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PMC:7324763 / 48514-49793 JSONTXT

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LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T788 58-63 CHEBI:23888;CHEBI:23888 denotes drugs
T789 94-101 CL:0000001 denotes primary
T790 102-110 CL:0000623 denotes NK cells
T791 125-135 UBERON:0013682 denotes peripheral
T792 136-141 UBERON:0000178 denotes blood
T793 142-153 GO:0005634;CL:0000842 denotes mononuclear
T794 154-159 CL:0000842 denotes cells
T795 190-199 CL:0000034 denotes stem cell
T796 214-225 SO:0000704 denotes genetically
T797 250-255 SP_6;NCBITaxon:9606 denotes human
T798 277-284 CL:0000001 denotes Primary
T799 285-292 CL:0000623 denotes NK cell
T800 459-465 UBERON:0002405 denotes immune
T801 495-499 PR:000001379 denotes IL-2
T802 509-514 PR:000001373 denotes IL-15
T803 643-651 SP_7 denotes COVID-19
T804 710-714 CHEBI:23888;CHEBI:23888 denotes drug
T805 765-773 SP_7 denotes COVID-19
T806 1062-1070 SP_7 denotes COVID-19
T807 1133-1142 UBERON:0001987 denotes placental
T808 1143-1147 PR:000001003 denotes CD34
T60801 58-63 CHEBI:23888;CHEBI:23888 denotes drugs
T69494 94-101 CL:0000001 denotes primary
T29383 102-110 CL:0000623 denotes NK cells
T72459 125-135 UBERON:0013682 denotes peripheral
T33253 136-141 UBERON:0000178 denotes blood
T84870 142-153 GO:0005634;CL:0000842 denotes mononuclear
T3404 154-159 CL:0000842 denotes cells
T37468 190-199 CL:0000034 denotes stem cell
T58409 214-225 SO:0000704 denotes genetically
T13798 250-255 SP_6;NCBITaxon:9606 denotes human
T99428 277-284 CL:0000001 denotes Primary
T79733 285-292 CL:0000623 denotes NK cell
T16237 459-465 UBERON:0002405 denotes immune
T53471 495-499 PR:000001379 denotes IL-2
T76976 509-514 PR:000001373 denotes IL-15
T28494 643-651 SP_7 denotes COVID-19
T61640 710-714 CHEBI:23888;CHEBI:23888 denotes drug
T89360 765-773 SP_7 denotes COVID-19
T74629 1062-1070 SP_7 denotes COVID-19
T32157 1133-1142 UBERON:0001987 denotes placental
T63952 1143-1147 PR:000001003 denotes CD34

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T582 12-19 Body_part denotes NK cell http://purl.org/sig/ont/fma/fma63147
T583 15-19 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T584 102-110 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T585 105-110 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T586 125-159 Body_part denotes peripheral blood mononuclear cells http://purl.org/sig/ont/fma/fma86713
T587 154-159 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T588 190-199 Body_part denotes stem cell http://purl.org/sig/ont/fma/fma63368
T589 195-199 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T590 256-263 Body_part denotes NK cell http://purl.org/sig/ont/fma/fma63147
T591 259-263 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T592 285-292 Body_part denotes NK cell http://purl.org/sig/ont/fma/fma63147
T593 288-292 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T594 351-360 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T595 391-396 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T596 495-499 Body_part denotes IL-2 http://purl.org/sig/ont/fma/fma84051
T597 495-497 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T598 509-511 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T599 593-600 Body_part denotes NK cell http://purl.org/sig/ont/fma/fma63147
T600 596-600 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T601 683-687 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T602 830-837 Body_part denotes NK cell http://purl.org/sig/ont/fma/fma63147
T603 833-837 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T604 1111-1119 Body_part denotes NK cells http://purl.org/sig/ont/fma/fma63147
T605 1114-1119 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T606 1143-1154 Body_part denotes CD34+ cells http://purl.org/sig/ont/fma/fma0326120
T607 1149-1154 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T46 136-141 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T376 643-651 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T377 765-773 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T378 902-908 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T379 1062-1070 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T585 12-19 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cell
T586 102-110 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cells
T587 125-159 http://purl.obolibrary.org/obo/CL_0000842 denotes peripheral blood mononuclear cells
T588 125-159 http://purl.obolibrary.org/obo/CL_2000001 denotes peripheral blood mononuclear cells
T589 190-199 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cell
T590 250-255 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T591 256-263 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cell
T592 285-292 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cell
T593 391-396 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T594 495-499 http://purl.obolibrary.org/obo/PR_000001379 denotes IL-2
T595 561-569 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T596 593-600 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cell
T597 628-634 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T598 683-687 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T599 754-761 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T600 830-837 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cell
T601 924-927 http://purl.obolibrary.org/obo/CLO_0001002 denotes 162
T602 1111-1119 http://purl.obolibrary.org/obo/CL_0000623 denotes NK cells
T603 1149-1154 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T604 1229-1230 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T605 1262-1263 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T606 1264-1267 http://purl.obolibrary.org/obo/CLO_0053733 denotes 1:1

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T291 58-63 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T292 495-497 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T294 509-511 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T296 710-714 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T297 1177-1179 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1422 495-499 Gene denotes IL-2 Gene:3558
1423 509-514 Gene denotes IL-15 Gene:3600
1424 250-255 Species denotes human Tax:9606
1425 423-431 Species denotes patients Tax:9606
1426 433-441 Species denotes Patients Tax:9606
1427 774-782 Species denotes patients Tax:9606
1428 1071-1079 Species denotes patients Tax:9606
1429 1208-1216 Species denotes patients Tax:9606
1430 643-651 Disease denotes COVID-19 MESH:C000657245
1431 765-773 Disease denotes COVID-19 MESH:C000657245
1432 902-908 Disease denotes cancer MESH:D009369
1433 1062-1070 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T73 902-908 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664

MyTest

Id Subject Object Predicate Lexical cue
32655581-31907401-34771744 271-274 31907401 denotes 158
32655581-19383914-34771745 501-504 19383914 denotes 159
32655581-31266741-34771746 516-519 31266741 denotes 160
32655581-31214177-34771747 611-614 31214177 denotes 161

TEST0

Id Subject Object Predicate Lexical cue
32655581-235-242-3171317 271-274 ["31907401"] denotes 158
32655581-68-75-3171318 501-504 ["19383914"] denotes 159
32655581-83-90-3171319 516-519 ["31266741"] denotes 160
32655581-178-185-3171320 611-614 ["31214177"] denotes 161

2_test

Id Subject Object Predicate Lexical cue
32655581-31907401-34771744 271-274 31907401 denotes 158
32655581-19383914-34771745 501-504 19383914 denotes 159
32655581-31266741-34771746 516-519 31266741 denotes 160
32655581-31214177-34771747 611-614 31214177 denotes 161

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T307 0-276 Sentence denotes Therapeutic NK cell products can be thought of as “living drugs” as they generally use either primary NK cells isolated from peripheral blood mononuclear cells (PBMCs) or are generated from stem cell precursors or genetically engineered immortalized human NK cell lines (158).
T308 277-432 Sentence denotes Primary NK cell products are often pre-treated and expanded in vitro with cytokines or via co-culture with target cells before being infused into patients.
T309 433-672 Sentence denotes Patients can also receive immune stimulants [e.g. recombinant IL-2 (159) or IL-15 (160)] with the goal of improving the in vivo activity and persistence of the NK cell products (161) as is being tested in this COVID-19 trial (NCT04344548).
T310 673-929 Sentence denotes The first cell-based investigational drug to be approved by the FDA for clinical testing in COVID-19 patients is an allogeneic, off-the-shelf, cryopreserved NK cell therapy made by Celularity (CYNK-001), originally developed for cancer immunotherapy (162).
T311 930-979 Sentence denotes The trial (NCT04365101) is split into two Phases.
T312 980-1155 Sentence denotes Phase I will assess the frequency and severity of adverse events in mild, non-ICU COVID-19 patients (n = 14) following infusion of NK cells derived from placental CD34+ cells.
T313 1156-1279 Sentence denotes The subsequent Phase II trial will recruit up to 72 patients and include a standard of care comparator at a 1:1 allocation.