PMC:7324763 / 47830-54091
Annnotations
LitCovid-PMC-OGER-BB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T778 | 79-89 | SP_7 | denotes | SARS-CoV-2 |
T779 | 159-167 | SP_7 | denotes | COVID-19 |
T780 | 245-255 | SP_7 | denotes | SARS-CoV-2 |
T781 | 277-288 | CL:0000080 | denotes | circulating |
T782 | 308-315 | GO:0010467 | denotes | express |
T783 | 363-368 | PR:000002023 | denotes | NKG2A |
T784 | 391-396 | PR:000000017 | denotes | IFN-γ |
T785 | 505-513 | SP_7 | denotes | COVID-19 |
T786 | 524-526 | CL:0000623 | denotes | NK |
T787 | 675-682 | NCBITaxon:10239 | denotes | viruses |
T788 | 742-747 | CHEBI:23888;CHEBI:23888 | denotes | drugs |
T789 | 778-785 | CL:0000001 | denotes | primary |
T790 | 786-794 | CL:0000623 | denotes | NK cells |
T791 | 809-819 | UBERON:0013682 | denotes | peripheral |
T792 | 820-825 | UBERON:0000178 | denotes | blood |
T793 | 826-837 | GO:0005634;CL:0000842 | denotes | mononuclear |
T794 | 838-843 | CL:0000842 | denotes | cells |
T795 | 874-883 | CL:0000034 | denotes | stem cell |
T796 | 898-909 | SO:0000704 | denotes | genetically |
T797 | 934-939 | SP_6;NCBITaxon:9606 | denotes | human |
T798 | 961-968 | CL:0000001 | denotes | Primary |
T799 | 969-976 | CL:0000623 | denotes | NK cell |
T800 | 1143-1149 | UBERON:0002405 | denotes | immune |
T801 | 1179-1183 | PR:000001379 | denotes | IL-2 |
T802 | 1193-1198 | PR:000001373 | denotes | IL-15 |
T803 | 1327-1335 | SP_7 | denotes | COVID-19 |
T804 | 1394-1398 | CHEBI:23888;CHEBI:23888 | denotes | drug |
T805 | 1449-1457 | SP_7 | denotes | COVID-19 |
T806 | 1746-1754 | SP_7 | denotes | COVID-19 |
T807 | 1817-1826 | UBERON:0001987 | denotes | placental |
T808 | 1827-1831 | PR:000001003 | denotes | CD34 |
T809 | 1964-1975 | SO:0000704 | denotes | Genetically |
T810 | 2043-2051 | SP_7 | denotes | COVID-19 |
T811 | 2062-2069 | CHEBI:59132;CHEBI:59132 | denotes | antigen |
T812 | 2121-2128 | GO:0010467 | denotes | express |
T813 | 2295-2299 | PR:000001002 | denotes | CD19 |
T814 | 2454-2459 | NCBITaxon:10239 | denotes | viral |
T815 | 2704-2712 | SP_7 | denotes | COVID-19 |
T816 | 2878-2884 | CL:0000084 | denotes | T cell |
T817 | 2929-2935 | CHEBI:15377;CHEBI:15377 | denotes | waters |
T818 | 3019-3027 | SP_7 | denotes | COVID-19 |
T819 | 3072-3080 | SP_7 | denotes | COVID-19 |
T820 | 3216-3221 | SP_6;NCBITaxon:9606 | denotes | human |
T821 | 3222-3242 | UBERON:0012168 | denotes | umbilical cord blood |
T822 | 3243-3253 | GO:0010467 | denotes | expressing |
T823 | 3254-3259 | PR:000001828 | denotes | NKG2D |
T824 | 3264-3268 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
T825 | 3403-3412 | GO:0046903 | denotes | secreting |
T826 | 3426-3431 | PR:000001828 | denotes | NKG2D |
T827 | 3451-3455 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
T828 | 3478-3483 | PR:000001828 | denotes | NKG2D |
T829 | 3484-3488 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
T830 | 3503-3508 | PR:000001828 | denotes | NKG2D |
T831 | 3616-3626 | SP_7 | denotes | SARS-CoV-2 |
T832 | 3646-3656 | GO:0010467 | denotes | expressing |
T833 | 3657-3662 | PR:000001828 | denotes | NKG2D |
T834 | 3694-3699 | PR:000001828 | denotes | NKG2D |
T835 | 3736-3743 | NCBITaxon:10239 | denotes | virally |
T836 | 3812-3822 | GO:0010467 | denotes | expressing |
T837 | 3823-3827 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T838 | 3875-3885 | SP_7 | denotes | SARS-CoV-2 |
T839 | 3928-3933 | NCBITaxon:10239 | denotes | viral |
T840 | 4101-4105 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T841 | 4120-4125 | NCBITaxon:10239 | denotes | viral |
T842 | 4173-4183 | GO:0010467 | denotes | expressing |
T843 | 4184-4188 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T844 | 4280-4285 | NCBITaxon:10239 | denotes | virus |
T845 | 4316-4320 | CL:0000082;UBERON:0002048 | denotes | lung |
T846 | 4321-4331 | UBERON:0000115;CL:0000066 | denotes | epithelial |
T847 | 4332-4337 | CL:0000066 | denotes | cells |
T848 | 4418-4423 | NCBITaxon:10239 | denotes | viral |
T849 | 4442-4452 | UBERON:0000483;CL:0000066 | denotes | epithelial |
T850 | 4453-4458 | CL:0000066 | denotes | cells |
T851 | 4493-4498 | NCBITaxon:10239 | denotes | viral |
T852 | 4513-4518 | NCBITaxon:10239 | denotes | virus |
T853 | 4523-4532 | GO:0006260 | denotes | replicate |
T854 | 4615-4622 | GO:0046903 | denotes | secrete |
T855 | 4623-4628 | PR:000001373 | denotes | IL-15 |
T856 | 4779-4784 | PR:000001373 | denotes | IL-15 |
T857 | 4844-4848 | UBERON:0000104 | denotes | life |
T858 | 4885-4890 | PR:000001373 | denotes | IL-15 |
T859 | 4941-4950 | UBERON:0002048 | denotes | pulmonary |
T860 | 4983-4991 | SP_9 | denotes | MERS-CoV |
T861 | 5053-5063 | SP_7 | denotes | SARS-CoV-2 |
T862 | 5097-5102 | PR:000001373 | denotes | IL-15 |
T863 | 5115-5119 | UBERON:0002048 | denotes | lung |
T864 | 5120-5126 | UBERON:0000479 | denotes | tissue |
T865 | 5149-5157 | SP_10 | denotes | SARS-CoV |
T866 | 5189-5196 | NCBITaxon:9527 | denotes | monkeys |
T867 | 5213-5218 | PR:000001373 | denotes | IL-15 |
T868 | 5265-5272 | NCBITaxon:9527 | denotes | monkeys |
T869 | 5333-5338 | PR:000001373 | denotes | IL-15 |
T870 | 5387-5395 | SP_7 | denotes | COVID-19 |
T871 | 5437-5442 | PR:000001373 | denotes | IL-15 |
T872 | 5524-5531 | GO:0046903 | denotes | secrete |
T873 | 5532-5538 | PR:000005931 | denotes | GM-CSF |
T874 | 5557-5567 | GO:0042571 | denotes | antibodies |
T875 | 5649-5656 | CL:0000084 | denotes | T cells |
T876 | 5705-5713 | SP_7 | denotes | COVID-19 |
T877 | 5762-5765 | PR:000001004 | denotes | CD4 |
T878 | 5924-5935 | NCBITaxon:1 | denotes | individuals |
T879 | 6051-6058 | CL:0000623 | denotes | NK cell |
T98539 | 79-89 | SP_7 | denotes | SARS-CoV-2 |
T86458 | 159-167 | SP_7 | denotes | COVID-19 |
T15394 | 245-255 | SP_7 | denotes | SARS-CoV-2 |
T17964 | 277-288 | CL:0000080 | denotes | circulating |
T9669 | 308-315 | GO:0010467 | denotes | express |
T92127 | 363-368 | PR:000002023 | denotes | NKG2A |
T50383 | 391-396 | PR:000000017 | denotes | IFN-γ |
T43708 | 505-513 | SP_7 | denotes | COVID-19 |
T82243 | 524-526 | CL:0000623 | denotes | NK |
T17543 | 675-682 | NCBITaxon:10239 | denotes | viruses |
T60801 | 742-747 | CHEBI:23888;CHEBI:23888 | denotes | drugs |
T69494 | 778-785 | CL:0000001 | denotes | primary |
T29383 | 786-794 | CL:0000623 | denotes | NK cells |
T72459 | 809-819 | UBERON:0013682 | denotes | peripheral |
T33253 | 820-825 | UBERON:0000178 | denotes | blood |
T84870 | 826-837 | GO:0005634;CL:0000842 | denotes | mononuclear |
T3404 | 838-843 | CL:0000842 | denotes | cells |
T37468 | 874-883 | CL:0000034 | denotes | stem cell |
T58409 | 898-909 | SO:0000704 | denotes | genetically |
T13798 | 934-939 | SP_6;NCBITaxon:9606 | denotes | human |
T99428 | 961-968 | CL:0000001 | denotes | Primary |
T79733 | 969-976 | CL:0000623 | denotes | NK cell |
T16237 | 1143-1149 | UBERON:0002405 | denotes | immune |
T53471 | 1179-1183 | PR:000001379 | denotes | IL-2 |
T76976 | 1193-1198 | PR:000001373 | denotes | IL-15 |
T28494 | 1327-1335 | SP_7 | denotes | COVID-19 |
T61640 | 1394-1398 | CHEBI:23888;CHEBI:23888 | denotes | drug |
T89360 | 1449-1457 | SP_7 | denotes | COVID-19 |
T74629 | 1746-1754 | SP_7 | denotes | COVID-19 |
T32157 | 1817-1826 | UBERON:0001987 | denotes | placental |
T63952 | 1827-1831 | PR:000001003 | denotes | CD34 |
T86578 | 1964-1975 | SO:0000704 | denotes | Genetically |
T21866 | 2043-2051 | SP_7 | denotes | COVID-19 |
T98034 | 2062-2069 | CHEBI:59132;CHEBI:59132 | denotes | antigen |
T96260 | 2121-2128 | GO:0010467 | denotes | express |
T13912 | 2295-2299 | PR:000001002 | denotes | CD19 |
T27980 | 2454-2459 | NCBITaxon:10239 | denotes | viral |
T57982 | 2704-2712 | SP_7 | denotes | COVID-19 |
T43379 | 2878-2884 | CL:0000084 | denotes | T cell |
T53349 | 2929-2935 | CHEBI:15377;CHEBI:15377 | denotes | waters |
T53390 | 3019-3027 | SP_7 | denotes | COVID-19 |
T8265 | 3072-3080 | SP_7 | denotes | COVID-19 |
T87861 | 3216-3221 | SP_6;NCBITaxon:9606 | denotes | human |
T40029 | 3222-3242 | UBERON:0012168 | denotes | umbilical cord blood |
T5067 | 3243-3253 | GO:0010467 | denotes | expressing |
T24199 | 3254-3259 | PR:000001828 | denotes | NKG2D |
T7795 | 3264-3268 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
T92307 | 3403-3412 | GO:0046903 | denotes | secreting |
T15812 | 3426-3431 | PR:000001828 | denotes | NKG2D |
T3528 | 3451-3455 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
T52973 | 3478-3483 | PR:000001828 | denotes | NKG2D |
T24178 | 3484-3488 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
T66586 | 3503-3508 | PR:000001828 | denotes | NKG2D |
T25049 | 3616-3626 | SP_7 | denotes | SARS-CoV-2 |
T39191 | 3646-3656 | GO:0010467 | denotes | expressing |
T58660 | 3657-3662 | PR:000001828 | denotes | NKG2D |
T65268 | 3694-3699 | PR:000001828 | denotes | NKG2D |
T73537 | 3736-3743 | NCBITaxon:10239 | denotes | virally |
T52755 | 3812-3822 | GO:0010467 | denotes | expressing |
T10971 | 3823-3827 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T53662 | 3875-3885 | SP_7 | denotes | SARS-CoV-2 |
T83539 | 3928-3933 | NCBITaxon:10239 | denotes | viral |
T6050 | 4101-4105 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T27359 | 4120-4125 | NCBITaxon:10239 | denotes | viral |
T56545 | 4173-4183 | GO:0010467 | denotes | expressing |
T45182 | 4184-4188 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T47546 | 4280-4285 | NCBITaxon:10239 | denotes | virus |
T4507 | 4316-4320 | CL:0000082;UBERON:0002048 | denotes | lung |
T41452 | 4321-4331 | UBERON:0000115;CL:0000066 | denotes | epithelial |
T5162 | 4332-4337 | CL:0000066 | denotes | cells |
T29321 | 4418-4423 | NCBITaxon:10239 | denotes | viral |
T90175 | 4442-4452 | UBERON:0000483;CL:0000066 | denotes | epithelial |
T15470 | 4453-4458 | CL:0000066 | denotes | cells |
T74548 | 4493-4498 | NCBITaxon:10239 | denotes | viral |
T85949 | 4513-4518 | NCBITaxon:10239 | denotes | virus |
T82582 | 4523-4532 | GO:0006260 | denotes | replicate |
T16660 | 4615-4622 | GO:0046903 | denotes | secrete |
T71169 | 4623-4628 | PR:000001373 | denotes | IL-15 |
T77287 | 4779-4784 | PR:000001373 | denotes | IL-15 |
T73970 | 4844-4848 | UBERON:0000104 | denotes | life |
T3045 | 4885-4890 | PR:000001373 | denotes | IL-15 |
T65128 | 4941-4950 | UBERON:0002048 | denotes | pulmonary |
T91135 | 4983-4991 | SP_9 | denotes | MERS-CoV |
T14885 | 5053-5063 | SP_7 | denotes | SARS-CoV-2 |
T83604 | 5097-5102 | PR:000001373 | denotes | IL-15 |
T70415 | 5115-5119 | UBERON:0002048 | denotes | lung |
T85555 | 5120-5126 | UBERON:0000479 | denotes | tissue |
T35978 | 5149-5157 | SP_10 | denotes | SARS-CoV |
T82192 | 5189-5196 | NCBITaxon:9527 | denotes | monkeys |
T7639 | 5213-5218 | PR:000001373 | denotes | IL-15 |
T50620 | 5265-5272 | NCBITaxon:9527 | denotes | monkeys |
T25413 | 5333-5338 | PR:000001373 | denotes | IL-15 |
T54490 | 5387-5395 | SP_7 | denotes | COVID-19 |
T83128 | 5437-5442 | PR:000001373 | denotes | IL-15 |
T7047 | 5524-5531 | GO:0046903 | denotes | secrete |
T68665 | 5532-5538 | PR:000005931 | denotes | GM-CSF |
T13827 | 5557-5567 | GO:0042571 | denotes | antibodies |
T59841 | 5649-5656 | CL:0000084 | denotes | T cells |
T40537 | 5705-5713 | SP_7 | denotes | COVID-19 |
T95642 | 5762-5765 | PR:000001004 | denotes | CD4 |
T40109 | 5924-5935 | NCBITaxon:1 | denotes | individuals |
T56740 | 6051-6058 | CL:0000623 | denotes | NK cell |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T574 | 0-7 | Body_part | denotes | NK Cell | http://purl.org/sig/ont/fma/fma63147 |
T575 | 3-7 | Body_part | denotes | Cell | http://purl.org/sig/ont/fma/fma68646 |
T576 | 289-297 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T577 | 292-297 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T578 | 462-469 | Body_part | denotes | NK cell | http://purl.org/sig/ont/fma/fma63147 |
T579 | 465-469 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T580 | 524-531 | Body_part | denotes | NK cell | http://purl.org/sig/ont/fma/fma63147 |
T581 | 527-531 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T582 | 696-703 | Body_part | denotes | NK cell | http://purl.org/sig/ont/fma/fma63147 |
T583 | 699-703 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T584 | 786-794 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T585 | 789-794 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T586 | 809-843 | Body_part | denotes | peripheral blood mononuclear cells | http://purl.org/sig/ont/fma/fma86713 |
T587 | 838-843 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T588 | 874-883 | Body_part | denotes | stem cell | http://purl.org/sig/ont/fma/fma63368 |
T589 | 879-883 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T590 | 940-947 | Body_part | denotes | NK cell | http://purl.org/sig/ont/fma/fma63147 |
T591 | 943-947 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T592 | 969-976 | Body_part | denotes | NK cell | http://purl.org/sig/ont/fma/fma63147 |
T593 | 972-976 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T594 | 1035-1044 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
T595 | 1075-1080 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T596 | 1179-1183 | Body_part | denotes | IL-2 | http://purl.org/sig/ont/fma/fma84051 |
T597 | 1179-1181 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T598 | 1193-1195 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T599 | 1277-1284 | Body_part | denotes | NK cell | http://purl.org/sig/ont/fma/fma63147 |
T600 | 1280-1284 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T601 | 1367-1371 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T602 | 1514-1521 | Body_part | denotes | NK cell | http://purl.org/sig/ont/fma/fma63147 |
T603 | 1517-1521 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T604 | 1795-1803 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T605 | 1798-1803 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T606 | 1827-1838 | Body_part | denotes | CD34+ cells | http://purl.org/sig/ont/fma/fma0326120 |
T607 | 1833-1838 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T608 | 1985-1993 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T609 | 1988-1993 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T610 | 2079-2087 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T611 | 2082-2087 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T612 | 2093-2101 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T613 | 2096-2101 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T614 | 2222-2230 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T615 | 2225-2230 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T616 | 2251-2256 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T617 | 2352-2356 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T618 | 2434-2442 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T619 | 2437-2442 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T620 | 2571-2579 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T621 | 2574-2579 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T622 | 2736-2744 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T623 | 2739-2744 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T624 | 2815-2823 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T625 | 2880-2884 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T626 | 2961-2969 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T627 | 2964-2969 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T628 | 3132-3139 | Body_part | denotes | NK cell | http://purl.org/sig/ont/fma/fma63147 |
T629 | 3135-3139 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T630 | 3194-3202 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T631 | 3197-3202 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T632 | 3222-3236 | Body_part | denotes | umbilical cord | http://purl.org/sig/ont/fma/fma85541 |
T633 | 3237-3242 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
T634 | 3307-3310 | Body_part | denotes | arm | http://purl.org/sig/ont/fma/fma24890 |
T635 | 3379-3387 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T636 | 3382-3387 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T637 | 3394-3402 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T638 | 3397-3402 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T639 | 3413-3415 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T640 | 3436-3444 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T641 | 3439-3444 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T642 | 3460-3468 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T643 | 3463-3468 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T644 | 3493-3501 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T645 | 3496-3501 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T646 | 3513-3521 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T647 | 3516-3521 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T648 | 3753-3758 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T649 | 3831-3839 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T650 | 3834-3839 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T651 | 3907-3912 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T652 | 3940-3948 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T653 | 3986-3994 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T654 | 3989-3994 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T655 | 4032-4037 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T656 | 4073-4080 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T657 | 4106-4114 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T658 | 4109-4114 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T659 | 4192-4200 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T660 | 4195-4200 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T661 | 4246-4250 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T662 | 4316-4320 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
T663 | 4321-4337 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
T664 | 4332-4337 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T665 | 4442-4458 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
T666 | 4453-4458 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T667 | 4536-4544 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T668 | 4539-4544 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T669 | 4582-4590 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T670 | 4585-4590 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T671 | 4623-4625 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T672 | 4690-4698 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T673 | 4693-4698 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T674 | 4770-4778 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T675 | 4779-4781 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T676 | 4885-4887 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T677 | 5097-5099 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T678 | 5115-5119 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
T679 | 5120-5126 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
T680 | 5213-5215 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T681 | 5333-5335 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T682 | 5437-5439 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T683 | 5501-5509 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T684 | 5504-5509 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T685 | 5535-5538 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
T686 | 5580-5588 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T687 | 5651-5656 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T688 | 5767-5776 | Body_part | denotes | Th1 cells | http://purl.org/sig/ont/fma/fma84382 |
T689 | 5771-5776 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T690 | 5793-5800 | Body_part | denotes | NK cell | http://purl.org/sig/ont/fma/fma63147 |
T691 | 5796-5800 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T692 | 6051-6058 | Body_part | denotes | NK cell | http://purl.org/sig/ont/fma/fma63147 |
T693 | 6054-6058 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T694 | 6195-6203 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T695 | 6198-6203 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T696 | 6252-6260 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
T697 | 6255-6260 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T46 | 820-825 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T47 | 2512-2517 | Body_part | denotes | scale | http://purl.obolibrary.org/obo/UBERON_0002542 |
T48 | 3222-3242 | Body_part | denotes | umbilical cord blood | http://purl.obolibrary.org/obo/UBERON_0012168 |
T49 | 3222-3236 | Body_part | denotes | umbilical cord | http://purl.obolibrary.org/obo/UBERON_0002331 |
T50 | 3237-3242 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T51 | 3307-3310 | Body_part | denotes | arm | http://purl.obolibrary.org/obo/UBERON_0001460 |
T52 | 4316-4320 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T53 | 5115-5119 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T54 | 5120-5126 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T369 | 79-87 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T370 | 79-83 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T371 | 159-167 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T372 | 245-253 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T373 | 245-249 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T374 | 505-513 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T375 | 591-597 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
T376 | 1327-1335 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T377 | 1449-1457 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T378 | 1586-1592 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
T379 | 1746-1754 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T380 | 2043-2051 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T381 | 2244-2250 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
T382 | 2333-2339 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
T383 | 2454-2470 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
T384 | 2583-2589 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
T385 | 2704-2712 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T386 | 2842-2845 | Disease | denotes | CRS | http://purl.obolibrary.org/obo/MONDO_0007399|http://purl.obolibrary.org/obo/MONDO_0017361 |
T388 | 3019-3027 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T389 | 3072-3080 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T390 | 3566-3572 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
T391 | 3616-3624 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T392 | 3616-3620 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T393 | 3875-3883 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T394 | 3875-3879 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T395 | 4120-4135 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
T396 | 4126-4135 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T397 | 4702-4708 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
T398 | 4951-4972 | Disease | denotes | inflammatory diseases | http://purl.obolibrary.org/obo/MONDO_0021166 |
T399 | 4992-5001 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T400 | 5053-5061 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T401 | 5053-5057 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T402 | 5149-5167 | Disease | denotes | SARS-CoV infection | http://purl.obolibrary.org/obo/MONDO_0005091 |
T403 | 5149-5153 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T404 | 5158-5167 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T405 | 5286-5295 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T406 | 5387-5395 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T407 | 5609-5612 | Disease | denotes | CRS | http://purl.obolibrary.org/obo/MONDO_0007399|http://purl.obolibrary.org/obo/MONDO_0017361 |
T409 | 5616-5622 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
T410 | 5705-5713 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T411 | 5866-5872 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T576 | 0-7 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK Cell |
T577 | 41-42 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T578 | 289-297 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T579 | 316-317 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T580 | 437-438 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T581 | 462-469 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cell |
T582 | 489-490 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T583 | 524-531 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cell |
T584 | 675-682 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T585 | 696-703 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cell |
T586 | 786-794 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T587 | 809-843 | http://purl.obolibrary.org/obo/CL_0000842 | denotes | peripheral blood mononuclear cells |
T588 | 809-843 | http://purl.obolibrary.org/obo/CL_2000001 | denotes | peripheral blood mononuclear cells |
T589 | 874-883 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | stem cell |
T590 | 934-939 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T591 | 940-947 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cell |
T592 | 969-976 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cell |
T593 | 1075-1080 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T594 | 1179-1183 | http://purl.obolibrary.org/obo/PR_000001379 | denotes | IL-2 |
T595 | 1245-1253 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
T596 | 1277-1284 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cell |
T597 | 1312-1318 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
T598 | 1367-1371 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T599 | 1438-1445 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | testing |
T600 | 1514-1521 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cell |
T601 | 1608-1611 | http://purl.obolibrary.org/obo/CLO_0001002 | denotes | 162 |
T602 | 1795-1803 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T603 | 1833-1838 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T604 | 1913-1914 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T605 | 1946-1947 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T606 | 1948-1951 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 1:1 |
T607 | 1985-1993 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T608 | 2079-2087 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T609 | 2089-2092 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
T610 | 2093-2101 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T611 | 2222-2230 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T612 | 2251-2256 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T613 | 2287-2290 | http://purl.obolibrary.org/obo/CLO_0001003 | denotes | 163 |
T614 | 2295-2299 | http://purl.obolibrary.org/obo/CLO_0053432 | denotes | CD19 |
T615 | 2350-2356 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cell |
T616 | 2430-2433 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
T617 | 2434-2442 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T618 | 2471-2474 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T619 | 2496-2502 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
T620 | 2567-2570 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
T621 | 2571-2579 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T622 | 2647-2650 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
T623 | 2732-2735 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
T624 | 2736-2744 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T625 | 2848-2849 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T626 | 2874-2877 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
T627 | 2878-2884 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
T628 | 2957-2960 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
T629 | 2961-2969 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T630 | 3038-3039 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T631 | 3128-3131 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
T632 | 3132-3139 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cell |
T633 | 3167-3173 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
T634 | 3194-3202 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T635 | 3216-3221 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T636 | 3222-3236 | http://purl.obolibrary.org/obo/UBERON_0002331 | denotes | umbilical cord |
T637 | 3222-3236 | http://www.ebi.ac.uk/efo/EFO_0001415 | denotes | umbilical cord |
T638 | 3237-3242 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T639 | 3237-3242 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
T640 | 3269-3273 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CARs |
T641 | 3307-3310 | http://www.ebi.ac.uk/efo/EFO_0001410 | denotes | arm |
T642 | 3356-3359 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
T643 | 3379-3387 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T644 | 3394-3402 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T645 | 3432-3435 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
T646 | 3436-3444 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T647 | 3456-3459 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
T648 | 3460-3468 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T649 | 3489-3492 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
T650 | 3493-3501 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T651 | 3509-3512 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
T652 | 3513-3521 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T653 | 3753-3758 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T654 | 3831-3844 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells will |
T655 | 3907-3912 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T656 | 3982-3985 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
T657 | 3986-3994 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T658 | 4032-4037 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T659 | 4106-4114 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T660 | 4192-4200 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T661 | 4215-4216 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T662 | 4238-4239 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T663 | 4246-4250 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T664 | 4280-4285 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T665 | 4316-4337 | http://purl.obolibrary.org/obo/CL_0000082 | denotes | lung epithelial cells |
T666 | 4442-4452 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
T667 | 4453-4458 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T668 | 4513-4518 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T669 | 4536-4544 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T670 | 4549-4553 | http://www.ebi.ac.uk/efo/EFO_0001410 | denotes | arms |
T671 | 4578-4581 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
T672 | 4582-4590 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T673 | 4686-4689 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
T674 | 4690-4698 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T675 | 4891-4894 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T676 | 5031-5034 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T677 | 5080-5081 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T678 | 5115-5119 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T679 | 5115-5119 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
T680 | 5189-5196 | http://purl.obolibrary.org/obo/NCBITaxon_9479 | denotes | monkeys |
T681 | 5265-5272 | http://purl.obolibrary.org/obo/NCBITaxon_9479 | denotes | monkeys |
T682 | 5457-5460 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T683 | 5497-5500 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
T684 | 5501-5509 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T685 | 5589-5592 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T686 | 5593-5594 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T687 | 5645-5648 | http://purl.obolibrary.org/obo/CLO_0002199 | denotes | CAR |
T688 | 5649-5656 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
T689 | 5668-5671 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T690 | 5762-5765 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
T691 | 5771-5776 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T692 | 5793-5800 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cell |
T693 | 5953-5956 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T694 | 6051-6058 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cell |
T695 | 6156-6163 | http://purl.obolibrary.org/obo/CLO_0009985 | denotes | focused |
T696 | 6179-6180 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T697 | 6195-6203 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
T698 | 6252-6260 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T291 | 742-747 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T292 | 1179-1181 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T294 | 1193-1195 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T296 | 1394-1398 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T297 | 1861-1863 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
T81162 | 2062-2069 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
T71004 | 3048-3050 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
T92218 | 3413-3415 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T12622 | 3700-3707 | Chemical | denotes | ligands | http://purl.obolibrary.org/obo/CHEBI_52214 |
T31754 | 3940-3948 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T57638 | 4073-4080 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T24473 | 4623-4625 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T12770 | 4779-4781 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T51865 | 4885-4887 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T29785 | 5097-5099 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T88235 | 5213-5215 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T55189 | 5333-5335 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T97929 | 5437-5439 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T22 | 5532-5534 | Chemical | denotes | GM | http://purl.obolibrary.org/obo/CHEBI_74120 |
T73813 | 5988-5997 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
1401 | 363-368 | Gene | denotes | NKG2A | Gene:3821 |
1402 | 391-396 | Gene | denotes | IFN-γ | Gene:3458 |
1403 | 79-89 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1404 | 222-230 | Species | denotes | patients | Tax:9606 |
1405 | 245-255 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1406 | 159-167 | Disease | denotes | COVID-19 | MESH:C000657245 |
1407 | 231-239 | Disease | denotes | infected | MESH:D007239 |
1408 | 505-513 | Disease | denotes | COVID-19 | MESH:C000657245 |
1409 | 591-597 | Disease | denotes | cancer | MESH:D009369 |
1422 | 1179-1183 | Gene | denotes | IL-2 | Gene:3558 |
1423 | 1193-1198 | Gene | denotes | IL-15 | Gene:3600 |
1424 | 934-939 | Species | denotes | human | Tax:9606 |
1425 | 1107-1115 | Species | denotes | patients | Tax:9606 |
1426 | 1117-1125 | Species | denotes | Patients | Tax:9606 |
1427 | 1458-1466 | Species | denotes | patients | Tax:9606 |
1428 | 1755-1763 | Species | denotes | patients | Tax:9606 |
1429 | 1892-1900 | Species | denotes | patients | Tax:9606 |
1430 | 1327-1335 | Disease | denotes | COVID-19 | MESH:C000657245 |
1431 | 1449-1457 | Disease | denotes | COVID-19 | MESH:C000657245 |
1432 | 1586-1592 | Disease | denotes | cancer | MESH:D009369 |
1433 | 1746-1754 | Disease | denotes | COVID-19 | MESH:C000657245 |
1450 | 2281-2285 | Gene | denotes | EGFR | Gene:1956 |
1451 | 2567-2570 | Gene | denotes | CAR | Gene:653108 |
1452 | 2732-2735 | Gene | denotes | CAR | Gene:653108 |
1453 | 2957-2960 | Gene | denotes | CAR | Gene:653108 |
1454 | 2874-2877 | Gene | denotes | CAR | Gene:653108 |
1455 | 2590-2598 | Species | denotes | patients | Tax:9606 |
1456 | 2713-2721 | Species | denotes | patients | Tax:9606 |
1457 | 3028-3036 | Species | denotes | patients | Tax:9606 |
1458 | 2043-2051 | Disease | denotes | COVID-19 | MESH:C000657245 |
1459 | 2244-2250 | Disease | denotes | cancer | MESH:D009369 |
1460 | 2333-2339 | Disease | denotes | cancer | MESH:D009369 |
1461 | 2371-2383 | Disease | denotes | malignancies | MESH:D009369 |
1462 | 2454-2470 | Disease | denotes | viral infections | MESH:D001102 |
1463 | 2583-2589 | Disease | denotes | cancer | MESH:D009369 |
1464 | 2704-2712 | Disease | denotes | COVID-19 | MESH:C000657245 |
1465 | 3019-3027 | Disease | denotes | COVID-19 | MESH:C000657245 |
1525 | 3128-3131 | Gene | denotes | CAR | Gene:653108 |
1526 | 3254-3259 | Gene | denotes | NKG2D | Gene:22914 |
1527 | 3264-3268 | Gene | denotes | ACE2 | Gene:59272 |
1528 | 3413-3418 | Gene | denotes | IL-15 | Gene:3600 |
1529 | 3432-3435 | Gene | denotes | CAR | Gene:653108 |
1530 | 3451-3455 | Gene | denotes | ACE2 | Gene:59272 |
1531 | 3456-3459 | Gene | denotes | CAR | Gene:653108 |
1532 | 3478-3483 | Gene | denotes | NKG2D | Gene:22914 |
1533 | 3484-3488 | Gene | denotes | ACE2 | Gene:59272 |
1534 | 3489-3492 | Gene | denotes | CAR | Gene:653108 |
1535 | 3503-3507 | Gene | denotes | NKG2 | Gene:3821 |
1536 | 3509-3512 | Gene | denotes | CAR | Gene:653108 |
1537 | 3657-3662 | Gene | denotes | NKG2D | Gene:22914 |
1538 | 3694-3699 | Gene | denotes | NKG2D | Gene:22914 |
1539 | 3709-3715 | Gene | denotes | NKG2DL | Gene:3821 |
1540 | 3823-3827 | Gene | denotes | ACE2 | Gene:59272 |
1541 | 3982-3985 | Gene | denotes | CAR | Gene:653108 |
1542 | 4067-4072 | Gene | denotes | spike | Gene:43740568 |
1543 | 4101-4105 | Gene | denotes | ACE2 | Gene:59272 |
1544 | 4184-4188 | Gene | denotes | ACE2 | Gene:59272 |
1545 | 4578-4581 | Gene | denotes | CAR | Gene:653108 |
1546 | 4623-4628 | Gene | denotes | IL-15 | Gene:3600 |
1547 | 4686-4689 | Gene | denotes | CAR | Gene:653108 |
1548 | 4779-4784 | Gene | denotes | IL-15 | Gene:3600 |
1549 | 4885-4890 | Gene | denotes | IL-15 | Gene:3600 |
1550 | 5097-5102 | Gene | denotes | IL-15 | Gene:3600 |
1551 | 5213-5218 | Gene | denotes | IL-15 | Gene:3600 |
1552 | 5333-5338 | Gene | denotes | IL-15 | Gene:3600 |
1553 | 5437-5442 | Gene | denotes | IL-15 | Gene:3600 |
1554 | 5532-5538 | Gene | denotes | GM-CSF | Gene:1437 |
1555 | 5552-5556 | Gene | denotes | scFv | Gene:652070 |
1556 | 5762-5765 | Gene | denotes | CD4 | Gene:920 |
1557 | 3426-3430 | Gene | denotes | NKG2 | Gene:3821 |
1558 | 3934-3939 | Gene | denotes | spike | Gene:43740568 |
1559 | 5645-5648 | Gene | denotes | CAR | Gene:653108 |
1560 | 3081-3089 | Species | denotes | patients | Tax:9606 |
1561 | 3216-3221 | Species | denotes | human | Tax:9606 |
1562 | 3616-3626 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1563 | 3875-3885 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1564 | 4709-4717 | Species | denotes | patients | Tax:9606 |
1565 | 5053-5063 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
1566 | 5396-5404 | Species | denotes | patients | Tax:9606 |
1567 | 5623-5631 | Species | denotes | patients | Tax:9606 |
1568 | 3072-3080 | Disease | denotes | COVID-19 | MESH:C000657245 |
1569 | 3566-3572 | Disease | denotes | cancer | MESH:D009369 |
1570 | 3744-3752 | Disease | denotes | infected | MESH:D007239 |
1571 | 3898-3906 | Disease | denotes | infected | MESH:D007239 |
1572 | 4023-4031 | Disease | denotes | infected | MESH:D007239 |
1573 | 4120-4135 | Disease | denotes | viral infection | MESH:D001102 |
1574 | 4264-4272 | Disease | denotes | infected | MESH:D007239 |
1575 | 4702-4708 | Disease | denotes | cancer | MESH:D009369 |
1576 | 4861-4871 | Disease | denotes | toxicities | MESH:D064420 |
1577 | 4941-4972 | Disease | denotes | pulmonary inflammatory diseases | MESH:D011014 |
1578 | 4983-5001 | Disease | denotes | MERS-CoV infection | MESH:D018352 |
1579 | 5149-5167 | Disease | denotes | SARS-CoV infection | MESH:C000657245 |
1580 | 5285-5295 | Disease | denotes | -infection | MESH:D007239 |
1581 | 5387-5395 | Disease | denotes | COVID-19 | MESH:C000657245 |
1582 | 5616-5622 | Disease | denotes | cancer | MESH:D009369 |
1583 | 5705-5713 | Disease | denotes | COVID-19 | MESH:C000657245 |
1587 | 5873-5881 | Species | denotes | patients | Tax:9606 |
1588 | 6181-6188 | Species | denotes | patient | Tax:9606 |
1589 | 5866-5872 | Disease | denotes | cancer | MESH:D009369 |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T72 | 591-597 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
T73 | 1586-1592 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
T74 | 2244-2250 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
T75 | 2333-2339 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
T76 | 2583-2589 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
T77 | 2815-2840 | Phenotype | denotes | cytokine release syndrome | http://purl.obolibrary.org/obo/HP_0033041 |
T78 | 3566-3572 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
T79 | 4702-4708 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
T80 | 5616-5622 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
T81 | 5866-5872 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T139 | 2281-2285 | http://purl.obolibrary.org/obo/GO_0005006 | denotes | EGFR |
T140 | 2454-2470 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infections |
T141 | 4120-4135 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
MyTest
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32655581-32203188-34771743 | 398-401 | 32203188 | denotes | 127 |
32655581-31907401-34771744 | 955-958 | 31907401 | denotes | 158 |
32655581-19383914-34771745 | 1185-1188 | 19383914 | denotes | 159 |
32655581-31266741-34771746 | 1200-1203 | 31266741 | denotes | 160 |
32655581-31214177-34771747 | 1295-1298 | 31214177 | denotes | 161 |
32655581-26155832-34771748 | 2287-2290 | 26155832 | denotes | 163 |
32655581-32023374-34771749 | 2301-2304 | 32023374 | denotes | 164 |
32655581-32023374-34771750 | 2399-2402 | 32023374 | denotes | 164 |
32655581-31790761-34771751 | 2894-2897 | 31790761 | denotes | 165 |
32655581-30651290-34771752 | 3582-3585 | 30651290 | denotes | 166 |
32655581-30026479-34771753 | 3760-3763 | 30026479 | denotes | 167 |
32655581-25833053-34771754 | 4719-4722 | 25833053 | denotes | 168 |
32655581-11742275-34771755 | 4974-4977 | 11742275 | denotes | 169 |
32655581-32460144-34771756 | 5003-5006 | 32460144 | denotes | 170 |
32655581-24642138-34771757 | 5297-5300 | 24642138 | denotes | 171 |
32655581-30463995-34771758 | 5658-5661 | 30463995 | denotes | 172 |
32655581-32350134-34771759 | 5778-5781 | 32350134 | denotes | 173 |
TEST0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32655581-203-210-3171316 | 398-401 | ["32203188"] | denotes | 127 |
32655581-235-242-3171317 | 955-958 | ["31907401"] | denotes | 158 |
32655581-68-75-3171318 | 1185-1188 | ["19383914"] | denotes | 159 |
32655581-83-90-3171319 | 1200-1203 | ["31266741"] | denotes | 160 |
32655581-178-185-3171320 | 1295-1298 | ["31214177"] | denotes | 161 |
32655581-234-241-3171321 | 2287-2290 | ["26155832"] | denotes | 163 |
32655581-231-238-3171322 | 2301-2304 | ["32023374"] | denotes | 164 |
32655581-232-239-3171323 | 2399-2402 | ["32023374"] | denotes | 164 |
32655581-171-178-3171324 | 2894-2897 | ["31790761"] | denotes | 165 |
32655581-79-86-3171325 | 3582-3585 | ["30651290"] | denotes | 166 |
32655581-233-240-3171326 | 3760-3763 | ["30026479"] | denotes | 167 |
32655581-173-180-3171327 | 4719-4722 | ["25833053"] | denotes | 168 |
32655581-236-243-3171328 | 4974-4977 | ["11742275"] | denotes | 169 |
32655581-233-240-3171329 | 5003-5006 | ["32460144"] | denotes | 170 |
32655581-117-124-3171330 | 5297-5300 | ["24642138"] | denotes | 171 |
32655581-177-184-3171331 | 5658-5661 | ["30463995"] | denotes | 172 |
32655581-226-233-3171332 | 5778-5781 | ["32350134"] | denotes | 173 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32655581-32203188-34771743 | 398-401 | 32203188 | denotes | 127 |
32655581-31907401-34771744 | 955-958 | 31907401 | denotes | 158 |
32655581-19383914-34771745 | 1185-1188 | 19383914 | denotes | 159 |
32655581-31266741-34771746 | 1200-1203 | 31266741 | denotes | 160 |
32655581-31214177-34771747 | 1295-1298 | 31214177 | denotes | 161 |
32655581-26155832-34771748 | 2287-2290 | 26155832 | denotes | 163 |
32655581-32023374-34771749 | 2301-2304 | 32023374 | denotes | 164 |
32655581-32023374-34771750 | 2399-2402 | 32023374 | denotes | 164 |
32655581-31790761-34771751 | 2894-2897 | 31790761 | denotes | 165 |
32655581-30651290-34771752 | 3582-3585 | 30651290 | denotes | 166 |
32655581-30026479-34771753 | 3760-3763 | 30026479 | denotes | 167 |
32655581-25833053-34771754 | 4719-4722 | 25833053 | denotes | 168 |
32655581-11742275-34771755 | 4974-4977 | 11742275 | denotes | 169 |
32655581-32460144-34771756 | 5003-5006 | 32460144 | denotes | 170 |
32655581-24642138-34771757 | 5297-5300 | 24642138 | denotes | 171 |
32655581-30463995-34771758 | 5658-5661 | 30463995 | denotes | 172 |
32655581-32350134-34771759 | 5778-5781 | 32350134 | denotes | 173 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T302 | 0-22 | Sentence | denotes | NK Cell-Based Products |
T303 | 23-194 | Sentence | denotes | In the absence of a clinically approved vaccine against SARS-CoV-2, scientists have begun developing therapeutics to halt the spread of COVID-19 by alternative strategies. |
T304 | 195-413 | Sentence | denotes | Studies have reported that patients infected with SARS-CoV-2 have lower levels of circulating NK cells and these express a greater level of inhibitory receptors (e.g., NKG2A) while producing less IFN-γ (127, 129, 130). |
T305 | 414-514 | Sentence | denotes | These findings provide a rationale for pursuing NK cell-based therapies as a tool to fight COVID-19. |
T306 | 515-683 | Sentence | denotes | Although NK cell-based therapies have mostly been developed for use against cancer, similar concepts and mechanisms could provide guidance in the fight against viruses. |
T307 | 684-960 | Sentence | denotes | Therapeutic NK cell products can be thought of as “living drugs” as they generally use either primary NK cells isolated from peripheral blood mononuclear cells (PBMCs) or are generated from stem cell precursors or genetically engineered immortalized human NK cell lines (158). |
T308 | 961-1116 | Sentence | denotes | Primary NK cell products are often pre-treated and expanded in vitro with cytokines or via co-culture with target cells before being infused into patients. |
T309 | 1117-1356 | Sentence | denotes | Patients can also receive immune stimulants [e.g. recombinant IL-2 (159) or IL-15 (160)] with the goal of improving the in vivo activity and persistence of the NK cell products (161) as is being tested in this COVID-19 trial (NCT04344548). |
T310 | 1357-1613 | Sentence | denotes | The first cell-based investigational drug to be approved by the FDA for clinical testing in COVID-19 patients is an allogeneic, off-the-shelf, cryopreserved NK cell therapy made by Celularity (CYNK-001), originally developed for cancer immunotherapy (162). |
T311 | 1614-1663 | Sentence | denotes | The trial (NCT04365101) is split into two Phases. |
T312 | 1664-1839 | Sentence | denotes | Phase I will assess the frequency and severity of adverse events in mild, non-ICU COVID-19 patients (n = 14) following infusion of NK cells derived from placental CD34+ cells. |
T313 | 1840-1963 | Sentence | denotes | The subsequent Phase II trial will recruit up to 72 patients and include a standard of care comparator at a 1:1 allocation. |
T314 | 1964-2052 | Sentence | denotes | Genetically modified NK cells are also being investigated for efficacy against COVID-19. |
T315 | 2053-2404 | Sentence | denotes | Chimeric antigen receptor NK cells (CAR-NK cells) are engineered to express virtually any receptor(s) of interest and were originally designed to enhance the ability of NK cells to eliminate cancer cells via receptors targeting EGFR (163) or CD19 (164), which are present on many cancer types and B cell hematological malignancies, respectively (164). |
T316 | 2405-2722 | Sentence | denotes | Although the efficacy of CAR-NK cells to control viral infections has yet to be rigorously tested in large scale clinical trials, the promising safety profile of CAR-NK cells in cancer patients, who are often immunocompromised, suggests that CAR-NK therapy can be well-tolerated in early phase/mild COVID-19 patients. |
T317 | 2723-2899 | Sentence | denotes | Notably, CAR-NK cells are considered “safe” largely because they are less likely to lead to cytokine release syndrome (CRS), a severe adverse event of CAR-T cell therapy (165). |
T318 | 2900-3037 | Sentence | denotes | But as these are unchartered waters, it is critical that CAR-NK cells are used cautiously and not given to late/severe COVID-19 patients. |
T319 | 3038-3288 | Sentence | denotes | A Phase I/II study in early stage COVID-19 patients (within 14 days of illness) employing CAR-NK cell therapy is currently being tested using off-the-shelf NK cells derived from human umbilical cord blood expressing NKG2D and ACE2 CARs (NCT04324996). |
T320 | 3289-3502 | Sentence | denotes | This complex five-arm study will compare the efficacy of different CAR-NK constructs: (i) NK cells, (ii) NK cells secreting IL-15, (iii) NKG2D CAR-NK cells, (iv) ACE2 CAR-NK cells, and (v) NKG2D-ACE2 CAR-NK cells. |
T321 | 3503-3765 | Sentence | denotes | NKG2D CAR-NK cells have shown promising preclinical results in cancer studies (166), and although not proven for SARS-CoV-2, the rationale for expressing NKG2D derives from work showing that NKG2D-ligands (NKG2DL) are upregulated on virally infected cells (167). |
T322 | 3766-4136 | Sentence | denotes | Similarly, the investigators hypothesize that expressing ACE2 on NK cells will facilitate the elimination of SARS-CoV-2 virions and infected cells by binding the viral spike proteins–but it is unknown whether or not CAR-NK cells can eliminate virions or if infected cells display sufficient levels of spike protein to be recognized by ACE2-NK cells upon viral infection. |
T323 | 4137-4338 | Sentence | denotes | The investigators also suggest that expressing ACE2 on NK cells may also have a secondary benefit as a decoy cell that will be infected by the virus thereby indirectly protecting lung epithelial cells. |
T324 | 4339-4545 | Sentence | denotes | As described previously, it is unclear whether this strategy will work to stop viral spread to healthy epithelial cells or if it will serve to perpetuate viral spread if the virus can replicate in NK cells. |
T325 | 4546-4724 | Sentence | denotes | In arms ii-v of this trial, the CAR-NK cells have been engineered to secrete IL-15 based on studies showing improved in vivo persistence of CAR-NK cells in cancer patients (168). |
T326 | 4725-5064 | Sentence | denotes | However, the addition of the proinflammatory cytokine IL-15 to this treatment strategy should be monitored closely for life-threatening toxicities, as elevated IL-15 has been previously reported to accompany chronic pulmonary inflammatory diseases (169) and MERS-CoV infection (170) even if no correlation has been reported for SARS-CoV-2. |
T327 | 5065-5302 | Sentence | denotes | Interestingly, a study compared IL-15 levels from lung tissue homogenates following SARS-CoV infection in aged vs. juvenile monkeys and showed that IL-15 concentrations were only elevated in juvenile monkeys 10 days post-infection (171). |
T328 | 5303-5480 | Sentence | denotes | This study would suggest that IL-15 therapy may be tolerated and effective in older COVID-19 patients that may not be able to produce IL-15, however this has not been confirmed. |
T329 | 5481-5783 | Sentence | denotes | Lastly, all the CAR-NK cells in this trial secrete GM-CSF neutralizing scFv antibodies, since this cytokine has a known role in CRS in cancer patients treated with CAR-T cells (172), and has been shown to be correlated with COVID-19 disease severity in association with pathogenic CD4+ Th1 cells (173). |
T330 | 5784-6006 | Sentence | denotes | Although NK cell based therapies are versatile, have shown safety and efficacy in cancer patients, and can be utilized in immunocompromised individuals, their potential has yet to be fully realized as an antiviral therapy. |
T331 | 6007-6128 | Sentence | denotes | Furthermore, the logistics of manufacturing NK cell products (cost and time) may pose limitations and barriers to access. |
T332 | 6129-6261 | Sentence | denotes | For this reason, therapies focused on stimulating a patient's own NK cells offer many advantages over adoptive transfer of NK cells. |