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PMC:7324763 / 77047-77682 JSONTXT

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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T1240 0-5 CHEBI:35472;CHEBI:35472 denotes NSAID
T1241 84-90 UBERON:0002405;GO:0006955 denotes immune
T1242 91-100 GO:0006955 denotes responses
T1243 124-134 GO:0042571 denotes antibodies
T1244 141-150 CHEBI:5855;CHEBI:5855 denotes ibuprofen
T1245 210-219 CHEBI:5855;CHEBI:5855 denotes ibuprofen
T1246 254-264 GO:0010467 denotes expression
T1247 272-276 G_3;PG_10;PR:000003622 denotes ACE2
T1248 315-325 SP_7 denotes SARS-CoV-2
T1249 326-331 NCBITaxon:10239;GO:0035376 denotes viral
T1250 332-337 GO:0035376 denotes entry
T1251 417-425 SP_7 denotes COVID-19
T1252 451-460 CHEBI:5855;CHEBI:5855 denotes ibuprofen
T1253 470-476 CHEBI:35472;CHEBI:35472 denotes NSAIDs
T1254 545-550 PR:000000017 denotes IFN-γ
T1255 555-560 PR:000000134;GO:0032640 denotes TNF-α
T1256 561-571 GO:0032640 denotes production
T1257 617-625 SP_7 denotes COVID-19
T47072 0-5 CHEBI:35472;CHEBI:35472 denotes NSAID
T70483 84-90 UBERON:0002405;GO:0006955 denotes immune
T5444 91-100 GO:0006955 denotes responses
T46572 124-134 GO:0042571 denotes antibodies
T16119 141-150 CHEBI:5855;CHEBI:5855 denotes ibuprofen
T35977 210-219 CHEBI:5855;CHEBI:5855 denotes ibuprofen
T46174 254-264 GO:0010467 denotes expression
T58823 272-276 G_3;PG_10;PR:000003622 denotes ACE2
T10504 315-325 SP_7 denotes SARS-CoV-2
T61782 326-331 NCBITaxon:10239;GO:0035376 denotes viral
T47807 332-337 GO:0035376 denotes entry
T12613 417-425 SP_7 denotes COVID-19
T40182 451-460 CHEBI:5855;CHEBI:5855 denotes ibuprofen
T89863 470-476 CHEBI:35472;CHEBI:35472 denotes NSAIDs
T60778 545-550 PR:000000017 denotes IFN-γ
T93145 555-560 PR:000000134;GO:0032640 denotes TNF-α
T95675 561-571 GO:0032640 denotes production
T36464 617-625 SP_7 denotes COVID-19

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T875 537-544 Body_part denotes NK cell http://purl.org/sig/ont/fma/fma63147
T876 540-544 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T538 315-323 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T539 315-319 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T540 417-425 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T541 617-625 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T918 220-223 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T919 506-507 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T920 537-544 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T72788 0-5 Chemical denotes NSAID http://purl.obolibrary.org/obo/CHEBI_35475
T203 141-150 Chemical denotes ibuprofen http://purl.obolibrary.org/obo/CHEBI_132922|http://purl.obolibrary.org/obo/CHEBI_5855
T33962 210-219 Chemical denotes ibuprofen http://purl.obolibrary.org/obo/CHEBI_132922|http://purl.obolibrary.org/obo/CHEBI_5855
T73535 451-460 Chemical denotes ibuprofen http://purl.obolibrary.org/obo/CHEBI_132922|http://purl.obolibrary.org/obo/CHEBI_5855
T209 470-476 Chemical denotes NSAIDs http://purl.obolibrary.org/obo/CHEBI_35475

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2168 272-276 Gene denotes ACE2 Gene:59272
2169 545-550 Gene denotes IFN-γ Gene:3458
2170 555-560 Gene denotes TNF-α Gene:7124
2171 315-325 Species denotes SARS-CoV-2 Tax:2697049
2172 626-634 Species denotes patients Tax:9606
2173 141-150 Chemical denotes ibuprofen MESH:D007052
2174 210-219 Chemical denotes ibuprofen MESH:D007052
2175 451-460 Chemical denotes ibuprofen MESH:D007052
2176 417-425 Disease denotes COVID-19 MESH:C000657245
2177 617-625 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T181 84-100 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses

MyTest

Id Subject Object Predicate Lexical cue
32655581-19345936-34771861 191-194 19345936 denotes 266
32655581-32171062-34771862 287-290 32171062 denotes 267
32655581-17083365-34771863 573-576 17083365 denotes 268

TEST0

Id Subject Object Predicate Lexical cue
32655581-191-198-3171434 191-194 ["19345936"] denotes 266
32655581-90-97-3171435 287-290 ["32171062"] denotes 267
32655581-103-110-3171436 573-576 ["17083365"] denotes 268

2_test

Id Subject Object Predicate Lexical cue
32655581-19345936-34771861 191-194 19345936 denotes 266
32655581-32171062-34771862 287-290 32171062 denotes 267
32655581-17083365-34771863 573-576 17083365 denotes 268

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T466 0-196 Sentence denotes NSAID therapy should be used with caution as they have been shown to interfere with immune responses and ability to produce antibodies, with ibuprofen having the greatest suppressive effect (266).
T467 197-338 Sentence denotes Furthermore, ibuprofen has been reported to increase the expression of the ACE2 receptor (267) which could facilitate SARS-CoV-2 viral entry.
T468 339-469 Sentence denotes This finding should be considered for any current (NCT04334629) and potential COVID-19 clinical trial assessing ibuprofen therapy.
T469 470-635 Sentence denotes NSAIDs also have been shown to have a direct suppressive effect on NK cell IFN-γ and TNF-α production (268) which may be beneficial for late stage COVID-19 patients.