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PMC:7324763 / 72982-73497 JSONTXT

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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T1167 0-4 PR:000009196 denotes Jak1
T1168 7-17 CHEBI:35222;CHEBI:35222 denotes inhibitors
T1169 80-88 SP_7 denotes COVID-19
T1170 107-118 DG_41 denotes baricitinib
T1171 191-195 PR:000001393 denotes IL-6
T1172 273-284 GO:0072583 denotes endocytosis
T1173 402-413 DG_41 denotes baricitinib
T1174 497-505 SP_7 denotes COVID-19
T91493 0-4 PR:000009196 denotes Jak1
T58584 7-17 CHEBI:35222;CHEBI:35222 denotes inhibitors
T50670 80-88 SP_7 denotes COVID-19
T22229 107-118 DG_41 denotes baricitinib
T68856 191-195 PR:000001393 denotes IL-6
T24099 273-284 GO:0072583 denotes endocytosis
T60677 402-413 DG_41 denotes baricitinib
T73273 497-505 SP_7 denotes COVID-19

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T861 191-193 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T862 255-263 Body_part denotes clathrin http://purl.org/sig/ont/fma/fma62262
T863 381-389 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T864 384-389 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T503 80-88 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T504 221-233 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T505 422-442 Disease denotes Rheumatoid Arthritis http://purl.obolibrary.org/obo/MONDO_0008383
T506 497-505 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T895 296-297 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T896 381-389 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cells

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T4327 7-17 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T96858 191-193 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2037 0-6 Gene denotes Jak1/2 Gene:3716
2038 191-195 Gene denotes IL-6 Gene:3569
2039 89-97 Species denotes patients Tax:9606
2040 443-451 Species denotes patients Tax:9606
2041 506-514 Species denotes patients Tax:9606
2042 107-118 Chemical denotes baricitinib MESH:C000596027
2043 402-413 Chemical denotes baricitinib MESH:C000596027
2044 80-88 Disease denotes COVID-19 MESH:C000657245
2045 221-233 Disease denotes inflammation MESH:D007249
2046 422-442 Disease denotes Rheumatoid Arthritis MESH:D001172
2047 497-505 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T107 422-442 Phenotype denotes Rheumatoid Arthritis http://purl.obolibrary.org/obo/HP_0001370

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T172 221-233 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T173 255-284 http://purl.obolibrary.org/obo/GO_0072583 denotes clathrin mediated endocytosis
T174 273-284 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis

MyTest

Id Subject Object Predicate Lexical cue
32655581-32385052-34771842 318-321 32385052 denotes 241
32655581-30058112-34771843 453-456 30058112 denotes 250

TEST0

Id Subject Object Predicate Lexical cue
32655581-184-191-3171415 318-321 ["32385052"] denotes 241
32655581-129-136-3171416 453-456 ["30058112"] denotes 250

2_test

Id Subject Object Predicate Lexical cue
32655581-32385052-34771842 318-321 32385052 denotes 241
32655581-30058112-34771843 453-456 30058112 denotes 250

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T440 0-133 Sentence denotes Jak1/2 inhibitors (JAKi) are also undergoing clinical trials in moderate-severe COVID-19 patients, such as baricitinib (NCT04320277).
T441 134-323 Sentence denotes In addition to their ability to impede the production of IL-6, thus curb the excessive inflammation, they may also block clathrin mediated endocytosis–indicating a dual role for JAKi (241).
T442 324-515 Sentence denotes However, JAKi can also lead to the transient increase in NK cells as shown in baricitinib treated Rheumatoid Arthritis patients (250), which could be detrimental for severe COVID-19 patients.