PMC:7335494 / 41913-43495
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T339 | 471-482 | Body_part | denotes | fatty acids | http://purl.org/sig/ont/fma/fma82738 |
| T340 | 515-523 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T341 | 536-549 | Body_part | denotes | carbohydrates | http://purl.org/sig/ont/fma/fma82737 |
| T342 | 802-814 | Body_part | denotes | interleukins | http://purl.org/sig/ont/fma/fma86578 |
| T343 | 976-983 | Body_part | denotes | insulin | http://purl.org/sig/ont/fma/fma83365 |
| T344 | 1289-1294 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T345 | 1340-1348 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T346 | 1439-1446 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T347 | 1552-1556 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T348 | 1563-1576 | Body_part | denotes | interleukin 1 | http://purl.org/sig/ont/fma/fma86583 |
| T349 | 1563-1574 | Body_part | denotes | interleukin | http://purl.org/sig/ont/fma/fma86578 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T142 | 887-899 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T143 | 1137-1163 | Disease | denotes | neurodegenerative diseases | http://purl.obolibrary.org/obo/MONDO_0005559 |
| T144 | 1179-1197 | Disease | denotes | pulmonary diseases | http://purl.obolibrary.org/obo/MONDO_0005275 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T428 | 30-32 | http://purl.obolibrary.org/obo/CLO_0007622 | denotes | MD |
| T429 | 267-268 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T430 | 269-271 | http://purl.obolibrary.org/obo/CLO_0007622 | denotes | MD |
| T431 | 346-350 | http://purl.obolibrary.org/obo/CLO_0001185 | denotes | 2018 |
| T432 | 445-446 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T433 | 619-629 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T434 | 976-983 | http://purl.obolibrary.org/obo/PR_000009054 | denotes | insulin |
| T435 | 1049-1050 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T436 | 1277-1286 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T437 | 1287-1294 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cells |
| T438 | 1358-1364 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | Signal |
| T439 | 1380-1389 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activator |
| T440 | 1429-1438 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T441 | 1552-1558 | http://purl.obolibrary.org/obo/CLO_0053703 | denotes | IL-1/6 |
| T442 | 1563-1576 | http://purl.obolibrary.org/obo/PR_000001091 | denotes | interleukin 1 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T545 | 30-32 | Chemical | denotes | MD | http://purl.obolibrary.org/obo/CHEBI_74699 |
| T546 | 99-108 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T547 | 269-271 | Chemical | denotes | MD | http://purl.obolibrary.org/obo/CHEBI_74699 |
| T548 | 461-482 | Chemical | denotes | saturated fatty acids | http://purl.obolibrary.org/obo/CHEBI_26607 |
| T549 | 471-482 | Chemical | denotes | fatty acids | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T550 | 477-482 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T551 | 515-523 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T552 | 525-531 | Chemical | denotes | lipids | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T553 | 536-549 | Chemical | denotes | carbohydrates | http://purl.obolibrary.org/obo/CHEBI_16646 |
| T554 | 592-601 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T555 | 691-693 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T558 | 802-814 | Chemical | denotes | interleukins | http://purl.obolibrary.org/obo/CHEBI_52998 |
| T559 | 976-983 | Chemical | denotes | insulin | http://purl.obolibrary.org/obo/CHEBI_145810 |
| T560 | 1036-1045 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T561 | 1224-1226 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T564 | 1340-1348 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T565 | 1421-1428 | Chemical | denotes | mitogen | http://purl.obolibrary.org/obo/CHEBI_52290 |
| T566 | 1439-1446 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T567 | 1545-1550 | Chemical | denotes | alpha | http://purl.obolibrary.org/obo/CHEBI_30216 |
| T568 | 1552-1554 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T129 | 356-377 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
| T130 | 709-713 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | MAPK |
| T131 | 802-825 | http://purl.obolibrary.org/obo/GO_0001816 | denotes | interleukins production |
| T132 | 830-845 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcriptional |
| T133 | 846-856 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
| T134 | 887-899 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T135 | 1393-1406 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T136 | 1414-1418 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | MAPK |
| T137 | 1529-1537 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T138 | 1529-1537 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T139 | 1529-1537 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T140 | 1529-1537 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T230 | 0-242 | Sentence | denotes | In healthy subjects, even one MD-style meal was shown to reduce the expression of pro-inflammatory molecules (De Lorenzo et al., 2017), with no differences between sexes regarding effects on systemic inflammatory status (Bedard et al., 2015). |
| T231 | 243-493 | Sentence | denotes | In elderly individuals, a MD intervention lead to lower glycoxidative impairment (Lopez-Moreno et al., 2018) and inflammatory response (Camargo et al., 2012; Yubero-Serrano et al., 2012), paralleled to a diet based on saturated fatty acids (Fig. 2 ). |
| T232 | 494-729 | Sentence | denotes | Fig. 2 Diets rich in proteins, lipids and carbohydrates induce the production of pro-inflammatory molecules that lead to the activation of several inflammatory pathways including JAK/STAT pathway, NF-Kβ pathway and MAPK kinase cascade. |
| T233 | 730-900 | Sentence | denotes | These pathways lead to oxidative stress, as wells as, COX-2, TNF-α, and interleukins production via transcriptional regulation ultimately leading to chronic inflammation. |
| T234 | 901-1582 | Sentence | denotes | Oxidative stress either directly or via metabolic dysfunctions causing e.g insulin resistance, as well as the rest of the inflammatory molecules as a result of unhealthy diet promote the onset of several chronic diseases including CVD, neurodegenerative diseases, autoimmunity, pulmonary diseases and are-related frailty; (NF-kβ – nuclear factor kappa-light-chain-enhancer of activated B cells heterodimer, consisting of p50, p65 and IkBα proteins; STAT3 – Signal transducer and activator of transcription 3; ERK/MAPK – mitogen-activated protein kinases; JNK – c-Jun N-terminal kinases; COX-2 – cyclooxygenase 2; TNF-α – Tumour necrosis factor alpha; IL-1/6/8 – interleukin 1/6/8). |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T78 | 753-769 | Phenotype | denotes | oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
| T79 | 901-917 | Phenotype | denotes | Oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
| T80 | 976-994 | Phenotype | denotes | insulin resistance | http://purl.obolibrary.org/obo/HP_0000855 |
| T81 | 1137-1163 | Phenotype | denotes | neurodegenerative diseases | http://purl.obolibrary.org/obo/HP_0002180 |
| T82 | 1165-1177 | Phenotype | denotes | autoimmunity | http://purl.obolibrary.org/obo/HP_0002960 |
| T83 | 1522-1528 | Phenotype | denotes | Tumour | http://purl.obolibrary.org/obo/HP_0002664 |
MyTest
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32640331-27709360-30720864 | 129-133 | 27709360 | denotes | 2017 |
| 32640331-25962728-30720865 | 236-240 | 25962728 | denotes | 2015 |
| 32640331-28329789-30720866 | 346-350 | 28329789 | denotes | 2018 |
| 32640331-22085595-30720867 | 395-399 | 22085595 | denotes | 2012 |
| 32640331-22016358-30720868 | 424-428 | 22016358 | denotes | 2012 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32640331-27709360-30720864 | 129-133 | 27709360 | denotes | 2017 |
| 32640331-25962728-30720865 | 236-240 | 25962728 | denotes | 2015 |
| 32640331-28329789-30720866 | 346-350 | 28329789 | denotes | 2018 |
| 32640331-22085595-30720867 | 395-399 | 22085595 | denotes | 2012 |
| 32640331-22016358-30720868 | 424-428 | 22016358 | denotes | 2012 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2113 | 802-829 | UBERON:0005169 | denotes | interleukins production via |
| T2114 | 1244-1264 | UBERON:0000062 | denotes | or kappa-light-chain |