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PMC:7324763 / 73499-75851 JSONTXT

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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T1175 0-15 CHEBI:50858;CHEBI:50858 denotes Corticosteroids
T1176 16-31 CHEBI:50858;CHEBI:50858 denotes Corticosteroids
T1177 75-79 UBERON:0002405 denotes auto
T1178 80-86 UBERON:0002405 denotes immune
T1179 164-179 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T1180 203-214 CL:0000080 denotes circulating
T1181 215-224 CL:0000576 denotes monocytes
T1182 229-240 CL:0000542 denotes lymphocytes
T1183 295-299 PR:000001379 denotes IL-2
T1184 301-305 PR:000001393 denotes IL-6
T1185 307-312 PR:000000134 denotes TNF-α
T1186 356-373 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T1187 463-469 UBERON:0002405 denotes immune
T1188 481-486 NCBITaxon:10239 denotes viral
T1189 499-514 CHEBI:50858;CHEBI:50858 denotes Corticosteroids
T1190 592-607 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T1191 618-627 GO:0043277 denotes clearance
T1192 693-699 GO:0045087 denotes innate
T1193 700-706 GO:0045087;UBERON:0002405 denotes immune
T1194 707-716 GO:0045087 denotes responses
T1195 734-738 UBERON:0002048 denotes lung
T1196 782-787 NCBITaxon:10239 denotes viral
T1197 873-888 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T1198 896-900 SP_9 denotes MERS
T1199 905-909 SP_10 denotes SARS
T1200 945-953 SP_7 denotes COVID-19
T1201 1006-1021 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T1202 1214-1228 CHEBI:50858;CHEBI:50858 denotes corticosteroid
T1203 1229-1240 CHEBI:31397;CHEBI:31397 denotes ciclesonide
T1204 1244-1250 UBERON:0007023 denotes adults
T1205 1261-1269 SP_7 denotes COVID-19
T1206 1378-1389 CHEBI:31397;CHEBI:31397 denotes ciclesonide
T1207 1398-1408 SP_7 denotes SARS-CoV-2
T1208 1448-1463 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T1209 1562-1570 SP_7 denotes COVID-19
T1210 1677-1692 CHEBI:50858;CHEBI:50858 denotes Corticosteroids
T1211 1906-1921 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T1212 2083-2098 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T1213 2105-2113 SP_7 denotes COVID-19
T1214 2172-2187 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T1215 2192-2197 NCBITaxon:10239 denotes viral
T1216 2343-2351 SP_7 denotes COVID-19
T26239 0-15 CHEBI:50858;CHEBI:50858 denotes Corticosteroids
T72902 16-31 CHEBI:50858;CHEBI:50858 denotes Corticosteroids
T14927 75-79 UBERON:0002405 denotes auto
T1856 80-86 UBERON:0002405 denotes immune
T27189 164-179 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T31503 203-214 CL:0000080 denotes circulating
T18169 215-224 CL:0000576 denotes monocytes
T3631 229-240 CL:0000542 denotes lymphocytes
T61581 295-299 PR:000001379 denotes IL-2
T18952 301-305 PR:000001393 denotes IL-6
T66866 307-312 PR:000000134 denotes TNF-α
T8101 356-373 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T15917 463-469 UBERON:0002405 denotes immune
T39683 481-486 NCBITaxon:10239 denotes viral
T20558 499-514 CHEBI:50858;CHEBI:50858 denotes Corticosteroids
T14223 592-607 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T57701 618-627 GO:0043277 denotes clearance
T41082 693-699 GO:0045087 denotes innate
T9065 700-706 GO:0045087;UBERON:0002405 denotes immune
T60637 707-716 GO:0045087 denotes responses
T7059 734-738 UBERON:0002048 denotes lung
T52637 782-787 NCBITaxon:10239 denotes viral
T18416 873-888 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T11241 896-900 SP_9 denotes MERS
T86850 905-909 SP_10 denotes SARS
T72326 945-953 SP_7 denotes COVID-19
T9935 1006-1021 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T95985 1214-1228 CHEBI:50858;CHEBI:50858 denotes corticosteroid
T73836 1229-1240 CHEBI:31397;CHEBI:31397 denotes ciclesonide
T75559 1244-1250 UBERON:0007023 denotes adults
T9272 1261-1269 SP_7 denotes COVID-19
T51527 1378-1389 CHEBI:31397;CHEBI:31397 denotes ciclesonide
T21065 1398-1408 SP_7 denotes SARS-CoV-2
T75412 1448-1463 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T37153 1562-1570 SP_7 denotes COVID-19
T61966 1677-1692 CHEBI:50858;CHEBI:50858 denotes Corticosteroids
T53528 1906-1921 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T53714 2083-2098 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T16797 2105-2113 SP_7 denotes COVID-19
T5076 2172-2187 CHEBI:50858;CHEBI:50858 denotes corticosteroids
T63377 2192-2197 NCBITaxon:10239 denotes viral
T25282 2343-2351 SP_7 denotes COVID-19

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T865 215-224 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T866 229-240 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T867 284-293 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T868 295-299 Body_part denotes IL-2 http://purl.org/sig/ont/fma/fma84051
T869 295-297 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T870 301-303 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T871 542-550 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T872 545-550 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T873 734-738 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T62 734-738 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T507 75-95 Disease denotes auto-immune diseases http://purl.obolibrary.org/obo/MONDO_0007179
T508 432-444 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T509 458-477 Disease denotes auto-immune disease http://purl.obolibrary.org/obo/MONDO_0007179
T510 463-477 Disease denotes immune disease http://purl.obolibrary.org/obo/MONDO_0005046
T511 481-497 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T512 631-641 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T513 750-754 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T514 782-798 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T515 905-909 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T516 910-920 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T517 945-953 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T518 1086-1090 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T519 1261-1269 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T520 1270-1280 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T521 1398-1406 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T522 1398-1402 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T523 1519-1523 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T524 1562-1570 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T525 1746-1763 Disease denotes diabetes mellitus http://purl.obolibrary.org/obo/MONDO_0005015
T526 1765-1777 Disease denotes osteoporosis http://purl.obolibrary.org/obo/MONDO_0005298
T527 1801-1811 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T528 1875-1884 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T529 1993-2003 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T530 2105-2113 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T531 2343-2351 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T897 44-45 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T898 215-224 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T899 295-299 http://purl.obolibrary.org/obo/PR_000001379 denotes IL-2
T900 542-550 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cells
T901 734-738 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T902 734-738 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T903 1025-1026 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T904 1366-1374 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T905 1429-1430 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T906 1467-1468 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T907 1704-1705 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T908 1836-1837 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T60576 164-179 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T34421 295-297 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T49300 301-303 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T49507 592-607 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T62551 873-888 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T172 1006-1021 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T71459 1214-1228 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T19477 1356-1365 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T24115 1448-1463 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T5105 1906-1921 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T32605 2083-2098 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T75442 2172-2187 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2070 295-299 Gene denotes IL-2 Gene:3558
2071 301-305 Gene denotes IL-6 Gene:3569
2072 307-312 Gene denotes TNF-α Gene:7124
2073 1061-1069 Species denotes patients Tax:9606
2074 1398-1408 Species denotes SARS-CoV-2 Tax:2697049
2075 1229-1240 Chemical denotes ciclesonide MESH:C120481
2076 1378-1389 Chemical denotes ciclesonide MESH:C120481
2077 432-444 Disease denotes inflammation MESH:D007249
2078 458-477 Disease denotes auto-immune disease MESH:C538437
2079 481-497 Disease denotes viral infections MESH:D001102
2080 631-641 Disease denotes infections MESH:D007239
2081 734-745 Disease denotes lung damage MESH:D008171
2082 750-754 Disease denotes ARDS MESH:D012128
2083 782-798 Disease denotes viral infections MESH:D001102
2084 905-920 Disease denotes SARS infections MESH:D045169
2085 945-953 Disease denotes COVID-19 MESH:C000657245
2086 1046-1060 Disease denotes critically-ill MESH:D016638
2087 1086-1090 Disease denotes ARDS MESH:D012128
2088 1092-1098 Disease denotes sepsis MESH:D018805
2089 1103-1115 Disease denotes septic shock MESH:D012772
2090 1261-1269 Disease denotes COVID-19 MESH:C000657245
2091 1270-1280 Disease denotes infections MESH:D007239
2107 1494-1502 Species denotes patients Tax:9606
2108 1885-1893 Species denotes patients Tax:9606
2109 2114-2122 Species denotes patients Tax:9606
2110 1875-1884 Species denotes influenza Tax:11320
2111 1479-1493 Disease denotes critically-ill MESH:D016638
2112 1519-1523 Disease denotes ARDS MESH:D012128
2113 1527-1533 Disease denotes sepsis MESH:D018805
2114 1562-1570 Disease denotes COVID-19 MESH:C000657245
2115 1746-1763 Disease denotes diabetes mellitus MESH:D003920
2116 1765-1777 Disease denotes osteoporosis MESH:D010024
2117 1801-1811 Disease denotes infections MESH:D007239
2118 1948-1957 Disease denotes mortality MESH:D003643
2119 1983-2003 Disease denotes secondary infections MESH:D060085
2120 2105-2113 Disease denotes COVID-19 MESH:C000657245
2121 2343-2351 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T108 75-95 Phenotype denotes auto-immune diseases http://purl.obolibrary.org/obo/HP_0002960
T109 458-477 Phenotype denotes auto-immune disease http://purl.obolibrary.org/obo/HP_0002960
T110 775-798 Phenotype denotes severe viral infections http://purl.obolibrary.org/obo/HP_0031691
T111 1092-1098 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T112 1110-1115 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T113 1527-1533 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T114 1746-1763 Phenotype denotes diabetes mellitus http://purl.obolibrary.org/obo/HP_0000819
T115 1765-1777 Phenotype denotes osteoporosis http://purl.obolibrary.org/obo/HP_0000939

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T175 254-263 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T176 432-444 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T177 481-497 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T178 693-716 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune responses
T179 782-798 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections

MyTest

Id Subject Object Predicate Lexical cue
32655581-31396235-34771844 120-123 31396235 denotes 251
32655581-32205186-34771845 125-128 32205186 denotes 252
32655581-31396235-34771846 315-318 31396235 denotes 251
32655581-7389219-34771847 575-578 7389219 denotes 253
32655581-28450865-34771848 580-583 28450865 denotes 254
32655581-16968120-34771849 800-803 16968120 denotes 255
32655581-29161116-34771849 800-803 29161116 denotes 255
32655581-32296012-34771849 800-803 32296012 denotes 255
32655581-16968120-34771850 922-925 16968120 denotes 255
32655581-29161116-34771851 927-930 29161116 denotes 256
32655581-32296012-34771852 1127-1130 32296012 denotes 257
32655581-32296012-34771853 1535-1538 32296012 denotes 257
32655581-32043983-34771854 1667-1670 32043983 denotes 258
32655581-32256706-34771854 1667-1670 32256706 denotes 258
32655581-31396235-34771855 1813-1816 31396235 denotes 251
32655581-30917856-34771856 2005-2008 30917856 denotes 261
32655581-32266987-34771857 2264-2267 32266987 denotes 262

TEST0

Id Subject Object Predicate Lexical cue
32655581-104-111-3171417 120-123 ["31396235"] denotes 251
32655581-109-116-3171418 125-128 ["32205186"] denotes 252
32655581-184-191-3171419 315-318 ["31396235"] denotes 251
32655581-76-83-3171420 575-578 ["7389219"] denotes 253
32655581-81-88-3171421 580-583 ["28450865"] denotes 254
32655581-214-221-3171422 800-803 ["16968120", "29161116", "32296012"] denotes 255
32655581-112-119-3171423 922-925 ["16968120"] denotes 255
32655581-117-124-3171424 927-930 ["29161116"] denotes 256
32655581-194-201-3171425 1127-1130 ["32296012"] denotes 257
32655581-125-132-3171426 1535-1538 ["32296012"] denotes 257
32655581-236-243-3171427 1667-1670 ["32043983", "32256706"] denotes 258
32655581-136-143-3171428 1813-1816 ["31396235"] denotes 251
32655581-186-193-3171429 2005-2008 ["30917856"] denotes 261
32655581-235-242-3171430 2264-2267 ["32266987"] denotes 262

2_test

Id Subject Object Predicate Lexical cue
32655581-31396235-34771844 120-123 31396235 denotes 251
32655581-32205186-34771845 125-128 32205186 denotes 252
32655581-31396235-34771846 315-318 31396235 denotes 251
32655581-7389219-34771847 575-578 7389219 denotes 253
32655581-28450865-34771848 580-583 28450865 denotes 254
32655581-16968120-34771849 800-803 16968120 denotes 255
32655581-29161116-34771849 800-803 29161116 denotes 255
32655581-32296012-34771849 800-803 32296012 denotes 255
32655581-16968120-34771850 922-925 16968120 denotes 255
32655581-29161116-34771851 927-930 29161116 denotes 256
32655581-32296012-34771852 1127-1130 32296012 denotes 257
32655581-32296012-34771853 1535-1538 32296012 denotes 257
32655581-32043983-34771854 1667-1670 32043983 denotes 258
32655581-32256706-34771854 1667-1670 32256706 denotes 258
32655581-31396235-34771855 1813-1816 31396235 denotes 251
32655581-30917856-34771856 2005-2008 30917856 denotes 261
32655581-32266987-34771857 2264-2267 32266987 denotes 262

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T443 0-15 Sentence denotes Corticosteroids
T444 16-130 Sentence denotes Corticosteroids have played a key role in the treatment of auto-immune diseases over the past 70 years (251, 252).
T445 131-320 Sentence denotes Whether endogenous or exogenous, corticosteroids decrease the number of circulating monocytes and lymphocytes and decrease synthesis of pro-inflammatory cytokines (IL-2, IL-6, TNF-α) (251).
T446 321-498 Sentence denotes Their strong anti-inflammatory and immunosuppressive effects make them good candidates for rapidly suppressing inflammation during early auto-immune disease or viral infections.
T447 499-585 Sentence denotes Corticosteroids have been shown to inhibit NK cells in ex vivo experiments (253, 254).
T448 586-809 Sentence denotes While corticosteroids may delay clearance of infections, their major benefit lies in suppressing excessive innate immune responses, thus preventing lung damage and ARDS commonly present in severe viral infections (255–257).
T449 810-932 Sentence denotes In fact, this was the main rationale for the widespread use of corticosteroids during MERS and SARS infections (255, 256).
T450 933-1132 Sentence denotes Specific to COVID-19, some groups have advocated for the use of low-dose corticosteroids in a specific subset of critically-ill patients with refractory ARDS, sepsis, or septic shock (Table 2) (257).
T451 1133-1295 Sentence denotes There is one known ongoing randomized clinical trial examining the effect of the corticosteroid ciclesonide in adults with mild COVID-19 infections (NCT04330586).
T452 1296-1409 Sentence denotes This trial is based on preclinical studies showing in vitro antiviral activity of ciclesonide against SARS-CoV-2.
T453 1410-1676 Sentence denotes While there may be a benefit to using corticosteroids in a subset of critically-ill patients with refractory ARDS or sepsis (257), their routine use in COVID-19 is not recommended outside of clinical trials, based on expert opinion and WHO recommendations (258–260).
T454 1677-1818 Sentence denotes Corticosteroids also cause a multitude of side effects, most notably diabetes mellitus, osteoporosis, and increased risk of infections (251).
T455 1819-2010 Sentence denotes Controversially, a 2019 systematic review of over 6,500 influenza patients showed that corticosteroids actually led to increased mortality, length of ICU stay, and secondary infections (261).
T456 2011-2269 Sentence denotes Additionally, one retrospective observational study examined the use of corticosteroids in 31 COVID-19 patients, and reported no significant association between corticosteroids and viral clearance time, hospital length of stay, or duration of symptoms (262).
T457 2270-2352 Sentence denotes These studies highlight the need to be vigilant in our attempts to fight COVID-19.