PMC:7324763 / 43411-47828 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7324763","sourcedb":"PMC","sourceid":"7324763","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7324763","text":"Table 2 List of COVID-19 clinical trials investigating immunotherapies for mitigating immunopathology.\nCategory Therapeutic(s) Trial identifier Phase Location (centers) Patients (n) Study eligibility Mechanism of action(s)\nAnti-cytokine therapy\n      Anti IL-6 Tocilizumab NCT04315480 II Italy 38 Pneumatic COVID19+ Anti-IL6R mAB to prevent virus-related cytokine storm and reduce symptoms of severe COVID-19\nTocilizumab NCT04317092 II Italy (27) 400 Pneumatic COVID19+\nTocilizumab NCT04320615 III Not listed 330 Pneumatic COVID19+\nTocilizumab NCT04332913 N/A Italy 30 Pneumatic COVID19+\nTocilizumab NCT04335071 II Switzerland (3) 100 Pneumatic COVID19+\nTocilizumab NCT04322773 II Denmark (2) 200 Pneumatic COVID19+ I.V. vs. S.C. routes of administration\nTocilizumab NCT04331795 II Illinois, USA 50 COVID19+, not on ventilator Low (80mg) vs. standard dose (200mg) in non-critically ill patients\nTocilizumab NCT04346355 II Italy (24) 398 Pneumatic COVID19+, non-ICU Early administration of tocilizumab on reduced ventilation time\nTocilizumab NCT04331808 II Paris, France 240 Group 1: non-ICU; Group 2: ICU\nTocilizumab (vs. CRRT) NCT04306705 N/A Hubei, China 120 Pneumatic COVID19+ CRRT = continuous renal replacement therapy\nTocilizumab (vs. Anakinra) NCT04339712 II Greece (17) 20 Pneumatic COVID19+, non-ICU Anakinra - IL1r antagonist\nTocilizumab (vs. GNS651) NCT04333914 II France (4) 273 Pneumatic COVID19+ Efficacy in COVID19+ advanced or metastatic cancer patients; GNS651 = chloroquine analog\nSarilumab NCT04315298 II/III USA (57) 400 Pneumatic COVID19+ Low vs. high dose of sarilumab\nSarilumab NCT04324073 II/III France (4) 239 Group 1: non-ICU; Group 2: ICU\nSarilumab NCT04327388 II/III Canada+France (8) 300 Pneumatic COVID19+\nHydroxychloroquine + Axithromycin ± Tocilizumab NCT04332094 II Barcelona, Spain 276 Early COVID19+, not on ventilator\nTocilizumab + Favipiravir NCT04310228 N/A China (11) 150 COVID19+\nTocilizumab + Anakinra + Siltuximab NCT04330638 III Belgium (9) 342 Pneumatic COVID19+ Anakinra - IL1r antagonist and Siltuximab - IL6r antagonist\n      Anti-IL-8 Anti-IL-8 (BMS-986253) NCT04347226 II New York, USA 138 Pneumatic COVID19+ Prevent recruitment of inflammatory cells\n      Anti IL-1R/Anti IFNγ Anakinra vs. Emapalumab NCT04324021 II/III Italy (4) 54 Pneumatic COVID19+ Anakinra (IL1r antagonist); Emapalumab (anti-IFNγ)\nAnakinra ± Ruxolitinib NCT04366232 II France (3) 54 Severe COVID19+\n      Anti-GM-CSF Mavrilimumab NCT04337216 II Virginia, USA 10 Pneumatic COVID19+ GM-CSF is one of the main mediators of CRS in severe COVID19 patients\n      Jak Inhibitor Baricitinib NCT04399798 II Pavia, Italy 13 Pneumatic COVID19+ Inhibits JAK1-/JAK2-mediated cytokine release and TNF-alpha\nRitonavir ± Baricitinib NCT04320277 III Tuscany, Italy 60 Moderate/pneumonia COVID19+\n      Extracorporeal adsorption CytoSorb absorber NCT04324528 N/A Freiburg, Germany 30 Pneumatic COVID19+ “Absorbs” IL-6 in effort to reduce inflammation in ARDS patients\nAnti-inflammatories\n      Corticosteroid Ciclesonide ± Hydroxychloroquine NCT04330586 II Seoul, Korea 141 Early COVID19+ (within 7 days) Ciclesonide is an anti-inflammatory corticosteroid\nPrednisone NCT04344288 II Bron, France 304 Pneumatic COVID19+ Prednisone is an anti-inflammatory corticosteroid\nHydrocortisone NCT04348305 III Denmark 1000 Pneumatic COVID19+ Low-dose hydrocortisone for 7 days\nDexamethasone NCT04344730 N/A Paris, France 550 COVID19+ ICU within 48hrs Dexamethasone is an anti-inflammatory corticosteroid\nDexamethasone NCT04325061 IV Spain (24) 200 Severe COVID19+ on ventilator\nDexamethasone NCT04327401 III Brazil (21) 290 ARDS patients\nMethylprednisolone NCT04343729 II Brazil 420 Pneumatic COVID19+ Methylprednisolone is an anti-inflammatory corticosteroid\nMethylprednisolone (vs. Tocilizumab) NCT04345445 III Kuala Lumpur, Malaysia 310 COVID19+ with high risk of CRS\nMethylprednisolone (vs. Siltuximab) NCT04329650 II Barcelona, Spain 200 Pneumatic COVID19+\n      NSAID Naproxen NCT04325633 III Paris, France 584 Pneumatic COVID19+ COX-2 inhibitor\nIbuprofen NCT04334629 IV Not listed 230 NEWS2 \u003e 5 overall, Pneumatic\nNEWS, National Early Warning Score; HCW, Healthcare Workers; As of June 1, 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