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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 284-299 Body_part denotes lung parenchyma http://purl.org/sig/ont/fma/fma27360
T2 1699-1703 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T3 1749-1754 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T4 1755-1762 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T5 1880-1883 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T6 5620-5625 Body_part denotes Serum http://purl.org/sig/ont/fma/fma63083
T7 5664-5669 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T8 5808-5813 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 284-299 Body_part denotes lung parenchyma http://purl.obolibrary.org/obo/UBERON_0008946
T2 284-288 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T3 289-299 Body_part denotes parenchyma http://purl.obolibrary.org/obo/UBERON_0000353
T4 1749-1754 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T5 5620-5625 Body_part denotes Serum http://purl.obolibrary.org/obo/UBERON_0001977
T6 5664-5669 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T7 5808-5813 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 19-29 Disease denotes fusariosis http://purl.obolibrary.org/obo/MONDO_0016426
T2 87-95 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T3 135-182 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T4 135-168 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T5 184-192 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 236-244 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T7 250-275 Disease denotes acute respiratory failure http://purl.obolibrary.org/obo/MONDO_0001208|http://purl.obolibrary.org/obo/MONDO_0021113
T9 336-346 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T10 476-498 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T11 485-498 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T12 565-574 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T13 578-586 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T14 608-641 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T15 707-729 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T16 716-729 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T17 787-795 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T18 881-889 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T19 927-935 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T20 983-996 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T21 1130-1138 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T22 1165-1175 Disease denotes fusariosis http://purl.obolibrary.org/obo/MONDO_0016426
T23 1387-1412 Disease denotes acute respiratory failure http://purl.obolibrary.org/obo/MONDO_0001208|http://purl.obolibrary.org/obo/MONDO_0021113
T25 1500-1502 Disease denotes he http://purl.obolibrary.org/obo/MONDO_0017319
T26 1624-1640 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T27 1659-1678 Disease denotes respiratory disease http://purl.obolibrary.org/obo/MONDO_0005087
T28 1732-1747 Disease denotes type 2 diabetes http://purl.obolibrary.org/obo/MONDO_0005148
T29 1739-1747 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T30 1816-1828 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T31 1847-1861 Disease denotes hypothyroidism http://purl.obolibrary.org/obo/MONDO_0005420
T32 1863-1871 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T33 2084-2091 Disease denotes sterile http://purl.obolibrary.org/obo/MONDO_0005047
T34 3090-3100 Disease denotes fusariosis http://purl.obolibrary.org/obo/MONDO_0016426
T35 3115-3123 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T36 4017-4020 Disease denotes MEC http://purl.obolibrary.org/obo/MONDO_0003036|http://purl.obolibrary.org/obo/MONDO_0006860
T38 4048-4051 Disease denotes MEC http://purl.obolibrary.org/obo/MONDO_0003036|http://purl.obolibrary.org/obo/MONDO_0006860
T40 4147-4150 Disease denotes MEC http://purl.obolibrary.org/obo/MONDO_0003036|http://purl.obolibrary.org/obo/MONDO_0006860
T42 5031-5053 Disease denotes Invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T43 5040-5053 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T44 5098-5107 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T45 5108-5117 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T46 5157-5165 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T47 5170-5178 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T48 5181-5191 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T49 5202-5212 Disease denotes fusariosis http://purl.obolibrary.org/obo/MONDO_0016426
T50 5253-5266 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T51 5286-5296 Disease denotes fusariosis http://purl.obolibrary.org/obo/MONDO_0016426
T52 5412-5422 Disease denotes fusariosis http://purl.obolibrary.org/obo/MONDO_0016426
T53 5427-5440 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T54 5486-5496 Disease denotes fusariosis http://purl.obolibrary.org/obo/MONDO_0016426
T55 5565-5587 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T56 5574-5587 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T57 5751-5773 Disease denotes invasive aspergillosis http://purl.obolibrary.org/obo/MONDO_0000240
T58 5760-5773 Disease denotes aspergillosis http://purl.obolibrary.org/obo/MONDO_0005657
T59 5946-5956 Disease denotes fusariosis http://purl.obolibrary.org/obo/MONDO_0016426
T60 5999-6007 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T61 6010-6019 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T62 6157-6165 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 284-288 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T2 284-288 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T3 499-502 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T4 697-698 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 939-940 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 1153-1154 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 1237-1238 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T8 1749-1754 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T9 1749-1754 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T10 1833-1834 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 1900-1901 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T12 1974-1975 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T13 2006-2007 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 2022-2023 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T15 2146-2147 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T16 2236-2239 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T17 2287-2295 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T18 2325-2326 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 2418-2425 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T20 2653-2654 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 2678-2679 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T22 2785-2792 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T23 2996-2997 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T24 3490-3491 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25 3549-3550 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T26 3561-3565 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T27 3663-3664 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T28 3795-3796 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 3971-3972 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T30 4005-4006 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T31 4090-4098 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T32 4194-4195 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T33 4447-4449 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T34 4458-4460 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T35 4524-4525 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T36 4582-4583 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37 4643-4650 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T38 4691-4692 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T39 4760-4762 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T40 4778-4779 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T41 4802-4810 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T42 4951-4952 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T43 4991-4992 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T44 5027-5029 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T45 5057-5058 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T46 5122-5125 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T47 5393-5394 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T48 5466-5467 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T49 5653-5660 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T50 5696-5697 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T51 5808-5813 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T52 5808-5813 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T53 5814-5819 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T54 5926-5927 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T55 6352-6359 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 1755-1762 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167
T3 2172-2175 Chemical denotes BAL http://purl.obolibrary.org/obo/CHEBI_64198
T4 2334-2337 Chemical denotes BAL http://purl.obolibrary.org/obo/CHEBI_64198
T5 2430-2443 Chemical denotes galactomannan http://purl.obolibrary.org/obo/CHEBI_27680
T6 2444-2451 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T7 2665-2679 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T8 2919-2931 Chemical denotes voriconazole http://purl.obolibrary.org/obo/CHEBI_10023
T9 2933-2945 Chemical denotes posaconazole http://purl.obolibrary.org/obo/CHEBI_64355
T10 2950-2963 Chemical denotes isavuconazole http://purl.obolibrary.org/obo/CHEBI_85979
T11 2969-2972 Chemical denotes MIC http://purl.obolibrary.org/obo/CHEBI_59059
T12 2983-2997 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T13 3204-3207 Chemical denotes BAL http://purl.obolibrary.org/obo/CHEBI_64198
T14 3233-3235 Chemical denotes GM http://purl.obolibrary.org/obo/CHEBI_74120
T15 3237-3250 Chemical denotes galactomannan http://purl.obolibrary.org/obo/CHEBI_27680
T16 3281-3287 Chemical denotes glucan http://purl.obolibrary.org/obo/CHEBI_37163
T17 3377-3389 Chemical denotes voriconazole http://purl.obolibrary.org/obo/CHEBI_10023
T18 3458-3469 Chemical denotes caspofungin http://purl.obolibrary.org/obo/CHEBI_474180
T19 3536-3550 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T20 3650-3664 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T21 3669-3680 Chemical denotes caspofungin http://purl.obolibrary.org/obo/CHEBI_474180
T22 3686-3689 Chemical denotes MIC http://purl.obolibrary.org/obo/CHEBI_59059
T23 3698-3702 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T24 3954-3957 Chemical denotes MIC http://purl.obolibrary.org/obo/CHEBI_59059
T25 3958-3972 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T26 3988-3991 Chemical denotes MIC http://purl.obolibrary.org/obo/CHEBI_59059
T27 3992-4006 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T28 4021-4032 Chemical denotes caspofungin http://purl.obolibrary.org/obo/CHEBI_474180
T29 4052-4063 Chemical denotes caspofungin http://purl.obolibrary.org/obo/CHEBI_474180
T30 4103-4114 Chemical denotes caspofungin http://purl.obolibrary.org/obo/CHEBI_474180
T31 4167-4170 Chemical denotes MIC http://purl.obolibrary.org/obo/CHEBI_59059
T32 4181-4195 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T33 4370-4381 Chemical denotes caspofungin http://purl.obolibrary.org/obo/CHEBI_474180
T34 4834-4844 Chemical denotes antibiotic http://purl.obolibrary.org/obo/CHEBI_33281
T35 4978-4992 Chemical denotes amphotericin B http://purl.obolibrary.org/obo/CHEBI_2682
T36 5628-5634 Chemical denotes glucan http://purl.obolibrary.org/obo/CHEBI_37163
T37 5639-5652 Chemical denotes galactomannan http://purl.obolibrary.org/obo/CHEBI_27680
T38 6326-6336 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 2430-2443 GlycoEpitope denotes galactomannan http://www.glycoepitope.jp/epitopes/EP0510
T2 3237-3250 GlycoEpitope denotes galactomannan http://www.glycoepitope.jp/epitopes/EP0510
T3 4629-4642 GlycoEpitope denotes Galactomannan http://www.glycoepitope.jp/epitopes/EP0510
T4 5639-5652 GlycoEpitope denotes galactomannan http://www.glycoepitope.jp/epitopes/EP0510

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 256-275 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T2 322-346 Phenotype denotes opportunistic infections http://purl.obolibrary.org/obo/HP_0031690
T3 1296-1301 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T4 1306-1311 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T5 1393-1412 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T6 1624-1640 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T7 1687-1697 Phenotype denotes overweight http://purl.obolibrary.org/obo/HP_0025502
T8 1732-1747 Phenotype denotes type 2 diabetes http://purl.obolibrary.org/obo/HP_0005978
T9 1779-1789 Phenotype denotes glycosuria http://purl.obolibrary.org/obo/HP_0003076
T10 1816-1828 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T11 1847-1861 Phenotype denotes hypothyroidism http://purl.obolibrary.org/obo/HP_0000821
T12 1911-1921 Phenotype denotes aspiration http://purl.obolibrary.org/obo/HP_0002835
T13 5108-5117 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T14 6010-6019 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
4 67-74 Species denotes patient Tax:9606
5 0-29 Disease denotes Invasive pulmonary fusariosis MESH:D060585
6 52-66 Disease denotes critically ill MESH:D016638
7 87-95 Disease denotes COVID-19 MESH:C000657245
28 112-120 Species denotes Patients Tax:9606
29 135-182 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
30 184-194 Species denotes SARS-CoV-2 Tax:2697049
31 466-474 Species denotes patients Tax:9606
32 542-550 Species denotes patients Tax:9606
33 578-586 Species denotes SARS-CoV Tax:694009
34 767-774 Species denotes patient Tax:9606
35 890-898 Species denotes patients Tax:9606
36 121-129 Disease denotes infected MESH:D007239
37 215-234 Disease denotes coronavirus disease MESH:D018352
38 236-244 Disease denotes COVID-19 MESH:C000657245
39 256-275 Disease denotes respiratory failure MESH:D012131
40 322-346 Disease denotes opportunistic infections MESH:D009894
41 476-498 Disease denotes invasive aspergillosis MESH:D055744
42 551-559 Disease denotes infected MESH:D007239
43 608-641 Disease denotes severe acute respiratory syndrome MESH:D045169
44 707-729 Disease denotes invasive aspergillosis MESH:D055744
45 752-766 Disease denotes critically ill MESH:D016638
46 787-795 Disease denotes COVID-19 MESH:C000657245
47 881-889 Disease denotes COVID-19 MESH:C000657245
55 1110-1117 Species denotes patient Tax:9606
56 1214-1235 Species denotes Fusarium proliferatum Tax:948311
57 927-935 Disease denotes COVID-19 MESH:C000657245
58 958-993 Disease denotes invasive pulmonary mould infections MESH:D012141
59 1101-1109 Disease denotes diabetic MESH:D003920
60 1130-1138 Disease denotes COVID-19 MESH:C000657245
61 1155-1175 Disease denotes pulmonary fusariosis MESH:D060585
70 3049-3056 Species denotes patient Tax:9606
71 3146-3153 Species denotes patient Tax:9606
72 3233-3235 Chemical denotes GM MESH:D005839
73 3237-3250 Chemical denotes galactomannan MESH:C012990
74 3272-3275 Chemical denotes BDG
75 3277-3287 Chemical denotes β-D-glucan
76 3071-3100 Disease denotes invasive pulmonary fusariosis MESH:D060585
77 3115-3123 Disease denotes COVID-19 MESH:C000657245
100 1360-1367 Species denotes patient Tax:9606
101 1572-1579 Species denotes patient Tax:9606
102 1863-1873 Species denotes SARS-CoV-2 Tax:2697049
103 1940-1947 Species denotes patient Tax:9606
104 2103-2110 Species denotes patient Tax:9606
105 2566-2587 Species denotes Fusarium proliferatum Tax:948311
106 1755-1762 Chemical denotes glucose MESH:D005947
107 2430-2443 Chemical denotes galactomannan MESH:C012990
108 2665-2679 Chemical denotes amphotericin B MESH:D000666
109 2919-2931 Chemical denotes voriconazole MESH:D065819
110 2933-2945 Chemical denotes posaconazole MESH:C101425
111 2950-2963 Chemical denotes isavuconazole MESH:C508735
112 2983-2997 Chemical denotes amphotericin B MESH:D000666
113 1296-1301 Disease denotes fever MESH:D005334
114 1306-1311 Disease denotes cough MESH:D003371
115 1387-1412 Disease denotes acute respiratory failure MESH:D012120
116 1614-1640 Disease denotes inherited immunodeficiency MESH:D007153
117 1659-1678 Disease denotes respiratory disease MESH:D012140
118 1732-1747 Disease denotes type 2 diabetes MESH:D003924
119 1779-1789 Disease denotes glycosuria MESH:D006029
120 1816-1828 Disease denotes hypertension MESH:D006973
121 1847-1861 Disease denotes hypothyroidism MESH:D007037
143 4048-4051 Gene denotes MEC Gene:56477
144 4017-4020 Gene denotes MEC Gene:56477
145 4147-4150 Gene denotes MEC Gene:56477
146 3342-3349 Species denotes patient Tax:9606
147 4324-4331 Species denotes patient Tax:9606
148 4477-4498 Species denotes Fusarium proliferatum Tax:948311
149 4860-4867 Species denotes patient Tax:9606
150 3377-3389 Chemical denotes voriconazole MESH:D065819
151 3458-3469 Chemical denotes caspofungin MESH:D000077336
152 3536-3550 Chemical denotes amphotericin B MESH:D000666
153 3650-3664 Chemical denotes amphotericin B MESH:D000666
154 3669-3680 Chemical denotes caspofungin MESH:D000077336
155 3958-3972 Chemical denotes amphotericin B MESH:D000666
156 3992-4006 Chemical denotes amphotericin B MESH:D000666
157 4021-4032 Chemical denotes caspofungin MESH:D000077336
158 4052-4063 Chemical denotes caspofungin MESH:D000077336
159 4103-4114 Chemical denotes caspofungin MESH:D000077336
160 4181-4195 Chemical denotes amphotericin B MESH:D000666
161 4370-4381 Chemical denotes caspofungin MESH:D000077336
162 4629-4642 Chemical denotes Galactomannan MESH:C012990
163 4978-4992 Chemical denotes amphotericin B MESH:D000666
182 5143-5151 Species denotes patients Tax:9606
183 5157-5165 Species denotes SARS-CoV Tax:694009
184 5331-5339 Species denotes patients Tax:9606
185 5793-5801 Species denotes patients Tax:9606
186 5606-5614 Species denotes patients Tax:9606
187 5626-5634 Chemical denotes β-glucan MESH:D047071
188 5639-5652 Chemical denotes galactomannan MESH:C012990
189 5031-5053 Disease denotes Invasive aspergillosis MESH:D055744
190 5108-5117 Disease denotes pneumonia MESH:D011014
191 5170-5191 Disease denotes SARS-CoV-2 infections MESH:C000657245
192 5253-5266 Disease denotes aspergillosis MESH:D001228
193 5316-5330 Disease denotes critically ill MESH:D016638
194 5352-5368 Disease denotes pulmonary damage MESH:D008171
195 5427-5440 Disease denotes aspergillosis MESH:D001228
196 5477-5496 Disease denotes invasive fusariosis MESH:D060585
197 5565-5587 Disease denotes invasive aspergillosis MESH:D055744
198 5591-5605 Disease denotes critically ill MESH:D016638
199 5751-5773 Disease denotes invasive aspergillosis MESH:D055744
204 5979-5986 Species denotes patient Tax:9606
205 5936-5956 Disease denotes pulmonary fusariosis MESH:D060585
206 5999-6019 Disease denotes SARS-CoV-2 pneumonia MESH:C000657245
207 6157-6165 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-95 Sentence denotes Invasive pulmonary fusariosis in an immunocompetent critically ill patient with severe COVID-19
T2 97-111 Sentence denotes To the Editor,
T3 112-276 Sentence denotes Patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may develop severe coronavirus disease (COVID-19) and acute respiratory failure.
T4 277-358 Sentence denotes As the lung parenchyma is seriously damaged, opportunistic infections are feared.
T5 359-665 Sentence denotes While invasive pulmonary mould superinfections are usually diagnosed primarily in highly immunocompromised patients, invasive aspergillosis has also been described in immunocompetent patients infected with influenza or SARS-CoV (responsible for the severe acute respiratory syndrome outbreak in 2002–2003).
T6 666-800 Sentence denotes Moreover, we recently reported a case of invasive aspergillosis in an immunocompetent critically ill patient with severe COVID-19 [1].
T7 801-903 Sentence denotes Another study also suggested an increased risk of Aspergillus superinfection in COVID-19 patients [2].
T8 904-1054 Sentence denotes To know whether or not COVID-19 is a factor promoting invasive pulmonary mould infections in immunocompetent individuals is of great medical interest.
T9 1055-1236 Sentence denotes We report here the case of an immunocompetent diabetic patient with severe COVID-19 who developed a pulmonary fusariosis due to the common environmental mould Fusarium proliferatum.
T10 1237-1342 Sentence denotes A 57-year-old man was sent to our hospital after 7 days of fever and cough worsening over the last 24 hr.
T11 1343-1567 Sentence denotes On admission the patient presented signs of acute respiratory failure and was rapidly transferred to our intensive care unit (ICU) on March 26 (day 1) where he was intubated and placed under mechanical ventilation (Fig. 1 ).
T12 1568-1679 Sentence denotes The patient had no history of any acquired or inherited immunodeficiency and no underlying respiratory disease.
T13 1680-1862 Sentence denotes He was overweight (body mass index 30.6 kg/m2) with type 2 diabetes (blood glucose 11.6 mmol/L and glycosuria 1.4 mmol/L on admission), hypertension and a substituted hypothyroidism.
T14 1863-1935 Sentence denotes SARS-CoV-2 viral RNA was detected in a tracheal aspiration on admission.
T15 1936-2021 Sentence denotes The patient's condition worsened with a PaO2/FiO2 ratio <90 mmHg with a FiO2 of 100%.
T16 2022-2092 Sentence denotes A protected specimen brush sample performed on day 2 remained sterile.
T17 2093-2200 Sentence denotes While the patient's condition showed no improvement, a bronchoalveolar lavage (BAL) was performed on day 7.
T18 2201-2310 Sentence denotes On day 9 this sample grew with 7 × 102/mL colony-forming unit (CFU) of mould while no bacteria were detected.
T19 2311-2472 Sentence denotes The same day, a second BAL was performed: atypical fungal hyphae were detected on microscopic examination, testing for galactomannan antigen was positive (index:
T20 2473-2523 Sentence denotes 1.7) and the sample grew with 103/mL CFU of mould.
T21 2524-2758 Sentence denotes The different cultures were identified as Fusarium proliferatum using mass spectrometry (Bruker Microflex with MSI database) and a liposomal amphotericin B-based therapy was started on day 12 (5 mg/kg/day for 2 days then 7 mg/kg/day).
T22 2759-2964 Sentence denotes Antifungal susceptibility testing determined using the gradient concentration strips method showed high minimal inhibitory concentrations (MICs) (>32 mg/L) for voriconazole, posaconazole and isavuconazole.
T23 2965-3009 Sentence denotes The MIC value for amphotericin B was 2 mg/L.
T24 3010-3124 Sentence denotes Fig. 1 Timeline for an immunocompetent patient who developed invasive pulmonary fusariosis during severe COVID-19.
T25 3125-3194 Sentence denotes Day 1 is the day the patient was admitted to the intensive care unit.
T26 3195-3295 Sentence denotes D, days; BAL, bronchoalveolar lavage; GM, galactomannan index determination; BDG, β-D-glucan dosage.
T27 3296-3557 Sentence denotes Considering the very serious condition of the patient, and despite the fact that voriconazole is suggested as first-line treatment (alone or in combination) [3], caspofungin was added, assuming a potential synergistic effect with liposomal amphotericin B [4,5].
T28 3558-3681 Sentence denotes To test this hypothesis in vitro, we used the checkerboard method to assess combinations of amphotericin B and caspofungin.
T29 3682-3838 Sentence denotes The MIC of each drug alone and the combinations of the two were determined concomitantly on the same plate using a method adapted from the EUCAST procedure.
T30 3839-4071 Sentence denotes Interaction was determined by calculating the fractional inhibitory concentration index (FICI) as follows: FICI = (MIC amphotericin B in combination/MIC amphotericin B alone) + (MEC caspofungin in combination/MEC caspofungin alone).
T31 4072-4162 Sentence denotes Results showed no activity for caspofungin either alone or in combination (MEC > 32 mg/L).
T32 4163-4238 Sentence denotes The MIC value for amphotericin B was 1 mg/L either alone or in combination.
T33 4239-4306 Sentence denotes The FICI value was equal to 2, which is indicative of indifference.
T34 4307-4404 Sentence denotes Moreover, as the patient's condition was beginning to improve, caspofungin was stopped on day 29.
T35 4405-4499 Sentence denotes Three other BALs performed on day 15, day 22 and day 27 still grew with Fusarium proliferatum.
T36 4500-4628 Sentence denotes Importantly, we noticed a gradual increase in the delay of culture positivity and a decrease in the number of colonies obtained.
T37 4629-4722 Sentence denotes Galactomannan testing became negative, all of which indicated a reduction of the fungal load.
T38 4723-4855 Sentence denotes The BALs performed on day 15 and day 27 also grew with a significant amount of bacteria, which led to specific antibiotic treatment.
T39 4856-4904 Sentence denotes The patient's general condition slowly improved.
T40 4905-4967 Sentence denotes He was extubated on day 30 then discharged to a post-ICU area.
T41 4968-5030 Sentence denotes Liposomal amphotericin B administration was stopped on day 35.
T42 5031-5198 Sentence denotes Invasive aspergillosis is a well-recognized complication of severe influenza pneumonia and has been reported in patients with SARS-CoV and SARS-CoV-2 infections [1,2].
T43 5199-5381 Sentence denotes As fusariosis shares many common characteristics with aspergillosis [6], occurrence of fusariosis in immunocompetent critically ill patients with severe pulmonary damage is possible.
T44 5382-5619 Sentence denotes If we draw a parallel between fusariosis and aspergillosis, the case we describe is a putative invasive fusariosis according to the classification by Blot et al. for the diagnosis of invasive aspergillosis in critically ill patients [7].
T45 5620-5684 Sentence denotes Serum β-glucan and galactomannan testing in serum were negative.
T46 5685-5893 Sentence denotes Here again a resemblance can be seen with what is observed during invasive aspergillosis in immunocompetent patients where blood tests are often negative while respiratory samples establish the diagnosis [7].
T47 5894-6020 Sentence denotes In conclusion, we have reported a case of pulmonary fusariosis in an immunocompetent patient with severe SARS-CoV-2 pneumonia.
T48 6021-6166 Sentence denotes As the outbreak continues to spread worldwide, other reports are needed to assess the frequency of fungal superinfections during severe COVID-19.
T49 6168-6192 Sentence denotes Transparency declaration
T50 6193-6201 Sentence denotes Funding:
T51 6202-6207 Sentence denotes None.
T52 6208-6251 Sentence denotes The authors declare no competing interests.
T53 6253-6273 Sentence denotes Author contributions
T54 6274-6425 Sentence denotes C.P. and M.B. collected mycological data, performed antifungal susceptibility testing and the EUCAST checkboard method and participated in the writing.
T55 6426-6529 Sentence denotes C.V. participated in the therapeutic decision, collected clinical data and participated in the writing.
T56 6530-6595 Sentence denotes A.L. participated in the therapeutic decision and in the writing.
T57 6596-6699 Sentence denotes A.M. participated in the therapeutic decision, collected clinical data and participated in the writing.
T58 6700-6782 Sentence denotes A.F. participated in the therapeutic decision, collected data and wrote the paper.

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T1 9-18 UBERON:0002048 denotes pulmonary
T2 87-95 SP_7 denotes COVID-19
T3 135-147 SP_7 denotes severe acute
T4 148-159 SP_7;UBERON:0001004 denotes respiratory
T5 160-182 SP_7 denotes syndrome coronavirus 2
T6 184-194 SP_7 denotes SARS-CoV-2
T7 215-226 NCBITaxon:11118 denotes coronavirus
T8 236-244 SP_7 denotes COVID-19
T9 256-267 UBERON:0001004 denotes respiratory
T10 284-299 UBERON:0008946 denotes lung parenchyma
T11 374-383 UBERON:0002048 denotes pulmonary
T12 578-586 SP_10 denotes SARS-CoV
T13 621-632 UBERON:0001004 denotes respiratory
T14 787-795 SP_7 denotes COVID-19
T15 851-862 NCBITaxon:5052 denotes Aspergillus
T16 881-889 SP_7 denotes COVID-19
T17 927-935 SP_7 denotes COVID-19
T18 967-976 UBERON:0002048 denotes pulmonary
T19 1013-1024 NCBITaxon:1 denotes individuals
T20 1130-1138 SP_7 denotes COVID-19
T21 1155-1164 UBERON:0002048 denotes pulmonary
T22 1251-1254 NCBITaxon:9606 denotes man
T23 1306-1311 UBERON:0001004 denotes cough
T24 1393-1404 UBERON:0001004 denotes respiratory
T25 1659-1670 UBERON:0001004 denotes respiratory
T26 1749-1754 UBERON:0000178 denotes blood
T27 1755-1762 CHEBI:17234;CHEBI:17234 denotes glucose
T28 1863-1873 SP_7 denotes SARS-CoV-2
T29 1874-1879 NCBITaxon:10239 denotes viral
T30 1902-1910 UBERON:0003126 denotes tracheal
T31 2008-2012 CHEBI:16526;CHEBI:16526 denotes FiO2
T32 2148-2163 UBERON:0002186 denotes bronchoalveolar
T33 2222-2226 GO:0040007 denotes grew
T34 2287-2295 NCBITaxon:2 denotes bacteria
T35 2430-2443 CHEBI:27680;CHEBI:27680 denotes galactomannan
T36 2444-2451 CHEBI:59132;CHEBI:59132 denotes antigen
T37 2493-2497 GO:0040007 denotes grew
T38 2566-2587 NCBITaxon:948311 denotes Fusarium proliferatum
T39 2665-2679 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T40 2919-2931 CHEBI:10023;CHEBI:10023 denotes voriconazole
T41 2933-2945 CHEBI:64355;CHEBI:64355 denotes posaconazole
T42 2950-2963 CHEBI:85979;CHEBI:85979 denotes isavuconazole
T43 2969-2972 SO:0000154 denotes MIC
T44 2983-2997 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T45 3080-3089 UBERON:0002048 denotes pulmonary
T46 3115-3123 SP_7 denotes COVID-19
T47 3184-3193 UBERON:0007221 denotes care unit
T48 3209-3224 UBERON:0002186 denotes bronchoalveolar
T49 3237-3250 CHEBI:27680;CHEBI:27680 denotes galactomannan
T50 3281-3287 CHEBI:28793;CHEBI:28793 denotes glucan
T57 3377-3389 CHEBI:10023;CHEBI:10023 denotes voriconazole
T58 3536-3550 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T59 3650-3664 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T60 3698-3702 CHEBI:23888;CHEBI:23888 denotes drug
T61 3958-3972 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T62 3992-4006 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T63 4181-4195 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T64 4467-4471 GO:0040007 denotes grew
T65 4477-4498 NCBITaxon:948311 denotes Fusarium proliferatum
T66 4629-4642 CHEBI:27680;CHEBI:27680 denotes Galactomannan
T67 4768-4772 GO:0040007 denotes grew
T68 4802-4810 NCBITaxon:2 denotes bacteria
T69 4834-4844 CHEBI:33282;CHEBI:33282 denotes antibiotic
T70 4968-4977 GO:0005764 denotes Liposomal
T71 4978-4992 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T72 5157-5165 SP_10 denotes SARS-CoV
T73 5170-5180 SP_7 denotes SARS-CoV-2
T74 5352-5361 UBERON:0002048 denotes pulmonary
T75 5620-5625 UBERON:0001977 denotes Serum
T76 5628-5634 CHEBI:37163;CHEBI:37163 denotes glucan
T77 5639-5652 CHEBI:27680;CHEBI:27680 denotes galactomannan
T78 5664-5669 UBERON:0001977 denotes serum
T79 5808-5813 UBERON:0000178 denotes blood
T80 5845-5856 UBERON:0001004 denotes respiratory
T81 5936-5945 UBERON:0002048 denotes pulmonary
T82 5999-6009 SP_7 denotes SARS-CoV-2
T83 6120-6126 NCBITaxon:4751 denotes fungal
T84 6157-6165 SP_7 denotes COVID-19
T61666 9-18 UBERON:0002048 denotes pulmonary
T6294 87-95 SP_7 denotes COVID-19
T32209 135-147 SP_7 denotes severe acute
T19930 148-159 SP_7;UBERON:0001004 denotes respiratory
T63040 160-182 SP_7 denotes syndrome coronavirus 2
T63916 184-194 SP_7 denotes SARS-CoV-2
T99154 215-226 NCBITaxon:11118 denotes coronavirus
T72851 236-244 SP_7 denotes COVID-19
T97997 256-267 UBERON:0001004 denotes respiratory
T16258 284-299 UBERON:0008946 denotes lung parenchyma
T31204 374-383 UBERON:0002048 denotes pulmonary
T76318 578-586 SP_10 denotes SARS-CoV
T48167 621-632 UBERON:0001004 denotes respiratory
T61071 787-795 SP_7 denotes COVID-19
T78957 851-862 NCBITaxon:5052 denotes Aspergillus
T68889 881-889 SP_7 denotes COVID-19
T59645 927-935 SP_7 denotes COVID-19
T66365 967-976 UBERON:0002048 denotes pulmonary
T67497 1013-1024 NCBITaxon:1 denotes individuals
T80740 1130-1138 SP_7 denotes COVID-19
T5442 1155-1164 UBERON:0002048 denotes pulmonary
T84384 1251-1254 NCBITaxon:9606 denotes man
T13089 1306-1311 UBERON:0001004 denotes cough
T29928 1393-1404 UBERON:0001004 denotes respiratory
T68878 1659-1670 UBERON:0001004 denotes respiratory
T86378 1749-1754 UBERON:0000178 denotes blood
T94726 1755-1762 CHEBI:17234;CHEBI:17234 denotes glucose
T78314 1863-1873 SP_7 denotes SARS-CoV-2
T40427 1874-1879 NCBITaxon:10239 denotes viral
T2505 1902-1910 UBERON:0003126 denotes tracheal
T67814 2008-2012 CHEBI:16526;CHEBI:16526 denotes FiO2
T97680 2148-2163 UBERON:0002186 denotes bronchoalveolar
T41320 2222-2226 GO:0040007 denotes grew
T29670 2287-2295 NCBITaxon:2 denotes bacteria
T41230 2430-2443 CHEBI:27680;CHEBI:27680 denotes galactomannan
T76288 2444-2451 CHEBI:59132;CHEBI:59132 denotes antigen
T91801 2493-2497 GO:0040007 denotes grew
T24803 2566-2587 NCBITaxon:948311 denotes Fusarium proliferatum
T75536 2665-2679 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T7769 2919-2931 CHEBI:10023;CHEBI:10023 denotes voriconazole
T37012 2933-2945 CHEBI:64355;CHEBI:64355 denotes posaconazole
T51161 2950-2963 CHEBI:85979;CHEBI:85979 denotes isavuconazole
T30376 2969-2972 SO:0000154 denotes MIC
T19946 2983-2997 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T13465 3080-3089 UBERON:0002048 denotes pulmonary
T81946 3115-3123 SP_7 denotes COVID-19
T88494 3184-3193 UBERON:0007221 denotes care unit
T46519 3209-3224 UBERON:0002186 denotes bronchoalveolar
T16525 3237-3250 CHEBI:27680;CHEBI:27680 denotes galactomannan
T97325 3281-3287 CHEBI:28793;CHEBI:28793 denotes glucan
T52 6157-6165 SP_7 denotes COVID-19
T53 3184-3193 UBERON:0007221 denotes care unit
T54 3209-3224 UBERON:0002186 denotes bronchoalveolar
T55 3237-3250 CHEBI:27680;CHEBI:27680 denotes galactomannan
T56 3281-3287 CHEBI:28793;CHEBI:28793 denotes glucan
T971 3377-3389 CHEBI:10023;CHEBI:10023 denotes voriconazole
T98852 3536-3550 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T82144 3650-3664 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T89447 3698-3702 CHEBI:23888;CHEBI:23888 denotes drug
T33586 3958-3972 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T76702 3992-4006 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T42104 4181-4195 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T33396 4467-4471 GO:0040007 denotes grew
T78053 4477-4498 NCBITaxon:948311 denotes Fusarium proliferatum
T89176 4629-4642 CHEBI:27680;CHEBI:27680 denotes Galactomannan
T7633 4768-4772 GO:0040007 denotes grew
T99376 4802-4810 NCBITaxon:2 denotes bacteria
T48876 4834-4844 CHEBI:33282;CHEBI:33282 denotes antibiotic
T84617 4968-4977 GO:0005764 denotes Liposomal
T4681 4978-4992 CHEBI:2682;CHEBI:2682 denotes amphotericin B
T37554 5157-5165 SP_10 denotes SARS-CoV
T55412 5170-5180 SP_7 denotes SARS-CoV-2
T31163 5352-5361 UBERON:0002048 denotes pulmonary
T43968 5620-5625 UBERON:0001977 denotes Serum
T95642 5628-5634 CHEBI:37163;CHEBI:37163 denotes glucan
T55093 5639-5652 CHEBI:27680;CHEBI:27680 denotes galactomannan
T54683 5664-5669 UBERON:0001977 denotes serum
T14799 5808-5813 UBERON:0000178 denotes blood
T78928 5845-5856 UBERON:0001004 denotes respiratory
T70703 5936-5945 UBERON:0002048 denotes pulmonary
T9047 5999-6009 SP_7 denotes SARS-CoV-2
T39367 6120-6126 NCBITaxon:4751 denotes fungal
T79225 6157-6165 SP_7 denotes COVID-19