PMC:7324763 / 58910-59755
Annnotations
LitCovid-PMC-OGER-BB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T932 | 24-29 | PR:000001373 | denotes | IL-15 |
T933 | 89-94 | PR:000001373 | denotes | IL-15 |
T934 | 121-126 | PR:000001373 | denotes | IL-15 |
T935 | 220-225 | PR:000001373 | denotes | IL-15 |
T936 | 265-270 | PR:000001373 | denotes | IL-15 |
T937 | 329-337 | SP_7 | denotes | COVID-19 |
T938 | 348-353 | PR:000001373 | denotes | IL-15 |
T939 | 377-380 | PR:000023847 | denotes | ALT |
T940 | 398-404 | NCBITaxon:9606 | denotes | humans |
T941 | 563-573 | GO:0000075 | denotes | checkpoint |
T942 | 574-584 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
T943 | 728-736 | CL:0000623 | denotes | NK cells |
T88350 | 24-29 | PR:000001373 | denotes | IL-15 |
T43303 | 89-94 | PR:000001373 | denotes | IL-15 |
T78067 | 121-126 | PR:000001373 | denotes | IL-15 |
T19413 | 220-225 | PR:000001373 | denotes | IL-15 |
T12514 | 265-270 | PR:000001373 | denotes | IL-15 |
T37844 | 329-337 | SP_7 | denotes | COVID-19 |
T12024 | 348-353 | PR:000001373 | denotes | IL-15 |
T21289 | 377-380 | PR:000023847 | denotes | ALT |
T81107 | 398-404 | NCBITaxon:9606 | denotes | humans |
T33457 | 563-573 | GO:0000075 | denotes | checkpoint |
T57505 | 574-584 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
T94885 | 728-736 | CL:0000623 | denotes | NK cells |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T738 | 24-26 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T739 | 44-51 | Body_part | denotes | NK cell | http://purl.org/sig/ont/fma/fma63147 |
T740 | 47-51 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T741 | 89-91 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T742 | 121-123 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T743 | 127-129 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T744 | 220-222 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T745 | 265-267 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T746 | 348-350 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T747 | 518-525 | Body_part | denotes | NK cell | http://purl.org/sig/ont/fma/fma63147 |
T748 | 521-525 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T749 | 544-551 | Body_part | denotes | NK cell | http://purl.org/sig/ont/fma/fma63147 |
T750 | 547-551 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T751 | 685-693 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T752 | 728-736 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T753 | 731-736 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T754 | 760-768 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T429 | 329-337 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T430 | 609-615 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
T431 | 810-813 | Disease | denotes | CRS | http://purl.obolibrary.org/obo/MONDO_0007399|http://purl.obolibrary.org/obo/MONDO_0017361 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T746 | 30-39 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
T747 | 44-51 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cell |
T748 | 398-404 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humans |
T749 | 514-517 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
T750 | 518-525 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cell |
T751 | 544-551 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cell |
T752 | 728-736 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T753 | 777-780 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T754 | 781-782 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T39 | 24-26 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T97824 | 89-91 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T43 | 121-123 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T45 | 127-129 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T5691 | 220-222 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T49 | 265-267 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T66378 | 348-350 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T53 | 574-584 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
T93921 | 594-597 | Chemical | denotes | BCG | http://purl.obolibrary.org/obo/CHEBI_41001 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
1671 | 24-29 | Gene | denotes | IL-15 | Gene:3600 |
1672 | 89-94 | Gene | denotes | IL-15 | Gene:3600 |
1673 | 121-126 | Gene | denotes | IL-15 | Gene:3600 |
1674 | 220-225 | Gene | denotes | IL-15 | Gene:3600 |
1675 | 265-270 | Gene | denotes | IL-15 | Gene:3600 |
1676 | 348-353 | Gene | denotes | IL-15 | Gene:3600 |
1677 | 514-517 | Gene | denotes | CAR | Gene:653108 |
1678 | 338-346 | Species | denotes | patients | Tax:9606 |
1679 | 398-404 | Species | denotes | humans | Tax:9606 |
1680 | 329-337 | Disease | denotes | COVID-19 | MESH:C000657245 |
1681 | 609-615 | Disease | denotes | cancer | MESH:D009369 |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T87 | 609-615 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T143 | 30-39 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
T144 | 127-133 | http://purl.obolibrary.org/obo/GO_0042010 | denotes | IL-15R |
MyTest
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32655581-25833053-34771778 | 227-230 | 25833053 | denotes | 168 |
32655581-29628312-34771779 | 406-409 | 29628312 | denotes | 188 |
32655581-28823521-34771780 | 617-620 | 28823521 | denotes | 189 |
TEST0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32655581-227-234-3171351 | 227-230 | ["25833053"] | denotes | 168 |
32655581-173-180-3171352 | 406-409 | ["29628312"] | denotes | 188 |
32655581-231-238-3171353 | 617-620 | ["28823521"] | denotes | 189 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32655581-25833053-34771778 | 227-230 | 25833053 | denotes | 168 |
32655581-29628312-34771779 | 406-409 | 29628312 | denotes | 188 |
32655581-28823521-34771780 | 617-620 | 28823521 | denotes | 189 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T361 | 0-232 | Sentence | denotes | Given the importance of IL-15 signaling and NK cell function, researchers have developed IL-15 “superagonists” which are IL-15:IL-15R heterodimers that have better in vivo stability and bioactivity compared to monomeric IL-15 (168). |
T362 | 233-622 | Sentence | denotes | Although at the time of writing IL-15 superagonists are not being studied for their efficacy in COVID-19 patients, IL-15 superagonists, such as ALT-803, are safe in humans (188) and have been used in conjunction with many of the therapies being discussed in this review including: CAR-NK cell therapy, adoptive NK cell transfers, checkpoint inhibitors, and the BCG vaccine in cancer (189). |
T363 | 623-845 | Sentence | denotes | It should be noted that although the therapeutic potential of cytokine therapy to specifically stimulate NK cells is enticing, exogenous cytokine therapy has a high risk for exacerbating CRS if given at the incorrect time. |