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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 187-202 Body_part denotes lung parenchyma http://purl.org/sig/ont/fma/fma27360
T2 1602-1606 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T3 1652-1657 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T4 1658-1665 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T5 1783-1786 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T6 5523-5528 Body_part denotes Serum http://purl.org/sig/ont/fma/fma63083
T7 5567-5572 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T8 5711-5716 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 187-202 Body_part denotes lung parenchyma http://purl.obolibrary.org/obo/UBERON_0008946
T2 187-191 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T3 192-202 Body_part denotes parenchyma http://purl.obolibrary.org/obo/UBERON_0000353
T4 1652-1657 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T5 5523-5528 Body_part denotes Serum http://purl.obolibrary.org/obo/UBERON_0001977
T6 5567-5572 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T7 5711-5716 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T3 38-85 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T4 38-71 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T5 87-95 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 139-147 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T7 153-178 Disease denotes acute respiratory failure http://purl.obolibrary.org/obo/MONDO_0001208|http://purl.obolibrary.org/obo/MONDO_0021113
T9 239-249 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T10 379-401 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T11 388-401 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T12 468-477 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T13 481-489 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T14 511-544 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T15 610-632 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T16 619-632 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T17 690-698 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T18 784-792 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T19 830-838 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T20 886-899 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T21 1033-1041 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T22 1068-1078 Disease denotes fusariosis http://purl.obolibrary.org/obo/MONDO_0016426
T23 1290-1315 Disease denotes acute respiratory failure http://purl.obolibrary.org/obo/MONDO_0001208|http://purl.obolibrary.org/obo/MONDO_0021113
T25 1403-1405 Disease denotes he http://purl.obolibrary.org/obo/MONDO_0017319
T26 1527-1543 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T27 1562-1581 Disease denotes respiratory disease http://purl.obolibrary.org/obo/MONDO_0005087
T28 1635-1650 Disease denotes type 2 diabetes http://purl.obolibrary.org/obo/MONDO_0005148
T29 1642-1650 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T30 1719-1731 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T31 1750-1764 Disease denotes hypothyroidism http://purl.obolibrary.org/obo/MONDO_0005420
T32 1766-1774 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T33 1987-1994 Disease denotes sterile http://purl.obolibrary.org/obo/MONDO_0005047
T34 2993-3003 Disease denotes fusariosis http://purl.obolibrary.org/obo/MONDO_0016426
T35 3018-3026 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T36 3920-3923 Disease denotes MEC http://purl.obolibrary.org/obo/MONDO_0003036|http://purl.obolibrary.org/obo/MONDO_0006860
T38 3951-3954 Disease denotes MEC http://purl.obolibrary.org/obo/MONDO_0003036|http://purl.obolibrary.org/obo/MONDO_0006860
T40 4050-4053 Disease denotes MEC http://purl.obolibrary.org/obo/MONDO_0003036|http://purl.obolibrary.org/obo/MONDO_0006860
T42 4934-4956 Disease denotes Invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T43 4943-4956 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T44 5001-5010 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T45 5011-5020 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T46 5060-5068 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T47 5073-5081 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T48 5084-5094 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T49 5105-5115 Disease denotes fusariosis http://purl.obolibrary.org/obo/MONDO_0016426
T50 5156-5169 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T51 5189-5199 Disease denotes fusariosis http://purl.obolibrary.org/obo/MONDO_0016426
T52 5315-5325 Disease denotes fusariosis http://purl.obolibrary.org/obo/MONDO_0016426
T53 5330-5343 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T54 5389-5399 Disease denotes fusariosis http://purl.obolibrary.org/obo/MONDO_0016426
T55 5468-5490 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T56 5477-5490 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T57 5654-5676 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T58 5663-5676 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T59 5849-5859 Disease denotes fusariosis http://purl.obolibrary.org/obo/MONDO_0016426
T60 5902-5910 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T61 5913-5922 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T62 6060-6068 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 187-191 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T2 187-191 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T3 402-405 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T4 600-601 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 842-843 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 1056-1057 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 1140-1141 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T8 1652-1657 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T9 1652-1657 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T10 1736-1737 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 1803-1804 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T12 1877-1878 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T13 1909-1910 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 1925-1926 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T15 2049-2050 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T16 2139-2142 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T17 2190-2198 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T18 2228-2229 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 2321-2328 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T20 2556-2557 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 2581-2582 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T22 2688-2695 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T23 2899-2900 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T24 3393-3394 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25 3452-3453 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T26 3464-3468 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T27 3566-3567 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T28 3698-3699 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 3874-3875 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T30 3908-3909 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T31 3993-4001 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T32 4097-4098 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T33 4350-4352 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T34 4361-4363 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T35 4427-4428 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T36 4485-4486 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37 4546-4553 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T38 4594-4595 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T39 4663-4665 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T40 4681-4682 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T41 4705-4713 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T42 4854-4855 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T43 4894-4895 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T44 4930-4932 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T45 4960-4961 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T46 5025-5028 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T47 5296-5297 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T48 5369-5370 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T49 5556-5563 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T50 5599-5600 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T51 5711-5716 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T52 5711-5716 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T53 5717-5722 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T54 5829-5830 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T55 6255-6262 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 1658-1665 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167
T3 2075-2078 Chemical denotes BAL http://purl.obolibrary.org/obo/CHEBI_64198
T4 2237-2240 Chemical denotes BAL http://purl.obolibrary.org/obo/CHEBI_64198
T5 2333-2346 Chemical denotes galactomannan http://purl.obolibrary.org/obo/CHEBI_27680
T6 2347-2354 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T7 2568-2582 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T8 2822-2834 Chemical denotes voriconazole http://purl.obolibrary.org/obo/CHEBI_10023
T9 2836-2848 Chemical denotes posaconazole http://purl.obolibrary.org/obo/CHEBI_64355
T10 2853-2866 Chemical denotes isavuconazole http://purl.obolibrary.org/obo/CHEBI_85979
T11 2872-2875 Chemical denotes MIC http://purl.obolibrary.org/obo/CHEBI_59059
T12 2886-2900 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T13 3107-3110 Chemical denotes BAL http://purl.obolibrary.org/obo/CHEBI_64198
T14 3136-3138 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T15 3140-3153 Chemical denotes galactomannan http://purl.obolibrary.org/obo/CHEBI_27680
T16 3184-3190 Chemical denotes glucan http://purl.obolibrary.org/obo/CHEBI_37163
T17 3280-3292 Chemical denotes voriconazole http://purl.obolibrary.org/obo/CHEBI_10023
T18 3361-3372 Chemical denotes caspofungin http://purl.obolibrary.org/obo/CHEBI_474180
T19 3439-3453 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T20 3553-3567 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T21 3572-3583 Chemical denotes caspofungin http://purl.obolibrary.org/obo/CHEBI_474180
T22 3589-3592 Chemical denotes MIC http://purl.obolibrary.org/obo/CHEBI_59059
T23 3601-3605 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T24 3857-3860 Chemical denotes MIC http://purl.obolibrary.org/obo/CHEBI_59059
T25 3861-3875 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T26 3891-3894 Chemical denotes MIC http://purl.obolibrary.org/obo/CHEBI_59059
T27 3895-3909 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T28 3924-3935 Chemical denotes caspofungin http://purl.obolibrary.org/obo/CHEBI_474180
T29 3955-3966 Chemical denotes caspofungin http://purl.obolibrary.org/obo/CHEBI_474180
T30 4006-4017 Chemical denotes caspofungin http://purl.obolibrary.org/obo/CHEBI_474180
T31 4070-4073 Chemical denotes MIC http://purl.obolibrary.org/obo/CHEBI_59059
T32 4084-4098 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T33 4273-4284 Chemical denotes caspofungin http://purl.obolibrary.org/obo/CHEBI_474180
T34 4737-4747 Chemical denotes antibiotic http://purl.obolibrary.org/obo/CHEBI_33281
T35 4881-4895 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T36 5531-5537 Chemical denotes glucan http://purl.obolibrary.org/obo/CHEBI_37163
T37 5542-5555 Chemical denotes galactomannan http://purl.obolibrary.org/obo/CHEBI_27680
T38 6229-6239 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 2333-2346 GlycoEpitope denotes galactomannan http://www.glycoepitope.jp/epitopes/EP0510
T2 3140-3153 GlycoEpitope denotes galactomannan http://www.glycoepitope.jp/epitopes/EP0510
T3 4532-4545 GlycoEpitope denotes Galactomannan http://www.glycoepitope.jp/epitopes/EP0510
T4 5542-5555 GlycoEpitope denotes galactomannan http://www.glycoepitope.jp/epitopes/EP0510

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 159-178 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T2 225-249 Phenotype denotes opportunistic infections http://purl.obolibrary.org/obo/HP_0031690
T3 1199-1204 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T4 1209-1214 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T5 1296-1315 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T6 1527-1543 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T7 1590-1600 Phenotype denotes overweight http://purl.obolibrary.org/obo/HP_0025502
T8 1635-1650 Phenotype denotes type 2 diabetes http://purl.obolibrary.org/obo/HP_0005978
T9 1682-1692 Phenotype denotes glycosuria http://purl.obolibrary.org/obo/HP_0003076
T10 1719-1731 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T11 1750-1764 Phenotype denotes hypothyroidism http://purl.obolibrary.org/obo/HP_0000821
T12 1814-1824 Phenotype denotes aspiration http://purl.obolibrary.org/obo/HP_0002835
T13 5011-5020 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T14 5913-5922 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
28 15-23 Species denotes Patients Tax:9606
29 38-85 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
30 87-97 Species denotes SARS-CoV-2 Tax:2697049
31 369-377 Species denotes patients Tax:9606
32 445-453 Species denotes patients Tax:9606
33 481-489 Species denotes SARS-CoV Tax:694009
34 670-677 Species denotes patient Tax:9606
35 793-801 Species denotes patients Tax:9606
36 24-32 Disease denotes infected MESH:D007239
37 118-137 Disease denotes coronavirus disease MESH:D018352
38 139-147 Disease denotes COVID-19 MESH:C000657245
39 159-178 Disease denotes respiratory failure MESH:D012131
40 225-249 Disease denotes opportunistic infections MESH:D009894
41 379-401 Disease denotes invasive aspergillosis MESH:D055744
42 454-462 Disease denotes infected MESH:D007239
43 511-544 Disease denotes severe acute respiratory syndrome MESH:D045169
44 610-632 Disease denotes invasive aspergillosis MESH:D055744
45 655-669 Disease denotes critically ill MESH:D016638
46 690-698 Disease denotes COVID-19 MESH:C000657245
47 784-792 Disease denotes COVID-19 MESH:C000657245
55 1013-1020 Species denotes patient Tax:9606
56 1117-1138 Species denotes Fusarium proliferatum Tax:948311
57 830-838 Disease denotes COVID-19 MESH:C000657245
58 861-896 Disease denotes invasive pulmonary mould infections MESH:D012141
59 1004-1012 Disease denotes diabetic MESH:D003920
60 1033-1041 Disease denotes COVID-19 MESH:C000657245
61 1058-1078 Disease denotes pulmonary fusariosis MESH:D060585
70 2952-2959 Species denotes patient Tax:9606
71 3049-3056 Species denotes patient Tax:9606
72 3136-3138 Chemical denotes GM MESH:D005839
73 3140-3153 Chemical denotes galactomannan MESH:C012990
74 3175-3178 Chemical denotes BDG
75 3180-3190 Chemical denotes β-D-glucan
76 2974-3003 Disease denotes invasive pulmonary fusariosis MESH:D060585
77 3018-3026 Disease denotes COVID-19 MESH:C000657245
100 1263-1270 Species denotes patient Tax:9606
101 1475-1482 Species denotes patient Tax:9606
102 1766-1776 Species denotes SARS-CoV-2 Tax:2697049
103 1843-1850 Species denotes patient Tax:9606
104 2006-2013 Species denotes patient Tax:9606
105 2469-2490 Species denotes Fusarium proliferatum Tax:948311
106 1658-1665 Chemical denotes glucose MESH:D005947
107 2333-2346 Chemical denotes galactomannan MESH:C012990
108 2568-2582 Chemical denotes amphotericin B MESH:D000666
109 2822-2834 Chemical denotes voriconazole MESH:D065819
110 2836-2848 Chemical denotes posaconazole MESH:C101425
111 2853-2866 Chemical denotes isavuconazole MESH:C508735
112 2886-2900 Chemical denotes amphotericin B MESH:D000666
113 1199-1204 Disease denotes fever MESH:D005334
114 1209-1214 Disease denotes cough MESH:D003371
115 1290-1315 Disease denotes acute respiratory failure MESH:D012120
116 1517-1543 Disease denotes inherited immunodeficiency MESH:D007153
117 1562-1581 Disease denotes respiratory disease MESH:D012140
118 1635-1650 Disease denotes type 2 diabetes MESH:D003924
119 1682-1692 Disease denotes glycosuria MESH:D006029
120 1719-1731 Disease denotes hypertension MESH:D006973
121 1750-1764 Disease denotes hypothyroidism MESH:D007037
143 3951-3954 Gene denotes MEC Gene:56477
144 3920-3923 Gene denotes MEC Gene:56477
145 4050-4053 Gene denotes MEC Gene:56477
146 3245-3252 Species denotes patient Tax:9606
147 4227-4234 Species denotes patient Tax:9606
148 4380-4401 Species denotes Fusarium proliferatum Tax:948311
149 4763-4770 Species denotes patient Tax:9606
150 3280-3292 Chemical denotes voriconazole MESH:D065819
151 3361-3372 Chemical denotes caspofungin MESH:D000077336
152 3439-3453 Chemical denotes amphotericin B MESH:D000666
153 3553-3567 Chemical denotes amphotericin B MESH:D000666
154 3572-3583 Chemical denotes caspofungin MESH:D000077336
155 3861-3875 Chemical denotes amphotericin B MESH:D000666
156 3895-3909 Chemical denotes amphotericin B MESH:D000666
157 3924-3935 Chemical denotes caspofungin MESH:D000077336
158 3955-3966 Chemical denotes caspofungin MESH:D000077336
159 4006-4017 Chemical denotes caspofungin MESH:D000077336
160 4084-4098 Chemical denotes amphotericin B MESH:D000666
161 4273-4284 Chemical denotes caspofungin MESH:D000077336
162 4532-4545 Chemical denotes Galactomannan MESH:C012990
163 4881-4895 Chemical denotes amphotericin B MESH:D000666
182 5046-5054 Species denotes patients Tax:9606
183 5060-5068 Species denotes SARS-CoV Tax:694009
184 5234-5242 Species denotes patients Tax:9606
185 5696-5704 Species denotes patients Tax:9606
186 5509-5517 Species denotes patients Tax:9606
187 5529-5537 Chemical denotes β-glucan MESH:D047071
188 5542-5555 Chemical denotes galactomannan MESH:C012990
189 4934-4956 Disease denotes Invasive aspergillosis MESH:D055744
190 5011-5020 Disease denotes pneumonia MESH:D011014
191 5073-5094 Disease denotes SARS-CoV-2 infections MESH:C000657245
192 5156-5169 Disease denotes aspergillosis MESH:D001228
193 5219-5233 Disease denotes critically ill MESH:D016638
194 5255-5271 Disease denotes pulmonary damage MESH:D008171
195 5330-5343 Disease denotes aspergillosis MESH:D001228
196 5380-5399 Disease denotes invasive fusariosis MESH:D060585
197 5468-5490 Disease denotes invasive aspergillosis MESH:D055744
198 5494-5508 Disease denotes critically ill MESH:D016638
199 5654-5676 Disease denotes invasive aspergillosis MESH:D055744
204 5882-5889 Species denotes patient Tax:9606
205 5839-5859 Disease denotes pulmonary fusariosis MESH:D060585
206 5902-5922 Disease denotes SARS-CoV-2 pneumonia MESH:C000657245
207 6060-6068 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T2 0-14 Sentence denotes To the Editor,
T3 15-179 Sentence denotes Patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may develop severe coronavirus disease (COVID-19) and acute respiratory failure.
T4 180-261 Sentence denotes As the lung parenchyma is seriously damaged, opportunistic infections are feared.
T5 262-568 Sentence denotes While invasive pulmonary mould superinfections are usually diagnosed primarily in highly immunocompromised patients, invasive aspergillosis has also been described in immunocompetent patients infected with influenza or SARS-CoV (responsible for the severe acute respiratory syndrome outbreak in 2002–2003).
T6 569-703 Sentence denotes Moreover, we recently reported a case of invasive aspergillosis in an immunocompetent critically ill patient with severe COVID-19 [1].
T7 704-806 Sentence denotes Another study also suggested an increased risk of Aspergillus superinfection in COVID-19 patients [2].
T8 807-957 Sentence denotes To know whether or not COVID-19 is a factor promoting invasive pulmonary mould infections in immunocompetent individuals is of great medical interest.
T9 958-1139 Sentence denotes We report here the case of an immunocompetent diabetic patient with severe COVID-19 who developed a pulmonary fusariosis due to the common environmental mould Fusarium proliferatum.
T10 1140-1245 Sentence denotes A 57-year-old man was sent to our hospital after 7 days of fever and cough worsening over the last 24 hr.
T11 1246-1470 Sentence denotes On admission the patient presented signs of acute respiratory failure and was rapidly transferred to our intensive care unit (ICU) on March 26 (day 1) where he was intubated and placed under mechanical ventilation (Fig. 1 ).
T12 1471-1582 Sentence denotes The patient had no history of any acquired or inherited immunodeficiency and no underlying respiratory disease.
T13 1583-1765 Sentence denotes He was overweight (body mass index 30.6 kg/m2) with type 2 diabetes (blood glucose 11.6 mmol/L and glycosuria 1.4 mmol/L on admission), hypertension and a substituted hypothyroidism.
T14 1766-1838 Sentence denotes SARS-CoV-2 viral RNA was detected in a tracheal aspiration on admission.
T15 1839-1924 Sentence denotes The patient's condition worsened with a PaO2/FiO2 ratio <90 mmHg with a FiO2 of 100%.
T16 1925-1995 Sentence denotes A protected specimen brush sample performed on day 2 remained sterile.
T17 1996-2103 Sentence denotes While the patient's condition showed no improvement, a bronchoalveolar lavage (BAL) was performed on day 7.
T18 2104-2213 Sentence denotes On day 9 this sample grew with 7 × 102/mL colony-forming unit (CFU) of mould while no bacteria were detected.
T19 2214-2375 Sentence denotes The same day, a second BAL was performed: atypical fungal hyphae were detected on microscopic examination, testing for galactomannan antigen was positive (index:
T20 2376-2426 Sentence denotes 1.7) and the sample grew with 103/mL CFU of mould.
T21 2427-2661 Sentence denotes The different cultures were identified as Fusarium proliferatum using mass spectrometry (Bruker Microflex with MSI database) and a liposomal amphotericin B-based therapy was started on day 12 (5 mg/kg/day for 2 days then 7 mg/kg/day).
T22 2662-2867 Sentence denotes Antifungal susceptibility testing determined using the gradient concentration strips method showed high minimal inhibitory concentrations (MICs) (>32 mg/L) for voriconazole, posaconazole and isavuconazole.
T23 2868-2912 Sentence denotes The MIC value for amphotericin B was 2 mg/L.
T24 2913-3027 Sentence denotes Fig. 1 Timeline for an immunocompetent patient who developed invasive pulmonary fusariosis during severe COVID-19.
T25 3028-3097 Sentence denotes Day 1 is the day the patient was admitted to the intensive care unit.
T26 3098-3198 Sentence denotes D, days; BAL, bronchoalveolar lavage; GM, galactomannan index determination; BDG, β-D-glucan dosage.
T27 3199-3460 Sentence denotes Considering the very serious condition of the patient, and despite the fact that voriconazole is suggested as first-line treatment (alone or in combination) [3], caspofungin was added, assuming a potential synergistic effect with liposomal amphotericin B [4,5].
T28 3461-3584 Sentence denotes To test this hypothesis in vitro, we used the checkerboard method to assess combinations of amphotericin B and caspofungin.
T29 3585-3741 Sentence denotes The MIC of each drug alone and the combinations of the two were determined concomitantly on the same plate using a method adapted from the EUCAST procedure.
T30 3742-3974 Sentence denotes Interaction was determined by calculating the fractional inhibitory concentration index (FICI) as follows: FICI = (MIC amphotericin B in combination/MIC amphotericin B alone) + (MEC caspofungin in combination/MEC caspofungin alone).
T31 3975-4065 Sentence denotes Results showed no activity for caspofungin either alone or in combination (MEC > 32 mg/L).
T32 4066-4141 Sentence denotes The MIC value for amphotericin B was 1 mg/L either alone or in combination.
T33 4142-4209 Sentence denotes The FICI value was equal to 2, which is indicative of indifference.
T34 4210-4307 Sentence denotes Moreover, as the patient's condition was beginning to improve, caspofungin was stopped on day 29.
T35 4308-4402 Sentence denotes Three other BALs performed on day 15, day 22 and day 27 still grew with Fusarium proliferatum.
T36 4403-4531 Sentence denotes Importantly, we noticed a gradual increase in the delay of culture positivity and a decrease in the number of colonies obtained.
T37 4532-4625 Sentence denotes Galactomannan testing became negative, all of which indicated a reduction of the fungal load.
T38 4626-4758 Sentence denotes The BALs performed on day 15 and day 27 also grew with a significant amount of bacteria, which led to specific antibiotic treatment.
T39 4759-4807 Sentence denotes The patient's general condition slowly improved.
T40 4808-4870 Sentence denotes He was extubated on day 30 then discharged to a post-ICU area.
T41 4871-4933 Sentence denotes Liposomal amphotericin B administration was stopped on day 35.
T42 4934-5101 Sentence denotes Invasive aspergillosis is a well-recognized complication of severe influenza pneumonia and has been reported in patients with SARS-CoV and SARS-CoV-2 infections [1,2].
T43 5102-5284 Sentence denotes As fusariosis shares many common characteristics with aspergillosis [6], occurrence of fusariosis in immunocompetent critically ill patients with severe pulmonary damage is possible.
T44 5285-5522 Sentence denotes If we draw a parallel between fusariosis and aspergillosis, the case we describe is a putative invasive fusariosis according to the classification by Blot et al. for the diagnosis of invasive aspergillosis in critically ill patients [7].
T45 5523-5587 Sentence denotes Serum β-glucan and galactomannan testing in serum were negative.
T46 5588-5796 Sentence denotes Here again a resemblance can be seen with what is observed during invasive aspergillosis in immunocompetent patients where blood tests are often negative while respiratory samples establish the diagnosis [7].
T47 5797-5923 Sentence denotes In conclusion, we have reported a case of pulmonary fusariosis in an immunocompetent patient with severe SARS-CoV-2 pneumonia.
T48 5924-6069 Sentence denotes As the outbreak continues to spread worldwide, other reports are needed to assess the frequency of fungal superinfections during severe COVID-19.
T49 6071-6095 Sentence denotes Transparency declaration
T50 6096-6104 Sentence denotes Funding:
T51 6105-6110 Sentence denotes None.
T52 6111-6154 Sentence denotes The authors declare no competing interests.
T53 6156-6176 Sentence denotes Author contributions
T54 6177-6328 Sentence denotes C.P. and M.B. collected mycological data, performed antifungal susceptibility testing and the EUCAST checkboard method and participated in the writing.
T55 6329-6432 Sentence denotes C.V. participated in the therapeutic decision, collected clinical data and participated in the writing.
T56 6433-6498 Sentence denotes A.L. participated in the therapeutic decision and in the writing.
T57 6499-6602 Sentence denotes A.M. participated in the therapeutic decision, collected clinical data and participated in the writing.
T58 6603-6685 Sentence denotes A.F. participated in the therapeutic decision, collected data and wrote the paper.

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T3 38-50 SP_7 denotes severe acute
T4 51-62 SP_7;UBERON:0001004 denotes respiratory
T5 63-85 SP_7 denotes syndrome coronavirus 2
T6 87-97 SP_7 denotes SARS-CoV-2
T7 118-129 NCBITaxon:11118 denotes coronavirus
T8 139-147 SP_7 denotes COVID-19
T9 159-170 UBERON:0001004 denotes respiratory
T10 187-202 UBERON:0008946 denotes lung parenchyma
T11 277-286 UBERON:0002048 denotes pulmonary
T12 481-489 SP_10 denotes SARS-CoV
T13 524-535 UBERON:0001004 denotes respiratory
T14 690-698 SP_7 denotes COVID-19
T15 754-765 NCBITaxon:5052 denotes Aspergillus
T16 784-792 SP_7 denotes COVID-19
T17 830-838 SP_7 denotes COVID-19
T18 870-879 UBERON:0002048 denotes pulmonary
T19 916-927 NCBITaxon:1 denotes individuals
T20 1033-1041 SP_7 denotes COVID-19
T21 1058-1067 UBERON:0002048 denotes pulmonary
T22 1154-1157 NCBITaxon:9606 denotes man
T23 1209-1214 UBERON:0001004 denotes cough
T24 1296-1307 UBERON:0001004 denotes respiratory
T25 1562-1573 UBERON:0001004 denotes respiratory
T26 1652-1657 UBERON:0000178 denotes blood
T27 1658-1665 CHEBI:17234;CHEBI:17234 denotes glucose
T28 1766-1776 SP_7 denotes SARS-CoV-2
T29 1777-1782 NCBITaxon:10239 denotes viral
T30 1805-1813 UBERON:0003126 denotes tracheal
T31 1911-1915 CHEBI:16526;CHEBI:16526 denotes FiO2
T32 2051-2066 UBERON:0002186 denotes bronchoalveolar
T33 2125-2129 GO:0040007 denotes grew
T34 2190-2198 NCBITaxon:2 denotes bacteria
T35 2333-2346 CHEBI:27680;CHEBI:27680 denotes galactomannan
T36 2347-2354 CHEBI:59132;CHEBI:59132 denotes antigen
T37 2396-2400 GO:0040007 denotes grew
T38 2469-2490 NCBITaxon:948311 denotes Fusarium proliferatum
T39 2568-2582 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T40 2822-2834 CHEBI:10023;CHEBI:10023 denotes voriconazole
T41 2836-2848 CHEBI:64355;CHEBI:64355 denotes posaconazole
T42 2853-2866 CHEBI:85979;CHEBI:85979 denotes isavuconazole
T43 2872-2875 SO:0000154 denotes MIC
T44 2886-2900 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T45 2983-2992 UBERON:0002048 denotes pulmonary
T46 3018-3026 SP_7 denotes COVID-19
T47 3087-3096 UBERON:0007221 denotes care unit
T48 3112-3127 UBERON:0002186 denotes bronchoalveolar
T49 3140-3153 CHEBI:27680;CHEBI:27680 denotes galactomannan
T50 3184-3190 CHEBI:28793;CHEBI:28793 denotes glucan
T57 3280-3292 CHEBI:10023;CHEBI:10023 denotes voriconazole
T58 3439-3453 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T59 3553-3567 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T60 3601-3605 CHEBI:23888;CHEBI:23888 denotes drug
T61 3861-3875 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T62 3895-3909 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T63 4084-4098 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T64 4370-4374 GO:0040007 denotes grew
T65 4380-4401 NCBITaxon:948311 denotes Fusarium proliferatum
T66 4532-4545 CHEBI:27680;CHEBI:27680 denotes Galactomannan
T67 4671-4675 GO:0040007 denotes grew
T68 4705-4713 NCBITaxon:2 denotes bacteria
T69 4737-4747 CHEBI:33282;CHEBI:33282 denotes antibiotic
T70 4871-4880 GO:0005764 denotes Liposomal
T71 4881-4895 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T72 5060-5068 SP_10 denotes SARS-CoV
T73 5073-5083 SP_7 denotes SARS-CoV-2
T74 5255-5264 UBERON:0002048 denotes pulmonary
T75 5523-5528 UBERON:0001977 denotes Serum
T76 5531-5537 CHEBI:37163;CHEBI:37163 denotes glucan
T77 5542-5555 CHEBI:27680;CHEBI:27680 denotes galactomannan
T78 5567-5572 UBERON:0001977 denotes serum
T79 5711-5716 UBERON:0000178 denotes blood
T80 5748-5759 UBERON:0001004 denotes respiratory
T81 5839-5848 UBERON:0002048 denotes pulmonary
T82 5902-5912 SP_7 denotes SARS-CoV-2
T83 6023-6029 NCBITaxon:4751 denotes fungal
T84 6060-6068 SP_7 denotes COVID-19
T32209 38-50 SP_7 denotes severe acute
T19930 51-62 SP_7;UBERON:0001004 denotes respiratory
T63040 63-85 SP_7 denotes syndrome coronavirus 2
T63916 87-97 SP_7 denotes SARS-CoV-2
T99154 118-129 NCBITaxon:11118 denotes coronavirus
T72851 139-147 SP_7 denotes COVID-19
T97997 159-170 UBERON:0001004 denotes respiratory
T16258 187-202 UBERON:0008946 denotes lung parenchyma
T31204 277-286 UBERON:0002048 denotes pulmonary
T76318 481-489 SP_10 denotes SARS-CoV
T48167 524-535 UBERON:0001004 denotes respiratory
T61071 690-698 SP_7 denotes COVID-19
T78957 754-765 NCBITaxon:5052 denotes Aspergillus
T68889 784-792 SP_7 denotes COVID-19
T59645 830-838 SP_7 denotes COVID-19
T66365 870-879 UBERON:0002048 denotes pulmonary
T67497 916-927 NCBITaxon:1 denotes individuals
T80740 1033-1041 SP_7 denotes COVID-19
T5442 1058-1067 UBERON:0002048 denotes pulmonary
T84384 1154-1157 NCBITaxon:9606 denotes man
T13089 1209-1214 UBERON:0001004 denotes cough
T29928 1296-1307 UBERON:0001004 denotes respiratory
T68878 1562-1573 UBERON:0001004 denotes respiratory
T86378 1652-1657 UBERON:0000178 denotes blood
T94726 1658-1665 CHEBI:17234;CHEBI:17234 denotes glucose
T78314 1766-1776 SP_7 denotes SARS-CoV-2
T40427 1777-1782 NCBITaxon:10239 denotes viral
T2505 1805-1813 UBERON:0003126 denotes tracheal
T67814 1911-1915 CHEBI:16526;CHEBI:16526 denotes FiO2
T97680 2051-2066 UBERON:0002186 denotes bronchoalveolar
T41320 2125-2129 GO:0040007 denotes grew
T29670 2190-2198 NCBITaxon:2 denotes bacteria
T41230 2333-2346 CHEBI:27680;CHEBI:27680 denotes galactomannan
T76288 2347-2354 CHEBI:59132;CHEBI:59132 denotes antigen
T91801 2396-2400 GO:0040007 denotes grew
T24803 2469-2490 NCBITaxon:948311 denotes Fusarium proliferatum
T75536 2568-2582 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T7769 2822-2834 CHEBI:10023;CHEBI:10023 denotes voriconazole
T37012 2836-2848 CHEBI:64355;CHEBI:64355 denotes posaconazole
T51161 2853-2866 CHEBI:85979;CHEBI:85979 denotes isavuconazole
T30376 2872-2875 SO:0000154 denotes MIC
T19946 2886-2900 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T13465 2983-2992 UBERON:0002048 denotes pulmonary
T81946 3018-3026 SP_7 denotes COVID-19
T88494 3087-3096 UBERON:0007221 denotes care unit
T46519 3112-3127 UBERON:0002186 denotes bronchoalveolar
T16525 3140-3153 CHEBI:27680;CHEBI:27680 denotes galactomannan
T97325 3184-3190 CHEBI:28793;CHEBI:28793 denotes glucan
T52 6060-6068 SP_7 denotes COVID-19
T53 3087-3096 UBERON:0007221 denotes care unit
T54 3112-3127 UBERON:0002186 denotes bronchoalveolar
T55 3140-3153 CHEBI:27680;CHEBI:27680 denotes galactomannan
T56 3184-3190 CHEBI:28793;CHEBI:28793 denotes glucan
T971 3280-3292 CHEBI:10023;CHEBI:10023 denotes voriconazole
T98852 3439-3453 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T82144 3553-3567 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T89447 3601-3605 CHEBI:23888;CHEBI:23888 denotes drug
T33586 3861-3875 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T76702 3895-3909 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T42104 4084-4098 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T33396 4370-4374 GO:0040007 denotes grew
T78053 4380-4401 NCBITaxon:948311 denotes Fusarium proliferatum
T89176 4532-4545 CHEBI:27680;CHEBI:27680 denotes Galactomannan
T7633 4671-4675 GO:0040007 denotes grew
T99376 4705-4713 NCBITaxon:2 denotes bacteria
T48876 4737-4747 CHEBI:33282;CHEBI:33282 denotes antibiotic
T84617 4871-4880 GO:0005764 denotes Liposomal
T4681 4881-4895 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T37554 5060-5068 SP_10 denotes SARS-CoV
T55412 5073-5083 SP_7 denotes SARS-CoV-2
T31163 5255-5264 UBERON:0002048 denotes pulmonary
T43968 5523-5528 UBERON:0001977 denotes Serum
T95642 5531-5537 CHEBI:37163;CHEBI:37163 denotes glucan
T55093 5542-5555 CHEBI:27680;CHEBI:27680 denotes galactomannan
T54683 5567-5572 UBERON:0001977 denotes serum
T14799 5711-5716 UBERON:0000178 denotes blood
T78928 5748-5759 UBERON:0001004 denotes respiratory
T70703 5839-5848 UBERON:0002048 denotes pulmonary
T9047 5902-5912 SP_7 denotes SARS-CoV-2
T39367 6023-6029 NCBITaxon:4751 denotes fungal
T79225 6060-6068 SP_7 denotes COVID-19