PMC:7324763 / 50868-53613
Annnotations
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T819 | 34-42 | SP_7 | denotes | COVID-19 |
| T820 | 178-183 | SP_6;NCBITaxon:9606 | denotes | human |
| T821 | 184-204 | UBERON:0012168 | denotes | umbilical cord blood |
| T822 | 205-215 | GO:0010467 | denotes | expressing |
| T823 | 216-221 | PR:000001828 | denotes | NKG2D |
| T824 | 226-230 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
| T825 | 365-374 | GO:0046903 | denotes | secreting |
| T826 | 388-393 | PR:000001828 | denotes | NKG2D |
| T827 | 413-417 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
| T828 | 440-445 | PR:000001828 | denotes | NKG2D |
| T829 | 446-450 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
| T830 | 465-470 | PR:000001828 | denotes | NKG2D |
| T831 | 578-588 | SP_7 | denotes | SARS-CoV-2 |
| T832 | 608-618 | GO:0010467 | denotes | expressing |
| T833 | 619-624 | PR:000001828 | denotes | NKG2D |
| T834 | 656-661 | PR:000001828 | denotes | NKG2D |
| T835 | 698-705 | NCBITaxon:10239 | denotes | virally |
| T836 | 774-784 | GO:0010467 | denotes | expressing |
| T837 | 785-789 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T838 | 837-847 | SP_7 | denotes | SARS-CoV-2 |
| T839 | 890-895 | NCBITaxon:10239 | denotes | viral |
| T840 | 1063-1067 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T841 | 1082-1087 | NCBITaxon:10239 | denotes | viral |
| T842 | 1135-1145 | GO:0010467 | denotes | expressing |
| T843 | 1146-1150 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T844 | 1242-1247 | NCBITaxon:10239 | denotes | virus |
| T845 | 1278-1282 | CL:0000082;UBERON:0002048 | denotes | lung |
| T846 | 1283-1293 | UBERON:0000115;CL:0000066 | denotes | epithelial |
| T847 | 1294-1299 | CL:0000066 | denotes | cells |
| T848 | 1380-1385 | NCBITaxon:10239 | denotes | viral |
| T849 | 1404-1414 | UBERON:0000483;CL:0000066 | denotes | epithelial |
| T850 | 1415-1420 | CL:0000066 | denotes | cells |
| T851 | 1455-1460 | NCBITaxon:10239 | denotes | viral |
| T852 | 1475-1480 | NCBITaxon:10239 | denotes | virus |
| T853 | 1485-1494 | GO:0006260 | denotes | replicate |
| T854 | 1577-1584 | GO:0046903 | denotes | secrete |
| T855 | 1585-1590 | PR:000001373 | denotes | IL-15 |
| T856 | 1741-1746 | PR:000001373 | denotes | IL-15 |
| T857 | 1806-1810 | UBERON:0000104 | denotes | life |
| T858 | 1847-1852 | PR:000001373 | denotes | IL-15 |
| T859 | 1903-1912 | UBERON:0002048 | denotes | pulmonary |
| T860 | 1945-1953 | SP_9 | denotes | MERS-CoV |
| T861 | 2015-2025 | SP_7 | denotes | SARS-CoV-2 |
| T862 | 2059-2064 | PR:000001373 | denotes | IL-15 |
| T863 | 2077-2081 | UBERON:0002048 | denotes | lung |
| T864 | 2082-2088 | UBERON:0000479 | denotes | tissue |
| T865 | 2111-2119 | SP_10 | denotes | SARS-CoV |
| T866 | 2151-2158 | NCBITaxon:9527 | denotes | monkeys |
| T867 | 2175-2180 | PR:000001373 | denotes | IL-15 |
| T868 | 2227-2234 | NCBITaxon:9527 | denotes | monkeys |
| T869 | 2295-2300 | PR:000001373 | denotes | IL-15 |
| T870 | 2349-2357 | SP_7 | denotes | COVID-19 |
| T871 | 2399-2404 | PR:000001373 | denotes | IL-15 |
| T872 | 2486-2493 | GO:0046903 | denotes | secrete |
| T873 | 2494-2500 | PR:000005931 | denotes | GM-CSF |
| T874 | 2519-2529 | GO:0042571 | denotes | antibodies |
| T875 | 2611-2618 | CL:0000084 | denotes | T cells |
| T876 | 2667-2675 | SP_7 | denotes | COVID-19 |
| T877 | 2724-2727 | PR:000001004 | denotes | CD4 |
| T8265 | 34-42 | SP_7 | denotes | COVID-19 |
| T87861 | 178-183 | SP_6;NCBITaxon:9606 | denotes | human |
| T40029 | 184-204 | UBERON:0012168 | denotes | umbilical cord blood |
| T5067 | 205-215 | GO:0010467 | denotes | expressing |
| T24199 | 216-221 | PR:000001828 | denotes | NKG2D |
| T7795 | 226-230 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
| T92307 | 365-374 | GO:0046903 | denotes | secreting |
| T15812 | 388-393 | PR:000001828 | denotes | NKG2D |
| T3528 | 413-417 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
| T52973 | 440-445 | PR:000001828 | denotes | NKG2D |
| T24178 | 446-450 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
| T66586 | 465-470 | PR:000001828 | denotes | NKG2D |
| T25049 | 578-588 | SP_7 | denotes | SARS-CoV-2 |
| T39191 | 608-618 | GO:0010467 | denotes | expressing |
| T58660 | 619-624 | PR:000001828 | denotes | NKG2D |
| T65268 | 656-661 | PR:000001828 | denotes | NKG2D |
| T73537 | 698-705 | NCBITaxon:10239 | denotes | virally |
| T52755 | 774-784 | GO:0010467 | denotes | expressing |
| T10971 | 785-789 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T53662 | 837-847 | SP_7 | denotes | SARS-CoV-2 |
| T83539 | 890-895 | NCBITaxon:10239 | denotes | viral |
| T6050 | 1063-1067 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T27359 | 1082-1087 | NCBITaxon:10239 | denotes | viral |
| T56545 | 1135-1145 | GO:0010467 | denotes | expressing |
| T45182 | 1146-1150 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T47546 | 1242-1247 | NCBITaxon:10239 | denotes | virus |
| T4507 | 1278-1282 | CL:0000082;UBERON:0002048 | denotes | lung |
| T41452 | 1283-1293 | UBERON:0000115;CL:0000066 | denotes | epithelial |
| T5162 | 1294-1299 | CL:0000066 | denotes | cells |
| T29321 | 1380-1385 | NCBITaxon:10239 | denotes | viral |
| T90175 | 1404-1414 | UBERON:0000483;CL:0000066 | denotes | epithelial |
| T15470 | 1415-1420 | CL:0000066 | denotes | cells |
| T74548 | 1455-1460 | NCBITaxon:10239 | denotes | viral |
| T85949 | 1475-1480 | NCBITaxon:10239 | denotes | virus |
| T82582 | 1485-1494 | GO:0006260 | denotes | replicate |
| T16660 | 1577-1584 | GO:0046903 | denotes | secrete |
| T71169 | 1585-1590 | PR:000001373 | denotes | IL-15 |
| T77287 | 1741-1746 | PR:000001373 | denotes | IL-15 |
| T73970 | 1806-1810 | UBERON:0000104 | denotes | life |
| T3045 | 1847-1852 | PR:000001373 | denotes | IL-15 |
| T65128 | 1903-1912 | UBERON:0002048 | denotes | pulmonary |
| T91135 | 1945-1953 | SP_9 | denotes | MERS-CoV |
| T14885 | 2015-2025 | SP_7 | denotes | SARS-CoV-2 |
| T83604 | 2059-2064 | PR:000001373 | denotes | IL-15 |
| T70415 | 2077-2081 | UBERON:0002048 | denotes | lung |
| T85555 | 2082-2088 | UBERON:0000479 | denotes | tissue |
| T35978 | 2111-2119 | SP_10 | denotes | SARS-CoV |
| T82192 | 2151-2158 | NCBITaxon:9527 | denotes | monkeys |
| T7639 | 2175-2180 | PR:000001373 | denotes | IL-15 |
| T50620 | 2227-2234 | NCBITaxon:9527 | denotes | monkeys |
| T25413 | 2295-2300 | PR:000001373 | denotes | IL-15 |
| T54490 | 2349-2357 | SP_7 | denotes | COVID-19 |
| T83128 | 2399-2404 | PR:000001373 | denotes | IL-15 |
| T7047 | 2486-2493 | GO:0046903 | denotes | secrete |
| T68665 | 2494-2500 | PR:000005931 | denotes | GM-CSF |
| T13827 | 2519-2529 | GO:0042571 | denotes | antibodies |
| T59841 | 2611-2618 | CL:0000084 | denotes | T cells |
| T40537 | 2667-2675 | SP_7 | denotes | COVID-19 |
| T95642 | 2724-2727 | PR:000001004 | denotes | CD4 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T628 | 94-101 | Body_part | denotes | NK cell | http://purl.org/sig/ont/fma/fma63147 |
| T629 | 97-101 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T630 | 156-164 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
| T631 | 159-164 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T632 | 184-198 | Body_part | denotes | umbilical cord | http://purl.org/sig/ont/fma/fma85541 |
| T633 | 199-204 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T634 | 269-272 | Body_part | denotes | arm | http://purl.org/sig/ont/fma/fma24890 |
| T635 | 341-349 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
| T636 | 344-349 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T637 | 356-364 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
| T638 | 359-364 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T639 | 375-377 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T640 | 398-406 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
| T641 | 401-406 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T642 | 422-430 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
| T643 | 425-430 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T644 | 455-463 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
| T645 | 458-463 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T646 | 475-483 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
| T647 | 478-483 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T648 | 715-720 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T649 | 793-801 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
| T650 | 796-801 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T651 | 869-874 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T652 | 902-910 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T653 | 948-956 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
| T654 | 951-956 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T655 | 994-999 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T656 | 1035-1042 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T657 | 1068-1076 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
| T658 | 1071-1076 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T659 | 1154-1162 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
| T660 | 1157-1162 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T661 | 1208-1212 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T662 | 1278-1282 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T663 | 1283-1299 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T664 | 1294-1299 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T665 | 1404-1420 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T666 | 1415-1420 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T667 | 1498-1506 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
| T668 | 1501-1506 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T669 | 1544-1552 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
| T670 | 1547-1552 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T671 | 1585-1587 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T672 | 1652-1660 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
| T673 | 1655-1660 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T674 | 1732-1740 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T675 | 1741-1743 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T676 | 1847-1849 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T677 | 2059-2061 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T678 | 2077-2081 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T679 | 2082-2088 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T680 | 2175-2177 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T681 | 2295-2297 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T682 | 2399-2401 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T683 | 2463-2471 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
| T684 | 2466-2471 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T685 | 2497-2500 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
| T686 | 2542-2550 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T687 | 2613-2618 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T688 | 2729-2738 | Body_part | denotes | Th1 cells | http://purl.org/sig/ont/fma/fma84382 |
| T689 | 2733-2738 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T48 | 184-204 | Body_part | denotes | umbilical cord blood | http://purl.obolibrary.org/obo/UBERON_0012168 |
| T49 | 184-198 | Body_part | denotes | umbilical cord | http://purl.obolibrary.org/obo/UBERON_0002331 |
| T50 | 199-204 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T51 | 269-272 | Body_part | denotes | arm | http://purl.obolibrary.org/obo/UBERON_0001460 |
| T52 | 1278-1282 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T53 | 2077-2081 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T54 | 2082-2088 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T389 | 34-42 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T390 | 528-534 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T391 | 578-586 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T392 | 578-582 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T393 | 837-845 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T394 | 837-841 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T395 | 1082-1097 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T396 | 1088-1097 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T397 | 1664-1670 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T398 | 1913-1934 | Disease | denotes | inflammatory diseases | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T399 | 1954-1963 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T400 | 2015-2023 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T401 | 2015-2019 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T402 | 2111-2129 | Disease | denotes | SARS-CoV infection | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T403 | 2111-2115 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T404 | 2120-2129 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T405 | 2248-2257 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T406 | 2349-2357 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T407 | 2571-2574 | Disease | denotes | CRS | http://purl.obolibrary.org/obo/MONDO_0007399|http://purl.obolibrary.org/obo/MONDO_0017361 |
| T409 | 2578-2584 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T410 | 2667-2675 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T630 | 0-1 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T631 | 90-93 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
| T632 | 94-101 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cell |
| T633 | 129-135 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
| T634 | 156-164 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
| T635 | 178-183 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T636 | 184-198 | http://purl.obolibrary.org/obo/UBERON_0002331 | denotes | umbilical cord |
| T637 | 184-198 | http://www.ebi.ac.uk/efo/EFO_0001415 | denotes | umbilical cord |
| T638 | 199-204 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T639 | 199-204 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T640 | 231-235 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CARs |
| T641 | 269-272 | http://www.ebi.ac.uk/efo/EFO_0001410 | denotes | arm |
| T642 | 318-321 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
| T643 | 341-349 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
| T644 | 356-364 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
| T645 | 394-397 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
| T646 | 398-406 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
| T647 | 418-421 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
| T648 | 422-430 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
| T649 | 451-454 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
| T650 | 455-463 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
| T651 | 471-474 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
| T652 | 475-483 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
| T653 | 715-720 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T654 | 793-806 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells will |
| T655 | 869-874 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T656 | 944-947 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
| T657 | 948-956 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
| T658 | 994-999 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T659 | 1068-1076 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
| T660 | 1154-1162 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
| T661 | 1177-1178 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T662 | 1200-1201 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T663 | 1208-1212 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T664 | 1242-1247 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T665 | 1278-1299 | http://purl.obolibrary.org/obo/CL_0000082 | denotes | lung epithelial cells |
| T666 | 1404-1414 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T667 | 1415-1420 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T668 | 1475-1480 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T669 | 1498-1506 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
| T670 | 1511-1515 | http://www.ebi.ac.uk/efo/EFO_0001410 | denotes | arms |
| T671 | 1540-1543 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
| T672 | 1544-1552 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
| T673 | 1648-1651 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
| T674 | 1652-1660 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
| T675 | 1853-1856 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T676 | 1993-1996 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T677 | 2042-2043 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T678 | 2077-2081 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T679 | 2077-2081 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T680 | 2151-2158 | http://purl.obolibrary.org/obo/NCBITaxon_9479 | denotes | monkeys |
| T681 | 2227-2234 | http://purl.obolibrary.org/obo/NCBITaxon_9479 | denotes | monkeys |
| T682 | 2419-2422 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T683 | 2459-2462 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
| T684 | 2463-2471 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
| T685 | 2551-2554 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T686 | 2555-2556 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T687 | 2607-2610 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
| T688 | 2611-2618 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T689 | 2630-2633 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T690 | 2724-2727 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T691 | 2733-2738 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T71004 | 10-12 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T92218 | 375-377 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T12622 | 662-669 | Chemical | denotes | ligands | http://purl.obolibrary.org/obo/CHEBI_52214 |
| T31754 | 902-910 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T57638 | 1035-1042 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T24473 | 1585-1587 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T12770 | 1741-1743 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T51865 | 1847-1849 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T29785 | 2059-2061 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T88235 | 2175-2177 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T55189 | 2295-2297 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T97929 | 2399-2401 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T22 | 2494-2496 | Chemical | denotes | GM | http://purl.obolibrary.org/obo/CHEBI_74120 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1525 | 90-93 | Gene | denotes | CAR | Gene:653108 |
| 1526 | 216-221 | Gene | denotes | NKG2D | Gene:22914 |
| 1527 | 226-230 | Gene | denotes | ACE2 | Gene:59272 |
| 1528 | 375-380 | Gene | denotes | IL-15 | Gene:3600 |
| 1529 | 394-397 | Gene | denotes | CAR | Gene:653108 |
| 1530 | 413-417 | Gene | denotes | ACE2 | Gene:59272 |
| 1531 | 418-421 | Gene | denotes | CAR | Gene:653108 |
| 1532 | 440-445 | Gene | denotes | NKG2D | Gene:22914 |
| 1533 | 446-450 | Gene | denotes | ACE2 | Gene:59272 |
| 1534 | 451-454 | Gene | denotes | CAR | Gene:653108 |
| 1535 | 465-469 | Gene | denotes | NKG2 | Gene:3821 |
| 1536 | 471-474 | Gene | denotes | CAR | Gene:653108 |
| 1537 | 619-624 | Gene | denotes | NKG2D | Gene:22914 |
| 1538 | 656-661 | Gene | denotes | NKG2D | Gene:22914 |
| 1539 | 671-677 | Gene | denotes | NKG2DL | Gene:3821 |
| 1540 | 785-789 | Gene | denotes | ACE2 | Gene:59272 |
| 1541 | 944-947 | Gene | denotes | CAR | Gene:653108 |
| 1542 | 1029-1034 | Gene | denotes | spike | Gene:43740568 |
| 1543 | 1063-1067 | Gene | denotes | ACE2 | Gene:59272 |
| 1544 | 1146-1150 | Gene | denotes | ACE2 | Gene:59272 |
| 1545 | 1540-1543 | Gene | denotes | CAR | Gene:653108 |
| 1546 | 1585-1590 | Gene | denotes | IL-15 | Gene:3600 |
| 1547 | 1648-1651 | Gene | denotes | CAR | Gene:653108 |
| 1548 | 1741-1746 | Gene | denotes | IL-15 | Gene:3600 |
| 1549 | 1847-1852 | Gene | denotes | IL-15 | Gene:3600 |
| 1550 | 2059-2064 | Gene | denotes | IL-15 | Gene:3600 |
| 1551 | 2175-2180 | Gene | denotes | IL-15 | Gene:3600 |
| 1552 | 2295-2300 | Gene | denotes | IL-15 | Gene:3600 |
| 1553 | 2399-2404 | Gene | denotes | IL-15 | Gene:3600 |
| 1554 | 2494-2500 | Gene | denotes | GM-CSF | Gene:1437 |
| 1555 | 2514-2518 | Gene | denotes | scFv | Gene:652070 |
| 1556 | 2724-2727 | Gene | denotes | CD4 | Gene:920 |
| 1557 | 388-392 | Gene | denotes | NKG2 | Gene:3821 |
| 1558 | 896-901 | Gene | denotes | spike | Gene:43740568 |
| 1559 | 2607-2610 | Gene | denotes | CAR | Gene:653108 |
| 1560 | 43-51 | Species | denotes | patients | Tax:9606 |
| 1561 | 178-183 | Species | denotes | human | Tax:9606 |
| 1562 | 578-588 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1563 | 837-847 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1564 | 1671-1679 | Species | denotes | patients | Tax:9606 |
| 1565 | 2015-2025 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1566 | 2358-2366 | Species | denotes | patients | Tax:9606 |
| 1567 | 2585-2593 | Species | denotes | patients | Tax:9606 |
| 1568 | 34-42 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1569 | 528-534 | Disease | denotes | cancer | MESH:D009369 |
| 1570 | 706-714 | Disease | denotes | infected | MESH:D007239 |
| 1571 | 860-868 | Disease | denotes | infected | MESH:D007239 |
| 1572 | 985-993 | Disease | denotes | infected | MESH:D007239 |
| 1573 | 1082-1097 | Disease | denotes | viral infection | MESH:D001102 |
| 1574 | 1226-1234 | Disease | denotes | infected | MESH:D007239 |
| 1575 | 1664-1670 | Disease | denotes | cancer | MESH:D009369 |
| 1576 | 1823-1833 | Disease | denotes | toxicities | MESH:D064420 |
| 1577 | 1903-1934 | Disease | denotes | pulmonary inflammatory diseases | MESH:D011014 |
| 1578 | 1945-1963 | Disease | denotes | MERS-CoV infection | MESH:D018352 |
| 1579 | 2111-2129 | Disease | denotes | SARS-CoV infection | MESH:C000657245 |
| 1580 | 2247-2257 | Disease | denotes | -infection | MESH:D007239 |
| 1581 | 2349-2357 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1582 | 2578-2584 | Disease | denotes | cancer | MESH:D009369 |
| 1583 | 2667-2675 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T78 | 528-534 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T79 | 1664-1670 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T80 | 2578-2584 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T141 | 1082-1097 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
MyTest
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32655581-30651290-34771752 | 544-547 | 30651290 | denotes | 166 |
| 32655581-30026479-34771753 | 722-725 | 30026479 | denotes | 167 |
| 32655581-25833053-34771754 | 1681-1684 | 25833053 | denotes | 168 |
| 32655581-11742275-34771755 | 1936-1939 | 11742275 | denotes | 169 |
| 32655581-32460144-34771756 | 1965-1968 | 32460144 | denotes | 170 |
| 32655581-24642138-34771757 | 2259-2262 | 24642138 | denotes | 171 |
| 32655581-30463995-34771758 | 2620-2623 | 30463995 | denotes | 172 |
| 32655581-32350134-34771759 | 2740-2743 | 32350134 | denotes | 173 |
TEST0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32655581-79-86-3171325 | 544-547 | ["30651290"] | denotes | 166 |
| 32655581-233-240-3171326 | 722-725 | ["30026479"] | denotes | 167 |
| 32655581-173-180-3171327 | 1681-1684 | ["25833053"] | denotes | 168 |
| 32655581-236-243-3171328 | 1936-1939 | ["11742275"] | denotes | 169 |
| 32655581-233-240-3171329 | 1965-1968 | ["32460144"] | denotes | 170 |
| 32655581-117-124-3171330 | 2259-2262 | ["24642138"] | denotes | 171 |
| 32655581-177-184-3171331 | 2620-2623 | ["30463995"] | denotes | 172 |
| 32655581-226-233-3171332 | 2740-2743 | ["32350134"] | denotes | 173 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32655581-30651290-34771752 | 544-547 | 30651290 | denotes | 166 |
| 32655581-30026479-34771753 | 722-725 | 30026479 | denotes | 167 |
| 32655581-25833053-34771754 | 1681-1684 | 25833053 | denotes | 168 |
| 32655581-11742275-34771755 | 1936-1939 | 11742275 | denotes | 169 |
| 32655581-32460144-34771756 | 1965-1968 | 32460144 | denotes | 170 |
| 32655581-24642138-34771757 | 2259-2262 | 24642138 | denotes | 171 |
| 32655581-30463995-34771758 | 2620-2623 | 30463995 | denotes | 172 |
| 32655581-32350134-34771759 | 2740-2743 | 32350134 | denotes | 173 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T319 | 0-250 | Sentence | denotes | A Phase I/II study in early stage COVID-19 patients (within 14 days of illness) employing CAR-NK cell therapy is currently being tested using off-the-shelf NK cells derived from human umbilical cord blood expressing NKG2D and ACE2 CARs (NCT04324996). |
| T320 | 251-464 | Sentence | denotes | This complex five-arm study will compare the efficacy of different CAR-NK constructs: (i) NK cells, (ii) NK cells secreting IL-15, (iii) NKG2D CAR-NK cells, (iv) ACE2 CAR-NK cells, and (v) NKG2D-ACE2 CAR-NK cells. |
| T321 | 465-727 | Sentence | denotes | NKG2D CAR-NK cells have shown promising preclinical results in cancer studies (166), and although not proven for SARS-CoV-2, the rationale for expressing NKG2D derives from work showing that NKG2D-ligands (NKG2DL) are upregulated on virally infected cells (167). |
| T322 | 728-1098 | Sentence | denotes | Similarly, the investigators hypothesize that expressing ACE2 on NK cells will facilitate the elimination of SARS-CoV-2 virions and infected cells by binding the viral spike proteins–but it is unknown whether or not CAR-NK cells can eliminate virions or if infected cells display sufficient levels of spike protein to be recognized by ACE2-NK cells upon viral infection. |
| T323 | 1099-1300 | Sentence | denotes | The investigators also suggest that expressing ACE2 on NK cells may also have a secondary benefit as a decoy cell that will be infected by the virus thereby indirectly protecting lung epithelial cells. |
| T324 | 1301-1507 | Sentence | denotes | As described previously, it is unclear whether this strategy will work to stop viral spread to healthy epithelial cells or if it will serve to perpetuate viral spread if the virus can replicate in NK cells. |
| T325 | 1508-1686 | Sentence | denotes | In arms ii-v of this trial, the CAR-NK cells have been engineered to secrete IL-15 based on studies showing improved in vivo persistence of CAR-NK cells in cancer patients (168). |
| T326 | 1687-2026 | Sentence | denotes | However, the addition of the proinflammatory cytokine IL-15 to this treatment strategy should be monitored closely for life-threatening toxicities, as elevated IL-15 has been previously reported to accompany chronic pulmonary inflammatory diseases (169) and MERS-CoV infection (170) even if no correlation has been reported for SARS-CoV-2. |
| T327 | 2027-2264 | Sentence | denotes | Interestingly, a study compared IL-15 levels from lung tissue homogenates following SARS-CoV infection in aged vs. juvenile monkeys and showed that IL-15 concentrations were only elevated in juvenile monkeys 10 days post-infection (171). |
| T328 | 2265-2442 | Sentence | denotes | This study would suggest that IL-15 therapy may be tolerated and effective in older COVID-19 patients that may not be able to produce IL-15, however this has not been confirmed. |
| T329 | 2443-2745 | Sentence | denotes | Lastly, all the CAR-NK cells in this trial secrete GM-CSF neutralizing scFv antibodies, since this cytokine has a known role in CRS in cancer patients treated with CAR-T cells (172), and has been shown to be correlated with COVID-19 disease severity in association with pathogenic CD4+ Th1 cells (173). |