: ↓ TNF-αKMD-O3: ↓ IL-1β, IL-6, TNF-α, ↑ adiponectin Paoli et al. (2015)\n\u2028\u2028\nControlled feeding study 50 overweight and obese subjects 13-week diet intervention: Caloric restriction, MD + dietary supplementation ↓ CRP (versus baseline) Tripp et al. (2019)\nClinical Trial 90 subjects with abdominal obesity 2-month diet intervention:➢ MD, using olive oil\nControl group MD: ↓ CRP, P-selectin, E-selectin (versus baseline) Rallidis et al. (2017)\nClinical Trial 40 subjects with metabolic syndrome 8-week diet hypocaloric MD intervention ↓ mRNA associated with the regulation of inflammatory genes Marques-Rocha et al. (2016)\nRandomized Controlled Trial 36 subjects with metabolic syndrome 3-month MD intervention ↓ CRP, insulin Bekkouche et al. (2014)\nRandomized Controlled Trial 24 T2DM patients 3-month diet intervention:➢ MD, using olive oil\nLow fat diet (LFD) MD: ↓ IL-6, ICAM-1, ↑ GLP-1 stimulated insulin secretion Ceriello et al. (2014)\nRandomized Controlled Trial 215 T2DM (newly diagnosed) 12-month diet intervention:➢ MD\nLow fat diet (LFD) MD: ↓ CRP (37%), ↑ adiponectin (43%) Maiorino et al. (2016)\nRandomized Controlled Trial 56 coronary heart disease patients 6-month diet intervention:➢ MD\nLow fat diet (LFD) ↓ dietary inflammatory index (including IL-1b, IL-4, IL-6, IL-10, TNF-α, CRP) Mayr et al. (2018)\nRandomized Controlled Trial 164 subjects with high cardiovascular risk 12-month diet intervention:➢ MD + 50 mL extra virgin olive oil (MD-O)\n➢ MD + 30 g nuts (MD-N)\nLow fat diet (LFD) MD-O: ↓ CRP (45%), IL-6 (35%), sICAM-1 (50%), P-selectin (27%)MD-N: ↓ CRP (45%), IL-6 (35%)(versus LFD) Casas et al. (2014)"}

PMC:7335494 / 44484-47797 JSONTXT

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PMC:7335494 / 44484-47797 JSON TXT