PMC:7335494 / 42407-43495
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T340 | 21-29 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T341 | 42-55 | Body_part | denotes | carbohydrates | http://purl.org/sig/ont/fma/fma82737 |
| T342 | 308-320 | Body_part | denotes | interleukins | http://purl.org/sig/ont/fma/fma86578 |
| T343 | 482-489 | Body_part | denotes | insulin | http://purl.org/sig/ont/fma/fma83365 |
| T344 | 795-800 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T345 | 846-854 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T346 | 945-952 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T347 | 1058-1062 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T348 | 1069-1082 | Body_part | denotes | interleukin 1 | http://purl.org/sig/ont/fma/fma86583 |
| T349 | 1069-1080 | Body_part | denotes | interleukin | http://purl.org/sig/ont/fma/fma86578 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T142 | 393-405 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T143 | 643-669 | Disease | denotes | neurodegenerative diseases | http://purl.obolibrary.org/obo/MONDO_0005559 |
| T144 | 685-703 | Disease | denotes | pulmonary diseases | http://purl.obolibrary.org/obo/MONDO_0005275 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T433 | 125-135 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T434 | 482-489 | http://purl.obolibrary.org/obo/PR_000009054 | denotes | insulin |
| T435 | 555-556 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T436 | 783-792 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T437 | 793-800 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cells |
| T438 | 864-870 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | Signal |
| T439 | 886-895 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activator |
| T440 | 935-944 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T441 | 1058-1064 | http://purl.obolibrary.org/obo/CLO_0053703 | denotes | IL-1/6 |
| T442 | 1069-1082 | http://purl.obolibrary.org/obo/PR_000001091 | denotes | interleukin 1 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T551 | 21-29 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T552 | 31-37 | Chemical | denotes | lipids | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T553 | 42-55 | Chemical | denotes | carbohydrates | http://purl.obolibrary.org/obo/CHEBI_16646 |
| T554 | 98-107 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T555 | 197-199 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T558 | 308-320 | Chemical | denotes | interleukins | http://purl.obolibrary.org/obo/CHEBI_52998 |
| T559 | 482-489 | Chemical | denotes | insulin | http://purl.obolibrary.org/obo/CHEBI_145810 |
| T560 | 542-551 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T561 | 730-732 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T564 | 846-854 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T565 | 927-934 | Chemical | denotes | mitogen | http://purl.obolibrary.org/obo/CHEBI_52290 |
| T566 | 945-952 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T567 | 1051-1056 | Chemical | denotes | alpha | http://purl.obolibrary.org/obo/CHEBI_30216 |
| T568 | 1058-1060 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T130 | 215-219 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | MAPK |
| T131 | 308-331 | http://purl.obolibrary.org/obo/GO_0001816 | denotes | interleukins production |
| T132 | 336-351 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcriptional |
| T133 | 352-362 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
| T134 | 393-405 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T135 | 899-912 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T136 | 920-924 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | MAPK |
| T137 | 1035-1043 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T138 | 1035-1043 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T139 | 1035-1043 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T140 | 1035-1043 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T232 | 0-235 | Sentence | denotes | Fig. 2 Diets rich in proteins, lipids and carbohydrates induce the production of pro-inflammatory molecules that lead to the activation of several inflammatory pathways including JAK/STAT pathway, NF-Kβ pathway and MAPK kinase cascade. |
| T233 | 236-406 | Sentence | denotes | These pathways lead to oxidative stress, as wells as, COX-2, TNF-α, and interleukins production via transcriptional regulation ultimately leading to chronic inflammation. |
| T234 | 407-1088 | Sentence | denotes | Oxidative stress either directly or via metabolic dysfunctions causing e.g insulin resistance, as well as the rest of the inflammatory molecules as a result of unhealthy diet promote the onset of several chronic diseases including CVD, neurodegenerative diseases, autoimmunity, pulmonary diseases and are-related frailty; (NF-kβ – nuclear factor kappa-light-chain-enhancer of activated B cells heterodimer, consisting of p50, p65 and IkBα proteins; STAT3 – Signal transducer and activator of transcription 3; ERK/MAPK – mitogen-activated protein kinases; JNK – c-Jun N-terminal kinases; COX-2 – cyclooxygenase 2; TNF-α – Tumour necrosis factor alpha; IL-1/6/8 – interleukin 1/6/8). |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T78 | 259-275 | Phenotype | denotes | oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
| T79 | 407-423 | Phenotype | denotes | Oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
| T80 | 482-500 | Phenotype | denotes | insulin resistance | http://purl.obolibrary.org/obo/HP_0000855 |
| T81 | 643-669 | Phenotype | denotes | neurodegenerative diseases | http://purl.obolibrary.org/obo/HP_0002180 |
| T82 | 671-683 | Phenotype | denotes | autoimmunity | http://purl.obolibrary.org/obo/HP_0002960 |
| T83 | 1028-1034 | Phenotype | denotes | Tumour | http://purl.obolibrary.org/obo/HP_0002664 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2113 | 308-335 | UBERON:0005169 | denotes | interleukins production via |
| T2114 | 750-770 | UBERON:0000062 | denotes | or kappa-light-chain |