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PMC:7324763 / 58910-59755 JSONTXT

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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T932 24-29 PR:000001373 denotes IL-15
T933 89-94 PR:000001373 denotes IL-15
T934 121-126 PR:000001373 denotes IL-15
T935 220-225 PR:000001373 denotes IL-15
T936 265-270 PR:000001373 denotes IL-15
T937 329-337 SP_7 denotes COVID-19
T938 348-353 PR:000001373 denotes IL-15
T939 377-380 PR:000023847 denotes ALT
T940 398-404 NCBITaxon:9606 denotes humans
T941 563-573 GO:0000075 denotes checkpoint
T942 574-584 CHEBI:35222;CHEBI:35222 denotes inhibitors
T943 728-736 CL:0000623 denotes NK cells
T88350 24-29 PR:000001373 denotes IL-15
T43303 89-94 PR:000001373 denotes IL-15
T78067 121-126 PR:000001373 denotes IL-15
T19413 220-225 PR:000001373 denotes IL-15
T12514 265-270 PR:000001373 denotes IL-15
T37844 329-337 SP_7 denotes COVID-19
T12024 348-353 PR:000001373 denotes IL-15
T21289 377-380 PR:000023847 denotes ALT
T81107 398-404 NCBITaxon:9606 denotes humans
T33457 563-573 GO:0000075 denotes checkpoint
T57505 574-584 CHEBI:35222;CHEBI:35222 denotes inhibitors
T94885 728-736 CL:0000623 denotes NK cells

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T738 24-26 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T739 44-51 Body_part denotes NK cell http://purl.org/sig/ont/fma/fma63147
T740 47-51 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T741 89-91 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T742 121-123 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T743 127-129 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T744 220-222 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T745 265-267 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T746 348-350 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T747 518-525 Body_part denotes NK cell http://purl.org/sig/ont/fma/fma63147
T748 521-525 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T749 544-551 Body_part denotes NK cell http://purl.org/sig/ont/fma/fma63147
T750 547-551 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T751 685-693 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T752 728-736 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T753 731-736 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T754 760-768 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T429 329-337 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T430 609-615 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T431 810-813 Disease denotes CRS http://purl.obolibrary.org/obo/MONDO_0007399|http://purl.obolibrary.org/obo/MONDO_0017361

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T746 30-39 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T747 44-51 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cell
T748 398-404 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T749 514-517 http://purl.obolibrary.org/obo/CLO_0002199 denotes CAR
T750 518-525 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cell
T751 544-551 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cell
T752 728-736 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cells
T753 777-780 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T754 781-782 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T39 24-26 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T97824 89-91 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T43 121-123 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T45 127-129 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T5691 220-222 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T49 265-267 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T66378 348-350 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T53 574-584 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T93921 594-597 Chemical denotes BCG http://purl.obolibrary.org/obo/CHEBI_41001

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1671 24-29 Gene denotes IL-15 Gene:3600
1672 89-94 Gene denotes IL-15 Gene:3600
1673 121-126 Gene denotes IL-15 Gene:3600
1674 220-225 Gene denotes IL-15 Gene:3600
1675 265-270 Gene denotes IL-15 Gene:3600
1676 348-353 Gene denotes IL-15 Gene:3600
1677 514-517 Gene denotes CAR Gene:653108
1678 338-346 Species denotes patients Tax:9606
1679 398-404 Species denotes humans Tax:9606
1680 329-337 Disease denotes COVID-19 MESH:C000657245
1681 609-615 Disease denotes cancer MESH:D009369

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T87 609-615 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T143 30-39 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T144 127-133 http://purl.obolibrary.org/obo/GO_0042010 denotes IL-15R

MyTest

Id Subject Object Predicate Lexical cue
32655581-25833053-34771778 227-230 25833053 denotes 168
32655581-29628312-34771779 406-409 29628312 denotes 188
32655581-28823521-34771780 617-620 28823521 denotes 189

TEST0

Id Subject Object Predicate Lexical cue
32655581-227-234-3171351 227-230 ["25833053"] denotes 168
32655581-173-180-3171352 406-409 ["29628312"] denotes 188
32655581-231-238-3171353 617-620 ["28823521"] denotes 189

2_test

Id Subject Object Predicate Lexical cue
32655581-25833053-34771778 227-230 25833053 denotes 168
32655581-29628312-34771779 406-409 29628312 denotes 188
32655581-28823521-34771780 617-620 28823521 denotes 189

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T361 0-232 Sentence denotes Given the importance of IL-15 signaling and NK cell function, researchers have developed IL-15 “superagonists” which are IL-15:IL-15R heterodimers that have better in vivo stability and bioactivity compared to monomeric IL-15 (168).
T362 233-622 Sentence denotes Although at the time of writing IL-15 superagonists are not being studied for their efficacy in COVID-19 patients, IL-15 superagonists, such as ALT-803, are safe in humans (188) and have been used in conjunction with many of the therapies being discussed in this review including: CAR-NK cell therapy, adoptive NK cell transfers, checkpoint inhibitors, and the BCG vaccine in cancer (189).
T363 623-845 Sentence denotes It should be noted that although the therapeutic potential of cytokine therapy to specifically stimulate NK cells is enticing, exogenous cytokine therapy has a high risk for exacerbating CRS if given at the incorrect time.